Lvprasad Eye Institute

Hyderabad, India

Lvprasad Eye Institute

Hyderabad, India
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Ali M.J.,Govindram Seksaria Institute of Dacryology | Mishra D.K.,Lvprasad Eye Institute | Naik M.N.,Govindram Seksaria Institute of Dacryology
International Journal of Pediatric Otorhinolaryngology Extra | Year: 2017

Fungal dacryocystitis is uncommon and usually occurs secondary to infection by Candida spp., Aspergillus spp., Curvularia and Pityrosporum spp. Although mostly seen in immunocompromised patients, it has been reported to involve immunocompetent patients. We describe a case of a fungal granuloma solely involving the lacrimal sac without sinus involvement in an immunocompetent infant. The patient responded to an excision biopsy. © 2017 Elsevier Ltd

Dave T.V.,Govindram Seksaria Institute of Dacryology | Mishra D.,Lvprasad Eye Institute | Mittal R.,Lvprasad Eye Institute | Ali M.J.,Govindram Seksaria Institute of Dacryology
Saudi Journal of Ophthalmology | Year: 2017

Lacrimal sac tumors are extremely rare but can be life threatening. Seventy percent of lacrimal sac tumors are of epithelial origin. Inverted transitional cell papilloma of the lacrimal sac is a rare epithelial sinonasal tumor of benign etiology with local invasion and malignant potential. These lesions may remain undiagnosed or may present with signs and symptoms of dacryocystitis or may transform to transitional cell carcinomas. Most lesions are diagnosed intra-operatively while performing a dacryocystorhinostomy. Biopsy and histopathological examination of mass lesions arising from the lacrimal sac helps in timely management of these rare tumors. © 2017.

Ali M.J.,Lvprasad Eye Institute | Psaltis A.J.,University of Adelaide | Murphy J.,University of Adelaide | Wormald P.J.,University of Adelaide
Ophthalmic Plastic and Reconstructive Surgery | Year: 2015

Purpose: To report a decade long experience with powered endoscopic dacryocystorhinostomy (DCR). Methods: A retrospective review of all consecutive patients undergoing powered endoscopic DCR was performed at this institution over a period of 11 years from 2002 to 2013. All patients completed a minimum of 3 months follow up following stent removal. Patient records were reviewed for demographic data, clinical and surgical profiles, adjunctive procedures, complications, and success rates at the last follow up. Anatomical success was defined as patent ostium on irrigation and functional success as free flow of dye into ostium on functional endoscopic dye test and resolution of epiphora. Results: Two hundred eighty-three powered endoscopic DCRs were performed on 214 patients. The mean age at surgery was 59.5 years (range, 3-95 years). All patients presented with epiphora. A total of 91.6% patients (196/214) had a primary DCR and 8.4% (18/214) had a revision DCR. In all, 50.4% patients (108/214) underwent adjunctive endonasal procedures. The mean follow up was 17.1 months (range, 3-103 months). At the last follow up, the final anatomical success was achieved in 96.9% cases of primary DCRs and 91.3% cases of revision DCRs. Functional success was achieved in 93% cases of primary DCRs and 86.9% cases of revision DCRs. Conclusions: Powered endoscopic DCR is a safe procedure and offers excellent results both in primary and revision DCRs. The threshold to perform adjunctive endonasal procedures should be very low when indicated. © Copyright 2014 The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc.

Mulay K.,Centre for Sight | Mulay K.,Lvprasad Eye Institute | Aggarwal E.,Vasan Eye Care Hospitals | Honavar S.G.,Centre for Sight | Honavar S.G.,Lvprasad Eye Institute
Graefe's Archive for Clinical and Experimental Ophthalmology | Year: 2015

Background: Involvement of orbital structures by immunoglobulin G4-related disease (IgG4-RD) is not uncommon. We conducted this study to evaluate the clinicopathologic features of orbital IgG4-RD. Material/Methods: This was a retrospective, clinicopathologic study. Clinical records, light microscopic features, results of immunostaining with IgG & IgG4 and laboratory findings were reviewed in 16 patients diagnosed with orbital IgG4-RD. Results: Eleven patients had a bilateral disease, and the lacrimal gland was involved in 14. Dense sclerosis, plasma cell aggregates and dense lymphoplasmacytic infiltrate were seen in all patients. Serum IgG4 titre was elevated in 12 patients. Nine patients responded completely to glucocorticoid treatment. Five patients had a relapse on discontinuation of treatment. Conclusion: Orbital IgG4-RD is a distinct clinicopathologic entity requiring increased awareness and needs to be differentiated from other orbital lymphoproliferative lesions. © 2015, Springer-Verlag Berlin Heidelberg.

Ali M.J.,Lvprasad Eye Institute
Ophthalmic Plastic and Reconstructive Surgery | Year: 2015

Purpose: To review and summarize the symptomatology, microbiology, special clinical entities, management, complications, and outcomes of pediatric acute dacryocystitis. Methods: The author performed a PubMed search of all articles published in English on acute dacryocystitis. Pediatric subpopulations of these articles were reviewed along with the scant literature of direct references to neonatal and pediatric acute dacryocystitis. Data reviewed included demographics, presentations, microbiological work up, management, complications, and outcomes. Results: Acute dacryocystitis is not very common in the pediatric age groups and occurs mostly as a complication of congenital nasolacrimal duct obstruction. The age of onset is usually in the neonatal period with a female preponderance. The clinical spectrum ranges from classic pediatric acute dacryocystitis to meningitis. Staphylococcus aureus is the commonest isolate. Occasionally acquired etiologies and rare organisms like Pantoea sp., Epstein-Barr Virus, and Sporothrix are implicated in the etiopathogenesis. The diagnosis is usually clinical aided by laboratory investigations. Better antibiotics, well-established laboratory techniques and surgical modalities, and improved patient care logistics have contributed to good outcomes; however, complications are still being noted although infrequently. Conclusions: Pediatric acute dacryocystitis is a distinct entity with unique features of its own. It is a serious infection that warrants careful evaluation and immediate management. In the era of antibiotic resistance, microbiological work up of Pediatric acute dacryocystitis is very useful for subsequent treatment. Surgical challenges in the pediatric age group are distinct and the outcomes are good if standard protocols are followed. Copyright © 2015 The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc.

Nabi S.A.,Sri Venkateswara University | Kasetti R.B.,Lvprasad Eye Institute | Sirasanagandla S.,Sri Venkateswara University | Tilak T.K.,Sri Venkateswara University | And 2 more authors.
BMC Complementary and Alternative Medicine | Year: 2013

Background: The available drugs for diabetes, Insulin or Oral hypoglycemic agents have one or more side effects. Search for new antidiabetic drugs with minimal or no side effects from medicinal plants is a challenge according to WHO recommendations. In this aspect, the present study was undertaken to evaluate the antihyperglycemic and antihyperlipidemic effects of Piper longum root aqueous extract (PlrAqe) in streptozotocin (STZ) induced diabetic rats.Methods: Diabetes was induced in male Wister albino rats by intraperitoneal administration of STZ (50 mg/kg.b.w). Fasting blood glucose (FBG) levels were measured by glucose-oxidase & peroxidase reactive strips. Serum biochemical parameters such as glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglycerides (TG), very low density lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein (HDL) cholesterol were estimated. The activities of liver and kidney functional markers were measured. The statistical analysis of results was carried out using Student t-test and one-way analysis (ANOVA) followed by DMRT.Results: During the short term study the aqueous extract at a dosage of 200 mg/kg.b.w was found to possess significant antidiabetic activity after 6 h of the treatment. The administration of aqueous extract at the same dose for 30 days in STZ induced diabetic rats resulted in a significant decrease in FBG levels with the corrections of diabetic dyslipidemia compared to untreated diabetic rats. There was a significant decrease in the activities of liver and renal functional markers in diabetic treated rats compared to untreated diabetic rats indicating the protective role of the aqueous extract against liver and kidney damage and its non-toxic property.Conclusions: From the above results it is concluded that the plant extract is capable of managing hyperglycemia and complications of diabetes in STZ induced diabetic rats. Hence this plant may be considered as one of the potential sources for the isolation of new oral anti hypoglycemic agent(s). © 2013 Nabi et al.; licensee BioMed Central Ltd.

Maharana P.K.,All India Institute of Medical Sciences | Dubey A.,All India Institute of Medical Sciences | Jhanji V.,Chinese University of Hong Kong | Sharma N.,All India Institute of Medical Sciences | And 2 more authors.
British Journal of Ophthalmology | Year: 2016

Corneal ectasias include a group of disorders characterised by progressive thinning, bulging and distortion of the cornea. Keratoconus is the most common disease in this group. Other manifestations include pellucid marginal degeneration, Terrien's marginal degeneration, keratoglobus and ectasias following surgery. Advanced ectasias usually present with loss of vision due to high irregular astigmatism. Management of these disorders is difficult due to the peripheral location of ectasia and associated severe corneal thinning. Newer contact lenses such as scleral lenses are helpful in a selected group of patients. A majority of these cases requires surgical intervention. This review provides an update on the current treatment modalities available for management of advanced corneal ectasias.

Dave V.P.,Lvprasad Eye Institute | Mathai A.,Lvprasad Eye Institute | Gupta A.,Lvprasad Eye Institute
Journal of Ophthalmic Inflammation and Infection | Year: 2012

Purpose: The purpose of this study is to report an uncommon presentation of anterior and posterior scleritis with central retinal vein occlusion Methods: We report a 30-year-old female presenting with unilateral anterior and posterior scleritis with concurrent central retinal vein occlusion, the subsequent work-up, and the management. The patient presented with decreased vision and extraocular and intraocular inflammatory signs in the left eye. Results: At presentation, the best corrected visual acuity in the right eye (OD) was 20/20 and left eye (OS) was perception of light, with inaccurate projection of rays in all quadrants. Intraocular pressure was 12 mmHg in both eyes. OS showed mild proptosis with lid edema. Ocular movements were free and full in both eyes. The bulbar conjunctiva showed nodular anterior scleritis. OS showed mild vitreous haze with an exudative detachment at the posterior pole, disc edema with dilated, congested and tortuous veins and multiple dot blot hemorrhages, flame-shaped hemorrhages, and soft exudates throughout the posterior pole and mid-periphery An ultrasound B scan showed a large hypoechoic area in the sub-Tenon's space (T-sign) suggestive of periocular fluid collection and thickened sclero-choroidal complex. Orbital ultrasound did not show evidence of any orbital mass or any increase in extraocular muscle thickness. Fundus fluorescein angiography showed few areas of pinpoint hyperfluorescence in the early phase with leakage in the late phase, leakage from the optic disc and vascular staining and pooling of dye in areas of exudative detachment in the late phases in the left eye. Systemic work-up was within normal limits. The patient responded well over the next month with systemic and topical steroids showing complete resolution of the scleritis and exudative retinal detachment. Conclusion: Simultaneous anterior and posterior scleritis with concurrent central retinal vein occlusion is a rare entity requiring prompt diagnosis and systemic work-up for efficient management. © 2012 The Author(s).

Ali M.J.,Lvprasad Eye Institute | Honavar S.G.,Lvprasad Eye Institute | Naik M.,Lvprasad Eye Institute
Minimally Invasive Therapy and Allied Technologies | Year: 2013

Aim: To report a series of 15 consecutive patients with complete proximal bicanalicular obstructions managed with endoscopically guided minimally invasive placement of bypass tubes without a dacryocystorhinostomy (DCR), their indications, interventions, complications and objective and uniform assessment of outcomes. Material and methods: Fifteen consecutive patients presenting with complete proximal bicanalicular obstructions were included in a retrospective, non-comparative case series. Medical records were reviewed for demographic data, etiology, symptoms at presentation, type of bypass tube used, length of the tubes, duration of follow-up, class of lacrimal drainage, patency of the tube, resolution of symptoms, complications and their outcomes. Results: The mean age at presentation was 18.7 years (range: 10-32 years). The most common indication was punctal agenesis (46.6%) followed by complete proximal bicanalicular block secondary to trauma (26.6%). All patients presented with epiphora. The most common bypass tube was a straight Jones variety (60%). The mean length of the bypass tubes was 21 mm (range 19-24 mm). All patients were followed up for a mean duration of 9.6 months following surgery (range 7-13 months). The majority of the patients were post-operatively objectively classified into type I lacrimal drainage (66.6%). At the last follow-up, the success rate was 86.6%. None of the tubes extruded but were removed in two patients due to peritubal soft tissue infection and conjunctival pressure necrosis. Conclusion: Endoscopically guided minimally invasive placement of a bypass tube without DCR is an easier and effective alternative to the traditional conjunctivodacryocystorhinostomy and is likely to help in avoiding major complications of tube extrusion and malpositions seen with the latter procedure. Objective evaluation of lacrimal drainage helps in typifying and uniformly assessing the outcomes. © 2013 Informa Healthcare.

Ali M.J.,Lvprasad Eye Institute | Gupta H.,Lvprasad Eye Institute | Naik M.N.,Lvprasad Eye Institute | Honavar S.G.,Lvprasad Eye Institute
Minimally Invasive Therapy and Allied Technologies | Year: 2013

Aims: To study the efficacy of a new technique of single self-linking silicone stent exclusively in pediatric external dacryocystorhinostomy (DCR) and to report the new use and advantages of endoscopic guidance for the same. Material and methods: Prospective interventional case series, including 11 eyes of ten patients with nasolacrimal duct obstruction. Data collected included demographic data, clinical presentation, laterality, status of lids and puncta, syringing findings, probing interpretations, types and duration of intubation. Consecutive pediatric patients with post-saccal obstruction who underwent an external dacryocystorhinostomy were included. Exclusion criteria included patients who had undergone a DCR in the past by any route via external, endonasal or transcanalicular. Primary outcome measures were stent retention and ease of stent removal. Secondary outcome measures were anatomic patency of the passage and resolution of symptoms. Results: There were three male and seven female patients. Mean age was 9.4 years (range 6-15). A total of 11 procedures were carried out. Following placement of self-linked stents, the removal was done at a mean duration of 13.2 weeks (range:12-16 weeks). None of the patients had a stent prolapse during this period. All stents were removed in the outpatient without the use of general anesthesia with minimal endoscopic guidance. A minimum follow-up of three months following removal was considered for final analysis. Follow-up ranged from three months to six months after tube removal. The anatomical and functional success rate was 91%. There was one anatomical failure three months following tube removal and the remaining patients were free of symptoms at the last follow-up. Conclusions: Self-linking stents are a useful modality in pediatric patients not only to prevent stent prolapse but also to allow easy removal with minimum discomfort. Endoscopic guidance is a useful addition to this technique. © 2013 Informa Healthcare.

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