North Ryde, Australia

Macquarie University
North Ryde, Australia

Macquarie University is a public research university based in Sydney, Australia, in the suburb of Macquarie Park. Founded in 1964 by the New South Wales Government, it was the third university to be established in the metropolitan area of Sydney. It is the fourth largest university in Sydney.The university comprises five faculties. Also affiliated with the university are several research centres, schools and institutes including the Macquarie Graduate School of Management, Australian Proteome Analysis Facility, the Institute of Human Cognition and Brain Science, the Macquarie University Research Park and the Macquarie University Hospital. At present, the university offers 87 undergraduate courses and 124 different postgraduate courses to students. The university is governed by a 17-member Council.Macquarie is ranked in the top 40 universities in the Asia-Pacific region and within Australia's top ten universities according to the Academic Ranking of World Universities, the U.S. News & World Report Rankings and the QS World University Rankings. According to the QS World University Rankings, Macquarie is the highest ranked university in Australia under the age of 50, it is ranked 18th in the world. Macquarie is ranked in the 201st-300th bracket and 8th-9th in Australia in the 2013 Academic Ranking of World Universities. The university is also ranked among the national top five recipients of relative research income. Macquarie University also has the largest student exchange programme in Australia.Researchers at Macquarie University, David James Skellern and Neil Weste, and the Commonwealth Scientific and Industrial Research Organisation helped develop Wi-Fi. David James Skellern has been a major donor to the University through the Skellern Family Trust. Macquarie University's linguistics department developed the Macquarie Dictionary. The dictionary is regarded as the standard reference on Australian English. Wikipedia.

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LONDON--(BUSINESS WIRE)--FutureStack — Digital intelligence leader New Relic, Inc. (NYSE:NEWR) unveiled new capabilities to the New Relic Digital Intelligence Platform that will enable enterprises to have greater visibility into the performance of their applications and the dynamic infrastructure that they rely on. With the new Health Map, New Relic is bringing together the power of New Relic APM and New Relic Infrastructure to deliver a high-density view of applications and the infrastructure supporting those applications. By standardizing monitoring within a single cloud platform, customers will be able to work better together to pinpoint issues and optimize their dynamic cloud or hybrid environments, in particular those leveraging Amazon Web Services (AWS). A bird’s-eye view of large and complex environments. As enterprises adopt more scalable microservice architectures, it becomes more difficult to pinpoint performance issues within the application stack. New Relic’s new Health Map feature brings together insights on application and infrastructure performance into a single, prioritized view. This unified view enables operations and DevOps teams to quickly understand if the source of a performance issue is from the application code or in the infrastructure layer. Integrated to support your AWS strategy. New Relic Infrastructure now boasts 20 out-of-the-box integrations to AWS services, including new integrations for Amazon Kinesis Firehose, Amazon Elasticsearch Service, Amazon Route 53, Amazon EC2 Container Service, and Amazon EC2 Container Registry. In addition, Billing and Cost Management features have been introduced, which will enable customers to monitor costs in real time and plan for the future. The breadth of New Relic’s integrations enable enterprises to effectively migrate, optimize, and scale the usage and data flow within AWS. Extend New Relic Infrastructure to monitor any custom host. With New Relic Infrastructure's new SDK, system administrators and DevOps teams can now standardize the monitoring of custom services alongside dynamic infrastructure instances within the context of the applications that they support. This visibility can lead to these teams improving their efficiency in diagnosing and resolving problems by viewing all the relevant information from a single source. “Enterprises are rapidly moving to dynamic infrastructure and scalable architectures so that they can move at the speed of the business. Our customers want a single monitoring platform, and New Relic is delivering end-to-end visibility and metrics that operations teams need to understand the health of all their applications, down to any host in their environment,“ said Jim Gochee, chief product officer, New Relic. “Macquarie is in the middle of a transformational change, and determining how we deliver and monitor infrastructure services to support the university’s requirements, both now and in the future, will be key to our success. New Relic’s new Health Map provides us a single pane of glass view displaying both the status of our environment as well as the relationships between our applications and the infrastructure that supports them. With the flexibility to provide an applications perspective of the environment, applications and their related hosts or an infrastructure perspective, hosts and their related applications, the Health Map display caters for the needs of a diverse support team; assisting the Help desk, Infrastructure, Applications and Development teams providing the necessary information to manage and support a large number of diverse systems and applications,” said Gavin Wilson, infrastructure manager, Macquarie University, one of Australia’s leading public research universities. “Historically, Spokeo has used lots of monitoring tools and we started consolidating our monitoring with New Relic because it gives us a holistic view of our applications and infrastructure. New Relic Infrastructure alerts us to server specific errors and the Health Map gives us the ability to understand our metrics in one dashboard. The integrations with AWS products have been pretty interesting to see and given us an automated way to pull in metrics in real time to understand the performance of those services in relation to the applications they support,” said Eric Liang, co-founder and chief information officer, Spokeo, a people search engine founded in California. Health Map is expected to be available at the end of May 2017 for paying New Relic APM customers who have either purchased or are trialing New Relic Infrastructure. For a free 30-day trial of New Relic Infrastructure visit here. The AWS integrations and New Relic Infrastructure SDK are immediately available to all Professional customers. Read blog posts on the latest updates to the Digital Intelligence Platform, the new Health Map, and New Relic Infrastructure’s AWS integrations. New Relic will be hosting a webinar on Thursday, June 15, 2017, at 11:00 AM PDT, Spring '17 New Relic Digital Intelligence Platform Updates. To register for the webinar and learn more about what's new in the New Relic Digital Intelligence Platform, visit here. Please note that events, dates, topics, and speakers are subject to change without notice. New Relic is a leading digital intelligence company, delivering full-stack visibility and analytics to over 40% of the Fortune 100. The New Relic Digital Intelligence Platform provides actionable insights to drive digital business. Companies of all sizes trust New Relic to monitor application and infrastructure performance so they can quickly resolve issues, and improve digital customer experiences. Learn more at This press release contains “forward-looking” statements, as that term is defined under the federal securities laws, including but not limited to statements regarding the New Relic Digital Intelligence Platform, particularly with respect to products and features thereof that are expected to be delivered in the future, such as health maps, as well as market trends and dynamics and future webinar events. The achievement or success of the matters covered by such forward-looking statements are based on New Relic’s current assumptions, expectations, and beliefs and are subject to substantial risks, uncertainties, assumptions, and changes in circumstances that may cause New Relic’s actual results, performance, or achievements to differ materially from those expressed or implied in any forward-looking statement. Further information on factors that could affect New Relic's financial and other results and the forward-looking statements in this press release is included in the filings New Relic makes with the SEC from time to time, including in New Relic's most recent Form 10-K, particularly under the captions "Risk Factors" and "Management's Discussion and Analysis of Financial Condition and Results of Operations." Copies of these documents may be obtained by visiting New Relic's Investor Relations website at or the SEC's website at New Relic assumes no obligation and does not intend to update these forward-looking statements, except as required by law. New Relic is a registered trademark of New Relic, Inc. All product and company names herein may be trademarks of their registered owners.

News Article | May 25, 2017

Studying biological events while they happen is essential to truly understanding the full process behind each occurrence. Live cell imaging using fluorescence microscopy is the perfect approach to explore these complex questions. In this webinar, the use of automated fluorescence microscopy methods will be discussed, from small animal models and tissues to individual organelle and protein observations using high content analyzers. Attendees will see demonstrations on how to capture high quality data while utilizing best methods for ensuring sample viability, including environmental control, sensitive signal detection, and precise instrument control. Participants will learn of the advantages of using live samples for HCA, along with the importance of quantitative analysis. Ultimately gaining an understanding of imaging system requirements for live cell observation. The team at GE Healthcare has selected Dr. Lynne Turnbull, lead applications support specialist at GE Healthcare, to be the speaker at this event. Turnbull completed her doctoral studies at Macquarie University, in Sydney, Australia and is best known for her research in microbial biofilms and cell biology. She recently joined GE Healthcare as a lead application support specialist, where her research interests focus on microbial biofilms and the application of optical and super resolution imaging techniques to the study of microbial cell biology. LabRoots will host the webinar June 14, 2017, beginning at 8 a.m. PDT, 11 a.m. EDT. To read more about this event, learn about the continuing education credits offered, or to register for free, click here. ABOUT GE GE Healthcare provides transformational technologies and services to meet the demand for increased access, enhanced quality and more affordable healthcare around the world. GE (NYSE: GE) works on things that matter - great people and technologies taking on tough challenges. The Life Sciences business of GE Healthcare exists to enable scientific discovery. We do this by helping our customers discover, make and use new ways to improve the human condition. ABOUT LABROOTS LabRoots is the leading scientific social networking website, which provides daily scientific trending news and science-themed apparel, as well as produces educational virtual events and webinars, on the latest discoveries and advancements in science. Contributing to the advancement of science through content sharing capabilities, LabRoots is a powerful advocate in amplifying global networks and communities. Founded in 2008, LabRoots emphasizes digital innovation in scientific collaboration and learning, and is a primary source for current scientific news, webinars, virtual conferences, and more. LabRoots has grown into the world’s largest series of virtual events within the Life Sciences and Clinical Diagnostics community.

A method and system for generating a Raman second Stokes light to a source light comprising generating a Raman first Stokes light from the source light by a Raman interaction in a nonlinear optical medium disposed in an optical resonator, and resonating the Raman first Stokes light in the optical resonator; generating a seed light at the frequency of the Raman second Stokes light from the source light and the Raman first Stokes light by a four wave mixing process which is not phase matched in the nonlinear medium; amplifying the seed light by transferring power from the first Stokes light resonating in the optical resonator to the seed light using a Raman amplification process in the nonlinear medium; and extracting from the optical resonator a majority of the power of the seed light so amplified.

Previous research has investigated the influence of long-term motor training on the brain activity of motor processes, but the findings are inconsistent. To clarify how acquiring motor expertise induces cortical reorganization during motor task performance, the current study conducted a quantitative meta-analysis on 26 functional magnetic resonance imaging (fMRI) studies that investigate motor task performance in people with long-term motor training experience (e.g., athletes, musicians, and dancers) and control participants. Meta-analysis of the brain activation in motor experts and novices showed similar effects in the bilateral frontal and parietal regions. The meta-analysis on the contrast between motor experts and novices indicated that experts showed stronger effects in the left inferior parietal lobule (BA 40) than did novices in motor execution and prediction tasks. In motor observation tasks, experts showed stronger effects in the left inferior frontal gyrus (BA 9) and left precentral gyrus (BA 6) than novices. On the contrary, novices had stronger effects in the right motor areas and basal ganglia as compared with motor experts. These results indicate that motor experts have effect increases in brain areas involved in action planning and action comprehension, and suggest that intensive motor training might elaborate the motor representation related to the task performance. © 2014, Psychonomic Society, Inc.

Coltheart M.,Macquarie University
Cortex | Year: 2017

Confabulation is sometimes defined – by Berlyne, for example – as a symptom that is seen only in one neuropsychological condition, amnesia. In this paper I argue for a somewhat more liberal – and, I contend, more productive – conception of confabulation, according to which it is seen not only in amnesia but also in other neuropsychological conditions such as delusion – and, indeed, even in healthy people. I also argue that it follows from this that in neuropsychological conditions where confabulations are seen, these are responses to abnormal experiences brought about by brain damage, but the occurrence of confabulation itself need not be seen as due to any impairment of cognitive processes due to the brain damage. It is instead a consequence of a general property of human cognition that is often referred to as “the drive for causal understanding”. © 2016 Elsevier Ltd

Carlson T.A.,Macquarie University
Journal of Neuroscience | Year: 2014

The development of multivariate pattern analysis or brain "decoding" methods has substantially altered the field of fMRI research. Although these methods are highly sensitive to whether or not decodable information exists, the information they discover and make use of for decoding is often concealed within complex patterns of activation. This opacity of interpretation is embodied in influential studies showing that the orientation of visual gratings can be decoded from brain activity in human visual cortex with fMRI. Although these studies provided a compelling demonstration of the power of these methods, their findings were somewhat mysterious as the scanning resolution was insufficient to resolve orientation columns, i.e., orientation information should not have been accessible. Two theories have been put forth to account for this result, the hyperacuity account and the biasedmapaccount, both of which assume that small biases in fMRI voxels are the source of decodable information. In the present study, we use Hubel and Wiesel's (1972) classic ice-cube model of visual cortex to show that the orientation of gratings can be decoded from an unbiased representation. In our analysis, we identify patterns of activity elicited by the edges of the stimulus as the source of the decodable information. Furthermore, these activation patterns masquerade as a radial bias, a key element of the biased map account. This classic model thus sheds new light on the mystery behind orientation decoding by unveiling a new source of decodable information. © 2014 the authors.

Gillings M.R.,Macquarie University
Microbiology and Molecular Biology Reviews | Year: 2014

Integrons are versatile gene acquisition systems commonly found in bacterial genomes. They are ancient elements that are a hot spot for genomic complexity, generating phenotypic diversity and shaping adaptive responses. In recent times, they have had a major role in the acquisition, expression, and dissemination of antibiotic resistance genes. Assessing the ongoing threats posed by integrons requires an understanding of their origins and evolutionary history. This review examines the functions and activities of integrons before the antibiotic era. It shows how antibiotic use selected particular integrons from among the environmental pool of these elements, such that integrons carrying resistance genes are now present in the majority of Gram-negative pathogens. Finally, it examines the potential consequences of widespread pollution with the novel integrons that have been assembled via the agency of human antibiotic use and speculates on the potential uses of integrons as platforms for biotechnology. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Gillings M.R.,Macquarie University
Frontiers in Microbiology | Year: 2013

The widespread use and abuse of antibiotic therapy has evolutionary and ecological consequences, some of which are only just beginning to be examined. One well known consequence is the fixation of mutations and lateral gene transfer (LGT) events that confer antibiotic resistance. Sequential selection events, driven by different classes of antibiotics, have resulted in the assembly of diverse resistance determinants and mobile DNAs into novel genetic elements of ever-growing complexity and flexibility. These novel plasmids, integrons, and genomic islands have now become fixed at high frequency in diverse cell lineages by human antibiotic use. Consequently they can be regarded as xenogenetic pollutants, analogous to xenobiotic compounds, but with the critical distinction that they replicate rather than degrade when released to pollute natural environments. Antibiotics themselves must also be regarded as pollutants, since human production overwhelms natural synthesis, and a major proportion of ingested antibiotic is excreted unchanged into waste streams. Such antibiotic pollutants have non-target effects, raising the general rates of mutation, recombination, and LGT in all the microbiome, and simultaneously providing the selective force to fix such changes. This has the consequence of recruiting more genes into the resistome and mobilome, and of increasing the overlap between these two components of microbial genomes. Thus the human use and environmental release of antibiotics is having second order effects on the microbial world, because these small molecules act as drivers of bacterial evolution. Continued pollution with both xenogenetic elements and the selective agents that fix such elements in populations has potentially adverse consequences for human welfare. © 2013 Gillings.

The initial (200-175 Ma) breakup of Pangea was marked by the emplacement of the Large Igneous Provinces (LIPs) of Karoo-Ferrar-SE Australia (KFS) in the back-arc of Panthalassan subduction and by the Central Atlantic Magmatic Province (CAMP) between Africa and the Americas. Seafloor spreading 190-180. Ma (Stage 1) about the CAMP split Pangea into northern (Laurasia) and southern (Gondwanaland) parts. Subsequent stages at 167 Ma (2), 147 Ma (3), 130 Ma (4), 118 Ma (5), and 83 Ma (6) split conjugate Africa, South America, India, Australia, and Zealandia from Antarctica. Here I review the reconstruction of Antarctica in Gondwanaland. First, seafloor spreading is unwound to re-unite the continent-ocean boundaries (COBs), then the extended (rifted) crust about the suture is restored to its original thickness. A comprehensive review of the U-Pb zircon geochronology of the reconstructed margins of Antarctica and its conjugates shows that certain coeval structures are aligned across the suture. Cross structures of high-order spatial continuity and age correlation are the Lambert-Mahanadi Rift, Pranhita-Godavari-Robert Glacier trend, Gawler-Adélie Craton, and western part of the Gondwanide Fold Belt. Cross structures of high-order age correlation but low structural continuity or alignment are, from Africa to Antarctica, the East African-Antarctic Orogen, the Natal and Maud Belts, the Umkondo Group-Ritscherflya Supergroup and LIP, and the Kalahari-Grunehogna Craton; from Antarctica to Zealandia, the Ross-Western and Amundsen-Eastern Provinces; and from Africa through Antarctica to Australia the KFS LIP. © 2011 Elsevier B.V.

Stevenson R.J.,Macquarie University
Psychological Bulletin | Year: 2014

The brain binds inputs from multiple senses to enhance our ability to identify key events in the environment. Understanding this process is based mainly on data from the major senses (vision and audition), yet compelling examples of binding occur in other domains. When we eat, in fact taste, smell, and touch combine to form flavor. This process can be so complete that most people fail to recognize that smell contributes to flavor. The flavor percept has other features: (a) it feels located in the mouth, even though smell is detected in the nose and taste on the tongue, and (b) it feels continuous, yet smell is delivered in pulses to the nose during eating. Furthermore, tastes can modify smell perception and vice versa. Current explanations of these binding-related phenomena are explored. Preattentive processing provides a well-supported account of taste-to-tongue binding. Learning between taste and smell can explain perceptual interactions between these senses and perhaps localization of smell to the mouth. Attentional processes may also be important, especially given their role in binding the major senses. Two are specifically examined. One claims that the failure to recognize smell's role in flavor stems from the role of involuntary attention's "defaulting" to the mouth and taste (i.e., binding by ignoring). Another claims that taste and smell form a common attentional channel in the mouth, in effect becoming one sense. Except for preattentive processing, the mechanisms involved in flavor binding differ markedly from those proposed for the major senses. This distinction may result from functional differences, with flavor supporting future food choice but not current identification. © 2013 American Psychological Association.

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