Maharaja Ganga Singh University
Bikaner, India

Maharaja Ganga Singh University , formerly University of Bikaner , is a university located in Bikaner in the state of Rajasthan, India. The university was established in 2003 and marks an important milestone in the evolution of tertiary education in Rajasthan. The University of Bikaner strives through teaching and research to achieve a better understanding of the unique issues affecting the local region. Wikipedia.

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Singh H.P.,Dasmesh Institute of Research and Dental science | Shetty S.,Dental College and Research Center | Patil P.,Malla Reddy Institute of Dental science | Sethi N.,Desh Bhagat Dental College and Hospital | And 2 more authors.
Journal of Clinical and Diagnostic Research | Year: 2014

Background: WHO has recently renamed odontogenic keratocyst as keratocystic odontogenic tumour (KCOT) depending on its tumour like behaviour. Aim: To quantitate and qualitate different types of collagen fibers in KCOT using picrosirius red stain under polarising microscopy and to correlate with different radiographic patterns of KCOT to elucidate its biological behaviour in order to determine whether all KCOTs behave like a tumour. Materials and Methods: Sixty histopathologically confirmed cases of KCOT were selected and stained histochemically using picrosirius red and examined under polarising microscope to evaluate colour of collagen fibers in the wall. Radiographic analysis of all the cases were also carried out and correlated with type of collagen of fibers. Results: Greenish yellow collagen fibers were present statistically significantly more in multilocular KCOT and KCOT with multiple radiolucencies (both syndromic and non-syndromic) as compare to unilocular whereas orange red were significantly more in unilocular variety. Syndromic variety showed significantly higher number of greenish yellow collagen fibers than non-syndromic variety. Conclusion: Quality, organization and packing of collagen fibers of unilocular type is different than other radiographic patterns which accounts for difference in biological behaviour of these lesion, so we conclude that aggressive treatment should be reserved for selected cases.

Pareek A.,Mahatma Gandhi Institute | Pareek A.,University of Kota | Vashishtha A.,Maharaja Ganga Singh University | Moin S.,Maharaja Ganga Singh University | Menghani E.,Maharaja Ganga Singh University
International Journal on Algae | Year: 2014

Fluoride is one of the most hazardous problems associated with drinking water. Many areas have been abandoned due to high fluoride content. The state of Rajasthan (India) in particular is facing many problems due to high levels of salts, especially fluoride in ground water. Concentration of fluoride higher than permissible limits may cause impairment of normal functioning in plants and animals. Two oscillatorial species viz Oscillatoria anguina (Bory) Gomond and O. laete-virens (Crouan) Gomond were studied for their fluoride absorption potential. Water samples collected from affected fluoride areas of Jaipur (Rajasthan) were separately treated with different concentrations of unialgal cultures of Oscillatoria. Measurements of pH, chloride, alkanity, BOD, and COD revealed the overall physio-chemistry of both species samples. Twenty-thirty percent (20%-30%) concentrations (w/v) of inoculated Oscillatoria were found to be optimum for fluoride reduction. Fluoride was absorbed up to a certain level of incubation period (132-144 h). Further increase in either the concentration of the inoculants or incubation period did not have any effect. © Begell House Inc., 2014.

Pathak C.,Maharaja Ganga Singh University | Pathak C.,Kab Laboratories Inc. | Ghouri S.K.,Maharaja Ganga Singh University | Kumar S.K.,Maharaja Ganga Singh University | And 2 more authors.
Indian Journal of Animal Sciences | Year: 2015

Haemonchus contortus is an economically important, highly pathogenic blood-sucking nematode parasite of ruminants. A study was conducted to characterize the cathepsin B-like cysteine protease gene of H. contortus of Indian origin, which has been explored as potential target for vaccine development. Adult H. contortus worms were collected from the abomasum of sheep and goats and whole genomic DNA was extracted and amplified using appropriate primers. The expected amplicon of 767 bp was cloned into T-vector using GeNeiTM Instant cloning kit. Immunization study was conducted to examine the effect of cysteine protease fraction on the faecal egg counts in lambs. It was found that the egg per gram of faeces was lower in immunized group as compared to control group (at 10, 11, 12, and 15 week). At post mortem, the worms recovered from the abomasa were lower in immunized group (800.40±101.8) as compared to control group (950.93±300.29). The results indicated that the immunization with cysteine protease fraction in lambs reduces the faecal egg count, but did not remove all the worms from lambs.

Kaur L.,Maharaja Ganga Singh University | Gadgil K.,P.A. College | Sharma S.,Indian Institute of Technology Delhi
Journal of Solid Waste Technology and Management | Year: 2013

The presence of heavy metals in water is wide spreading all over the world. Aquatic plants are being used to remediate heavy metal contaminated wastewater. The present study evaluated the effect of pH on the uptake of nickel from nickel contaminated water by "Common duckweed" (Lemna minor). Lemna minor demonstrated the ability to remove nickel passively by root ab-sorption and bioaccumulation. 10 mg/l nickel was used through out the experiments. Removal was studied in both the acidic and alkaline ranges of pH, maintained by using HCl and NaOH. The results indicated that Lemna minor grows best at pH 6-8 range. Growth of Lemna plants helped in the accumulation of Ni. The removal of nickel was dependent on the pH parameter. Maximum nickel removal was observed at pH 6. The efficiency of common duckweed for nickel removal was 98.8% at pH 6 for 28 days. At pH >8, the nickel ions get precipitated due to hy-droxide anions forming a nickel hydroxide precipitate. Ni accumulation increased with the in-creasing exposure time. The results revealed that duckweed may efficiently be used for the re-moval of nickel from industrial effluents with pH around 6. Copyright © 2013 Widener University.

Harwani D.,Indian Institute of Science | Harwani D.,Maharaja Ganga Singh University | Zangoui P.,Indian Institute of Science | Mahadevan S.,Indian Institute of Science
Journal of Bacteriology | Year: 2012

We report that the bgl operon of Escherichia coli, encoding the functions necessary for the uptake and metabolism of aryl-β-glucosides, is involved in the regulation of oligopeptide transport during stationary phase. Global analysis of intracellular proteins from Bgl-positive (Bgl +) and Bgl-negative (Bgl -) strains revealed that the operon exerts regulation on at least 12 downstream target genes. Of these, oppA, which encodes an oligopeptide transporter, was confirmed to be upregulated in the Bgl + strain. Loss of oppA function results in a partial loss of the growth advantage in stationary-phase (GASP) phenotype of Bgl + cells. The regulatory effect of the bgl operon on oppA expression is indirect and is mediated via gcvA, the activator of the glycine cleavage system, and gcvB, which regulates oppA at the posttranscriptional level. We show that BglG destabilizes the gcvA mRNA in vivo, leading to reduced expression of gcvA in the stationary phase. Deletion of gcvA results in the downregulation of gcvB and upregulation of oppA and can partially rescue the loss of the GASP phenotype seen in ΔbglG strains. A possible mechanism by which oppA confers a competitive advantage to Bgl + cells relative to Bgl - cells is discussed. © 2012, American Society for Microbiology.

Gupta S.,Maharaja Ganga Singh University | Sawal R.,Swami Keshwanand Institute of Pharmacy
Journal of Chemical and Pharmaceutical Research | Year: 2013

Lime stone is the most common type of rock found on earth's surface. During the process of manufacture, quick lime is produced in many sizes in the kilns. Large sized pieces find use for construction purposes, food processing and many more however, finer fractions find less utility. Such material is mostly dumped for earth filling. Suitability of such waste was evaluated as it was found to be rich source of Calcium. Lime stone processing waste was further processed to find out which fraction could be used to prepare mineral supplement for livestock as it was a rich source of Calcium. As physical attribute of materials affect its solubility and bioavailability of the element. The waste fraction of industry was fractionated into 3 fractions viz with particle size >1 mm, 0.25-1 mm and <0.25 mm. Solubility of each fraction was observed in water and in HCl (0.04N, 0.08N, 0.16N). Salts of Calcium (Calcium Chloride, Rock phosphate, Di Calcium phosphate, Tri Calcium phosphate, Calcium hydroxide and Calcium sulphate) were also tested for their solubility. Solubility of limestone fractions improved with decrease in particle size. Solubility of salts and fractions of limestone waste improved with increase in normality of HCl. Results indicate significant (P≤0.0001) increase in solubility of lime stone fractions in water with decrease in particle size (8.62, 20.20, 32.50%). Increase in solubility increased pH significantly (P≤0.05) from slightly acidic 6.27 with higher particle size to 7.36 with lowest particle size. The results reflect that fractions with lower particle size have an advantage due to their solubility in dilute HCl and even with water as solvent and they have excellent flow property, which could prove useful for preparation of mineral supplements as well ease mixing in the feed mixtures. Thus major fraction out of the limestone waste can find its use as a mineral supplement in the animal feed industry.

Gupta S.,Maharaja Ganga Singh University | Sawal R.,Swami Keshwanand Institute of Pharmacy
Journal of Chemical and Pharmaceutical Research | Year: 2013

An experiment was conducted to evaluate mineral supplement prepared using limestone waste. Limestone waste (dust) available was collected from industries processing Lime. It was sieved with mesh size upto 1 mm and the material was used as source of Calcium for preparation of the mineral supplement. A total of 121.98 kg of mineral supplement was prepared for the feeding trial.Milch animals of similar parity (3-4) were selected from the field area in Bikaner district and supplemented with mineral supplement. The animals were milked twice a day, during morning and evening after interval of 12 hours. In the first phase 8 animals (2 each owned by each farmer) were divided into two groups of 4 each. All the animals were provided a mixed diet of wheat straw and groundnut fodder (1:1) along with Cottonseed cake 5 kg which was soaked in water for 3-4 hours before mixing with equal quantity of dry fodder (wheat straw and groundnut fodder). One animal of each farmer was offered mineral supplement and the other served as control. In the first phase mineral supplement was offered in the treatment group (along with the concentrate) for a period of 56 days. Observations on milk production were recorded daily during the period. The study was continued in second phase with one animal to observe long term effect of the supplement for which one cow was provided mineral supplement for a period of 150 days. Since all the animals were not similar in milk production, fixed quantity of 50g/h/d was given in two equal doses of 25g each. Data reflected that 51.1% of milk was produced during morning and 48.9% during evening milking. Feeding of supplement had a significant effect on milk production per cow. Milk production was sustained at an higher level due to feeding of mineral supplement which otherwise would have decreased due to higher demand of Ca and P for milk secretion. It could be concluded from the studies that cheaper source of Calcium as limestone dust could be used effectively for preparation of mineral supplement. Feeding of mineral supplement containing Lime stone dust did not have any negative effect on animal health. Its feeding consistently improved milk production and sustained it for a long period in cattle. Thus limestone waste could serve as a useful ingredient for production of mineral waste for livestock. Milk production was similar at the start of experiment. Differences in milk production were observed which increased gap among the groups. Significantly higher (P≤0.01) milk production was observed in animals supplemented with mineral mixture. Week had a significant effect on milk production per cow. Milk production was sustained at a higher level due to feeding of mineral supplement which otherwise would have decreased due to higher demand of Ca and P for milk secretion. Data reflected that 51.1% of milk was produced during morning and 48.9% during evening milking. To study the long term effect of mineral supplementation observations on milk production were recorded for nearly 150 days with one farmer. It was observed that milk production follows a zig zag curve. Considering that the management factors were optimized, results on long term feeding of supplement containing lime stone waste indicated that milk production could be sustained for a long period as it dropped slowly to a tune of 0.006kg/d after obtaining peak, thus reflecting that it had positive effect.

Harwani D.,Maharaja Ganga Singh University
International Journal of Pharma and Bio Sciences | Year: 2013

The continuous use of fuels like petroleum is recognized as unsustainable because of their natural exhaustion and contribution to the pollution in the environment. Not only for the environmental perspective but also for the economic sustainability, we necessarily need to develop alternative, renewable and pollution free fuels. Harvesting energy from the sun (solar energy), earth (geothermal energy), water (hydropower), or wind are few of the alternative and renewable energy sources. It has been well appreciated that fuels, such as ethanol, butanol, methane and hydrogen can be produced by microorganisms. But by using bacteria in a microbial fuel cell (MFC), electricity can be extracted from wastewater, converting organic material in the waste water to electricity using bacteria, leaving behind clean drinking water in the process (bacteria are appreciated as electricigens). Harvesting electricity with microbial fuel cells can proficiently convert organic wastes, renewable biomass and even mud into electricity and harmless byproducts. This capability offers the potential for using bacteria (or their components) to generate electricity at low cost while transforming industrial, domestic, and farm toxic pollution. This is an exciting aspect for human kind around the world who lacks adequate sanitation and resources to clean up toxic waste. Though the MFC technology is not yet well developed to produce substantial quantities of energy in a cost effective way, the area reviewed in the present communication requires more research and is highly prospective.

PubMed | Maharaja Ganga Singh University
Type: Journal Article | Journal: Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] | Year: 2015

Bacteria have evolved various mechanisms to extract utilizable substrates from available resources and consequently acquire fitness advantage over competitors. One of the strategies is the exploitation of cryptic cellular functions encoded by genetic systems that are silent under laboratory conditions, such as the bgl (-glucoside) operon of E. coli. The bgl operon of Escherichia coli, involved in the uptake and utilization of aromatic -glucosides salicin and arbutin, is maintained in a silent state in the wild type organism by the presence of structural elements in the regulatory region. This operon can be activated by mutations that disrupt these negative elements. The fact that the silent bgl operon is retained without accumulating deleterious mutations seems paradoxical from an evolutionary view point. Although this operon appears to be silent, specific physiological conditions might be able to regulate its expression and/or the operon might be carrying out function(s) apart from the utilization of aromatic -glucosides. This is consistent with the observations that the activated operon confers a Growth Advantage in Stationary Phase (GASP) phenotype to Bgl(+) cells and exerts its regulation on at least twelve downstream target genes.

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