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Luhans'k, Ukraine

State Establishment "Lugansk State Medical University" SE LSMU. Established on 6 May 1956, and Currently, the university is a powerful educational - scientific and medical complex that includes medical and biological boarding schools, gymnasium, classrooms in remote areas of the region, and six faculties. The University enrolled nearly 3,000 students, including foreigners from more than 60 countries. The School has 40 departments, among them - 22 clinical and 18 theoretical. Postgraduate education is on the faculty of postgraduate education, where there are 6 chairs. Diploma studies based on the application of modern educational technologies aimed at improving the quality and effectiveness of the learning process. The university employs 400 teachers, among them 76 doctors of science, professors, 288 candidates of science, associate professors, 9 Honored Science and Technology and one Honored Worker of Education of Ukraine, 5 winners of the State Prize of Ukraine, two experts LHC. Wikipedia.

Manns M.P.,Hannover Medical School | Wedemeyer H.,Hannover Medical School | Singer A.,PharmaPart GmbH | Khomutjanskaja N.,Lugansk State Medical University | And 5 more authors.
Journal of Viral Hepatitis | Year: 2012

Chronic hepatitis C patients often fail to respond to interferon-based therapies. This phase III study aimed at confirming the efficacy and safety of glycyrrhizin in interferon + ribavirin-based therapy non-responders. A randomised, double-blind, placebo-controlled, comparison of glycyrrhizin, administered intravenously 5×/or 3×/week, and 5×/week placebo for 12 weeks to 379 patients, was followed by a randomised, open comparison of glycyrrhizin i.v. 5×/versus 3×/week for 40 weeks. Primary endpoints were: (1) the proportion of patients with â¥50% ALT (alanine aminotransferase) reduction after 12 weeks double-blind phase, and (2) the proportion of patients with improvement of necro-inflammation after 52 weeks as compared with baseline. The proportion of patients with ALT reduction â¥50% after 12 weeks was significantly higher with 5×/week glycyrrhizin (28.7%, P < 0.0001) and 3×/week glycyrrhizin (29.0%, P < 0.0001) compared with placebo (7.0%). The proportion of patients with improvement in necro-inflammation after 52 weeks was 44.9% with 5×/week and 46.0% with 3×/week, respectively. Glycyrrhizin exhibited a significantly higher ALT reduction compared to placebo after 12 weeks of therapy and an improvement of necro-inflammation and fibrosis after 52-weeks treatment. Generally, glycyrrhizin treatment was well tolerated. © 2012 Blackwell Publishing Ltd. Source

Belaya I.E.,Lugansk State Medical University
Russian Journal of Cardiology | Year: 2014

Aim. To study plasma lipid profile, systemic inflammation and endotelial function in patients with acute period of MI with Q-wave and liver steatosis (LS) or non-alcoholic steatohepatits (NASH). Material and methods. Totally 48 patients with acute MI of the left ventricle were studied (1st group), with average age 66,33±1,66; 53 — with acute MI and LS (2nd group) — average age 63,74±1,87, and 7 — with acute MI and NASH (3rd group) — average age 58,86±4,47. In all groups men dominated. We measured the levels of liver enzymes, bilirubin, total cholesterol, LDP cholesterol, VLDL cholesterol, triglycerides, atrogenity coefficient, cholesterol-accepting properties of HDL, level of nitrite- and nitrate-anions in serum, hsC-reactive protein. Results. The disordered lipid profile in patients of both groups shows the increased levels of total cholesterol, LDL (p<0,001) and VLDL (p<0,01), atherogenity coefficient (p<0,001) and lowering of HDL and their cholesterol-accepting properties (p<0,001). In patients of 2nd and 3rd groups there is an increase of nitrites (p<0,001) and nitrates (p<0,001). Endothelial dysfunction was the worse in acute MI with NASH. In patients with combined pathology there is increase of C-reactive protein (p<0,001). The parameter of systemic inflammation is higher in patients with acute MI with NASH. Conclusion. In patients with combined MI and LS or NASH there is an increase of atherogenity and decrease of anti-atherogenity in lipid profile, increase of stable NO metabolites with maximally prominent endothelial dysfunction in patients with NASH, due to aseptic inflammation. Marker of inflammation severity is higher in those with NASH comparing to LS. © 2015, Silicea-Poligraf. All Rights Reserved. Source

Belaya I.Y.,Lugansk State Medical University
Russian Journal of Cardiology | Year: 2014

In the article the sensitivity of new vectorcardiographic research method of patients on the cardiodiagnostic complex МТМ-SКМ in the process of thrombolytic therapy is proved by clinical example. Clinical case. In a patient with acute myocardial infarction of anterior wall of the left ventricle vectorcardiogram results give the opportunity to confirm a significant diminution of the area of myocardial damage with concomitant deterioration of conductivity and preserving of ischemic events due to reduction of electromotive force of the heart in the anterior wall of the left ventricle. In addition, the dynamic decrease of the electrical activity of the atria with a significant slowing of the pulse and repolarization disorder may indicate involvement of atriums in the pathological process with a considerable blood flow disorder in them. Conclusion.This method allows to make a quality and quantitative evaluation of the efficiency of the reperfusion therapy, as well as to obtain the information about the electromotive force of the heart both in the necrobiosis zone and out of myocardium affection zone. © 2015, Silicea-Poligraf All rights reserved. Source

Pivovarova O.A.,Lugansk State Medical University | Mankovsky B.N.,Plshupik National Medical Academy Of Postgraduate Education
Diabetes Mellitus | Year: 2013

Aim. To study the morphology of bronchial epithelium in a rodent streptozotocin-induced (STZ) diabetes mellitus. Materials and Methods. Diabetes mellitus was introduced in 47 white Wistar rats aged 5-6 months (body weight 234.0±2.64 g). 43 white Wistar rats of the same age were used as control subjects (body weight 242.0±2.13). Diabetes was induced by single intraperitoneal injection of STZ (SIGMA, USA) 60 mg/kg in 0.1 M citrate buffer, pH 4.5. Results. A statistically significant decrease in the total epithelial area by 25.9% was observed in the study group, accompanied by a reduction of the supranuclear zone by 22.1% vs. the control group. Conclusion. We found that bronchial mucous membrane in rodents with STZ-induced diabetes mellitus exhibits signs of atrophy and partial loss of mucous production by bronchial secretory cells. Source

Gal'Chenko V.Ya.,Lugansk State Medical University | Yakimov A.N.,Lugansk State Medical University
Russian Journal of Nondestructive Testing | Year: 2014

A method is proposed to achieve uniform magnetization in ferromagnetic samples based on the bionic parametric optimal synthesis of the magnetization source that provides the necessary magnetization distribution. Simulation results are reported that illustrate the efficiency of the method. Numerical examples show that the proposed method allows the achievement of more uniform magnetization in short samples by using a magnetization system with ferromagnetic elements. © 2014 Pleiades Publishing, Ltd. Source

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