Macau, China

Macau University of Science and Technology is a university located in Macau, China on the Cotai Strip opposite the Venetian Macau on Taipa Island, next to the Macau International Airport. It is a private institution managed by the MUST Foundation and the first college established after the handover of Macau to the People’s Republic of China. The university offers full-time and part-time programs.The General Studies programs, the School of Graduate Studies and the School of Continuing Studies offer a broad range of programs. MUST is authorized to award Ph.D. degrees, master degrees and bachelor degrees in their residence programs. The university enrolls 5,000 full-time students. MUST recruits students from all over the world as well as 20 provinces and cities in Mainland China for its undergraduate and graduate programs. Wikipedia.


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Patent
Macau University of Science and Technology | Date: 2015-10-30

The administration of a compound advantageously efficacious as ROS1 inhibitor and its effect on subjects with cancer includes administering a compound having certain structural components such as a quinoline moiety in the backbone and at least one tertiary amine containing moiety in a side chain as well as heteroatoms, in particular oxygen atoms, present in the backbone and the side chain for treating a subject suffering from a disease such as cancer. The presence of such structural components allows for an advantageous interaction with the ROS1 kinase domain, in particular with the hinge region. The administered compounds represent a highly promising opportunity in particular for patients bearing ROS1-dependent cancer. A method for targeting tumor cells harboring an abnormality in ROS1 gene includes contacting a cell with compounds of the present invention as well as pharmaceutical compositions comprising such compounds.


Patent
Macau University of Science and Technology | Date: 2015-09-09

The present invention discloses a pharmaceutical composition of treating multidrug resistance cancer, comprising a citrus methoxyflavone and a chemotherapeutic drug, in which the citrus methoxyflavone is tangeretin. A method of treating multidrug resistance cancer comprising administrating citrus methoxyflavone and a chemotherapeutic drug is also disclosed.


Patent
Macau University of Science and Technology | Date: 2015-09-09

The present invention discloses a pharmaceutical composition of treating multidrug resistance cancer, comprising a citrus methoxyflavone and a chemotherapeutic drug, in which the citrus methoxyflavone is nobiletin. A method of treating multidrug resistance cancer comprising administrating citrus methoxyflavone and a chemotherapeutic drug is also disclosed.


The present invention discloses a method of treating cancer and/or multidrug-resistant cancer, comprising administering an effective amount of hernandezine or thalidezine. A pharmaceutical composition comprising hernandezine or thalidezine admixed with a pharmaceutical carrier for treating cancers and/or multidrug-resistant cancer is also disclosed.


Patent
Macau University of Science and Technology | Date: 2015-10-20

Due to the trend of using larger wafer diameter and smaller lot size, cluster tools need to switch from processing one lot of wafers to another frequently. It leads to more transient periods in wafer fabrication. Their efficient scheduling and control problems become more and more important. It becomes difficult to solve such problems, especially when wafer residency time constraints must be considered. This work develops a Petri net model to describe the behavior during the start-up transient processes of a single-arm cluster tool. Then, based on the model, for the case that the difference of workloads among the steps is not too large and can be properly balanced, a scheduling algorithm to find an optimal feasible schedule for the start-up process is given. For other cases schedulable at the steady state, a linear programming model is developed to find an optimal feasible schedule for the start-up process.


Patent
Macau University of Science and Technology | Date: 2015-10-21

It is very difficult to schedule a single-arm cluster tool with wafer revisiting such that wafer residency time constraints are satisfied. The present invention conducts a study on this challenging problem for a single-arm cluster tool with atomic layer deposition (ALD) process. With a so called p-backward strategy being applied, a Petri net model is developed to describe the dynamic behavior of the system. Based on the model, existence of a feasible schedule is analyzed, schedulability conditions are derived, and scheduling algorithms are presented if there is a schedule. A schedule is obtained by simply setting the robot waiting time if schedulable and it is very computationally efficient. The obtained schedule is shown to be optimal. Illustrative examples are given to demonstrate the proposed approach.


Patent
Macau University of Science and Technology | Date: 2015-10-21

The scheduling problem of a multi-cluster tool with a tree topology whose bottleneck tool is process-bound is investigated. A method for scheduling the multi-cluster tool to thereby generate an optimal one-wafer cyclic schedule for this multi-cluster tool is provided. A Petri net (PN) model is developed for the multi-cluster tool by explicitly modeling robot waiting times such that a schedule is determined by setting the robot waiting times. Based on the PN model, sufficient and necessary conditions under which a one-wafer cyclic schedule exists are derived and it is shown that an optimal one-wafer cyclic schedule can be always found. Then, efficient algorithms are given to find the optimal cycle time and its optimal schedule. Examples are used to demonstrate the scheduling method.


Patent
Macau University of Science and Technology | Date: 2015-10-21

Since single and dual-arm tools behave differently, it is difficult to coordinate their activities in a hybrid multi-cluster tool that is composed of both single- and dual-arm tools. Aiming at finding an optimal one-wafer cyclic schedule for a treelike hybrid multi-cluster tool whose bottleneck tool is process-bound, the present work extends a resource-oriented Petri net to model such system. By the developed Petri net model, to find a one-wafer cyclic schedule is to determine robot waiting times. By doing so, it is shown that, for any treelike hybrid multi-cluster tool whose bottleneck tool is process-bound, there is always a one-wafer cyclic schedule. Then, computationally efficient algorithms are developed to obtain the minimal cycle time and the optimal one-wafer cyclic schedule. Examples are given to illustrate the developed method.


Xu Q.,Macau University of Science and Technology
IEEE Transactions on Industrial Electronics | Year: 2013

This paper presents a new approach for hysteresis identification and compensation of piezoelectric actuators by resorting to an intelligent hysteresis model. In particular, a least squares support vector machine (LSSVM)-based hysteresis model is developed and used for both purposes of hysteresis identification and hysteresis compensation. By this way, the hysteresis inverse is not needed in the feedforward hysteresis compensator since the hysteresis model is directly used. To establish the LSSVM model, the problem of how to select input variables to convert the multivalued mapping into a single-valued one is addressed. The effectiveness of the presented idea is validated by a series of experimental studies on a piezoactuated system. Results show that the proposed approach is superior to the Bouc-Wen-model-based one in terms of both hysteresis modeling and compensation. The reported method is more computational effective than existing model-based hysteresis compensation approaches, and it is extensible to other smart actuator systems as well. © 1982-2012 IEEE.


Xu Q.,Macau University of Science and Technology
IEEE Transactions on Industrial Electronics | Year: 2014

This paper presents the design and development of a novel flexure parallel-kinematics precision positioning stage with a centimeter range and compact dimension. The stage mechanism is devised using leaf flexures to achieve a decoupled and modular structure. Structural parameters are carefully designed to guarantee the range, stiffness, resonant frequency, and payload capabilities in consideration of manufacturing tolerance. The parametric design is verified by conducting finite-element analysis, which reveals a reachable motion range over 20 mm in each working axis. Moreover, a prototype XY stage is fabricated, which is actuated and sensed by two voice coil motors and laser displacement sensors, respectively. Experimental results demonstrate that the stage is capable of positioning with a workspace over 11 mm × 11 mm. It is more compact than existing works, which is reflected by a larger area ratio of workspace to planar dimension. Both static and dynamic tests exhibit a small crosstalk between the two axes, which indicates a well-decoupled motion property. The implemented feedback control enables a precision positioning with submicrometer resolution and accuracy. The control bandwidth and payload influences on stage performances are experimentally examined as well. © 1982-2012 IEEE.

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