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Aalla S.,Dr. Reddys Laboratories Ltd | Gilla G.,Dr. Reddys Laboratories Ltd | Bojja Y.,Dr. Reddys Laboratories Ltd | Anumula R.R.,Dr. Reddys Laboratories Ltd | And 2 more authors.
Organic Process Research and Development | Year: 2012

An efficient, telescopic, and scalable process for an antihypertensive drug substance, valsartan with an overall yield of 58%, and ∼99.9% purity is described. A simple, and safe process is developed for the recovery of tributyltin chloride from the tributyltin hydroxide, byproduct formed in the tetrazole ring construction, and reused in the synthesis of valsartan. © 2012 American Chemical Society. Source


Aalla S.,Dr. Reddys Laboratories Ltd | Gilla G.,Dr. Reddys Laboratories Ltd | Anumula R.R.,Dr. Reddys Laboratories Ltd | Kurella S.,Dr. Reddys Laboratories Ltd | And 2 more authors.
Organic Process Research and Development | Year: 2012

An improved process has been developed for the active pharmaceutical ingredient, ranolazine with 99.9% purity and 47% overall yield (including three chemical reactions and one recrystallization). Formation and control of all the possible impurities is described. All the solvents used in the process were recovered and reused. The unreacted piperazine is recovered as piperazine monophosphate monohydrate salt. © 2012 American Chemical Society. Source


Aalla S.,Dr. Reddys Laboratories Ltd | Gilla G.,Dr. Reddys Laboratories Ltd | Metil D.S.,Dr. Reddys Laboratories Ltd | Anumula R.R.,Dr. Reddys Laboratories Ltd | And 2 more authors.
Organic Process Research and Development | Year: 2012

An improved process for the synthesis of prasugrel hydrochloride with an overall yield of 58%, 99.9% purity, and meeting all other quality requirements is described. © 2012 American Chemical Society. Source


Purandhar K.,Matrix | Jyothi V.,Matrix | Pratap Reddy P.,Macleods Pharmaceuticals Ltd | Adharvana Chari M.,Japan International Center for Materials Nanoarchitectonics | Mukkanti K.,JNTUH College of Engineering
Journal of Heterocyclic Chemistry | Year: 2012

Polyhydroquinolines have been synthesized in good to excellent yields (80-90%) and short reaction times (15-30 min) in the presence of aluminum phosphate [AlPO 4] as heterogeneous catalyst at 90°C; the reaction workup is simple and the catalyst aluminum phosphate [AlPO 4] can be easily separated from the product and reused.. © 2011 HeteroCorporation. Source


Desai K.G.,Macleods Pharmaceuticals Ltd | Naik J.I.,West Corporation | Raval J.P.,Ashok and Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied science | Desai K.R.,Cg Bhakta Institute Of Biotechnology
Arabian Journal of Chemistry | Year: 2014

Heterocyclic compounds containing pyrazolines were reported to possess significant biological activity. Synthesis of 2-(ω-chloroacetonyl)-3-p-fluorophenyl-6-bromoquinazoline-4(3H)-ones (2), 2-(ω-hydrazinoacetonyl)-3-p-fluorophenyl-6-bromoquinazoline-4(3H)-ones (3) and 1'-[3H-3-p-fluorophenyl-4-oxo-6-bromoquinazoline-2-acetonyl]-3'-[1-o-chlorophenyl-3-methyl-5-azomethine-2-pyrazolidene]-5'-(substituted phenyl)-δ2-pyrazolines (4a-j) have been described. Some of the new compounds were tested against bacteria (Gram -ve and Gram +ve) and fungi. © 2011. Source

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