Jamshoro, Pakistan
Jamshoro, Pakistan

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Khan A.H.,University of Sindh | Hayat A.S.,University of Sindh | Masood N.,LUMHS | Solangi N.M.,University of Sindh | Shaikh T.Z.,University of Sindh
Journal of the Liaquat University of Medical and Health Sciences | Year: 2010

OBJECTIVES: The aim of this study is to observe the clinical presentation and frequency of dengue as a cause of fever in our setup. METHODS: This retrospective study comprising of clinically suspected dengue infection, admitted to Liaquat University Hospital Hyderabad, during an epidemic from August 2006 to August 2007. Only adults with acute febrile illness were evaluated for clinical features of dengue fever, dengue hemorrhagic fever and dengue shock syndrome. RESULTS: Patients with acute febrile illness were evaluated during this study. Fifty (5%) patients presented with typical features of dengue fever. Age of the patients ranged between 13 and 70 years. All patients were males with mean age of 35 years. Only 20/50 (40%) were dengue proven while 30/50 (60%) were dengue suspected. Out of dengue proven, 18 patients had dengue fever and 2 had dengue hemorrhagic fever. Typical clinical features included chills and rigors in 16 (80%), myalgia in 14 (70%), vomiting in 12 (60%), headache in 10 (50%), rash in 5 (25%). Unusual clinical features were pharygitis in 7 (35%) and bleeding manifestations in 5% of patients. Laboratory investigations showed leucopenia (<4.0x109/L) in 80%, thrombocytopenia (<150x109/L) in 90%, and serum ALT was elevated (>40 U/L) in 40% cases. CONCLUSIONS: Fever associated with chills and rigors, bodyaches, bone pain, headache, myalgia, rash, low platelet count, decreased total leukocyte count, raised serum ALT, and hemorrhagic manifestations are satisfactory and important parameters to screen the cases of suspected dengue virus infection; however the diagnosis cannot be confirmed unless supported by molecular studies or dengue specific IgM.

Memon S.,LUMHS | Shaikh S.,LUMHS | Kousar T.,LUMHS | Memon Y.,LUMHS | Rubina,LUMHS
Journal of the Pakistan Medical Association | Year: 2010

Objective: To assess the practice and knowledge of mothers regarding breast feeding, complimentary feeding, and to find out socio-economic correlates of feeding practices. Methods: A cross sectional survey conducted at paediatric department of Liaquat University Hospital (LUH) from Jan-Dec 2008. During that period 500 mothers with children less than 24 months were included. Infant feeding patterns were assessed in relation to recommendations and household socio-economic factors by an Interview Technique. Results: Out of 500 mothers, 8.4% started exclusive breast feeding (EBF) while Pre-lacteal use was seen in 31.6%. Regarding the duration 52.2% mothers continued breast feeding for 2 years. Median duration of EBF was 3.5 months. It was seen that 60% of the 0-5 month-old infants breastfed 8 or more times per day. However, exclusiveness of breast feeding decreased from 60% at (0-2 months) to 40% (3-5 months). Majority 64.2% were poor and 61.5% had no education. There is a statistically significant difference in feeding practices of educated and uneducated (P < 0.0001) and also in poor and middle class mothers (P <0.0003). Regarding, age of their last born babies, 180 babies were under 6 months, and 320 were 6 to 23 months of age. The knowledge about complimentary feeding (CF) was inadequate. Around 21% of 2-3 months old babies received complementary food and 19% of 6-8 month-olds were only breastfed. In 78% mothers CF was advised by family members while in 23% mothers by doctors. Conclusion: Exclusive breastfeeding was not maintained upto recommended age of 6 months. Knowledge about CF was lacking in the mothers. Regarding, mothers' education and socioeconomic conditions, a positive correlation was noted with feeding practices.

Shaikh M.A.,LUMHS | Memon I.,LUMHS | Ghori R.A.,LUMHS
Journal of the Pakistan Medical Association | Year: 2010

Objective: To analyze the frequency and causes of anaemia in systemic lupus erythematosus (SLE) patients attending in department of medicine at tertiary care hospitals. Methods: This retrospective, descriptive and analytical study was planned to analyze the frequency and causes of anaemia in SLE patients attending the department of medicine at (MMC) and (LUMHS) hospitals during the period of Jan 2006 to Nov 2008. The criteria used in this study were from the American College of Rheumatology. Investigations recorded were blood complete picture, absolute values, peripheral smear, and reticulocyte count in all patients of anaemia. These investigations were necessary to analyse the cases of anaemia in SLE. All investigations were not done in all cases. Patients with hypochromic microcytic anaemia were advised to have serum iron and ferritin levels, seven patients with macrocytic anaemia were advised to have direct and indirect coomb's test, LFTs, serum LDH, serum B12 and folate levels. Patients with normochromic and normocytic anaemia were considered to have anaemia of chronic disease. Bone marrow aspiration and Hb electrophoresis were done in two patients with anaemia of chronic disease. Thirty adult patients were included in this study. Special proforma were prepared to record the information from case sheets of patients including basic information, symptomatology and laboratory investigations. Severity and various types of anaemias were recorded. Anaemia was graded according to severity, as mild (Hb 10-12 G/dl), Moderate (Hb 8-10 G/dl) and severe (Hb < 8 G/dl). Haemoglobinopathies and other types of anaemias were excluded from study. Results: Thirty adult diagnosed patients of SLE, were included. Their ages ranged from twenty years to fifty years at time of presentation. The mean age ± SD (range) was 28 ± 6.22 (20-50) years and median age was 31 years. Out of thirty patients, twenty seven (90%) were females and three (10%) were males. Twenty eight (93.33%) patients presented with anaemia, 14 (46.66%) patients were of mild anaemia, 8 (26.66%) patients were of moderate grade anaemia and 6 (20%) patients had severe anaemia. Iron deficiency anaemia was found in 9 (30%) patients, 12 (40%) patients had anaemia of chronic disease and 7 (23.33%) patients had haemolytic anaemia, out of theses 7 patients, 5 (16.66%) patients had Coomb's positive haemolytic anaemia. All thirty patients had ANA positive titres >1:80; and nineteen (63.33%) patients had anti ds DNA positive, titres >1:10. Conclusion: Haematologic abnormalities are common manifestations in patients with SLE. Most patients exhibit anaemia at some point during their disease course.

Qadeer-Ul-Hassan Prof.,LUMHS
Medical Forum Monthly | Year: 2014

Objective: To find out frequency and clinical presentation of dry socket in Department of Oral and Maxillofacial Surgery Liaquat University of Medical & Health Sciences, Jamshoro. Study Design: Obseervational study. Place and Duration of Study: This study was carried out at Department of Oral & Maxillofacial Surgery, Liaquat University of Medical & Health Sciences, Jamshoro from Jan 2011 to June 2012. Materials and Methods: Age from 11 to 70 years with both gender groups was included in the study. They were observed for the presence of dry socket. Patients with previous history of two or more days of extraction, pam. sensitivity on gentle probing of the extraction socket and empty/ partially empty socket were included m the study. Data was analyzed using SPSS version-13. Results: Total 2300 extractions were included in study; dry socket was recorded in 66 (3.3%) routine dental extraction except 3rd molars and 598 (26%) surgical& non-surgical extraction of 3rd molar respectively. Majority of the patients belong to 3rd decade of life Conclusion: In oral Surgery practice dry socket is unavoidable, but oral surgeons must identify additional risk factors in patients with particular medical conditions and include this information as a part of the informed consent.

Shafi M.,University of Sindh | Yousufani A.H.,LUMHS | Hussain S.I.,Dow University of Health Sciences
Journal of the Liaquat University of Medical and Health Sciences | Year: 2010

OBJECTIVE: To analyse the spectrum of presentation and management of foreign bodies in external auditory canal. STUDY DESIGN: Retrospective analysis of data. PLACE AND DURATION: District Government Hospital Paretabad Hyderabad (Sindh) Pakistan over a period of 8 years, i.e. from July 1999 to June 2007. Methods: A pre designed proforma was used to collect the data regarding patients' demographics, frequency and type of foreign body, management and outcome. RESULTS: Total 653 patients with foreign bodies in external auditory canals were dealt with over a period of about eight years. The age variance was from 1-65 years. Most of the foreign bodies i.e. 163 (25%) were retrieved in the children up to two years of age. A wide variety of foreign bodies totally numbering 41 were retrieved from external auditory canals. Stone/concretion were the single most frequently removed foreign body constituting 32.6%. Jobson Horne Probe was the single most frequently used tools which was utilized in 37% of the cases to remove different types of foreign bodies. General anesthesia was employed in only 11.79% of the cases. Operating loupe was used in 53.13% of the cases. Morbidity occurred in 11% of the cases with tympanic membrane perforation occurring in 0.6% of the case. CONCLUSION: Different types of foreign bodies are prevalent in different parts of the world. Similarly different methods of removal are adopted dictated by the nature, location and state of the foreign body at the particular instant.

Shah A.A.,Ghulam Muhammad Mahar Medical College | Soomro N.A.,Ghulam Muhammad Mahar Medical College | Talib R.K.,Sukkur CT Scan | Sadhayo A.N.,LUMHS | Soomro S.A.,LUMHS
Journal of the College of Physicians and Surgeons Pakistan | Year: 2014

Endometriosis is the condition where endometrium gets implanted and flourishes outside the uterine cavity, most commonly in ovary and on the peritoneum which lines the abdominal cavity and viscera. Endometrial cells in areas outside the uterus are influenced by hormonal changes and respond in a way similar to the endometrium inside the uterus. Symptoms often worsen with the menstrual cycle. We present a case of 50 years old female who presented with gross abdominal distension and abdominal pain over years. CT scan showed a huge intraabdominal cyst of unknown origin which was compressing adjacent structures. Patient underwent a high risk operation and whole cyst weighing 214 kg (471 lbs) was removed along with both ovaries and uterus. Histopathologically, it was reported as endometrial cyst.

Punjabi S.K.,LUMHS | Habib-ur-Rehman,Abbasi Shaheed Hospital | Ali Z.,Abbasi Shaheed Hospital | Ahmed S.,Abbasi Shaheed Hospital
Journal of the Pakistan Medical Association | Year: 2011

Objectives: To assess the causes and management of Zygomatic bone fractures at Abbasi Shaheed Hospital, Karachi. Methods: This study was carried out at Department of Oral & Maxillofacial surgery Abbasi Shaheed Hospital, Karachi. A total of 82 cases were studied. A detailed history was taken, clinical examination was performed and fractures were confirmed by radiography. Management of fractures was done by using different proposed modalities,suitable for every case. A number of factors, like age of patients, causes of trauma and gender were assessed. Results: The commonest cause of Zygomatic bone fracture was found to be road traffic accident (RTA) 50% (n=41), followed by assault 23.17% (n=19), fall 20.73% (n=17), sports injuries 3.65% (n=3), and others 2.43% (n=2) respectively. Right side (55%) was involved a little more than the left side (45%). Zygomatic bone fracture was more prevalent in age group between 21-30 years, while male to female ratio was 5.30:1. Remote reduction using Gillie's Temporal Approach with and without fixation using bone plates were the commonest management modalities used in this center. Conclusion: The commonest cause of Zygomatic bone fracture was found to be road traffic accident, with the right side fractures being more common. It reveals poor road traffic sense in road users, lack of road safety measures and legislation in our population.

Punjabi S.K.,University of Sindh | Khoso N.A.,LUMHS | Butt A.M.,LUMHS | Channar K.A.,LUMHS
Journal of the Liaquat University of Medical and Health Sciences | Year: 2013

OBJECTIVES: The objectives of this study are to analyze the pattern; symptoms and pathology associated with impacted mandibular third molar teeth. MATERIAL AND METHODS: This descriptive case series study was conducted at department of Oral &Maxillofacial Surgery Liaquat University Hospital Hyderabad. The duration of study was from 1st Nov 2011 to 31st July 2012.Patients complaining of impacted teeth along with two diagnostic x rays, age, gender, type of impaction and associated pathology were recorded. RESULTS: Total of 290 patients were included in this study. Out of these females were predominantly affected, mean age was found to be 24.41 years. Vertical impaction was the most common type of mandibular impaction(37.4%) and pain, caries was the common pathological symptom associated with impacted teeth. CONCLUSION: Our study showed most common age group involved was group 1 sample sizes. Vertical and Mesioangular were most common impaction seen in this study group with common symptoms pain and caries.

Khaskhelli L.B.,University of Sindh | Memon S.,LUMHS | Goswami P.,LUMHS | Bano S.,LUMHS
Journal of the Liaquat University of Medical and Health Sciences | Year: 2013

OBJECTIVES: To observe and compare gross and histological changes of the placenta of nondiabetic and diabetic mothers. And observe possible changes in the fetal weight of diabetic and non diabetic mothers. STUDY DESIGN: Case control study. PLACE AND DURATION: This study was conducted from June 2009 to July 2010 at the department of Anatomy of Liaquat University of Medical & Health Sciences Jamshoro. The placentae were collected from department of Gynecology & Obstetrics of Liaquat University Hospital. MATERIAL AND METHODS: Eighty freshly delivered placentae were collected forty placentae from diabetic's mothers & forty placentae from parturient belonged to uncomplicated pregnancy (control group). Ages of all parturient were between 17 to 32 years. Fetal outcome and data was recorded. Placentae were measured on a weighing machine graduated in grams and diameter was measured with the help of a measuring tape in centimeters. Approximately five mm piece of from diabetic placenta was taken and processed for histological examination. Fetal weight was also recorded. RESULTS: Morphological examination of placentae showed larger, heavier and more cotyledenous placentae group as compared to controls. Similarly microscopic examination revealed dilated blood vessels, necrotic and degenerative foci in placentae of diabetics as compared to controls. CONCLUSION: Diabetes Mellitus produces profound gross as well as histological changes in placentae which might result in large for date babies because of fetal compromises. A good glycemic control might be a better option for reducing diabetes induced abnormalities.

Memon S.,University of Sindh | Goswami P.,LUMHS | Lata H.,Muhammad Medical College Mirpurkhas
Journal of the Liaquat University of Medical and Health Sciences | Year: 2015

OBJECTIVE: This descriptive study aimed to observe the anatomical including both and microscopic changes in diabetic placenta to increase our knowledge as very few studies are done on anatomy of placenta. INTRODUCTION: The placenta is a dynamic organ of unique function with short life-span. It is physiological site of exchange between maternal-fetal circulation. It is responsible for respiratory, nutritional, excretory, endocrine, and immunological functions. MATERIALS AND METHODS: Macroscopic and microscopic examination was carried out on total of 50 freshly delivered placentae from diabetic’s mothers. Variables used for macroscopic examination are weight, diameter, number of cotyledons. On histology degenerative changes, fibrinoid necrosis, vessel thrombosis and infarction were examined. RESULTS: Morphological examination of placentae of diabetic mothers showed larger, heavier and more cotyledons. Similarly microscopic examination revealed dilated blood vessels, necrotic and degenerative foci, thrombosis and infarction in placentae of diabetic mothers. CONCLUSION: An adequate knowledge of the placental changes can prove to be valuable in the understanding the complications to fetus caused by diabetes. This study shows significant changes in placentae on gross as well as on microscopy. Out of many abnormal changes infarction is single most important change. Infarction lead to fibrin deposition in villi and leading to avascularity hence uteroplacental insufficiency which is important factor for fetal development. © 2015, Liaquat University of Medical and Health Sciences. All rights reserved.

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