Madurai Kamaraj University
Madurai, India

Madurai Kamaraj University is a public university in India located in Madurai city in southern Tamil Nadu, India. It was established in 1966 and has about 130,000 students in 18 schools comprising 72 departments, and 109 affiliated colleges. Wikipedia.

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Sivaraman G.,Madurai Kamaraj University | Chellappa D.,Madurai Kamaraj University
Journal of Materials Chemistry B | Year: 2013

A rhodamine based highly selective colorimetric and fluorescent probe for fluoride has been designed and synthesized. The fluorescent change is attributed to the fluoride triggered spirolactam ring opening which is augmented by density functional theory calculations and 1H NMR titrations. The sensor has been shown to be feasible for real sample analysis, and imaging of fluoride ions in the HeLa cells. © 2013 The Royal Society of Chemistry.

Dhakshinamoorthy A.,Madurai Kamaraj University | Garcia H.,Polytechnic University of Valencia | Garcia H.,King Abdulaziz University
Chemical Society Reviews | Year: 2014

Metal-organic frameworks (MOFs) are finding increasing application as solid catalysts for liquid phase reactions leading to the synthesis of fine chemicals. In the present review we have focused on those reports describing the use of MOFs as catalysts for the synthesis of N-containing heterocycles that is a class of organic compounds with high added value due to their therapeutic use as drugs and their remarkable biological activities. After an introduction describing relevant structural features of MOFs and the nature of their active sites, this manuscript is organized according to the type of N-containing heterocycle synthesized employing MOFs as catalysts including pyrimidines, N-substituted piperidines, quinolines, indoles, N-substituted imidazoles, triazoles and heterocyclic amides. Special attention has been paid to the structural stability of MOFs under the reaction conditions, to the occurrence of metal leaching and reusability. The final section of this review provides some concluding remarks and future prospects for the field, with emphasis on showing the superiority of MOFs with respect to other solid catalysts for this type of liquid phase organic reactions and pointing out that the final goal in this research would be the use of these materials as catalysts in real industrial synthesis. This journal is © the Partner Organisations 2014.

Navalon S.,Polytechnic University of Valencia | Dhakshinamoorthy A.,Madurai Kamaraj University | Alvaro M.,Polytechnic University of Valencia | Garcia H.,Polytechnic University of Valencia | Garcia H.,King Abdulaziz University
Chemical Reviews | Year: 2014

Carbons with large surface area such as active carbons and carbon black powders have since ever been considered as supports to deposit transition metals that were the relevant catalytic centers. In this type of materials the role of carbon is to disperse the metal on a very large surface area and maybe in the best case also adsorb reactants near the metal particles. In the case of carbocatalysts the key point is to incorporate the active sites into the carbon by suitable modifications, making metals unnecessary. The main purpose of the present review is to show the advantages and possibilities that G-mat offer in catalysis due to their 2D morphology and to the possibility of introducing heteroatoms and functional groups on the G sheet in such a way that they can act as catalytic center. Nevertheless, CVD techniques require specialized equipment and are still not routine in most of catalytic laboratories.

Namitharan K.,Madurai Kamaraj University | Pitchumani K.,Madurai Kamaraj University
Organic Letters | Year: 2011

A novel one-pot azide-alkyne/ketenimine-nitrone cycloaddition sequence that is induced by copper(I) and allows the transformation of sulfonyl azides, alkynes, and nitrones to highly substituted imidazolidin-4-ones is described. The corresponding heterogeneous version utilizing Cu(I)-modified zeolites as recyclable heterogeneous catalysts shows marginally improved yield and diastereoselectivity. © 2011 American Chemical Society.

Puthiaraj P.,Madurai Kamaraj University | Pitchumani K.,Madurai Kamaraj University
Chemistry - A European Journal | Year: 2014

The synthesis of a novel mesoporous covalent imine polymeric (MCIPs) material, involving simple Schiff-base chemistry, is reported. This highly functionalised nitrogen-rich material acts as a good support for immobilising CuII ions, exhibiting excellent catalytic activity in promoting the Chan-Lam cross-coupling reaction between biologically active amines and arylboronic acids. The performance of this catalyst is also evident from its broad substrate scope, high stability, real heterogeneity, mild reaction conditions and reusability without loss of activity. The observed results will provide additional scope on the design and catalytic applications of this emerging class of materials. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Pushpanathan M.,Madurai Kamaraj University
Protein and peptide letters | Year: 2012

A novel antifungal peptide with 36 amino acids was identified by functional screening of a marine metagenomic library. The peptide did not show similarity with any existing antimicrobial peptide sequences in the databank. The108 bp ORF designated as mmgp1 was cloned and expressed in Escherichia coli BL21 (DE3) using pET expression system. Mass spectrometry analysis of the purified recombinant peptide revealed a molecular mass of 5026.9 Da. The purified recombinant peptide inhibited the growth of Candida albicans and Aspergillus niger. The peptide was predicted to adopt α- helical conformation with an extended coil containing a ligand binding site for N-acetyl-D-glucosamine. The α- helicity of the peptide was demonstrated by circular dichroism spectroscopy in the presence of chitin or membrane mimicking solvent, trifluoroethanol. The chitin binding property of the peptide was also confirmed by fast performance liquid chromatography.

Puthiaraj P.,Madurai Kamaraj University | Pitchumani K.,Madurai Kamaraj University
Green Chemistry | Year: 2014

A novel class of mesoporous covalent organic polymer (MCOP) was synthesised by the nucleophilic substitution of cyanuric chloride with 4,4′- dihydroxybiphenyl. The MCOP was fully characterized using powder X-ray diffraction analysis, Fourier transform infrared spectroscopy, 13C-solid state NMR spectroscopy, field emission scanning electron microscopy and thermogravimetric analysis. These nitrogen rich materials act as good supports for palladium nanoparticles (Pd NPs) and exhibit excellent catalytic activity towards Mizoroki-Heck cross coupling between aryl bromides and alkenes. Hot filtration tests demonstrate that the presence of the triazine rings on the polymers is beneficial for enhancing the stability of Pd NPs. The polymers are also cheap, easy to synthesise and can be recycled up to five times with only a minor loss of activity. © the Partner Organisations 2014.

Gnana Kumar G.,Madurai Kamaraj University
Journal of Materials Chemistry | Year: 2011

Montmorillonite supported poly vinylidene fluoride-hexa fluoro propylene composite membranes have been functionalized by an irradiation technique for the application of direct ethanol fuel cells. Structural characterizations of the fabricated membranes are examined by infrared and X-ray photoelectron spectroscopy analyses. The montmorillonite particles reduce porosity and stimulate rough nature to the PVdF-HFP membrane. Thermal stability of the irradiated membranes gets increased by the restricted polymeric segmental motion given via the montmorillonite particles. The ion exchange capacity values purely depend on the grafting degree values whereas water uptake values are influenced by the grafting degree as well as the concentration of montmorillonite particles. Irrespective of the grafting degree values, the adsorbed water molecules dissociate sulfonic acid units in a greater extent and favor ionic conductivity values. Tortuous path ways generated by the montmorillonite particles distort the molecular permeation which in turn results in the lower fuel cross over. By the synergistic combination of irradiation and nanocomposite techniques, demerits of the aforementioned individual techniques have been effectively tackled which in turn results in the extended direct ethanol fuel cell efficiencies of the fabricated fuel cell membranes and emerges its large scale applications. © 2011 The Royal Society of Chemistry.

Dhakshinamoorthy A.,Madurai Kamaraj University | Garcia H.,Madurai Kamaraj University
ChemSusChem | Year: 2014

Cascade or tandem reactions where two or more individual reactions are carried out in one pot constitute a clear example of process intensification, targeting the maximization of spatial and temporal productivity with mobilization of minimum resources. In the case of catalytic reactions, cascade processes require bi-/multifunctional catalysts that contain different classes of active sites. Herein, we show that the features and properties of metal-organic frameworks (MOFs) make these solids very appropriate materials for the development of catalysts for cascade reactions. Due to composition and structure, MOFs can incorporate different types of sites at the metal nodes, organic linkers, or at the empty internal pores, allowing the flexible design and synthesis of multifunctional catalysts. After some introductory sections on the relevance of cascade reactions from the point of view of competitiveness, sustainability, and environmental friendliness, the main part of the text provides a comprehensive review of the literature reporting the use of MOFs as heterogeneous catalysts for cascade reactions including those that combine in different ways acid/base, oxidation/reduction, and metal-organic centers. The final section summarizes the current state of the art, indicating that the development of a first commercial synthesis of a high-added-value fine chemical will be a crucial milestone in this area. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Coronary artery disease (CAD) is a major health concern and the leading cause of death in individuals with type-2 diabetes mellitus (T2DM). Glutathione peroxidase-1 (GPx-1) and NAD(P)H: quinone oxidoreductase (NQO1) are known for its broad range of detoxification. The role of functional variants of these genes in the development of various disorders is proven. Hereby, we investigated the possible role of these variants in the development of CAD in T2DM patients of South Indian population. In this case-control study, a total of 539 patients (T2DM = 241; T2DM-CAD = 298) and 285 controls were included. The C198T GPx-1 and C609T NQO1 single-nucleotide polymorphisms were analyzed by PCR-RFLP. Further, these genotypes were correlated with blood lipid profile. Regression analysis showed that GPx1-C/T genotype is associated with a 1.35-fold increase (95% CI = 1.000-1.824; P = 0.048) and GPx1-T/T genotype is associated with a 1.76-fold increase (95% CI = 1.011 to 3.066; P = 0.046) to the T2DM development. Increased odds ratio showed that NQO1-T/T genotype had a higher occurrence of CAD in diabetic patients with CAD (95% CI = 1.003-2.674, P = 0.049) than T2DM patients without CAD. The level of triglycerides alone showed significant increase for GPx-1-C/T and -T/T genotypes in Tukey's Post hoc analysis (177.1 ± 19.2 vs. 184 ± 23.5; P = 0.039 and 177.1 ± 19.2 vs. 190 ± 22.4; P = 0.006) among the patients with T2DM-CAD. Our work concludes that GPx-1 variants might contribute to the development of diabetes and both GPx-1 and NQO1 variants confirm the association of CAD in people with T2DM of South Indian population.

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