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Yossi S.,luniversite Nantes Angers Le Mans | Yossi S.,Institute Of Cancerologie Of Louest Paul Papin | Sayegh J.,luniversite Nantes Angers Le Mans | Sayegh J.,Angers University Hospital Center | And 6 more authors.
Medecine Nucleaire | Year: 2013

Odontoid process is an atypical and very rare localization of osteomyelitis. We reported the case of a 72-year-old hemodialysed man with methicillin-sensitive Staphylococcus aureus osteomyelitis of the odontoid process. Osteomyelitis was diagnosed at MRI and 18F-FDG PET/CT. While clinical examination and conventional radiographs were non contributive, 18F-FDG PET/CT also allowed the diagnosis of right foot osteomylitis and multiple vertebral septic localizations. 18F-FDG PET/CT done at month 3 demonstrated a regression of the odontoid and foot hypermetabolic activity. This case illustrates the atypical presentation of this septic localization and the usefulness of 18F-FDG PET/CT to perform whole body screening and detect septic metastasis. © 2013 Elsevier Masson SAS.

PubMed | Indiana University, Stanford University, University of California at Los Angeles, Harvard University and 2 more.
Type: Journal Article | Journal: The American journal of pathology | Year: 2015

The hypoxia-inducible factor (Hif)-1 (Hif-1) and Hif-2 (Epas1) have a critical role in both normal development and cancer. von Hippel Lindau (Vhl) protein, encoded by a tumor suppressor gene, is an E3 ubiquitin ligase that targets Hif-1 and Epas1 to the proteasome for degradation. To better understand the role of Vhl in the biology of mesenchymal cells, we analyzed mutant mice lacking Vhl in mesenchymal progenitors that give rise to the soft tissues that form and surround synovial joints. Loss of Vhl in mesenchymal progenitors of the limb bud caused severe fibrosis of the synovial joints and formation of aggressive masses with histologic features of mesenchymal tumors. Hif-1 and its downstream target connective tissue growth factor were necessary for the development of these tumors, which conversely still developed in the absence of Epas1, but at lower frequency. Human tumors of the soft tissue are a very complex and heterogeneous group of neoplasias. Our novel findings in genetically altered mice suggest that activation of the HIF signaling pathway could be an important pathogenetic event in the development and progression of at least a subset of these tumors.

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