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Puiu M.,Victor Babes University of Medicine and Pharmacy Timisoara | Pienar C.,Victor Babes University of Medicine and Pharmacy Timisoara | Chirita Emandi A.,Victor Babes University of Medicine and Pharmacy Timisoara | Arghirescu S.,Victor Babes University of Medicine and Pharmacy Timisoara | And 2 more authors.
Acta Endocrinologica | Year: 2012

Introduction. The Antley-Bixler syndrome (ABS) is an extremely rare syndrome characterized by congenital craniosynostosis and radiohumeral synostosis. Many patients demonstrate defects in steroidogenesis and disturbances of sexual development. Aim: To present the first documented case of a Romanian patient with ABS. Material and Methods. Alexandru, a 3 year old child, was referred to our department for elucidating a complex malformative syndrome that consisted of ambiguous genitalia and skeletal anomalies. We performed a complete assessment that ranged from obtaining a detailed medical history to gene sequencing. The hospital's Ethical Committy gave the authors its approval for using the medical data concerning the case, after the parents signed an informed consent. Results. Medical history. We note 4 previous admissions to our hospital during which efforts were made to diagnose the child's disorder of sexual development. At 3 months Edwards syndrome was suspected, which was later infirmed. During the third and fourth admission (8 months, 10 months respectively) the suspicion of congenital adrenal hyperplasia (CAH) was raised and then confirmed (impaired steroidogenesis, 46 XX karyotype). The patient was lost to follow-up since then, probably due to the parents' inability to cope with the implications of their child's condition. Source


Arghirescu S.,Victor Babes University of Medicine and Pharmacy Timisoara | Bataneant M.,Victor Babes University of Medicine and Pharmacy Timisoara | Jinca C.,Victor Babes University of Medicine and Pharmacy Timisoara | Pascalau A.,Louis Turcanu Emergency Hospital for Children | And 6 more authors.
Revista Romana de Medicina de Laborator | Year: 2014

Pseudothrombocytopenia is an in vitro sampling problem which may mislead the diagnosis towards the more critical condition of thrombocytopenia. The phenomenon occurs when the anticoagulant used while testing the blood sample causes clumping of platelets which mimics low platelet count without any clinical signs. This may determine unnecessary, expensive and invasive investigations and even treatment. In this article we report two cases of pseudothrombocytopenia diagnosed in pediatric patients. Source


Laza R.,Victor Babes University of Medicine and Pharmacy Timisoara | Jurac R.,Louis Turcanu Emergency Hospital for Children | Crisan A.,Victor Babes University of Medicine and Pharmacy Timisoara | Lazureanu V.,Victor Babes University of Medicine and Pharmacy Timisoara | And 6 more authors.
BMC Infectious Diseases | Year: 2015

Background: The recent emergence of Clostridium difficile infections has included this condition among top nosocomial infections, due to its incidence, complications and important fatality, as well as to significant economic costs. Methods: A prospective surveillance study of Clostridium difficile enterocolitis cases was performed in "Victor Babeş" Infectious Diseases Hospital in Timişoara (Romania) between 01.01.2013 - 30.06.2014, to estimate the incidence and to investigate the risk factors for unfavourable outcome and relapse. Dichotomous variables were compared by the chi-square test or Fisher exact test and the Mann-Whitney U test was used for continuous variables. Risk factors for unfavourable outcome/recurrence were investigated by logistic regression. Results: 210 patients who experienced 219 episodes of infection with Clostridium difficile were identified, which gives an incidence per hospital of 20.57/15.70 to 1,000 discharged patients in 2013/2014 or 17.73/14.04 to 10,000 patient-days. In 162 patients (77.14%) the evolution was favourable while in 48 (22.86%) the outcome was unfavourable. In 42 patients (20.00%) recurrence of symptoms was identified. The multivariate analysis by logistic regression identified the ATLAS score (OR = 4.97, 95% CI = 2.12 to 11.66, p <0.001), age (OR = 1.12, 95% CI = 1.00 to 1.25, p = 0.046), and the number of antibiotics after episode onset (OR = 2.692, 95% CI = 1.01 to 7.17, p = 0.047) as predictors of an unfavourable evolution, while the number of hospitalization days (OR = 1.10, 95% CI = 1.03 to 1.16, p = 0.0015) was associated with recurrence of symptoms. Conclusions: The high incidence identified in our study is explained by the endemic character of these infections in some hospitals in Timişoara, released in late 2012, and the fact that "Victor Babeş" Hospital is the only one in our area that provides treatment in all suspected or confirmed cases of this condition requiring hospitalization. The study identified the ATLAS score, age, and the number of antibiotics after episode onset as predictors of unfavourable evolution, while the number of days of hospitalization was associated with the recurrence of symptoms. © Laza et al.; licensee BioMed Central. Source

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