Madonna della Navicella Hospital

Chioggia, Italy

Madonna della Navicella Hospital

Chioggia, Italy

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PubMed | University of Padua, S Maria Degli Angeli Hospital and Madonna della Navicella Hospital
Type: | Journal: Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery | Year: 2016

In patients with a history of lymphoma, each lymphadenopathy should be carefully evaluated. The aims of this study were to evaluate (i) the usefulness of high-resolution ultrasonography (US), US-guided fine-needle aspiration cytology (FNAC) and flow cytometry phenotyping (FCP) together in the diagnosis of recurrent lymphoma and (ii) whether these tools were independent predictors of correct results.Retrospective cohort study with stepwise forward logistic regression analysis of results.Tertiary referral centre.A total of 151 patients with a history of lymphoma who developed a cervical mass during follow-up.On neck US, a lymphadenopathy was shown in 129 (85.4%) patients (median age 57 years, range 18-78 years), and US-guided FNAC combined with FCP were immediately performed. All patients had surgical excision and subsequent histological examination of the enlarged node(s), to establish lymphoma subclassification.Final histology confirmed recurrence in 82 (63.6%) patients. According to the logistic regression analysis, FNAC and FCP were independent predictors of correct results (P = 0.009 and 0.028, respectively) and did not interfere with each other. The sensitivity, specificity and accuracy of the combination of all of the tools were 98.8%, 100% and 99.2%, respectively, and the area under the receiver operating characteristic curve was 0.902 (95% CI: 0.797-0.986).This minimally invasive procedure is easily performed and should be recommended for all patients with cervical lymphadenopathy and a history of lymphoma, avoiding the need of core-biopsy or surgical excision if recurrence was excluded.


Saccani G.,Orlandi General Hospital | Gessoni G.,Madonna della Navicella Hospital | Valverde S.,Madonna della Navicella Hospital | Manoni F.,Civil Hospital | Visconti M.,Orlandi General Hospital
Biochimica Clinica | Year: 2014

Urine culture is the most frequent test in microbiology laboratories. A screening tool, providing fast and reliable results to rule-out urinary tract infection (UTI), would be of great importance. We studied 1043 consecutive urine samples by Sysmex UF-1000i analyzer. Comparison was made by robotic urine culture on chromogenic agar with 1 μL loop, using 105 CFU/mL as a limit of positive growth. We evaluated bacteria quantification for rapid exclusion of UTI and bacteria forward scatter (B-FSC) in preliminary discrimination of UTI caused by Gram positive or Gram negative bacteria. For exclusion of UTI, the best cut-off value was 130 bacteria/μL. At this threshold, the sensitivity (SE) was 0.98 and the specificity (SP) 0.75. For exclusion of UTI sustained by Gram positive bacteria, the best cut-off value for B-FSC was 25ch. At this threshold, SE was 0.68 and SP was 0.89.


Gessoni G.,Madonna Della Navicella Hospital | Antico F.,Madonna Della Navicella Hospital | Caroli D.,Madonna Della Navicella Hospital | Nogara A.,Madonna Della Navicella Hospital | And 4 more authors.
Minerva Endocrinologica | Year: 2013

In type 3 polyendocrine syndrome (PAS3), autoimmune thyroiditis occurs with other organ-specific autoimmune disease, but not with autoimmune adrenalitis. In this report we described a family from Pakistan in which mother and three daughters were affected by a PAS3. We studied a family from Pakistan: Father MMu age 44, mother KN aged 44, three daughters MM age 20, MH age 16 and MA age 14 and a son MU age 18. These subjects were tested for thyroids function, metabolic function, adrenal function, autoimmune disease. In this family the four females were shown hypothyroidism with presence of anti thyroid autoantibodies (AA) and high TSH serum concentration in association with the presence of anti transglutaminase AA. Moreover KN, MM and MH were positive for anti nuclear AA (granular pattern) and for antibodies against Saccaromyces cerdevisiae. MM was positive for AA against nuclear extractable antigens (SSA and SSB) too. No diabetes or pernicious anemia were observed. Adrenal and Pituitary function were normal. PAS 3C is an uncommon disease. In this family from Pakistan we observed a PAS3C in the four female members: mother and three daughters while father and son were unaffected.


Gessoni G.,Madonna della Navicella Hospital | Canistro R.,Madonna della Navicella Hospital | Bergamini L.,Madonna della Navicella Hospital | Valverde S.,Madonna della Navicella Hospital | And 5 more authors.
Blood Coagulation and Fibrinolysis | Year: 2015

Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal nonneoplastic hematopoietic stem cell disease characterized by an acquired mutation of the PIG-A gene with reduction or absence of CD55 and CD59. The absence of these proteins renders PNH erythrocytes susceptible to complement-mediated hemolysis. We report the case of a PNH patient before and during pregnancy until delivery. We observed and treated some postpartum thrombotic complications. Eculizumab should be used with caution in pregnancy. There are several reports supporting its use in these patients. This case should be considered paradigmatic of a series of clinical situations that may occur in the course of a pregnancy in patients with PNH: increased need for transfusion, need to increase the dose of Eculizumab, and insurgence of fetal sufferance. Moreover, after delivery, the patient, despite adequate prophylaxis with low-molecular-weight heparins, presented severe complications: development of pleural and peritoneal effusion, pulmonary embolism, bilateral upper limbs thrombophlebitis, and a possible abdominal angina with a transient paralytic ileus. All these complications were overcome and now the baby is healthy and the mother has returned to the usual therapeutic regimen. © 2015 Wolters Kluwer Health, Inc. All rights reserved.


Gessoni G.,Madonna della Navicella Hospital | Saccani G.,Orlandi Hospital | Valverde S.,Madonna della Navicella Hospital | Manoni F.,Civil Hospital | Caputo M.,Fracastoro Hospital
Clinica Chimica Acta | Year: 2015

Urine culture is the most frequently requested test for a Microbiology Lab. A reliable screening tool would be of paramount importance both to clinicians and laboratorians, provided that it could get fast and accurate negative results in order to rule-out urinary tract infection (UTI). Materials and methods: We evaluated 1907 consecutive urine samples from outpatients. Culture was performed on chromogenic agar with 1μL loop, using 105CFU/mL as a limit of positive growth. Using Sysmex Uf-1000i analyzer we evaluated bacteria forward scatter (B_FSC) and fluorescent light scatter (B_FLH) in a preliminary discrimination step for UTI caused by Gram+ or Gram- bacteria. Results: We got 512 positive samples. A mono-microbial infection was observed in 490 samples; two bacterial strains were isolated in 22 samples, so 534 bacterial strains were found: 392 Gram-, 133 Gram. + and 9 yeasts. Comparing Gram. + and Gram. - bacteria we observed a statistically significant difference for B_FSC but not for B_FLH. In this application experimental cut-off value for B_FSC was 25ch. Using this cut-off to perform a presumptive identification of UTI sustained by Gram-+ bacteria, we observed a SE 0.68, SP 0.84. Conclusion: Our data although preliminary suggest that B_FSC could be useful in presumptive exclusion of UTI caused by Gram-positive bacteria. © 2014 Elsevier B.V.


PubMed | Madonna della Navicella Hospital
Type: Case Reports | Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis | Year: 2015

Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal nonneoplastic hematopoietic stem cell disease characterized by an acquired mutation of the PIG-A gene with reduction or absence of CD55 and CD59. The absence of these proteins renders PNH erythrocytes susceptible to complement-mediated hemolysis. We report the case of a PNH patient before and during pregnancy until delivery. We observed and treated some postpartum thrombotic complications. Eculizumab should be used with caution in pregnancy. There are several reports supporting its use in these patients. This case should be considered paradigmatic of a series of clinical situations that may occur in the course of a pregnancy in patients with PNH: increased need for transfusion, need to increase the dose of Eculizumab, and insurgence of fetal sufferance. Moreover, after delivery, the patient, despite adequate prophylaxis with low-molecular-weight heparins, presented severe complications: development of pleural and peritoneal effusion, pulmonary embolism, bilateral upper limbs thrombophlebitis, and a possible abdominal angina with a transient paralytic ileus. All these complications were overcome and now the baby is healthy and the mother has returned to the usual therapeutic regimen.

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