Plymouth, MI, United States
Plymouth, MI, United States

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The invention provides certain bicylic heterocyclic compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein X^(1), X^(2), R^(1), R^(2), R^(3), R4, and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.


The invention provides certain benzoxazine compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R^(1), R^(2), R^(a), R^(b), R^(c), R^(d), R^(g), and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.


The invention provides trifluoromethyl pyrazolyl guanidine compounds that inhibit F_(1)F_(0)-ATPase, and methods of using trifluoromethyl pyrazolyl guanidine compounds as therapeutic agents to treat medical disorders, such as an immune disorder, inflammatory condition, or cancer.


The invention provides trifluoromethyl pyrazolyl guanidine compounds that inhibit F_(1)F_(0)-ATPase, and methods of using trifluoromethyl pyrazolyl guanidine compounds as therapeutic agents to treat medical disorders, such as an immune disorder, inflammatory condition, or cancer.


The invention provides pyrazolyl guanidine compounds that inhibit F_(1)F_(0)-ATPase, and methods of using pyrazolyl guanidine compounds as therapeutic agents to treat medical disorders, such as an immune disorder, inflammatory condition, or cancer.


The invention provides pyrazolyl guanidine compounds that inhibit F_(1)F_(o)-ATPase, and methods of using pyrazolyl guanidine compounds as therapeutic agents to treat medical disorders, such as an immune disorder, inflammatory condition, or cancer.


The invention relates to medical therapy using an agonist of the retinoic acid receptor-related orphan receptor gamma (ROR) and provides adoptive cellular therapies using an agonist of ROR, populations of lymphocyte cells that have been exposed to an agonist of ROR, populations of dendritic cells that have been exposed to an agonist of ROR, pharmaceutical compositions, and methods for enhancing therapeutic effects of lymphocyte cells and/or dendritic cells in a patient by administering an agonist of ROR to a patient.


The invention provides pyridonyl guanidine compounds that inhibit F_(1)F_(0)-ATPase, and methods of using pyridonyl guanidine compounds as therapeutic agents to treat medical disorders, such as an immune disorder, inflammatory condition, or cancer.


The invention provides pyrazolyl guanidine compounds that inhibit F_(1)F_(o)-ATPase, and methods of using pyrazolyl guanidine compounds as therapeutic agents to treat medical disorders, such as an immune disorder, inflammatory condition, or cancer.


The invention provides tetrahydro[1,8]naphthyridine and related compounds, pharmaceutical compositions, methods of promoting ROR activity, increasing the amount of IL-17 in a subject, and treating cancer using such tetrahydro[1,8]naphthyridine and related compounds.

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