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Archana S.,The Madura College Autonomous | Malarvizhi M.,The Madura College Autonomous | Meenakshi Sundaram M.,Center for Research and Post Graduate Studies in Chemistry
Journal of Materials Science: Materials in Electronics | Year: 2016

In this study, conducting titania@poly(o-phenylenediamine) (TiO2@PoPD) core–shell nanocomposite was prepared by chemical oxidative polymerization method. The core–shell structure of the as-prepared nanocomposite was confirmed by atomic force microscopy, transmission electron microscopy and field emission scanning electron microscopy techniques. The structure of the PoPD and TiO2@PoPD core–shell nanocomposites were confirmed by Fourier transform infrared spectroscopy, ultra violet–visible diffusive reflectance spectroscopy, X-ray diffraction pattern and X-ray photoelectron spectroscopy studies. The photocatalytic efficiency of the TiO2@PoPD core shell nanocomposite was investigated by performing the photodegradation studies of acid orange 7 (AO7) dye under solar light irradiation. Admirable photodegradation efficiency against AO7 was achieved for TiO2@PoPD core shell nanocomposite under solar irradiation. The antibacterial activity of the TiO2@PoPD core shell nanocomposite was also investigated against two different pathogenic bacteria of Gram positive (Bacillus subtills) and Gram negative bacteria (Klebsiellapneumonia) by disc diffusion method. The present investigation concluded that, the TiO2@PoPD core shell nanocomposite exhibits superior photocatalytic and antibacterial property than TiO2 and PoPD materials. © 2016 Springer Science+Business Media New York


Kathiravan V.,The Madura College Autonomous | Panneerselvam N.,The Madura College Autonomous | Palanikumar L.,Ulsan National Institute of Science and Technology
International Journal of Pharma and Bio Sciences | Year: 2015

Marine algae are significant ingredients to formulate drugs for treating disease as they possess various bioactive potentials. This review expansively compares the antiinflammatory compounds from different marine algae. The anti-inflammatory effects of several different crude extracts and pure compounds of algae have been evaluated. Natural products from marine algae have potential resources in discovering anti-inflammatory drugs. These bioactive compounds can be characterized and tested the efficacy of the future use for the public. Research institutions should collaborate with industry in order to design and develop suitably appealing products with these bioactive compounds.


Thenmozhi C.,The Madura College Autonomous | Vignesh V.,Bharathidasan University | Thirumurugan R.,Bharathidasan University | Arun S.,Alagappa University
Iranian Journal of Environmental Health Science and Engineering | Year: 2011

Malathion was used in vivo on fresh water fish Labeo rohita to study its toxicity. The acute toxicity tests were conducted during certain intervals in various concentrations (5, 10, 15, 20, 25 and 30 mg/L) of malathion. The physical and chemical analyses of water were carried out by following APHA methods. While treating with malathion, the percentage of fish mortality was assessed during 24, 48, 72 and 96 hours. The lethal and sub-lethal concentration of malathion were found to be LC100 (25 mg/L) and LC0 (5 mg/L), respectively. The antioxidant enzyme activity (Catalase 43.1±2.3, 16.5±0.57, 23.9±0.17 μ moles of phenol liberated/min/100mg protein and Glutathion-S-transferase (GST) 270.5±0.16, 143.2±1.03, 215.5±0.72 μ moles of phenol liberated/min/100mg protein), in the liver, muscle and gill, respectively increased during the accumulation of malathion, whereas it decreased (Catalase 17±1.44, 7.9±0.23, 10.7±0.69 μ moles of phenol liberated/min/100mg protein and GST 219.5±1.12, 108.1±0.34, 160.2±0.46 μ moles of phenol liberated/min/100mg protein) in the liver, muscle and gill respectively during depuration period. The effects of malathion resulted in the gradual decrease of nucleic acids, protein, free amino acids (FAA) and glycogen. During recovery period, the levels of biochemical components progressively increased indicating a probable recovery from the disruption of internal organ. Hence, the pesticide intoxication has made defective consequences in the normal metabolic pathways which led increasing the rate of morality in fish population.


Senthilkumar K.P.,The Madura College Autonomous | Senthilkumar K.P.,Shree M And N Virani Science College | Thirumurugan R.,The Madura College Autonomous | Thirumurugan R.,Bharathidasan University
Asian Pacific Journal of Cancer Prevention | Year: 2012

Background: Tobacco contains agents which generate various potent DNA adducts that can cause gene mutations. Production of DNA adducts may be neutralized by glutathione S transferase (GST) along with other phase I and phase II enzyme systems. The existence of null type of GST among the population increases the susceptibility to various disorders and diseases. The present study focuses on the impact of high tobacco usage and possible null type mutation in GST loci. Methods: Genotypes of GST were detected by multiplex polymerase chain reaction in unrelated 504 volunteers of high tobacco using natives of Gujarat. Allelic frequencies were calculated using Statistical Package for Social Studies-16 software. Hardy Weinberg Equilibrium (HWE) was calculated using Chi square test. Two sided Fisher's significance test was used to compare allelic frequencies of different populations. Results: The frequency of homozygous null genotype of GSTM1 and GSTT1 were 20% (95% CI 16.7-23.9) and 35.5% (95% CI 31.4-39.9) respectively. The GSTM1 and GSTT1 null allele frequency distribution in the Gujarat population was significantly deviating from HWE. GSTT1 null frequency of Gujaratians was significantly higher and different to all reported low tobacco using Indian ethnics, while GSTM1 was not differing significantly. Conclusion: Tobacco usage significantly influences the rate of mutation and frequency of GSTT1 and M1 null types among the habituates. The rate of mutation in GSTT1 loci was an undeviating response to the dose of tobacco usage among the population. This mutational impact of tobacco on GSTT1 postulates the possible gene - environment interaction and selection of null genotype among the subjects to prone them under susceptible status for various cancers and even worst to cure the population with GSTT1 dependent drugs.


Senthilkumar K.P.,The Madura College Autonomous | Senthilkumar K.P.,Shree M And N Virani Science College | Thirumurugan R.,The Madura College Autonomous | Thirumurugan R.,Bharathidasan University
Asian Pacific Journal of Cancer Prevention | Year: 2012

Background: Glutathione-S-transferase (GST) is an important phase II xenobiotic compound metabolizing enzyme family, involved in tolerance to a particular drug or susceptibility to a diseasec. This study focused the GSTM1 and T1 null allele frequency in the Gujarat population with a comparison across other Inter- and Intra-Indian ethnic groups to predict variation in the possible susceptible status. Methods: DNA was isolated by a salting out method and GSTM1 and T1 homozygous null genotypes were detected by multiplex polymerase chain reaction in 504 unrelated individuals. The genotype distribution of null alleles was compared with Indian and non Indian ethnics reported earlier in the literature using Fisher's test. Results: The frequencies of the homozygous null genotypes of GSTM1 and GSTT1 were 20% (95%CI 16.7-23.9) and 35.5% (95%CI 31.4-39.9) respectively. GSTM1 null frequency did not deviate from most other Indian ethnic groups but differed from the majority of those of non Indian ethnicity studied. The frequency of homozygous null type of GSTT1 was significantly higher and deviated from all Indian groups and a few of non Indian ethnicity. Conclusions: Gujarat ethnicity, possibly the most susceptible for GSTT1 dependent drug disposition and diseases regarding effects of pollution. Further, the results have implications for GSTT1 dependent drugs used for treatment, a serious problem which needs to be solved by physicians and clinical researchers.


Meena A.,The Madura College Autonomous | Eswari A.,The Madura College Autonomous | Rajendran L.,The Madura College Autonomous
Journal of Mathematical Chemistry | Year: 2010

The boundary value problem in basic enzyme reactions is formulated and approximate expressions for substrate and product concentrations are presented. He's variational iteration method is used to give approximate and analytical solutions of non-linear reaction equations containing a non-linear term related to enzymatic reaction. The relevant analytical solutions for the substrate, enzyme, substrate-enzyme and product concentration profiles are discussed in terms of dimensionless reaction diffusion parameters K, λ and ε. © 2010 Springer Science+Business Media, LLC.


Mohan Das N.,P.A. College | Sivakama Sundari S.,Arignar Anna College | Karuppusamy S.,The Madura College Autonomous | Mohan V.R.,Ethnopharmacology Unit | Parthipan B.,P.A. College
Asian Journal of Pharmaceutical and Clinical Research | Year: 2014

Objective: GC-MS (Gas chromatography and mass spectroscopy) analysis of ethanol extracts of leaf and stem bark of Cleidion nitidum was carried out to detect the bioactive components. Methods: The chemical compositions of the ethanolic extract of leaves and bark of Cleidion nitidum were investigated using Perkin - Elmer Gas Chromatography - Mass Spectra while mass spectra of the compounds found in the extract was matched with the National Institute of Standards of Technology (NIST) library. Results: Gas chromatography mass spectra (GC-MS) analysis revealed the presence of 16 compounds from leaves and 5 compounds from bark of the Cledion nitidum were identified. In GC-MS analysis, some of the phytocomponents screened were squalene, 3, 7, 11, 15-Tetramethyl-2, hexadecen-1-ol, Phytol and Vitamin E in leaves whereas, Thiophene-3-carbonitrite tetrahydro-4-oxo-, Dimethyl-2,6,10-dodecatrien-1-ol, D-Mannotetradecane-1,2,3,4,5-pentaol and Octanal 7-methoxy-3-7-dimethyl (5.13%) major compounds in the bark extract. Conclusion: These results indicate the ethanol extract of leaf and stem bark of Cleidion nitidum possesses potent anti-tumor, anticancer, cancer preventive, anti-inflammatory, antioxidant, antibacterial and pesticide effects so that it can be recommended as a plant of phytopharmaceutical importance.


Senthamarai R.,The Madura College Autonomous | Rajendran L.,The Madura College Autonomous
Electrochimica Acta | Year: 2010

The theoretical analysis of the steady-state amperometric response for conducting polymer-modified ultramicroelectrodes is discussed. The effect of substrate diffusion in the solution adjacent to the polymer film on both the concentration profile and current response is also examined. Simple analytical expressions for substrate and mediator concentrations and current responses for all values of reaction/diffusion parameters are presented. The model is based on non-stationary system of coupled reaction/diffusion equations containing a non-linear term related to Michaelis-Menten kinetics of the enzymatic reactions. He's variational iteration method is used to give approximate analytical solutions of coupled non-linear reaction diffusion equations. A good agreement with available limiting case results is noticed. Crown Copyright © 2010.


Maheswari M.U.,The Madura College Autonomous | Rajendran L.,The Madura College Autonomous
Journal of Mathematical Chemistry | Year: 2011

The boundary value problem in basic enzyme reactions is formulated and approximate expressions for substrate and substrate-enzyme complex are presented. He's Homotopy Perturbation method is used to give approximate and analytical solutions of non-linear reaction equations containing a non-linear term related to enzymatic reaction. The pertinent analytical solutions for the substrate, enzyme- substrate complex and free enzyme are discussed in terms of dimensionless parameters σ,ρ.The obtained concentration results are compared with the numerical solution acquired using Matlab program. They are found to be in satisfactory agreement. © 2011 Springer Science+Business Media, LLC.


Ananthaswamy V.,The Madura College Autonomous | Sahaya Amalraj L.,Raja Doraisingam Government Arts College
ARPN Journal of Engineering and Applied Sciences | Year: 2015

This paper demonstrates the effect of convective cooling on a temperature dependent viscosity liquid flowing steadily through a cylindrical pipe. In this model, it is assumed that due to Newton's cooling law heat is exchanged with the ambient and the viscosity model varies as an inverse linear function of temperature. The analytical expressions for fluid velocity and temperature are derived using Homotopy Analysis method and entropy generation rate, total entropy generated and the Bejan number for various parametric values are determined. Our results are compared with the previous work and found to be in good agreement. © 2006-2015 Asian Research Publishing Network (ARPN).

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