Czupryniak L.,Medical University of Lódz |
Barkai L.,Debrecen University |
Bolgarska S.,National Medical Academy of Post Graduate Education |
Bronisz A.,Nicolaus Copernicus University |
And 12 more authors.
Endokrinologya | Year: 2014
Self-monitoring of blood glucose (SMBG) is universally considered to be an integral part of type 1 diabetes management and crucial for optimising the safety and efficacy of complex insulin regimens. This extends to type 2 diabetes patients on intensive insulin therapy. There is also a growing body of evidence suggesting that structured SMBG is beneficial for all type 2 diabetes patients, regardless of therapy. However, access to SMBG is limited in many countries in Central and Eastern Europe. Therefore a consensus group of diabetes experts from ten countries in this region (with overlapping historical, political and social environments) - Bulgaria, Croatia, Czech Republic, Hungary, Poland, Romania, Serbia, Slovakia, Slovenia and Ukraine has developed evidence-based recommendations for the appropriate use of SMBG as a part of the individualised patient management. The expert group considers SMBG to be an essential tool that should be accessible to all patients with diabetes, including those with non-insulin-treated type 2 diabetes. The ultimate goal of these guidelines is to help patients and healthcare providers in Central and Eastern Europe make optimal use of SMBG to maximise the efficacy and safety of glucose-lowering therapies, prevent complications and empower the patients to play a more active role in the management of their diabetes.
Szpinda M.,Ludwik Rydygier Collegium Medicum in Bydgoszcz |
Szpinda M.,Nicolaus Copernicus University |
Szpinda A.,Ludwik Rydygier Collegium Medicum in Bydgoszcz |
Szpinda A.,Nicolaus Copernicus University |
And 6 more authors.
Advances in Clinical and Experimental Medicine | Year: 2011
Background. Advances in perinatal medicine have required an exhaustive knowledge of fetal aorto-iliac diameters in the prenatal diagnosis of congenital aorto-iliac abnormalities. Objectives. This study defines the growth of absolute and relative external diameters of the abdominal aorta and iliac arteries in human fetuses. Material and Methods. Using anatomical dissection and digital-image analysis, the external diameters of the abdominal aorta, and common, external and internal iliac arteries in 124 spontaneously aborted human fetuses aged 15-34 weeks were examined. Results. No significant sex differences were found (P > 0.05). The strongest developmental dynamics referred to the abdominal aorta diameters, from 1.18 ± 0.25 to 5.19 ± 0.49 mm for its origin, and from 1.03 ± 0.23 to 4.92 ± 0.46 mm for its bifurcation. The intermediate values were found in both the common and internal iliac arteries: from 0.66 ± 0.19 to 2.30 ± 0.42 mm on the right, and from 0.66 ± 0.14 to 2.16 ± 0.42 mm on the left for the former, and from 0.52 ± 0.15 to 1.77 ± 0.44 mm on the right, and from 0.50 ± 0.14 to 1.65 ± 0.42 mm on the left for the latter. The smallest values were related to the external iliac arteries, which increased from 0.35 ± 0.09 to 1.28 ± 0.26 mm and from 0.31 ± 0.05 to 1.21 ± 0.22 mm on the right and left sides, respectively. The external diameter at the bifurcation of the abdominal aorta was relatively increasing throughout the study period. External diameters of the three iliac arteries were found to decrease in their relative values in the age range of 4-5 months, to start increasing gradually afterwards. Conclusions. The absolute values of the external diameters of the aorto-iliac segment increase linearly throughout gestation, whereas the relative values of the three iliac arteries decrease during the 4 th-5 th month period of gestation, to start increasing afterwards. © Copyright by Wroclaw Medical University.
Bujak R.,Nicolaus Copernicus University |
Daghir E.,Nicolaus Copernicus University |
Rybka J.,Ludwik Rydygier Collegium Medicum in Bydgoszcz |
Koslinski P.,Nicolaus Copernicus University |
And 2 more authors.
Bioanalysis | Year: 2011
Although in recent decades the development of many drugs against cancer has been witnessed, the morbidity and mortality for the most prevalent urogenital cancer have not been significantly reduced. A key task in cancer medicine is to detect the disease as early as possible. In order to achieve this, many new technologies have been developed for cancer biomarker discovery. Monitoring fluctuations of certain metabolite levels in body fluids, such as urine, has become an important way to detect early stages in carcinogenesis. Moreover metabolomic approaches are likely to be used to screen for potential diagnostic and prognostic biomarkers of urogenital cancer. In future work, these potential biomarkers should be further validated with a large enough patient cohort to achieve earlier diagnosis not only of urogenital cancer, but also other malignancies. Moreover, the improvement of patient prognosis will be another aim of such investigations. This novel metabolomic approach has the potential to provide more information about the pathophysiological status of an organism and distinguish precancerous and cancerous stages. © 2011 Future Science Ltd.
Kosinski A.,Medical University of Gdańsk |
Zajaczkowski M.,Medical University of Gdańsk |
Kuta W.,Medical University of Gdańsk |
Kozlowski D.,Medical University of Gdańsk |
And 2 more authors.
Folia Morphologica (Poland) | Year: 2013
The septomarginal trabecula is present in all human hearts as well as in the hearts of other primates. It usually connects the interventricular septum with the anterior papillary muscle, although there are many variations in how this is achieved. The object of the analyses was to estimate the bilateral topography of the septomarginal trabecula and the anterior papillary muscle in the context of the ontogeny and phylogeny of primates. A total of 138 hearts were examined from number of different non-human primates. The presence of the septomarginal trabecula was confirmed in 94.9% of cases, although not in the hearts of Lemur varius. Four configurations could be distinguished by defining the location of the septomarginal trabecula and its relation to the anterior papillary muscle. For the hearts of the Strepsirrhini and the majority of Platyrrhini neither structure was related, whereas in all examined representatives of Hominoidea they had fused and created morphologically varying forms. On the basis of these results, a concept was developed for the sequence of changes which the topography of the septomarginal trabecula and the anterior papillary muscle undergo during ontogeny and phylogeny. Copyright © 2013 Via Medica.