Louisiana Technical University
Louisiana Technical University
Li Y.Y.,Louisiana State University Health Sciences Center |
Li Y.Y.,Louisiana Technical University |
Cui J.G.,Louisiana State University Health Sciences Center |
Cui J.G.,Louisiana Technical University |
And 8 more authors.
Neuroscience Letters | Year: 2011
Micro RNA-146a (miRNA-146a) is an inducible, 22 nucleotide, small RNA over-expressed in Alzheimer's disease (AD) brain. Up-regulated miRNA-146a targets several inflammation-related and membrane-associated messenger RNAs (mRNAs), including those encoding complement factor-H (CFH) and the interleukin-1 receptor associated kinase-1 (IRAK-1), resulting in significant decreases in their expression (p<0.05, ANOVA). In this study we assayed miRNA-146a, CFH, IRAK-1 and tetraspanin-12 (TSPAN12), abundances in primary human neuronal-glial (HNG) co-cultures, in human astroglial (HAG) and microglial (HMG) cells stressed with Aβ42 peptide and tumor necrosis factor alpha (TNFα). The results indicate a consistent inverse relationship between miRNA-146a and CFH, IRAK-1 and TSPAN12 expression levels, and indicate that HNG, HAG and HMG cell types each respond differently to Aβ42-peptide. +. TNFα-triggered stress. While the strongest miRNA-146a-IRAK-1 response was found in HAG cells, the largest miRNA-146a-TSPAN12 response was found in HNG cells, and the most significant miRNA-146a-CFH changes were found in HMG cells, the 'resident scavenging macrophages' of the brain. © 2011 Elsevier Ireland Ltd.
Wang D.,University of Virginia |
Pan K.,Massachusetts Institute of Technology |
Subedi R.,University of Virginia |
Deng X.,University of Virginia |
And 97 more authors.
Physical Review Letters | Year: 2013
We report on parity-violating asymmetries in the nucleon resonance region measured using inclusive inelastic scattering of 5-6 GeV longitudinally polarized electrons off an unpolarized deuterium target. These results are the first parity-violating asymmetry data in the resonance region beyond the Δ(1232). They provide a verification of quark-hadron duality - the equivalence of the quark- and hadron-based pictures of the nucleon - at the (10-15)% level in this electroweak observable, which is dominated by contributions from the nucleon electroweak γZ interference structure functions. In addition, the results provide constraints on nucleon resonance models relevant for calculating background corrections to elastic parity-violating electron scattering measurements. © 2013 American Physical Society.
Ahmed Z.,Syracuse University |
Allada K.,University of Kentucky |
Aniol K.A.,California State University, Los Angeles |
Armstrong D.S.,College of William and Mary |
And 103 more authors.
Physical Review Letters | Year: 2012
The parity-violating cross-section asymmetry in the elastic scattering of polarized electrons from unpolarized protons has been measured at a four-momentum transfer squared Q2=0.624GeV2 and beam energy E b=3.48GeV to be A PV=-23.80±0.78(stat)±0. 36(syst) parts per million. This result is consistent with zero contribution of strange quarks to the combination of electric and magnetic form factors GEs+0.517GMs=0.003±0.010(stat)±0.004(syst)±0.009(ff), where the third error is due to the limits of precision on the electromagnetic form factors and radiative corrections. With this measurement, the world data on strange contributions to nucleon form factors are seen to be consistent with zero and not more than a few percent of the proton form factors. © 2012 American Physical Society.
Lowry P.B.,City University London |
Gaskin J.E.,Brigham Young University |
Twyman N.W.,University of Arizona |
Hammer B.,Oklahoma State University |
Roberts T.L.,Louisiana Technical University
Journal of the Association of Information Systems | Year: 2013
Hedonic-motivation systems (HMS)-systems used primarily to fulfill users' intrinsic motivations-are the elephant in the room for IS research. Growth in HMS sales has outperformed utilitarian-motivation systems (UMS) sales for more than a decade, generating billions in revenue annually; yet IS research focuses mostly on UMS. In this study, we explain the role of intrinsic motivations in systems use and propose the hedonic-motivation system adoption model (HMSAM) to improve the understanding of HMS adoption. Instead of a minor, general TAM extension, HMSAM is an HMS-specific system acceptance model based on an alternative theoretical perspective, which is in turn grounded in flow-based cognitive absorption (CA). The HMSAM extends van der Heijden's (2004) model of hedonic system adoption by including CA as a key mediator of perceived ease of use (PEOU) and of behavioral intentions to use (BIU) hedonic-motivation systems. Results from experiments involving 665 participants confirm that, in a hedonic context, CA is a more powerful and appropriate predictor of BIU than PEOU or joy, and that the effect of PEOU on BIU is fully mediated by CA sub-constructs. This study lays a foundation, provides guidance, and opens up avenues for future HMS, UMS, and mixed-motivation system research.