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Rastogi N.,Lucknow Christian Post Graduate College | Kant P.,University of Lucknow | Sethi R.,University of Lucknow | Shukla S.,Sri Jai Narain Post Graduate College | Tripathi D.,Sri Jai Narain Post Graduate College
Journal of the Indian Chemical Society | Year: 2011

2-{4′-(2″-Chlorobenzyloxy)-phenyl}-1,3,4-oxadiazolin-5-thione, 3-{4′-(2″-chlorobenzyloxy)-phenyl}-4-phenyl-1,2,4-triazolin-5- thione and their N and S substituted derivatives have been synthesized and screened for their antimicrobial potential against human pathogenic fungi Candida albicans (CA), Cryptococcus neoformans (CN), Aspergillus fumigatus (AF), Trichophyton mentagrophytes (TM), Candida parapsilosis (ATCC-22019) (CP) and bacteria Klebsiella pneumoniae (ATCC-27736) (KP), Escherichia coli (ATCC-9637) (EC), Pseudomonas aeruginosa (ATCCBAA-427) (PA) and Staphylococcus aureus (ATCC-25923) (SA). The structures of the compounds have been established by means of elemental analysis and spectral data (IR, PMR and Mass). Source


Rastogi N.,Lucknow Christian Post Graduate College | Harrison A.D.,Lucknow Christian Post Graduate College | Agarwal A.,University of Lucknow
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry | Year: 2011

A new series of 1-aminomethyl-3-[4′-(4″-nitrobenzyloxy)- benzohydrazono]isatins (Mannich bases) have been synthesized and screened for their antimicrobial potential against human pathogenic bacteria and fungi. The structures of the compounds have been established by means of elemental analysis and spectral data (IR and 1H NMR). Source


Rastogi N.,Lucknow Christian Post Graduate College | Kant P.,University of Lucknow | Sethi R.,University of Lucknow | Harrison D.A.,Lucknow Christian Post Graduate College | Shukla S.,Sri Jai Narain Post Graduate College
Journal of the Indian Chemical Society | Year: 2012

3-{4′-(Chlorobenzyloxy)-phenyl}-4-amino-5-mercapto-1,2,4-triazoies (1a-d) were prepared by treating 4-(chlorobenzyloxy)-benzoylhydrazines successively with alcoholic potassium hydroxide-carbon disulphide and hydrazine hydrate, which on reaction with hydrazine hydrate, carbon disulphide, benzoic acid, benzoin, phenacyl bromide, phenyl isothiocyanate, formic acid, chloroacetyl chloride, benzaldehyde and isatin gave condensed bridgehead heterocycles (triazolo-thiadiazoles and triazolo-thiadiazines). The structures of the compounds were established with the help of elemental analysis and spectral data (IR, PMR and Mass). Compounds were screened for their antimycotic potential against human pathogenic fungi. Source


Rastogi N.,Lucknow Christian Post Graduate College | Kant P.,University of Lucknow | Sethi R.,University of Lucknow | Harrison D.A.,Lucknow Christian Post Graduate College | Shukla S.,Sri Jai Narain Post Graduate College
Indian Journal of Heterocyclic Chemistry | Year: 2011

A new series of bridgehead nitrogen containing heterocyclic compounds like thiazolo [3,2-b]-s-triazole, isomeric thiazolo [2,3-c]-s-triazole, thiazolo [3,2-b]-s-triazole-5(6H)-one, imidazolo [2,3-i)]-1,3,4-thiadiazol-5-one, 1,3,4-oxadiazolo [3,2-a]-5-triazine -5,7 (6H) dithione and 1,3,4-triazolo [3,2-b]-s-triazine-5,7 (6H)-dithione have been synthesized and screened for their antimycotic and antileishmanial potential against human pathogenic fungi and Leishmania donovani. Source


Rastogi N.,Lucknow Christian Post Graduate College | Kant P.,University of Lucknow | Sethi R.,University of Lucknow | Shukla S.,Sri Jai Narain Post Graduate College | Harrison D.A.,Lucknow Christian Post Graduate College
Indian Journal of Heterocyclic Chemistry | Year: 2010

4-(Chlorobenzyloxy) anilines were incorporated into 5-nitro-1H-benzo [d] imidazole, 6-nitrobenzo [d] oxazol-2(3H)-one and 4-nitroisoindoline-1,3-dione in the presence of 40% aq formaldehyde to furnish a new series of 5-nitro-1-(4-chlorobenzyloxy)-anilinomethyl-1 H-benzo [d] imidazoles /6-nitro-3-(4-(chlorobenzyloxy)-anilinomethyl)-benzo [d] oxazol-2(3H)-ones and 4-nitro-2-(4-chlorobenzyloxy)-anilinomethyl) isoindoline-1,3-diones (11-25). The structures of the compounds were established by means of elemental analysis and spectral data (IR & PMR). Compounds were screened for their antileishmanial and antimicrobial potential. Source

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