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Asadi-Samani M.,Shahrekord University of Medical Sciences | Bahmani M.,Lorestan University of Medical Sciences | Rafieian-Kopaei M.,Shahrekord University of Medical Sciences
Asian Pacific Journal of Tropical Medicine | Year: 2014

Borage (Borago officinalis) is an annual herb which is cultivated for medicinal and culinary uses, although it is commercially cultivated for borage seed oil. Borage seed oil is the plant rich in the gamma-linolenic acid (26%-38%) which is used as dietary or food supplement. Other than seed oil it contains a lot of fatty acids such as linoleic acid (35%-38%), oleic acid (16%-20%), palmitic acid (10%-11%), stearic acid (3.5%-4.5%), eicosenoic acid (3.5%-5.5%) and erucic acid (1.5%-3.5%). It is used for the treatment of various diseases such as multiple sclerosis, diabetes, heart diseases, arthritis and eczema. In this study different aspects of borage such as plant characteristics, production, applications in traditional medicine, clinical considerations, its effects on patients' blood and urine biochemistry, and also the effect of the its products on liver and kidney performance tests are presented using published articles in scientific sites. © 2014 Hainan Medical College.


Khalatbary A.R.,Mazandaran University of Medical Sciences | Zarrinjoei G.R.,Lorestan University of Medical Sciences
Iranian Red Crescent Medical Journal | Year: 2012

Background: Spinal cord injury stimulates an inflammatory reaction that causes substantial secondary damage inside the injured spinal tissue. The purpose of this study was to determine the anti-inflammatory effect of oleuropein on traumatized spinal cord. Methods: Rats were randomly divided into four groups of 7 rats each as follows: Sham-operated group, trauma group, and oleuropein treatment groups (20 mg/kg, ip, immediately and 1 hour after spinal cord injury). Spinal cord samples were taken 24 hours after injury and studied for immunohistochemistry of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), nitrotyrosine, inducible nitric-oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and poly(ADP-ribose) polymerase (PARP). Results: Attenuated TNF-α, IL-1β, nitrotyrosine, iNOS, COX-2, and PARP expression could be detected in the oleuropein-treated rats. Conclusion: Oleuropein modulates inflammatory reactions following spinal cord injury. © Iranian Red Crescent Medical Journal.


Ginger (Zingiber officinale Roscoe), a well-known spice plant, has been used traditionally in the treatment of a wide variety of ailments. It has been shown that ginger is a calcium channel blocker; however, its influence on morphine analgesic effects has not been elucidated. We examined the effect of ginger root extract on nociceptive threshold and morphine-induced analgesia in male Wistar rats. To determine the effect of ginger on morphine analgesia, ginger extract (200, 400, and 600 mg/kg i.p.) was injected before a subeffective dose of morphine (2.5 mg/kg i.p.). The radiant heat tail-flick test was used to assess the nociceptive threshold before and at different times after drug administration. Our results showed that ginger extract elicited a significant antinociceptive effect. In addition, in groups that received both morphine and ginger, the observed analgesia was higher than that in groups treated with either morphine or ginger extract alone. Thus, the data indicate that ginger extract has a beneficial influence on morphine analgesia and can be an efficacious adjunct for pain management.


Ahmadvand H.,Lorestan University of Medical Sciences
Chinese Journal of Natural Medicines | Year: 2014

AIM: To examine the possible protective effect of Satureja khuzistanica essential oil (SKE) on antioxidant enzyme activity in alloxan-induced Type 1 diabetic rats. METHOD: Thirty Sprague-Dawley male rats were divided into three groups randomly; group one as control, group two diabetic, with no treatment, and group three treatment with SKE at 500 ppm in drinking water, respectively. Diabetes was induced in the second and third groups by alloxan injection subcutaneously. After eight weeks, animals were anaesthetized. Blood samples were also collected before killing to measure antioxidant enzymes activity. RESULTS: SKE significantly increased the serum level of glutathione and the serum activity of glutathione peroxidase, superoxide dismutase, and catalase in the treated group compared with the diabetic untreated group. CONCLUSION: The findings showed that SKE exerts beneficial effects on the antioxidant enzymes activity in alloxan-induced Type 1 diabetic rats. © 2014 China Pharmaceutical University.


Saki K.,Shahid Beheshti University of Medical Sciences | Bahmani M.,Lorestan University of Medical Sciences | Rafieian-Kopaei M.,Shahrekord University of Medical Sciences
Asian Pacific Journal of Tropical Medicine | Year: 2014

Anxiety and depression are highly comorbid psychiatric conditions that the prevalence will be increased to the second greatest risk of morbidity, causing a significant socioeconomic burden. Due to side effects and destructive effects of some chemical drugs, many patients prefer herbal medicines to treat diseases. Although there are key review papers in the area of medicinal plants and psychiatry disorders, they have either covered the area in a relatively cursory manner or focused on a specific plant medicine. In the present study, we tried to present the effect of most important medicinal plants on two important highly comorbid psychiatric conditions-anxiety and depression. © 2014 Hainan Medical College.


Tavafi M.,Lorestan University of Medical Sciences
Journal of Nephropathology | Year: 2013

Context: Oxidative stress has crucial role in pathogenesis of diabetic nephropathy (DN). Despite satisfactory results from antioxidant therapy in rodent, antioxidant therapy showed conflicting results in combat with DN in diabetic patients. Evidence Acquisitions: Directory of Open Access Journals (DOAJ), Google Scholar,Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched. Results: Treatment of DN in human are insufficient with rennin angiotensin system (RAS) blockers, so additional agent ought to combine with this management. Meanwhile based on DN pathogenesis and evidences in experimental and human researches, the antioxidants are the best candidate. New multi-property antioxidants may be improved human DN that show high power antioxidant capacity, long half-life time, high permeability to mitochondrion, improve body antioxidants enzymes activity and anti-inflammatory effects. Conclusions: Based on this review and our studies on diabetic rats, rosmarinic acid a multi-property antioxidant may be useful in DN patients, but of course, needs to be proven in clinical trials studies. © 2013, Society of Diabetic Nephropathy Prevention. All rights reserved.


Mohammadi M.,Lorestan University of Medical Sciences
Cancer Gene Therapy | Year: 2016

Neuroblastoma (NB) is known as a pediatric neoplasm that is associated with variable histopathological features. The use of biomarkers contributes to the monitoring and treatment of various malignancies such as NB. The identification of novel biomarkers such as (epi)genetic biomarkers and microRNAs (miRNAs) in NB has led to better treatments of NB. Among them, miRNAs have emerged as powerful tools in diagnosis, prognosis and therapeutic biomarkers for patients with NB. Circulating biomarkers such as circulating miRNAs present in body fluids (for example, plasma, serum and urine) provided an interesting field of study in NB treatment. The miRNAs have central roles in different pathogenic events in various malignancies such as NB. Hence, these molecules can be a suitable candidate for monitoring and treating NB patients. Here, we summarize some miRNAs as potential prognosis, diagnosis and therapeutic biomarkers in NB.Cancer Gene Therapy advance online publication, 14 October 2016; doi:10.1038/cgt.2016.45. © 2016 Nature America, Inc., part of Springer Nature.


Khalatbary A.R.,Lorestan University of Medical Sciences | Ahmadvand H.,Lorestan University of Medical Sciences
Neurological Research | Year: 2012

Objectives: Oleuropein (OE) is a well-known antioxidant polyphenol from olive oil. The purpose of this study was to determine the potential neuroprotective effects of oleuropein in an experimental spinal cord injury model. Methods: Rats were randomly divided into four groups of 21 rats each as follows: sham-operated group, trauma group, and OE treatment groups (20 mg/kg, i.p., immediately and 1 hour after spinal cord injury). Spinal cord samples were taken 24 hours after injury and studied for determination of malondialdehyde and glutathione levels, histopathological assessment, immunohistochemistry of Bax and Bcl-2, and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling reaction. Behavioral testing was performed weekly up to 6 weeks post-injury. Results: The results showed that malondialdehyde levels were significantly decreased, and glutathione levels were significantly increased in OE treatment groups. Greater Bcl-2 and attenuated Bax expression could be detected in the OE-treated rats. OE significantly reduced terminal deoxynucleotidyl transferasemediated dUTP nick end labeling-positive reaction and improved behavioral function than the trauma group. Discussion: These findings indicate that OE may be effective in protecting rat spinal cord from secondary injury. © W. S. Maney & Son Ltd 2012.


Zibaei M.,Lorestan University of Medical Sciences
Nepal Medical College journal : NMCJ | Year: 2010

Toxocariasis is a parasitic zoonose caused by the infection of larval nematode Toxocara species. A total of 285 soil samples from January to March 2009 in 18 public parks were collected to test for soil contamination with Toxocara eggs. Soil samples were investigated for the present of Toxocara eggs using sucrose flotation method. Distribution of Toxocara spp. eggs in samples collected from public parks was 63.3%. The highest number of eggs recovered from 200 g of soil was 128. A total 304 eggs were recovered and 42.1% fully developed to embryonated egg stages. The contamination rate in second region in the studied areas was higher than the other regions. A similar tendency was observed in parks size, so that parks higher than 10,000 m2 were more highly contaminated. The present investigation clearly shows that public parks have been contaminated with Toxocara eggs in Khorram Abad, suggesting that care should be taken when using public parks.


Tavafi M.,Lorestan University of Medical Sciences | Ahmadvand H.,Lorestan University of Medical Sciences
Tissue and Cell | Year: 2011

The present investigation reports the effect of rosmarinic acid (RA), an antioxidant on gentamicin sulphate (GS)-induced renal oxidative damage in rats. Rosmarinic acid (RA) has been demonstrated to have antioxidant, free radical scavenger and anti-inflamatory effects. Twenty-eight Sprague-Dawley rats were divided in to four equal groups as follows: group 1 (control), group 2 (GS 100. mg/kg/d ip), group 3 (GS 100. mg/kg/d ip. +. RA 50. mg/kg/d) and group 4 (GS 100. mg/kg/d ip. +. RA 100. mg/kg/d). Treatments were administrated once daily for 12 days. After 12 days 24. h urine was collected, blood was sampled and kidneys were removed. Serum and kidney tissue MDA assessed by thiobarbituric acid. Kidney paraffin sections (5 μm thickness) from the left kidney stained with periodic acid Schiff. Tubular necrosis was studied semiquantitatively and glomerular volume and volume density of proximal convoluted tubule (PCT) estimated stereologically. Kidney homogenize were prepared from right kidney. Serum creatinine, urea and kidney antioxidant enzymes activity were assessed by special kits. Data were compared by SPSS 13 software and Mann-Whitney test at p< 0.05. Co treatment of GS and RA (High dose) significantly decreased serum creatinine, MDA, urea, tubular necrosis (p< 0.05) and increase renal GSH, GPX, CAT, SOD, volume density of PCT and creatinine clearance significantly in comparison with GS group (p< 0.05). Treatment with RA (high dose) maintained serum creatinine, volume density of PCT, renal GSH, GPX, SOD and MDA as the same level as control group significantly (p< 0.05). In conclusion, RA alleviates GS nephrotoxicity via antioxidant activity, increase of renal GSH content and increase of renal antioxidant enzymes activity. © 2011 Elsevier Ltd.

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