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L'viv, Ukraine

Danylo Halytsky Lviv National Medical University , — formerly known as the Lvov State Medical Institute, earlier the Faculty of Medicine of the John Casimir University and, before that, Faculty of Medicine of the Francis I University — is one of the oldest and biggest medical universities in Ukraine.It is one of the leading medical universities of the IV level of accreditation. LNMU begins from the Medical Faculty of Lviv University, which was opened on November 16, 1784, according to the privilege of the Austrian emperor Josef II. In 2009 University celebrated its 225 anniversary. Wikipedia.

Zhuraev R.,Lviv National Medical University
Cardiology Journal | Year: 2016

Background: The studies on heart rate variability (HRV), a key predictor of all-cause mortality, in Marfan syndrome (MS), up to now have not been reported, especially in patients with FBN1 mutations. Methods: Among 18 MS patients with the phenotype of MS meeting inclusion criteria 15 have had a FBN1 gene mutation. Short electrocardiography records were taken in the supine position and during orthostatic tests. The control group consisted of 30 apparently healthy nonathletes matched by age and gender. Results: Heart rates in MS patients with the FBN1 mutation were increased in both the supine position and orthostatic test (p < 0.001). Most of the time-domain (standard deviation, pNN50) and frequency-domain (total power, very low, low, and high frequency) parameters of HRV were significantly reduced in the MS patients (p < 0.001). Conclusions: A marked decrease in HRV, documented in the study, may be an important clinical feature in MS patients with confirmed FBN1 gene mutations. © 2016 Via Medica. Source

Zayachkivska O.,Lviv National Medical University
Frontiers of Gastrointestinal Research | Year: 2012

Esophageal inflammation is the highly complex protective response to cellular/tissue injury, one of the fundamental features in gastro-esophageal reflux disease (GERD) that represents a wide group of acid-related disorders, where a majority of patients appear to have nonerosive reflux disease (NERD) with minimal change esophagitis and no endoscopic abnormalities. Despite recent advances and better understanding of the physiopathogenesis of GERD and NERD, the molecular events of inflammation leading to erosive esophagitis (EE) and nonerosive esophagitis (NEE) development, their delay in healing and recurrence remains unclear. Membrane and integral glycoconjugate transformation of different cells in the esophageal barrier (EB) is associated with the reprogramming of pathways that control inflammation, survival and proliferation. The focus of this review is to summarize our data on the bidirectional relationship between the glycoconjugates - variable mediators for structural, modality roles and inflammatory settings in esophageal disorders. We designed and carried out experimental studies that induced esophageal damage, mimicking the esophageal injury of human GERD and NERD. We examined it using functional, morphologic and molecular biologic tests, and which and if pathways of inflammation precede changes in EB and development of mucosal lesions during the early stages of NEE or EE. We showed that glycoconjugates operate as tags for esophageal mucosal inflammation, ulceration and control communication between cell populations in repair. Detailed characterization of sialoglycans and their dynamics offers insights into functional interplay in the esophageal cellular community, whereas they switch the pro-inflammatory events involved in early nonepithelial cell activation and mucosal restitution. Esophageal mucosal repair and ulcer healing through different responses cannot be separated from changes in glycoconjugates upon modulation activity of limited and localized inflammation, cytotoxic nitrogen effects, and oxidative injury of epithelial and endothelial cells, cell proliferation, and migration. This new approach to glycobiology will provide an innovative view on inflammation in the physiopathogenesis of NERD and GERD. Copyright © 2012 S. Karger AG, Basel. Source

Besedina A.,Lviv National Medical University
Journal of Medical Biochemistry | Year: 2016

Background: Coronary heart disease is the leading cause of death and disability worldwide. Hypertension is a major independent risk factor for the development of CHD. Abnormalities in NO generation or activity have been proposed as a major mechanism of CHD. The purpose of this article is to determine the activity of eNOS and iNOS in patients with isolated CHD and CHD associated with HT of different age groups. Methods: Fifty patients with isolated CHD and 42 patients with CHD associated with HT were enrolled in this study. NOS activity was determined by nitrite anion formed in the reaction. Results: A statistically significant increase in iNOS activity is observed in elderly donors. In patients with isolated coronary heart disease cNOS activity is statistically significantly reduced with respect to the control group. The reduction of enzymatic activity of cNOS is more expressed in elderly patients than in middle-aged patients with coronary heart disease. Alterations in eNOS activity are more expressed in patients with coronary heart disease associated with hypertension than in patients with isolated coronary heart disease. Against the background of cNOS inhibition in the patients, a sharp increase in iNOS activity is observed. Conclusions: It has been shown that disturbance of endo - thelial function in patients with coronary heart disease associated with hypertension is characterized by reduced endothelial NO synthesis by cNOS and increased systemic NO synthesis due to increased iNOS activity. It has been found that the lack of endothelial NO and hyperproduction of "harmful" NO by iNOS are more expressed in elderly patients. © by Anna Besedina 2016. Source

Objective. To analyze the effect of long-chain (LC) polyunsaturated w-3 fatty acids (PUFAs) on the daily arterial stiffness parameters in patients with type 2 diabetes (DM2) and cardiovascular autonomic neuropathy (CAN). Material and methods. The study involved 39 patients with DM2 and verified functional stage of CAN. Patients were divided into 2 groups: therapy group (n=21) and control group (n=18). Patients of the control group received traditional hypoglycemic therapy; patients of the therapy group additionally received 1 capsule/day of the ω-3 PUFAs for three months. Results. The use of the ω-3 PUFAs resulted in a statistically significant decrease in aortic augmentation index (AAI) and pulse wave velocity in the aorta (PWV) during the active period. There was a decrease in AAI in the aorta and the brachial artery and in PWV in the aorta during the night. Conclusion. The efficacy of ω-3-PUFAs is a result of a direct effect of the pharmacological agent on the circadian arterial stiffness parameters. © 2015, Media Sphera. All rights reserved. Source

Urbanovych A.,Lviv National Medical University
Current Issues in Pharmacy and Medical Sciences | Year: 2015

Resistin is still a little known hormone of the adipose tissue. The potential role of resistin in the development of DM2 has been currently investigated. The aim of our study was to detect the resistin blood level in patients with DM2, depending on the duration of the disease. In so doing, a determination of resistin and insulin blood level was conducted in 305 patients with DM2, and in a control group of 32 persons. Before testing, the patients were placed into four groups, depending on the duration of type 2 diabetes. Our results indicate that the resistin level was significantly lower in the control group of patients, in comparison with the DM2 patients groups. Moreover, a significantly lower resistin level was found in group I (firstly diagnosed DM2), in comparison with the groups of patients with a different duration of DM2. No correlation between resistin level and BMI, and between resistin and insulin blood level was found. However, a tendency towards increase of resistin blood level is noticeably evident in co-relation with increment of DM2 duration. In addition, the resistin level was considerably lower in patients with no DM2, when compared with patients with diagnosed DM2. Yet, there was no significant difference in the resistin blood level depending on the sex of the patients at the same duration of DM2. © 2015 Medical University of Lublin. All rights reserved. Source

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