Rani M.S.,Entomology Research Institute |
Emmanuel S.,Loyola Academy |
Sreekanth M.R.,Loyola Academy |
Ignacimuthu S.,Entomology Research Institute
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2010
The present study was aimed at evaluating the protective role of methanol fraction and its pure compound chrysophanol from Cassia occidentalis Linn. Against paracetamol-induced hepatotoxicity in rats. Adult male albino Wistar rats, weighing 110-150g, were randomized into control and experimental group. Test group of animals were treated with paracetamol (2g/kg bw on 8th day). Liv-52 was used as a standard reference Chrysophanol (50 mg/kg bw) and methanol fraction (COLMF) (200 mg/kg bw) were administered to the paracetamol treated rats for seven days Oral administration of chrysophanol and COLMF significantly normalized the values of SOD, CAT, GPx, GSH, Vit-C and Vit-E. And the elevated serum enzymatic levels of AST, ALT, ACP and ALP were significantly restored towards normalization by pre-treatment with Chrysophanol and COLMF (p>0.05). The histopathological studies also confirmed the hepatoprotective nature of the extracts. The results of this study strongly indicate tha Cassia occidentalis has potent hepatoprotective action against paracetamol induced hepatic damage in rats.
Emmanue S.,Loyola Academy |
Rani M.S.,Loyola Academy |
Sreekanth M.R.,Loyola Academy
International Journal of Pharma and Bio Sciences | Year: 2010
Cassia occidentalis Linn. is extensively used in the indigenous and folklore medicine systems to treat several illnesses. However adequate characterization of hypoglycemic activity of C.occidentalis has not yet been done. The scientific evaluation of its hypoglycemic activity was, therefore, explored and also compared with the effect of a standard hypoglycemic drug, Glibenclamide. In the present study methanol fraction of C.occidentalis leaves (COLMF) was tested against streptozotocin-induced diabetic rats. Adult male albino Wistar rats, weighing 150-200g, were randomized into control and experimental groups. Experiment group rats were induced diabetes by a single intraperitoneal injection of streptozotocin (STZ). Treatment with COLMF at different doses and times following in normal and diabetic rats significantly reduced the blood glucose level to normal in diabetic rats (99.68±3.57). Hemoglobin, glycosylated hemoglobin, hepatic glycogen, lipid peroxidation, antioxidants enzymes (TBARS, HP, SOD, CAT, GPx VitC, VitE, GSH) and hepatic marker enzymes (ALT, AST, ALP, ACP) were also evaluated in normal and diabetic rats. Oral administration of COLMF significantly and dose-dependently normalized the above mentioned parameters near to normal in STZ-diabetic rats (p<0.05). Histopathological examination showed that COLMF extract protected the pancreatic tissue from STZ-induced damage.
Krishna Mohan K.,Loyola Academy |
Raja Reddy A.,Loyola Academy |
Babu Rao S.,Loyola Academy |
Rama Krishna K.,Loyola Academy |
Saritha D.,Loyola Academy
Pestology | Year: 2011
A field experiment was conducted during kharif 2009, to know the effect of pre-emergence herbicides on growth, weed control and yield in black gram. The treatments comprised of control, hand weeding, pendimethalin (0.75 and 1.5 kg a.i/ha), oxyflurofen (0.10 and 0.20 kg a.i/ha) and fluchoralin (1.0 and 1.5 kg a.i/ha). The results indicated that plant height and number of branches/ plant were significantaly increased with herbicide treatments among which oxyflurofen @ 0.2 kg a.i/ha has recorded maximum followed by pendimethalin (0.75 kg) and hand weeding. The total dry matter production was maximum in hand weeding (426 g/m2) followed by lower concentrations of oxyflurofen @ 0.1 kg (388 g/m2) and pendimethalin @ 0.75 kg (365 g/m2) compared to unweeded control. Hand weeding and herbicide treatments at lower concentrations had significant effect on LAI, NAR and weed control efficiency compared to control. The number of pods/plant and seed yield were more with herbicide treatments. The nutrient percent (N, P and K) in leaves and pods was increased at lower concentration of herbicide treatments .
Suchitra N.T.,Acharya Nagarjuna University |
Emmanuel S.,Loyola Academy |
Sheeba R.M.,Indian Institute of Chemical Technology
Research Journal of Pharmacy and Technology | Year: 2013
Ichnocarpus frutescens L (Apocynaceae), is a large, branched climbing shrub with white latex in all its parts. It is an important medicinal plant found throughout India. Tribes in India use it as a substitute for sarsaparilla (Hemidesmus indicus) in the treatment of atrophy, convulsions, cough, delirium, dysentery, measles, splenomegaly, tuberculosis, tumour, diabetes, antipyretic, diaphrotic, demulcent and in skin diseases. Phytochemical screening of the plant reports compounds such as flavonoids, triterpenes, phytosterol, glycosides and other phenolic compounds. Pharmacological study reveals hepatoprotective, antioxidant, anti inflammatory, analgesic, antidiabetic and antitumour activity of various parts of the plant. © RJPT All right reserved.
Emmanuel S.,Loyola Academy |
Sheeba Rani M.,Loyola Academy |
Raja Sreekanth M.,Loyola Academy
Research Journal of Pharmacy and Technology | Year: 2011
The present investigation was aimed at evaluating the wound healing potential of aerial parts and roots of Cleome viscosa Linn on albino Wistar rats. Excision and incision models were employed. In each wound model, male albino Wistar rats weighing 180-200g were divided into four groups of 6 animals each. In both the models, group I served as control and group II as reference standard treated with Soframycin. In an excision wound model, group III animals were treated with methanol extract of the aerial parts of C.viscosa (CVAMExt) 500 mg kg/ kg b.w and group IV animals were treated with methanol extract of the roots of C.viscosa (CVRMExt) 500 mg/ kg b.w, for 16 days respectively. In incision wound model, group III and IV animals were treated with CVAMExt and CVRMExt 500 mg/ kg b.w, for 9 days respectively. CVAMExt showed a 91.53% contraction in excision wounds, which was close to the contraction value of the reference drug Soframycin (100%). On the other hand, the same extract used on the incision wound model showed a significant increase (414.37±3.0) in wound tensile strength, which was almost similar to Soframycin. CVRMExt was also showed better wound healing activity in excision wound model 90.75% on day 16. Similarly the same extract used on the incision wound model also showed a better tensile strength (385.23±2.28). © RJPT All right reserved.
Clothing, namely, golf shirts and ties. Educational services, namely, conducting classes, seminars and lectures in a secondary education; entertainment services in the nature of amateur youth sporting events.
Loyola Academy | Date: 2010-10-19
Loyola Academy | Date: 2013-12-24
Loyola Academy | Date: 2011-08-02
Clothing, namely, t-shirts, polo shirts. Educational services, namely, conducting classes, seminars and lectures in a secondary education; entertainment services in the nature of amateur youth sporting events.
Loyola Academy | Date: 2011-04-19