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Marseille, France

Madsen F.,Lung Function Laboratory
Scandinavian Journal of Clinical and Laboratory Investigation

The volume calibration syringe is probably the single most important instrument in pulmonary function laboratories, yet no validation results have been published. In this study a sample of volume calibration syringes was validated. We weighed a 1-L and two 3-L calibration syringes before and after emptying them of water and determined the corresponding volume of gas by using a modified rolling seal spirometer. In this way we established an unbroken calibration chain between a certified weight of water and the corresponding volume of gas. The volume of a spirometer calibration syringe could be verified with an accuracy of ± 15 ml. The modified rolling seal spirometer had an accuracy of ±11 ml at a volume of 1 L and ±13 ml at a volume of 3 L. A sample of spirometer calibration syringes was validated and all syringes except for two small 1-liter syringes all had volumes within the label claimed volume ± 0.5%. Spirometer calibration syringes have a stable stroke volume even after many years of use and storage but have to be calibrated yearly to comply with international standard. © 2012 Informa Healthcare. Source

Wang J.-Y.,Beijing University of Chinese Medicine | Wang X.-Y.,Dongzhimen Hospital | Wu H.-Y.,Dongzhimen Hospital | Sun H.-Y.,Dongzhimen Hospital | And 4 more authors.
Chinese Journal of Integrative Medicine

Objective To investigated the involvement of pulmonary function impairment in ulcerative colitis (UC), to explore a scientific basis for the Chinese medicine (CM) theory of exterior-interior correlation between Lung (Fei) and Large intestine (Dachang). Methods Totally 120 patients with a diagnosis of UC were recruited and the demographics, clinical data, and blood samples were collected. C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) concentrations were measured. Every patient accepted pulmonary function test and took chest radiograph (CXR).> Results Pulmonary function abnormalities were present in 72 of 120 patients. The median (interquartile range) vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), carbon monoxide diffusion capacity (DLCO) of lung, total lung capacity (TLC) and functional residual volume (FRV) were decreased in distal UC and pancolitis compared with ulcerative prochitis (P <0.0005). Male patients had increased VC, FEV1/FVC, and residual volume (RV)/TLC compared with female (P <0.0005), but decreased DLCO and carbon monoxide iffusion capacity (KCO) of lung/alveolar ventilation (P <0.0005). Age was strongly correlated with RV (Spearman rank correlation coefficient (rs)=-0.57,P <0.0001), and RV/TLC (rs=0.48,P<0.0001). Age was also correlated with FEV1/FVC (rs=-0.29, P=0.001), forced expiratory flow in 75% vital capacity (FEF75%, rs=-0.20, P=0.03), DLCO (rs=-0.21, P=0.02), TLC (rs=-0.25, P=0.006), and FRV (rs=-0.28, P=0.002). The course of disease was correlated with FEF75% (rs=-0.18, P=0.049) and KCO (rs=-0.19, P=0.036). Chest radiograph abnormalities were presented in 38 of 120. Pulmonary symptoms were presented in 10 of 120. Other extraintestinal complications were presented in 21 of 120. Conclusions Pulmonary function impairment was more frequently than other extraintestinal complications in UC patients, which may be affected by sex, age, extent and course of disease. These results may be a scientific basis for the theory of exterior-interior correlation between Lung and Large intestine. © 2014 Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg. Source

van Staden S.R.,Lung Function Laboratory | Groenewald M.,Allergy Clinic | Engelbrecht R.,Lung Function Laboratory | Becker P.J.,Biostatistics Unit | Hazelhurst L.T.,Tshwane University of Technology
South African Medical Journal

Background. Chronic obstructive pulmonary disease and lung cancer are diseases associated with smoking tobacco cigarettes. Smokers find cessation difficult. Objectives. To determine whether smoking the Twisp electronic cigarette (e-cigarette), containing nicotine in a vegetable-based glycerine substance, would reduce carboxyhaemoglobin (COHb) levels in regular cigarette smokers by (i) comparing arterial and venous COHb levels before and after smoking the Twisp e-cigarette for 2 weeks; and (ii) evaluating changes in participants' perception of their health and lifestyle following the use of Twisp e-cigarettes. Methods. A single group within-subject design was used where tobacco cigarette smokers converted to Twisp e-cigarettes for 2 weeks. Prior to using the Twisp e-cigarette and after using this device for 2 weeks, arterial COHb, venous COHb and venous cotinine levels were determined. Additionally, the participants were asked to complete a questionnaire outlining their perceptions on health and lifestyle. Results. Thirteen participants of median age 38 years (range 23 - 46) with a smoking median of 20 cigarettes/day (range 12 - 30) completed the study. COHb levels (%) were significantly reduced after smoking Twisp e-cigarettes for 2 weeks (mean ± standard deviation (SD) arterial COHb before 4.66±1.99 v. after 2.46±1.35; p=0.014 and mean ±SD venous COHb before 4.37±2.1 v. after 2.50±1.23; p=0.018). There was excellent agreement between arterial and venous COHb levels (intraclass correlation coefficient 0.916). A decrease in cotinine levels (p=0.001) and an increase in oxygen saturation (p=0.002) were also observed. The majority of participants perceived improvements in their health and lifestyle parameters. Conclusion. Smoking the Twisp e-cigarette may be a healthier and more acceptable alternative to smoking tobacco cigarettes. Source

Jammes Y.,Roche Holding AG | Jammes Y.,Lung Function Laboratory | Budin-Poirier C.,Roche Holding AG | Budin-Poirier C.,Lung Function Laboratory | And 2 more authors.
Clinical Physiology and Functional Imaging

Non-invasive measurements of the phrenic nerve conduction time (CT) and diaphragmatic electromyographic response to voluntary inspiratory efforts may help to document an abnormal diaphragmatic function in the presence of hemidiaphragm elevation on chest radiographs. Twenty-one patients were addressed for the diagnosis of abnormal placement and motion of the right (13) or left (8) cupola on chest radiographs. CT was measured by recording the diaphragmatic M-wave evoked by electrical transcutaneous phrenic nerve stimulation. The integrated diaphragmatic surface electromyogram (Edi) was recorded during sniff and Müller manoeuvres. Four patients were followed up during the next 8-16 months. Among the twenty-one patients, five (24%) had a lengthened or absent CT. A right-to-left peak Edi asymmetry was measured in fourteen (67%), including those having abnormal CT. Agreement between side-related radiographic abnormalities and Edi asymmetry was high in the cases of an elevation of the right cupola (12/13, 92%) but poor when the left cupola was suspected (1/8, 13%). Long-term follow-up of Edi asymmetry showed a partial or total recovery. Thus, the combination of measurements of phrenic nerve CT and Edi recordings during voluntary inspiratory efforts confirmed 67% of the radiographic suspicion of diaphragmatic dysfunction. © 2009 The Authors. Journal compilation © 2009 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Source

Rivera J.M.O.,Lung Function Laboratory | Alvarez Puebla M.J.,Lung Function Laboratory | Arroabarren Aleman E.,Lung Function Laboratory | Cambra K.,Navarrabiomed | And 2 more authors.
Journal of Investigational Allergology and Clinical Immunology

Background and Objective: Preschool children can perform quality, reproducible spirometric maneuvers, provided appropriate equipment is used and specially trained nursing staff training are available. However, use of spirometry for the diagnosis and follow-up of preschool children with respiratory diseases remains limited in clinical practice, because consensus on test quality and acceptability criteria and reference data are lacking. We initiated the present study with the aim of developing reference equations, since tables of normal values for this age group are not available in our area. Patients and Methods: The study population comprised healthy preschool children in our community. Normal values for exhaled nitric oxide in this age range were assessed. Regression equations were constructed using univariate and multivariate models. Results: A total of 114 healthy preschool children aged 3 to 6 years were enrolled. According to the criteria of the American Thoracic Society/ European Respiratory Society, 60 children were able to perform acceptable and reproducible spirometric maneuvers. The best correlations were observed for the untransformed linear regression model that included height. The correlation coefficients for forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), and FEV0.5 were 0.89, 0.88, and 0.86, respectively. The regression equations for the calculation of reference values were as follows: FVC = -2.6 + 0.036 × height, cm FEV1 = -2.04 + 0.029 × height, cm FEV0.5 = -1.53 + 0.022 × height, cm We obtained fraction of inhaled nitric oxygen (FeNO) values for 56 children. The mean (SD) value was 11 (4.9) ppb. Conclusions: Most preschool children in our area were able to perform quality spirometry maneuvers. We obtained regression equations that allowed us to calculate the reference ranges in our population and the distribution of normal FeNO values. © 2014 Esmon Publicidad. Source

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