Mafraq Hospital

Abu Dhabi, United Arab Emirates

Mafraq Hospital

Abu Dhabi, United Arab Emirates
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Raufi M.A.,Mafraq Hospital | Baig A.S.,Mafraq Hospital
Reviews in Cardiovascular Medicine | Year: 2014

Coronary artery fistulae and coronary cameral fistulae are rare anomalies that are discovered incidentally in patients undergoing coronary angiography. This article reviews the classification, management, and complications of these fistulae, and discusses a variety of presentations. © 2014 MedReviews®, LLC.

Malik A.,Mafraq Hospital | El Masry K.M.,Mafraq Hospital | Ravi M.,Mafraq Hospital | Sayed F.,Mafraq Hospital
Emerging Infectious Diseases | Year: 2016

As of June 19, 2015, the World Health Organization had received 1,338 notifications of laboratory-confirmed infection with Middle East respiratory syndrome coronavirus (MERS-CoV). Little is known about the course of or treatment for MERS-CoV in pregnant women. We report a fatal case of MERS-CoV in a pregnant woman administered combination ribavirin-peginterferon-α therapy. © 2016, Centers for Disease Control and Prevention (CDC). All rights reserved.

Ali N.A.,Mafraq Hospital
BMJ case reports | Year: 2013

We present a female patient in her late 30s, with baseline vegetative state following prior traumatic brain injury, who presented with prolonged right hemispheric status epilepticus. The neuroimaging revealed a striking right-sided pancortical oedema with left (crossed) cerebellar diaschisis and dilation of right hemispheric arteries. EEG was concordant and showed nearly continuous right hemispheric seizure discharges with suppressed background. Infective and vascular aetiologies were ruled out. The patient showed clinical and electrographic improvement following treatment with antiepileptic drugs. Unilateral cerebral oedema is a rare presentation of focal status epilepticus, and should be considered as a differential diagnosis in the appropriate clinical scenario.

Pretzel D.,University Hospital Jena | Pretzel D.,Friedrich - Schiller University of Jena | Linss S.,University Hospital Jena | Rochler S.,University Hospital Jena | And 4 more authors.
Arthritis Research and Therapy | Year: 2010

Introduction: Mesenchymal stem cells (MSC) are highly attractive for use in cartilage regeneration. To date, MSC are usually recruited from subchondral bone marrow using microfracture. Recent data suggest that isolated cells from adult human articular cartilage, which express the combination of the cell-surface markers CD105 and CD166, are multi-potent mesenchymal progenitor cells (MPC) with characteristics similar to MSC. MPC within the cartilage matrix, the target of tissue regeneration, may provide the basis for in situ regeneration of focal cartilage defects. However, there is only limited information concerning the presence/abundance of CD105+/CD166+MPC in human articular cartilage. The present study therefore assessed the relative percentage and particularly the zonal distribution of cartilage MPC using the markers CD105/CD166.Methods: Specimens of human osteoarthritic (OA; n = 11) and normal (n = 3) cartilage were used for either cell isolation or immunohistochemistry. Due to low numbers, isolated cells were expanded for 2 weeks and then analyzed by flow cytometry (FACS) or immunofluorescence in chamber slides for the expression of CD105 and CD166. Following immunomagnetic separation of CD166+/-OA cells, multi-lineage differentiation assays were performed. Also, the zonal distribution of CD166+cells within the matrix of OA and normal cartilage was analyzed by immunohistochemistry.Results: FACS analysis showed that 16.7 ± 2.1% (mean ± SEM) of OA and 15.3 ± 2.3 of normal chondrocytes (n.s.) were CD105+/CD166+and thus carried the established MPC marker combination. Similarly, 13.2% ± 0.9% and 11.7 ± 2.1 of CD105+/CD166+cells, respectively, were identified by immunofluorescence in adherent OA and normal chondrocytes. The CD166+enriched OA cells showed a stronger induction of the chondrogenic phenotype in differentiation assays than the CD166+depleted cell population, underlining the chondrogenic potential of the MPC. Strikingly, CD166+cells in OA and normal articular cartilage sections (22.1 ± 1.7% and 23.6% ± 1.4%, respectively; n.s.) were almost exclusively located in the superficial and middle zone.Conclusions: The present results underline the suitability of CD166 as a biomarker to identify and, in particular, localize and/or enrich resident MPC with a high chondrogenic potential in human articular cartilage. The percentage of MPC in both OA and normal cartilage is substantially higher than previously reported, suggesting a yet unexplored reserve capacity for regeneration. © 2011 Pretzel et al.; licensee BioMed Central Ltd.

Al Sayari S.,University of Basel | Al Sayari S.,Mafraq Hospital | Kopp S.,University of Basel | Bremerich J.,University of Basel
Radiologic Clinics of North America | Year: 2015

Stress cardiac magnetic resonance imaging can provide valuable information for the diagnosis and management of ischemic heart disease (IHD). It plays an important role in the initial diagnosis in patients with acute chest pain, in the diagnosis of complications post myocardial infarction (MI), in the assessment of the right ventricle after an acute MI, to detect complications due to or after interventions, in prediction of myocardial recovery, to detect inducible ischemia in patients with known IHD, in differentiating ischemic from non-ischemic dilated cardiomyopathy, and in risk stratification. © 2015 Elsevier Inc.

Khan K.Z.,Manchester Medical School | Khan K.Z.,Mafraq Hospital | Gaunt K.,Lancashire Teaching Hospitals NHS Trust | Ramachandran S.,Lancashire Teaching Hospitals NHS Trust | Pushkar P.,Aintree University Hospitals Trust
Medical Teacher | Year: 2013

The organisation, administration and running of a successful OSCE programme need considerable knowledge, experience and planning. Different teams looking after various aspects of OSCE need to work collaboratively for an effective question bank development, examiner training and standardised patients' training. Quality assurance is an ongoing process taking place throughout the OSCE cycle. In order for the OSCE to generate reliable results it is essential to pay attention to each and every element of quality assurance, as poorly standardised patients, untrained examiners, poor quality questions and inappropriate scoring rubrics each will affect the reliability of the OSCE. The validity will also be influenced if the questions are not realistic and mapped against the learning outcomes of the teaching programme. This part of the Guide addresses all these important issues in order to help the reader setup and quality assure their new or existing OSCE programmes. © 2013 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Richter T.,TU Dresden | Koch T.,TU Dresden | Langer K.-A.,Mafraq Hospital
Journal of Anesthesia | Year: 2012

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an inflammatory disorder of the peripheral nervous system with progressive or relapsing signs in more than one limb, ending in prolonged periods of disability. There are no guidelines for anesthesia in this uncommon paralyzing disease. This report features a 19-year-old woman with CIDP scheduled for an elective cesarean section who had prolonged recovery of motor function after the administration of spinal anesthesia. Although a partial neural block in both feet persisted for 1 day, we conclude that spinal anesthesia is acceptable for cesarean delivery in CIDP-patients when reasonable precautions have been taken. © 2011 Japanese Society of Anesthesiologists.

Vaswani P.R.,Mafraq Hospital | Balachandran L.,Mafraq Hospital
Clinical Epidemiology and Global Health | Year: 2013

Introduction: The prevalence of obesity and overweight in United Arab Emirates (UAE) reaches 39.9% among females and the WHO estimates that obesity prevalence will reach 44.6% among females by the year 2015. Objective: To evaluate the effect of varying degrees of maternal obesity on perinatal outcomes. Methods: Retrospective study of 1985 women grouped into 5 groups according to the body mass index (BMI) measurements in early pregnancy. Group 1 - BMI 18.5-24.9 (normal weight), Group 2 - BMI 25-29.9 (overweight), Group 3 - BMI 30-34.9 (obesity class I), Group 4 - BMI 35-39.9 (obesity class II), Group 5 - BMI 40 or more (obesity class III). The obstetric and perinatal outcomes were compared by creating multiple logistic regression models. Results: Morbidly obese women were about 5 times more likely to develop hypertensive disorders of pregnancy (OR = 4.97, 95% CI, 1.35-18.33, p = 0.016), 4 times more likely to develop gestational diabetes (OR 3.75, 95% CI, 1.83-7.69, p = 0.001), 3 times more likely to deliver post-term (OR 2.99, 95% CI1.35-6.65, p = 0.007), 3 times more at risk of delivering by caesarean section (OR 2.73, 95% CI, 1.61-4.65, p = 0.0001) and at a very high risk of delivering big babies, OR 17.30 (95% CI, 15.48-54.62, p = 0.001). Conclusion: Maternal obesity especially morbid obesity in early pregnancy is strongly associated with a number of obstetrical and perinatal complications. Pregnancies in obese women should be managed as high risk pregnancies with strategies for prevention, early detection and management of complications arising from obesity. © 2012 INDIACLEN.

Galloway G.M.,Ohio State University | Zamel K.,Mafraq Hospital
Pediatric Neurology | Year: 2011

Neurophysiologic intraoperative monitoring, using somatosensory, brainstem auditory, and visual evoked potentials, transcranial electric motor stimulation, and electromyography, is typically used during complex surgeries involving the motor and sensory cortex, brainstem, cranial nerves, spinal cord, nerve root, peripheral roots, brachial plexus, lumbar plexus, and peripheral nerves. The particular type of surgery and the neurologic structures at risk determine the type of monitoring chosen. Although many methods are the same in adult and pediatric patients, some differences in the pediatric population will be discussed here. In general, monitoring consists of two types. The first involves monitoring data which is obtained on an ongoing basis, with comparisons to data obtained at the outset of surgery (baseline). The second form of monitoring involves mapping neural structures, so that a neural structure in the field is identified accurately, to avoid injuring it, or to demonstrate its degree of neurophysiologic function or impairment. In this paper we discuss both forms of monitoring and their general applications, including unique features or modifications needed in the pediatric population. © 2011 Elsevier Inc. All rights.

Khan K.Z.,Manchester Medical School | Khan K.Z.,Mafraq Hospital | Ramachandran S.,Lancashire Teaching Hospitals NHS Trust | Gaunt K.,Lancashire Teaching Hospitals NHS Trust | Pushkar P.,Aintree University Hospitals Trust
Medical Teacher | Year: 2013

The Objective Structured Clinical Examination (OSCE) was first described by Harden in 1975 as an alternative to the existing methods of assessing clinical performance (Harden et al. 1975). The OSCE was designed to improve the validity and reliability of assessment of performance, which was previously assessed using the long case and short case examinations. Since then the use of the OSCE has become widespread within both undergraduate and postgraduate clinical education. We recognise that the introduction of the OSCE into an existing assessment programme is a challenging process requiring a considerable amount of theoretical and practical knowledge. The two parts of this Guide are designed to assist all those who intend implementing the OSCE into their assessment systems. Part I addresses the theoretical aspects of the OSCE, exploring its historical development, its place within the range of assessment tools and its core applications. Part II offers more practical information on the process of implementing an OSCE, including guidance on developing OSCE stations, choosing scoring rubrics, training examiners and standardised patients and managing quality assurance processes. Together we hope these two parts will act as a useful resource both for those choosing to implement the OSCE for the first time and also those wishing to quality assure their existing OSCE programme. © 2013 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

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