Loyola University Chicago is a private Jesuit university located in Chicago, Illinois. It was founded by the Roman Catholic Society of Jesus in 1870 under the name of "St. Ignatius College", and has grown to be the largest Jesuit university in the United States with a total enrollment of 15,068 and over 150,000 alumni.Loyola University has six campuses throughout the Chicago metropolitan area, and it also has a permanent overseas campus in Rome, Italy and guest programs in Beijing, China and Ho Chi Minh City, Vietnam. Loyola has twelve undergraduate, graduate, and professional schools offering 71 undergraduate degrees, 85 master's degrees, 31 doctoral degrees, and 26 graduate-level certificate programs.The main campus, the Lake Shore Campus, is located in the Rogers Park and Edgewater neighborhoods of the City of Chicago, located along the shore of Lake Michigan. Loyola University Chicago's intercollegiate sports teams, commonly called the "Loyola Ramblers", compete in National Collegiate Athletic Association Division I and the Missouri Valley Conference. As of 2013, Loyola University is still the only Division I school in the State of Illinois to win a national championship in men's basketball. Wikipedia.
Marchese A.,Loyola University Chicago
Current Opinion in Cell Biology | Year: 2014
Chemokine receptors belong to the super family of G protein-coupled receptors (GPCRs). The cognate ligands for chemokine receptors are small circulating proteins known as chemokines. Upon binding to their cognate chemokines, receptors are rapidly desensitized, internalized onto early endosomes and sorted either into a recycling pathway or degradative pathway. Chemokine receptor trafficking is essential because it limits the magnitude and duration of signaling by removing receptors from the cell surface thereby limiting access to their ligands, but it also delivers bound chemokines to lysosomes for degradation. Receptor sorting into the recycling pathway contributes to resensitization of receptor signaling, whereas sorting into the degradative pathway leads to long-term attenuation of signaling. Recent studies have revealed some key information regarding the molecular determinants mediating chemokine receptor internalization and have shed light on the mechanisms dictating sorting into either the recycling or degradative pathways. Here I discuss our current understanding of the mechanisms mediating chemokine receptor trafficking with a focus primarily on recent findings for the chemokine receptor CXCR4. © 2013. Source
Wolfe A.J.,Loyola University Chicago
Current Opinion in Microbiology | Year: 2010
Recent reports support the long-standing hypothesis that acetyl phosphate, a physiologically relevant small molecule, can serve as a phosphoryl donor to a subset of two-component response regulators that regulate diverse cellular processes. Since acetyl phosphate is a central metabolite, this ability would link nutritional status to global signaling. This review will first introduce acetyl phosphate and its pathway. It will then summarize the most compelling evidence supporting the hypothesis and list predicted properties of an acetyl phosphate-sensitive pathway. Next, it will describe emerging evidence that acetyl phosphate and/or its pathway can influence diverse cellular processes across a broad spectrum of bacteria. Finally, the review will explore the possibility that other metabolites can function in a capacity similar to acetyl phosphate. © 2010 Elsevier Ltd. All rights reserved. Source
Loyola University Chicago | Date: 2014-09-04
Surface-modified organic semiconductors and methods for making surface-modified organic semiconductors are disclosed. More particularly, surface-modified thin films are provided, the surface-modified thin films comprising a first layer comprising a polyaromatic organic semiconductor and a surface layer in direct contact with the first layer, the surface layer comprising an addition reaction product of the polyaromatic organic semiconductor with, for example, a dienophile, wherein the first layer is substantially free of the addition reaction product of the organic semiconductor with the dienophile. Also provided are surface-modified single crystals comprising a core comprising a polyaromatic organic semiconductor and a coating in direct contact with the core, the coating comprising, for example, an addition reaction product of the polyaromatic organic semiconductor with a dienophile, wherein the core is substantially free of the addition reaction product of the organic semiconductor with the dienophile.
Loyola University Chicago | Date: 2014-02-27
An imaging process capable of selectively enhancing visualization of soft tissues, for example, a tumor. The imaging process includes producing a hard tissue-enhanced image of a body containing both soft and hard tissues, wherein the hard tissue-enhanced image contains images of the hard tissues that are enhanced relative to the soft tissues. A radiographic image of the body and the soft and hard tissues thereof are then obtained, after which a weighted subtraction algorithm is performed between the radiographic image and the hard tissue-enhanced image to produce a soft tissue-enhanced image in which imaging of the soft tissues is enhanced relative to the hard tissues. The hard tissue-enhanced image may be produced by obtaining first and second initial radiographic images of the body including the soft and hard tissues, and then performing a weighted subtraction algorithm on the first and second initial radiographic images to produce the hard tissue-enhanced image.
Loyola University Chicago | Date: 2014-02-07
Methods and combination pharmaceuticals for treating bronchospastic medical conditions by utilizing the electrophysiology of proteinacious channels in lipid membranes of mammalian cells. The combination pharmaceuticals include at least one -adrenergic receptor agonist, and at least one composition adapted to effect the electrophysiology of Kv7 potassium channels of a lipid membrane of an airway smooth muscle cell. The pharmaceutical may be administered to a living body in a therapeutic amount sufficient to activate the Kv7 potassium channels of an airway smooth muscle cell.