Macau, China

Macau University of Science and Technology is a university located in Macau, China on the Cotai Strip opposite the Venetian Macau on Taipa Island, next to the Macau International Airport. It is a private institution managed by the MUST Foundation and the first college established after the handover of Macau to the People’s Republic of China. The university offers full-time and part-time programs.The General Studies programs, the School of Graduate Studies and the School of Continuing Studies offer a broad range of programs. MUST is authorized to award Ph.D. degrees, master degrees and bachelor degrees in their residence programs. The university enrolls 5,000 full-time students. MUST recruits students from all over the world as well as 20 provinces and cities in Mainland China for its undergraduate and graduate programs. Wikipedia.


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Patent
Macau University of Science and Technology | Date: 2015-12-16

A quinonemethide triterpenoid is administered to subjects with multidrug-resistant cancer, in particular a cancer with enhanced expression and/or functional activity of ABC transporter proteins such as P-glycoprotein and/or an apoptosis-deficient, in particular p53-, Bax- or Bak-deficient, cancer, i.e. specific subgroups of subjects with cancer. The quinonemethide triterpenoid is suitable to treat cancer allowing for an accumulation of cytotoxic or therapeutic compounds in the cells while having exceptionally increased cytotoxic activity towards the multidrug-resistant cancer cells and while allowing for an increased activity of chemotherapeutic compounds. Methods for specifically targeting cancer cells with multidrug-resistance and methods for potentiating the activity of a chemotherapeutic compound in those cancer cells are also disclosed. A kit including a quinonemethide triterpenoid and a chemotherapeutic compound is also provided.


Patent
Macau University of Science and Technology | Date: 2016-04-18

A method of isolating at least one sphingolipid portion selected from a sphingoid base portion, a ceramide portion, a glycosphingolipid portion or a phosphosphingolipid portion from Cordyceps, in particular from wild-type Cordyceps, allows for obtaining sphingolipid portions having an increased amount of one of sphingoid bases, ceramides, glycosphingolipids or phosphosphingolipids. The sphingolipid portions isolated contained significant amounts of sphingolipids not reported so far, and possess exceptional immunosuppressive activities. A method of treating a subject suffering from an inflammatory disease like an autoimmune disease or an allergic disease includes administering sphingolipids isolated from Cordyceps, in particular from wild-type Cordyceps. A method of treating a subject suffering from an inflammatory disease includes administering certain sphingolipids to the subject. Still further in accordance with the present invention is a composition, in particular a pharmaceutical composition comprising at least one sphingolipid portion.


Patent
Macau University of Science and Technology | Date: 2016-04-18

The present invention relates to a method of identifying and preferably quantifying at least one sphingolipid, in particular the sphingolipid portion in wild-type Cordyceps or Cordyceps derivates. A further aspect relates to a method of identifying wild-type Cordyceps in a Cordyceps sample as well as for identifying Cordyceps derivates in a Cordyceps sample. The methods of the present invention, thus, allow for determining the quality and safety of Cordyceps products and for advantageously differentiating between wild-type Cordyceps and Cordyceps derivates via the ratio and/or presence of certain sphingolipids especially suitable as markers.


Patent
Macau University of Science and Technology | Date: 2015-11-16

A method for implementing a new reactive system and a new reactive system includes applying at least one input suitable for the new reactive system to an existing reactive system to obtain at least one output produced by the existing reactive system; comparing the at least one output with an expected output representative of an output expected to be obtained by applying the at least one input to the new reactive system; determining if the at least one output would be compatible with the expected output; and using the compatibility between the at least one output and the expected output to generate a supervisory control rule set arranged for supervisory control of the existing reactive system when used as part or whole of the new reactive system.


Patent
Macau University of Science and Technology | Date: 2015-10-01

A caffeoylquinic acid-rich extract obtained from Erigeron multiradiatus and a method for producing the same. A caffeoylquinic acid-rich extract includes at least 15% by weight of a mixture of certain caffeoylquinic acids. The extract with the mixture of caffeoylquinic acids is highly efficacious in treating and preventing myocardial ischemia or myocardial ischemia reperfusion injuries. A method for treating or preventing a disease caused by myocardial ischemia or myocardial ischemia reperfusion includes administering a therapeutically effective amount of the caffeoylquinic acid-rich extract to a subject. Pharmaceutical compositions including the caffeoylquinic acid-rich extract are also disclosed.


Patent
Macau University of Science and Technology | Date: 2015-11-13

The present invention relates to the administration of a novel compound advantageously efficacious as PDE inhibitor and its effects on subjects with cancer. More specifically, the present invention is directed to a method for administering a compound having favorable geometric properties for interacting with the PDE prenyl-binding pocket, namely has certain structural components such as a three-cyclic backbone and at least one benzoyl-moiety in a side chain having at least two substituents containing highly electronegative atoms and being linked to the backbone via an aliphatic chain, for treating a subject suffering from a disease such as cancer, in particular non-small-cell lung cancer. The presence of said structural components particularly contributes to an advantageous interaction with PDE, in particular with amino acids deep in the binding pocket. The present invention further provides a method to target tumor cells harboring an RAS gene mutation as well as pharmaceutical compositions comprising said compound.


Patent
Macau University of Science and Technology | Date: 2017-01-26

The present invention discloses a pharmaceutical composition of treating multidrug resistance cancer, comprising a citrus methoxyflavone and a chemotherapeutic drug, in which the citrus methoxyflavone is nobiletin. A method of treating multidrug resistance cancer comprising administrating citrus methoxyflavone and a chemotherapeutic drug is also disclosed.


Patent
Macau University of Science and Technology | Date: 2015-12-16

A method for implementing a packet I/O engine on a programmable computing platform is provided, where the engine performs I/O functions for plural threads generated by a plurality of user applications. In the method, the platform is configured such that only one thread is permitted to initialize and configure the resources. Furthermore, I/O-device queues each for buffering packets either transmitted to or received from an individual external I/O device are set up. For a plurality of unsafe I/O-device queues determined, among the I/O-device queues, to be multi-thread unsafe, a plurality of multi-producer, multi-consumer software queues for buffering packets delivered between the plurality of the unsafe I/O-device queues and the plurality of user applications is set up. In particular, the plurality of multi-producer, multi-consumer software queues is configured such that the unsafe I/O-device queues are collectively synchronized to maintain data consistency in packet delivery in the presence of multiple threads.


Patent
Macau University of Science and Technology | Date: 2015-12-16

Compute-intensive packet processing (CIPP) in a computer system comprising a programmable computing platform is accelerated by using a packet I/O engine, implemented on the platform, to perform packet I/O functions, where the packet I/O engine is configured to achieve direct access to a network interface card (NIC) from a user application. For a Linux-based computer system, standard I/O mechanisms of Linux are bypassed and only the packet I/O engine is used in performing the I/O functions. Furthermore, the computer system is configured to: process a batch of packets, instead of packet by packet, in every function call; and when moving a packet between a buffer of an individual user application and a queue of the packet I/O engine, copy a packet descriptor of the packet instead the entire packet. In addition, workflows across different working threads are balanced and parallelism is exploited to fully utilize resources of the platform.


A method for determining a background component and a dynamic component of an image frame from an under-sampled data sequence obtained in a dynamic MRI application is provided. The two components are determined by optimizing a low-rank component and a sparse component of the image frame in a sense of minimizing a weighted sum of terms. The terms include a Schatten_(p=1/2 )(S_(1/2)-norm) of the low-rank component, an L_(1/2)-norm of the sparse component additionally sparsified by a sparsifying transform, and an L_(2)-norm of a difference between the sensed data sequence and a reconstructed data sequence. The reconstructed one is obtained by sub-sampling the image frame according to an encoding or acquiring operation. The background and dynamic components are the low-rank and sparse components, respectively. Experimental results demonstrate that the method outperforms an existing technique that minimizes a nuclear-norm of the low-rank component and an L_(1)-norm of the sparse component.

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