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Karandikar K.G.,MACS Agharkar Research Institute | Singh S.K.,KMC College
Mycotaxon | Year: 2010

A new hyphomycete species, Lylea indica, from Nagzira, Vidharba region of Maharashtra state in India found on dead culms of Bambusa arundinacea is here described.

Kasote D.M.,MACS Agharkar Research Institute | Hegde M.V.,Bharati Vidyapeeth Deemed University | Katyare S.S.,Bharati Vidyapeeth Deemed University
BioFactors | Year: 2013

Mitochondrial dysfunction is at the base of development and progression of several psychiatric and neurologic diseases with different etiologies. MtDNA/nDNA mutational damage, failure of endogenous antioxidant defenses, hormonal malfunction, altered membrane permeability, metabolic dysregulation, disruption of calcium buffering capacity and ageing have been found to be the root causes of mitochondrial dysfunction in psychatric and neurodegenerative diseases. However, the overall consequences of mitochondrial dysfunction are only limited to increase in oxidative/nitrosative stress and cellular energy crises. Thus far, extensive efforts have been made to improve mitochondrial function through specific cause-dependent antioxidant therapy. However, owing to complex genetic and interlinked causes of mitochondrial dysfunction, it has not been possible to achieve any common, unique supportive antioxidant therapeutic strategy for the treatment of psychiatric and neurologic diseases. Hence, we propose an antioxidant therapeutic strategy for management of consequences of mitochondrial dysfunction in psychiatric and neurologic diseases. It is expected that this will not only reduces oxidative stress, but also promote anaerobic energy production. © 2013 International Union of Biochemistry and Molecular Biology, Inc.

Mukherjee G.,MACS Agharkar Research Institute | Singh S.K.,MACS Agharkar Research Institute
Process Biochemistry | Year: 2011

A metabolite was purified from Monascus perpureus culture broth with the aim of isolating economically viable new pigment having food coloring and therapeutic potential. Following optimization of physical and nutritional parameters of submerged fermentation the pigment was extracted using hexane, and purified by thin layer chromatography (TLC), column chromatography and semi-preparative HPLC. Based on UV-vis, IR, GC-MS and NMR analyses the pigment was chemically characterized as 9-(1-hydroxyhexyl)-3-(2-hydroxypropyl)-6a- methyl-9,9a-dihydrofuro[2,3-h]isoquinoline-6,8(2H,6aH)-dione with the molecular mass of m/z 375. The pigment presents numerous similarities with two classical red pigments, rubropunctamine and monascorubramine, but differs by the presence of hydroxy alkane substitutions at C-3 and C-9 positions. Antibacterial plate assay showed its inhibitory activity against Gram-positive bacteria. These results suggest the purified pigment is a new red pigment from Monascus purpureus with potential application in food coloring and antibacterial therapy. © 2010 Elsevier Ltd. All rights reserved.

Majumder D.R,MACS Agharkar Research Institute | Kanekar P.P,MACS Agharkar Research Institute
International Journal of Pharma and Bio Sciences | Year: 2012

Thermoactinomyces thalpophilus (Gene Bank accession number EF 397000) isolated from the waters of a thermal spring situated in Western Ghats, Maharashtra, India was found to be a potent producer of thermolysin-like protease (TLP). TLP was capable of bringing about condensation/ biotransformation of two amino acids, viz. Z-L-aspartic acid and L-phenylalanine methyl ester into aspartame, which is an artificial, nonsaccharide sweetener used as a sugar substitute in some foods and beverages. The maximum yield 181 U/ml/min was obtained at 55°C in glucose yeast extract medium(pH 7.2) containing CaCl2 (0.2 % w/v) with an inoculum size of 0.5% v/v after 18 hours incubation under shake-culture conditions (130 rpm).

Rajeshkumar K.C.,MACS Agharkar Research Institute | Singh S.K.,MACS Agharkar Research Institute
Mycotaxon | Year: 2012

Manoharachariella indica is described as a new species from India, differing from M. lignicola, the only other described species of the genus, by larger conidia, longer conidiophores, and additional conidiophore septa. © 2012. Mycotaxon, Ltd.

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