Lviv National Medical University
L'viv, Ukraine

Danylo Halytsky Lviv National Medical University , — formerly known as the Lvov State Medical Institute, earlier the Faculty of Medicine of the John Casimir University and, before that, Faculty of Medicine of the Francis I University — is one of the oldest and biggest medical universities in Ukraine.It is one of the leading medical universities of the IV level of accreditation. LNMU begins from the Medical Faculty of Lviv University, which was opened on November 16, 1784, according to the privilege of the Austrian emperor Josef II. In 2009 University celebrated its 225 anniversary. Wikipedia.

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Hryhoriy K.,Lviv National Medical University
Wiadomosci lekarskie (Warsaw, Poland : 1960) | Year: 2016

INTRODUCTION: type 2 diabetes mellitus is one of the most important medical and social problems in the world. Patients with diabetes are prone to coronary artery disease, in particular acute coronary syndrome, with atypical clinical signs and susceptibility to tachycardia. Elevated heart rate is an important factor of premature mortality in all patients with acute coronary syndrome. The aim of the investigation was to reveal the heart rate peculiarities in unstable angina and non-ST elevation myocardial infarction patients suffering from diabetes mellitus type 2 for more effective treatment of these patients.MATERIALS AND METHODS: 40 patients with unstable angina and non-ST elevation myocardial infarction were examined in the consecutive way during 2013- 2015 years. The patients were divided in two groups. The main group consisted of 25 patients with UA and NSTEMI with concomitant DM. The control group consisted of 15 patients with UA and NSTEMI but without DM. Basic clinical examinations, electrocardiography and 24 hours electrocardiography monitoring were performed. Carvedilol in the dose from 12.5 to 25 mg daily was also prescribed.RESULTS: we revealed statistically higher heart rate in the patients with unstable angina, non-ST elevation myocardial infarction and concomitant DM on hospitalization, at the fifth day of treatment and before their discharge from the hospital.CONCLUSIONS: 1. Patients with unstable angina and non-ST elevation myocardial infarction in associations with diabetes mellitus type 2 are characterized with increased heart rate partly resistant to β-blockers, which indicates worse prognosis of cardiovascular diseases. 2. Prescription of carvedilol in daily dose 12.5 - 25 mg. is inadequate for obtaining HR < 70 bmp. in some patients with acute coronary syndrome and diabetes mellitus. 3. According to heart rate resistance to β-blockers in patients with unstable angina and non-ST elevation myocardial infarction and concomitant diabetes mellitus patients need individual titration of higher doses of carvedilol.

Ieremeieva T.V.,Lviv National Medical University
Wiadomosci lekarskie (Warsaw, Poland : 1960) | Year: 2016

INTRODUCTION: nowadays, there are about 45 million blind individuals and, according to the prognosis, their quantity will reach over 76 million in 2020. In such a way, nowadays ophthalmological problems become more widespread, and the market of the ophthalmological services is not studied enough to understand all the tendencies and processes.AIM: was to study the patients' awareness on eye diseases and choice peculiarities of the information sources and medical institutions among various population age groups of Lutsk, Rivne and Ternopil cities.MATERIALS AND METHODS: the research was conducted as an anonymous questionnaire survey of respondents according to a specially designed integrated protocol by means of interviewing people at the streets of Lutsk (n=2000), Rivne (n=1500) and Ternopil (n=1500) cities.RESULTS: there was conducted a research on the population awareness concerning vision problems, analysis of social factors and peculiarities of the choice of information sources about eye diseases and factors influencing the choice of a medical institution and an ophthalmologist. It was determined that younger population prefers private medical institutions in almost half of the cases (95% confidence interval (CI) of the private institution choice probability: 0,48-0,52), while older population prefers mainly state ones (95% CI of the choice probability: 0,71-0,74).CONCLUSION: it was determined depending on the age, the range of people having vision problems varied from 22% in the "under 30 years" population group up to 76% in the "over 60 years" group, although at least 21,5% of the whole population realizing their problems do not address an ophthalmologist.

Nakonechnyy R.A.,Lviv National Medical University
Novosti Khirurgii | Year: 2017

Objectives. To determine cystoscopic prognostic markers of treatment effectiveness in children with different clinical forms of vesicoureteral reflux (VUR) for an adequate patients' treatment and defect correction. Methods. The patients (n=270) with various forms of VUR of II-IV grades at the age from 6 months up to 14 years the structure of the ureter ostium was analyzed during the endovesical treatment. Half a year after the endovesical treatment a cystoscopic picture was evaluated in 64 patients with VUR of I-IV grades in whom VUR of stage remained in the same condition or decreased. The position of the "volcano shape" protrusion, migration and extrusion of the implant and if the implant bulged - the hydrodilatation grade of the ureteral orifice sprawled on it were studied. Results. Six months after a single implantation the effectiveness of the minimally invasive treatment of VUR (II grades) was 87,84%, of III - 83,45% and of IV - 39,22%. The effectiveness of endovesical VUR re-treatment of I-IV grades reached 57,81%, which in general made gain on recovery by 13,7%. Generally, minimally invasive intervention efficiency has risen up to 90%. The lack of "volcano shape" protrusion after the first endovesical procedure turned out to be an evident negative prognostic marker regarding the effectiveness of repeated implantation - OR=0,24 [0,07-0,9], RR=0,36 [0,12-1,05], and the migration of the implant in the lateral direction was less pronounced negative marker - OR=0,76 [0,31-1,85], RR=0,84 [0,46-1,51]. Reducing the "volcano shape" protrusion and its displacement to the medial direction are positive prognostic markers regarding the effective re-implantation. The association was more significant with implant volume loss: OR=2,08 [0,82-5,28], RR=1,54 [0,92-2,57] if compared with OR=1,71 [0,69-4,25] and RR=1,39 [0,82-2,34] in case of migration to the midline of the bladder. Conclusion. While planning the endovesical re-treatment of VUR the personalized approach to a patient is necessary considering the prognostic cystoscopic markers.

Kryshchyshyn A.,Lviv National Medical University | Atamanyuk D.,Lviv National Medical University | Lesyk R.,Lviv National Medical University
Scientia Pharmaceutica | Year: 2012

rel-(5aR,11bR)-3,5a,6,11b-tetrahydro-2H,5H-chromeno[4',3':4,5]thiopyrano[2,3-d][1,3]thiazol-2-ones formed by the stereoselective Knoevenagel-hetero-Diels-Alder reaction were functionalized at the nitrogen in position 3 via reactions of alkylation, cyanoethylation, and acylation. The synthesized compounds were evaluated for their anticancer activity in NCI60 cell lines. Among the tested compounds, 3f was found to be the most active candidate with the greatest influence on leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, prostate cancer, and breast cancer subpanel cell lines with GI 50 values over a range of 0.37-0.67 μM. © Kryshchyshyn et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria.

Devinyak O.,Uzhgorod National University | Zimenkovsky B.,Lviv National Medical University | Lesyk R.,Lviv National Medical University
Current Topics in Medicinal Chemistry | Year: 2012

4-Thiazolidinone is a promising scaffold for the search of new potential antibacterial, antiviral, antidiabetic and anticancer agents etc. SAR nalysis of the most potent compounds and different activities evaluation provide a solid back- ground for de novo design of novel drugs. Current review summarizes recent QSAR studies on the 4-thiazolidinones making the emphasis on both technical and interpretative sides of reported models. Several papers among them are de- voted to the anticancer activity of 4-thiazolidinone derivatives and are reporting QSAR models that were obtained via multiple linear regressions (MLR). Additionally, a non-linear approach, namely Gaussian processes, has been applied to identify the relationships between 4-thiazolidinones structure and tumor cell growth inhibition. The interpretation of the reported model highlights the core template for the design of new highly-potent anticancer agents and proposes a hypothe- sis about key role of Hydrogen at the N-atom three bonds away from thiazolidine in the interaction with biotarget. © 2012 Bentham Science Publishers.

Lozynskyi A.,Lviv National Medical University | Zimenkovsky B.,Lviv National Medical University | Lesyk R.,Lviv National Medical University
Scientia Pharmaceutica | Year: 2014

Novel rel-(5R,6S,7S)-2-oxo-5-phenyl-7-aryl(hetaryl)-3,7-dihydro-2H-thiopyrano [2,3-d]thiazole-6-carboxylic acid amides were synthesized in a hetero-Diels-Alder reaction with a series of cinnamic acid amides. The synthesized compounds were tested for their anticancer activity in vitro in the standard National Cancer Institute 60 cancer cell line assay. Promising compounds 3e, 3g, and 3h with moderate antitumor activity were identified among the synthesized series. © Lozynskyi et al.

Yurevych V.R.,Lviv National Medical University
Oftalmologicheskii Zhurnal | Year: 2015

Background: Even though there has been significant advance in the care of ocular complications of diabetes mellitus, the issue related to the prevention of and therapy for this pathology is still an important area that needs to be addressed. Purpose: To investigate the effect of ocular hypertension on the levels of lipid peroxidation products in anterior eye tissues in experimental diabetes. Materials and Methods: Thirty-two rabbits were divided into four groups: group 1 (controls; 10 rabbits), group 2 (diabetes and ocular hypertension (D+OH) group; 8 rabbits), group 3 (diabetes-only group; 7 rabbits) and group 4 (ocular hypertension-only group; 7 rabbits). In these animals, the levels of malondialdehyde and diene conjugate in the anterior chamber angle tissue and aqueous humor were determined. Results: The activation of lipid peroxidation was seen as increased diene conjugate and malondialdehyde levels in the anterior chamber angle tissue and aqueous humor in animals with diabetes. In D+OH group, the levels of malondialdehyde and diene conjugates in the anterior chamber angle tissue, and the levels of malondialdehyde and diene conjugates in the aqueous humor were 23.8%, 21.1%, 31.9% and 28.1%, respectively, higher than those in diabetic animals without ocular hypertension. Conclusion: Increased lipid peroxidation imbalance found in anterior eye tissues and aqueous humor in animals with diabetes mellitus and experimental ocular hypertension is a key element of the mechanism of the accelerated destruction in the aqueous humor outflow pathways. © V.R. Yurevych, 2015.

Prystash Y.Y.,Lviv National Medical University
Wiadomosci lekarskie (Warsaw, Poland : 1960) | Year: 2017

RESULTS: The difference of the receptor status of the tumors is presented. In the group of patients with recurrent "triplet negative" cancer and patients with positive reaction of epidermal growth factor (HER2neo) is more than 15.2%. In patients where RC (control group in the study) was not observed we have the mass greater proportion of tumors with positive hormone receptors in various combinations.MATERIALS AND METHODS: Immunohistochemical study were conducted on 262 patients with invasive breast cancer. Patients were divided into two groups: only local RC - 131 women and primary tumors of patients without local RC - also 131 persons.CONCLUSIONS: Relapses are accompanied by lower levels of hormone receptors and increasing the frequency of "triplet negative" cancer as well as increasing of epidermal growth factor.THE AIM: To explore the changing of the receptor status of the primary tumor and local RC in patients with breast cancer.INTRODUCTION: Appearance of Recurrence (RC) of breast cancer (BC) is associated with a high risk of distant metastases, needs re-treatment and indicates the tumor aggressiveness. It has been remained unclear the molecular characteristics both of the RC and primary tumors in patients with invasive forms of breast cancer after mastectomy by Madden.

Ivanyushko-Nazarko N.V.,Lviv National Medical University
New Armenian Medical Journal | Year: 2017

The study aimed at identifying patterns of protein metabolism changes during toxico-allergic dermatoses for the correct choice of tactics for therapeutic interventions. In order to identify patterns the characteristics of amino acid composition of the serum of patients with polymorphic exudative erythema, patients with Stevens-Johnson syndrome and patients with toxic epidermal necrolysis were studied. Reduced amino acid content, involved in the synthesis of glutathione in the tissues (glycine, cysteine and glutamic acid) and increased arginine content (antioxidant nitrogen) were noted in blood. Changes in the content of other amino acids and amines (methionine, proline, ornithine, taurine) are associated with them metabolically. Toxico-allergic dermatoses are accompanied by significant changes in the blood parameters of the protein metabolism. Disaminoacidemia in case of multiform exudative erythema is a consequence of the activation of lipid peroxidation and weakening of the body antioxidant defenses. Hypoaminoacidemia in Stevens-Johnson syndrome and in the initial phase of toxico-allergic dermatitis can be caused by the violation of protein synthesis, increased permeability of blood vessels and release of proteins from the vascular bed. In the conditions of hypoxia the possibility of slowing down the speed of digestion of proteins to amino acids is not excluded. Reducing the level of free amino acids in blood in Stevens-Johnson syndrome and toxico-allergic dermatoses (in the initial period) is the result of intensive use of free amino acids for the synthesis of protein molecules as a result of skin lesion. The severity and nature of metabolic disorders determine the features of the content of free amino acids and their metabolites in patients. © 2017, Yerevan State Medical University. All rights reserved.

Zayachkivska O.,Lviv National Medical University
Frontiers of Gastrointestinal Research | Year: 2012

Esophageal inflammation is the highly complex protective response to cellular/tissue injury, one of the fundamental features in gastro-esophageal reflux disease (GERD) that represents a wide group of acid-related disorders, where a majority of patients appear to have nonerosive reflux disease (NERD) with minimal change esophagitis and no endoscopic abnormalities. Despite recent advances and better understanding of the physiopathogenesis of GERD and NERD, the molecular events of inflammation leading to erosive esophagitis (EE) and nonerosive esophagitis (NEE) development, their delay in healing and recurrence remains unclear. Membrane and integral glycoconjugate transformation of different cells in the esophageal barrier (EB) is associated with the reprogramming of pathways that control inflammation, survival and proliferation. The focus of this review is to summarize our data on the bidirectional relationship between the glycoconjugates - variable mediators for structural, modality roles and inflammatory settings in esophageal disorders. We designed and carried out experimental studies that induced esophageal damage, mimicking the esophageal injury of human GERD and NERD. We examined it using functional, morphologic and molecular biologic tests, and which and if pathways of inflammation precede changes in EB and development of mucosal lesions during the early stages of NEE or EE. We showed that glycoconjugates operate as tags for esophageal mucosal inflammation, ulceration and control communication between cell populations in repair. Detailed characterization of sialoglycans and their dynamics offers insights into functional interplay in the esophageal cellular community, whereas they switch the pro-inflammatory events involved in early nonepithelial cell activation and mucosal restitution. Esophageal mucosal repair and ulcer healing through different responses cannot be separated from changes in glycoconjugates upon modulation activity of limited and localized inflammation, cytotoxic nitrogen effects, and oxidative injury of epithelial and endothelial cells, cell proliferation, and migration. This new approach to glycobiology will provide an innovative view on inflammation in the physiopathogenesis of NERD and GERD. Copyright © 2012 S. Karger AG, Basel.

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