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Lowry P.B.,City University London | Gaskin J.E.,Brigham Young University | Twyman N.W.,University of Arizona | Hammer B.,Oklahoma State University | Roberts T.L.,Louisiana Technical University
Journal of the Association of Information Systems | Year: 2013

Hedonic-motivation systems (HMS)-systems used primarily to fulfill users' intrinsic motivations-are the elephant in the room for IS research. Growth in HMS sales has outperformed utilitarian-motivation systems (UMS) sales for more than a decade, generating billions in revenue annually; yet IS research focuses mostly on UMS. In this study, we explain the role of intrinsic motivations in systems use and propose the hedonic-motivation system adoption model (HMSAM) to improve the understanding of HMS adoption. Instead of a minor, general TAM extension, HMSAM is an HMS-specific system acceptance model based on an alternative theoretical perspective, which is in turn grounded in flow-based cognitive absorption (CA). The HMSAM extends van der Heijden's (2004) model of hedonic system adoption by including CA as a key mediator of perceived ease of use (PEOU) and of behavioral intentions to use (BIU) hedonic-motivation systems. Results from experiments involving 665 participants confirm that, in a hedonic context, CA is a more powerful and appropriate predictor of BIU than PEOU or joy, and that the effect of PEOU on BIU is fully mediated by CA sub-constructs. This study lays a foundation, provides guidance, and opens up avenues for future HMS, UMS, and mixed-motivation system research. Source


Wang D.,University of Virginia | Pan K.,Massachusetts Institute of Technology | Subedi R.,University of Virginia | Deng X.,University of Virginia | And 97 more authors.
Physical Review Letters | Year: 2013

We report on parity-violating asymmetries in the nucleon resonance region measured using inclusive inelastic scattering of 5-6 GeV longitudinally polarized electrons off an unpolarized deuterium target. These results are the first parity-violating asymmetry data in the resonance region beyond the Δ(1232). They provide a verification of quark-hadron duality - the equivalence of the quark- and hadron-based pictures of the nucleon - at the (10-15)% level in this electroweak observable, which is dominated by contributions from the nucleon electroweak γZ interference structure functions. In addition, the results provide constraints on nucleon resonance models relevant for calculating background corrections to elastic parity-violating electron scattering measurements. © 2013 American Physical Society. Source


Lukiw W.J.,Louisiana State University Health Sciences Center | Surjyadipta B.,Louisiana State University Health Sciences Center | Dua P.,Louisiana Technical University | Alexandrov P.N.,Russian Academy of Medical Sciences
International Journal of Biochemistry and Molecular Biology | Year: 2012

Alzheimer's disease (AD) and age-related macular degeneration (AMD) are complex and progressive inflammatory degenerations of the human neocortex and retina. Recent molecular, genetic and epigenetic evidence indicate that at least 4 micro RNAs (miRNAs)-including the NF-κB-regulated miRNA-9, miRNA-125b, miRNA-146a and miRNA-155-are progressively up-regulated in both AD and AMD. This quartet of up-regulated miRNAs in turn down-regulate a small brain-and retinal-cell-relevant family of target mRNAs, including that encoding complement factor H (CFH), a major negative regulator of the innate immune and inflammatory response. Together miRNA-146a and miRNA-155 recognize an overlapping miRNA regulatory control (MiRC) region in the CFH 3'-untranslated region (3'-UTR; 5'-TTTAGTATTAA-3') to which either of these miRNAs may interact. Progressive, pathogenic increases in specific miRNA binding to the entire 232 nucleotide CFH 3'-UTR appears to be a major regulator of CFH expression down-regulation, and the inflammatory pathology that characterizes both AMD and AD. The data presented in this review provides evidence that up-regulation of brain-and retinal-abundant miRNAs, including miRNA-9, miRNA-125b, miRNA-146a and miRNA-155, are common to the pathogenetic mechanism of CFH deficiency that drives inflammatory neurodegeneration, and for the first time indicates multiple, independent miRNA-mediated regulation of the CFH mRNA 3'-UTR. Source


Wang D.,University of Virginia | Pan K.,Massachusetts Institute of Technology | Subedi R.,University of Virginia | Ahmed Z.,Syracuse University | And 101 more authors.
Physical Review C - Nuclear Physics | Year: 2015

The parity-violating asymmetries between a longitudinally polarized electron beam and an unpolarized deuterium target have been measured recently. The measurement covered two kinematic points in the deep-inelastic scattering region and five in the nucleon resonance region. We provide here details of the experimental setup, data analysis, and results on all asymmetry measurements including parity-violating electron asymmetries and those of inclusive pion production and beam-normal asymmetries. The parity-violating deep-inelastic asymmetries were used to extract the electron-quark weak effective couplings, and the resonance asymmetries provided the first evidence for quark-hadron duality in electroweak observables. These electron asymmetries and their interpretation were published earlier, but are presented here in more detail. © 2015 American Physical Society. Source


Ahmed Z.,Syracuse University | Allada K.,University of Kentucky | Aniol K.A.,California State University, Los Angeles | Armstrong D.S.,College of William and Mary | And 103 more authors.
Physical Review Letters | Year: 2012

The parity-violating cross-section asymmetry in the elastic scattering of polarized electrons from unpolarized protons has been measured at a four-momentum transfer squared Q2=0.624GeV2 and beam energy E b=3.48GeV to be A PV=-23.80±0.78(stat)±0. 36(syst) parts per million. This result is consistent with zero contribution of strange quarks to the combination of electric and magnetic form factors GEs+0.517GMs=0.003±0.010(stat)±0.004(syst)±0.009(ff), where the third error is due to the limits of precision on the electromagnetic form factors and radiative corrections. With this measurement, the world data on strange contributions to nucleon form factors are seen to be consistent with zero and not more than a few percent of the proton form factors. © 2012 American Physical Society. Source

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