Lucknow Christian Post Graduate College

Lucknow, India

Lucknow Christian Post Graduate College

Lucknow, India

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Rastogi N.,Lucknow Christian Post Graduate College | Kant P.,University of Lucknow | Sethi R.,University of Lucknow | Shukla S.,Sri Jai Narain Post Graduate College | Tripathi D.,Sri Jai Narain Post Graduate College
Journal of the Indian Chemical Society | Year: 2011

2-{4′-(2″-Chlorobenzyloxy)-phenyl}-1,3,4-oxadiazolin-5-thione, 3-{4′-(2″-chlorobenzyloxy)-phenyl}-4-phenyl-1,2,4-triazolin-5- thione and their N and S substituted derivatives have been synthesized and screened for their antimicrobial potential against human pathogenic fungi Candida albicans (CA), Cryptococcus neoformans (CN), Aspergillus fumigatus (AF), Trichophyton mentagrophytes (TM), Candida parapsilosis (ATCC-22019) (CP) and bacteria Klebsiella pneumoniae (ATCC-27736) (KP), Escherichia coli (ATCC-9637) (EC), Pseudomonas aeruginosa (ATCCBAA-427) (PA) and Staphylococcus aureus (ATCC-25923) (SA). The structures of the compounds have been established by means of elemental analysis and spectral data (IR, PMR and Mass).


Rastogi N.,Lucknow Christian Post Graduate College | Harrison A.D.,Lucknow Christian Post Graduate College | Agarwal A.,University of Lucknow
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry | Year: 2011

A new series of 1-aminomethyl-3-[4′-(4″-nitrobenzyloxy)- benzohydrazono]isatins (Mannich bases) have been synthesized and screened for their antimicrobial potential against human pathogenic bacteria and fungi. The structures of the compounds have been established by means of elemental analysis and spectral data (IR and 1H NMR).


Rastogi N.,Lucknow Christian Post Graduate College | Kant P.,University of Lucknow | Sethi R.,University of Lucknow | Harrison D.A.,Lucknow Christian Post Graduate College | Shukla S.,Sri Jai Narain Post Graduate College
Journal of the Indian Chemical Society | Year: 2012

3-{4′-(Chlorobenzyloxy)-phenyl}-4-amino-5-mercapto-1,2,4-triazoies (1a-d) were prepared by treating 4-(chlorobenzyloxy)-benzoylhydrazines successively with alcoholic potassium hydroxide-carbon disulphide and hydrazine hydrate, which on reaction with hydrazine hydrate, carbon disulphide, benzoic acid, benzoin, phenacyl bromide, phenyl isothiocyanate, formic acid, chloroacetyl chloride, benzaldehyde and isatin gave condensed bridgehead heterocycles (triazolo-thiadiazoles and triazolo-thiadiazines). The structures of the compounds were established with the help of elemental analysis and spectral data (IR, PMR and Mass). Compounds were screened for their antimycotic potential against human pathogenic fungi.


Rastogi N.,Lucknow Christian Post Graduate College | Harrison D.A.,Lucknow Christian Post Graduate College
Journal of the Indian Chemical Society | Year: 2012

5-{4′-(2″,4″-Dichlorobenzyloxy)-phenyl}-1,3, 4-oxadiazole-2(3H)-thione (2) was prepared by the reaction of 4-(2′,4′-dichlorobenzyloxy)-benzoylhydrazine (1) with potassium isopropylxanthate in isopropyl alcohol. 5-{4′-(2″,4″- Dichlorobcnzyloxy)-phenyl}-1,3,4-oxadiazole-2(3H)-thione (2) on being subjected to aminomethylation with secondary amines in the presence of formaldehyde gave 3-aminomethyl-5-{4′-(2″,4″-dichlorobenzyloxy)-phenyl}-1,3, 4-oxadiazole-2(3H)-thiones (3-8). Compound 2 was treated with alkyl/aralkyl/aryl halides in dry acetone In the presence of potassium carbonate to get 3-alkyl/aralkyl/aryl-5-{4′-(2″,4″-dichlorobenzyloxy)-phenyl} -1,3,4-oxadiazole-2(3H)-thiones (9-14) while when compound 2 was treated with same halides in the presence of alcoholic potassium hydroxide, yielded 2-alkyl/aralkyl/arylthio-5-{4′-(2″,4″-dichlorobenzyloxy) -phenyl)-1,3,4-oxadiazoles (15-20). Oxadiazole 2 on reaction with acid chlorides in aqueous sodium hydroxide resulted in 2-aroyl/phenylacetylthio-5-{4′- (2″,4″-dichlorobenzyloxy)-phenyl}-,3,4-oxadiazoles (21-24). 2-Aryl5-{4′-(2″,4″-dichlorobenzyloxy)-phenyl}-1,3, 4-oxadiazoles (25-29) were obtained by refluxing benzoyl hydrazine 1 with aromatic acids in phosphorus oxychloride. The structures of the compounds were established by elemental analysis and spectral data (IR, 1H NMR and Mass). The compounds were screened for their antifungal potential against human pathogenic fungi.


Rastogi N.,Lucknow Christian Post Graduate College | Kant P.,University of Lucknow | Sethi R.,University of Lucknow | Harrison D.A.,Lucknow Christian Post Graduate College | Shukla S.,Sri Jai Narain Post Graduate College
Indian Journal of Heterocyclic Chemistry | Year: 2011

A new series of bridgehead nitrogen containing heterocyclic compounds like thiazolo [3,2-b]-s-triazole, isomeric thiazolo [2,3-c]-s-triazole, thiazolo [3,2-b]-s-triazole-5(6H)-one, imidazolo [2,3-i)]-1,3,4-thiadiazol-5-one, 1,3,4-oxadiazolo [3,2-a]-5-triazine -5,7 (6H) dithione and 1,3,4-triazolo [3,2-b]-s-triazine-5,7 (6H)-dithione have been synthesized and screened for their antimycotic and antileishmanial potential against human pathogenic fungi and Leishmania donovani.


Rastogi N.,Lucknow Christian Post Graduate College | Kant P.,University of Lucknow | Sethi R.,University of Lucknow | Shukla S.,Sri Jai Narain Post Graduate College | Harrison D.A.,Lucknow Christian Post Graduate College
Indian Journal of Heterocyclic Chemistry | Year: 2010

4-(Chlorobenzyloxy) anilines were incorporated into 5-nitro-1H-benzo [d] imidazole, 6-nitrobenzo [d] oxazol-2(3H)-one and 4-nitroisoindoline-1,3-dione in the presence of 40% aq formaldehyde to furnish a new series of 5-nitro-1-(4-chlorobenzyloxy)-anilinomethyl-1 H-benzo [d] imidazoles /6-nitro-3-(4-(chlorobenzyloxy)-anilinomethyl)-benzo [d] oxazol-2(3H)-ones and 4-nitro-2-(4-chlorobenzyloxy)-anilinomethyl) isoindoline-1,3-diones (11-25). The structures of the compounds were established by means of elemental analysis and spectral data (IR & PMR). Compounds were screened for their antileishmanial and antimicrobial potential.

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