Rapid method for the detection of metabolite of sulfur mustard 1,1'-sulfonylbis[2-S-(N-acetylcysteinyl)ethane] in plasma and urine by liquid chromatography-negative electrospray-tandem mass spectrometry
Rodin I.A.,Moscow State University |
Braun A.V.,Moscow State University |
Savelieva E.I.,Research Institute for Hygiene |
Rybalchenko I.V.,Lumex |
And 2 more authors.
Journal of Liquid Chromatography and Related Technologies | Year: 2011
A method for detection of an important biological marker, 1,1'-sulfonylbis[2-S-(N-acetylcysteinyl)ethane] (SBSNAE) of sulfur mustard agent [bis-(2-chloroethyl)sulfide] (HD) in human plasma and rat urine to quantify HD exposure, is presented. It employs solid-phase extraction sample preparation, followed by liquid-chromatography-negative ion-electrospray ionization-tandem mass spectrometry. The method limit of detection (LOD) for SBSNAE is 0.05ng/mL for rat urine samples with relative standard deviations of less than 10%. Application of this procedure was demonstrated in the HD animal exposure model. Rats were exposed intravenously to 5mg/kg HD, and SBSNAE levels in urine samples were analyzed for 22 days post-exposure. Copyright © Taylor & Francis Group, LLC.
Ahmed Y.,Lumex |
Electronic Products (Garden City, New York) | Year: 2011
Engineers should consider five key points when designing user interface technology for use in extreme cold and heat conditions. An important first step is to have a clear understanding of the environment in which the technology works. The significant understanding of environmental challenges helps in the selection of user interface technology suitable to each application. The understanding of visual display needs also prove essential in designing a user-interface that can perform in extreme conditions. The innovative displays provide full graphic capability with almost limitless customization, including daylight visibility. Users can either opt for a monochromatic screen with any color of LED backlight, or select a negative image option with mono-colored pixels and a dark background. Engineers need to compare the technology costs of various user interface technologies. They need to ensure that all possible expenses are considered in addition to simple technologies expenses.
Kirsanov D.,Saint Petersburg State University |
Zadorozhnaya O.,Saint Petersburg State University |
Krasheninnikov A.,Lumex |
Komarova N.,Lumex |
And 2 more authors.
Sensors and Actuators, B: Chemical | Year: 2013
A lot of various applications of the Electronic Tongue (ET) related to the detection and quantification of taste and flavour of different products were reported so far. For obvious reasons, one relies upon human perception and taste panel marks working with ET in this domain. However, there is an unusual, albeit wide, realm of perception-related analysis based on the "marks" produced by other biological species, besides human beings, from different mammals to microorganisms. Thus, a series of methodologies, which are based on an ample variety of species (e.g. Daphnia, algae, unicellular organisms, luminescent bacteria and many others) were applied for the evaluation and monitoring of water quality and detection of acute water toxicity. The present paper deals with the application of the potentiometric multisensor system for water toxicity estimation in terms of the bioassay with three living test organisms: Daphnia magna, Chlorella vulgaris and Paramecium caudatum. The prediction of water toxicity with relative errors 15-26% (depending on the test object) is possible using PLS (projection on latent structures) regression from the data obtained by potentiometric multisensor system. © 2012 Elsevier B.V. All rights reserved.