Lorestan University of Medical Sciences

www.lums.ac.ir
Khorramabad, Iran
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Mohsenzadeh A.,Lorestan University of Medical Sciences | Ahmadipour S.,Isfahan University of Medical Sciences | Ahmadipour S.,Lorestan University of Medical Sciences | Asadi-Samani M.,Shahrekord University of Medical Sciences
Der Pharmacia Lettre | Year: 2016

Fever is an important very prevalent disease in children. Fever is developed in the body during response to releasing internal pyrogenic agents throughout infections, malignancy, and inflammatory and rheumatic processes as well as external pyrogenic agents including microbes and toxins. In Iran, medicinal plants have long been used to treat diseases, and fever have been commonly treated with medicinal plants, as well. Therefore, this review article sought to report the medicinal plants used to treat fever in children. In this study, the key words including fever, children, medicinal plants, traditional medicine, and Iran were used to search in the databases Web of Science, PubMed, Scopus, International Science Citation Center, and Magiran, and the articles of interest were retrieved. The medicinal plants Matricaria recutita, Achilleamil lefolium, Sambucus nigra, Tilia cordata, Hyssopus officinalis, Allium sativum, Lavandula officinalis, and Mentha piperita were reported to have refrigerant properties. The antipyretic medicinal plants in the present study could relieve the intensity of fever in children and play a refrigerant role by means of the effective substances with antioxidant, antimicrobial, and anti-inflammatory properties through eliminating the involved factors of fever happening.


Bahmani M.,Lorestan University of Medical Sciences | Zargaran A.,Shiraz University of Medical Sciences | Rafieian-Kopaei M.,Shahrekord University of Medical Sciences
Brazilian Journal of Pharmacognosy | Year: 2014

The gastrointestinal tract is one of the most important organs of the human body and is vulnerable to different diseases. Available drugs often have low efficacy or are associated with many adverse effects. Therefore, alternative drugs are necessary to treat gastrointestinal complications. This study intended to identify medicinal plants in Urmia, Iran, that can affect common gastrointestinal disorders and diseases. Data was collected from public resources via interviews and questionnaires applied from April to June 2013. Herbarium specimens were collected from the region and authenticated by a botanist. A total of 41 indigenous medicinal plants from the Urmia region, belonging to twenty families, have a traditional medicinal role in the treatment of parasitic and infectious diseases, diarrhea, reflux, gastroenteritis, peptic ulcer, constipation, bloating, among other gastrointestinal tract disorders. Analysis showed that most plants affecting the gastrointestinal tract belonged in the Asteraceae family (24%). The most used part of the plants was the seed at 17%. Decoction at 65% was the most popular form of treatment used. Some of the medicinal plants discussed in this article have new implications presented for the first time. Pharmacological studies on the therapeutic effects of the indigenous plants mentioned in this study are necessary in order to investigate their claimed clinical effects and the use of their effective compounds to produce natural and useful drugs. Currently, there is no data on the herbal plants used to treat gastrointestinal disorders in northwestern Iran. Therefore, these findings are important for the management of gastrointestinal disorders and to conduct future studies on traditional medicine for drug development. © 2014 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. All rights reserved.


Jivad N.,Shahrekord University of Medical Sciences | Bahmani M.,Lorestan University of Medical Sciences | Asadi-Samani M.,Shahrekord University of Medical Sciences
Der Pharmacia Lettre | Year: 2016

Wound is referred to the disruption of joined structure of the body caused by physical, chemical, and biological agents. Wound healing is a reconstructive process which takes place after damage to skin and soft tissues. After damage, inflammatory response is developed and subdermal cells begin to increase the production of collagen and then epithelial tissue is gradually reconstructed. In Iran traditional medicine, natural substances and medicinal plants are used to heal wounds. This study was conducted to review the most important medicinal plants used for wound healing in different provinces of Iran. The key words including wound healing and skin healing combined with the words medicinal plants, ethnobotany, and traditional medicine in Iran were used to search for in the databases Information Sciences Institute, PubMed, Scopus, Islamic World Science Citation Center, and Magiran. The findings of this study on 15 different regions of Iran indicated use of 67 medicinal plants for wound healing. In some regions Scrophulariastriata, Althaea officinalis, Nerium oleander L. andPlantago major L. were jointly used for wound healing. The medicinal plants reported in this study with their wound-healing property are some alternatives that could be used to develop herbal medicines effective on wound healing if complementary studies confirm their properties.


Namdari M.,Lorestan University of Medical Sciences | Eatemadi A.,Tehran University of Medical Sciences
Biomedicine and Pharmacotherapy | Year: 2016

Heart valves are currently under thorough investigation in tissue engineering (TE) research. Mechanical and biological heart valve prostheses which are recently used have several shortcomings. While allogenic and xenogenic biological prostheses are related to graft rejection, degeneration and thrombosis, resulting in a high rate of reoperation. Mechanical prostheses on the other hand are based on metallic, carbon, and polymeric components, and require continuous treatment with anticoagulant, which result in adverse reactions, e.g. endocarditis and thromboembolic complications. Therefore, there has been efforts to synthesize bioartificial heart valve using bioengineering. The resulting product must be durable with appropriate mechanical properties, biocompatible, and have the ability to grow. Diseased heart valves replacement by surgery is now common, this enhances quality of life and survival for many patients. The center of attraction of recent methods in regenerative medicine are based on the restoration of pathologically altered tissue architectures by cells transplantation in combination with supportive scaffolds, and growth factors. We propose that nanofiber scaffold for paediatric Tissue Engineered Heart Valve (TEHV) will meet most of these requirements, particularly those related to somatic growth, in addition, as the nanofiber scaffold is eroded and new valve is formed, the valve develops in the child until adulthood. © 2016 Elsevier Masson SAS


Vahabi S.,Lorestan University of Medical Sciences | Eatemadi A.,Lorestan University of Medical Sciences | Eatemadi A.,University of Tehran
Biomedicine and Pharmacotherapy | Year: 2016

Over the years studies have shown the high prevalence rate in the use of herbal drugs among patients, doctors and health workers as such there is a need to take care of any health consequences associated with herbal drugs administrations. Herbal drugs are made of pharmacologically effective constituents, that can interact with anesthesia drugs that risk the life of the patients in question. In addition, pharmacokinetics and pharmacodynamics of herbal drugs are yet to be fully understood thus still needs more study. In view of this anesthesiologist should take a thorough history of the patient in question, taking into full consideration earlier use of herbal medicine/drugs by the patient. The aim of this article is to provide a mini-review on herb–anesthesia drug interactions. © 2016 Elsevier Masson SAS


Ginger (Zingiber officinale Roscoe), a well-known spice plant, has been used traditionally in the treatment of a wide variety of ailments. It has been shown that ginger is a calcium channel blocker; however, its influence on morphine analgesic effects has not been elucidated. We examined the effect of ginger root extract on nociceptive threshold and morphine-induced analgesia in male Wistar rats. To determine the effect of ginger on morphine analgesia, ginger extract (200, 400, and 600 mg/kg i.p.) was injected before a subeffective dose of morphine (2.5 mg/kg i.p.). The radiant heat tail-flick test was used to assess the nociceptive threshold before and at different times after drug administration. Our results showed that ginger extract elicited a significant antinociceptive effect. In addition, in groups that received both morphine and ginger, the observed analgesia was higher than that in groups treated with either morphine or ginger extract alone. Thus, the data indicate that ginger extract has a beneficial influence on morphine analgesia and can be an efficacious adjunct for pain management.


Ahmadvand H.,Lorestan University of Medical Sciences
Chinese Journal of Natural Medicines | Year: 2014

AIM: To examine the possible protective effect of Satureja khuzistanica essential oil (SKE) on antioxidant enzyme activity in alloxan-induced Type 1 diabetic rats. METHOD: Thirty Sprague-Dawley male rats were divided into three groups randomly; group one as control, group two diabetic, with no treatment, and group three treatment with SKE at 500 ppm in drinking water, respectively. Diabetes was induced in the second and third groups by alloxan injection subcutaneously. After eight weeks, animals were anaesthetized. Blood samples were also collected before killing to measure antioxidant enzymes activity. RESULTS: SKE significantly increased the serum level of glutathione and the serum activity of glutathione peroxidase, superoxide dismutase, and catalase in the treated group compared with the diabetic untreated group. CONCLUSION: The findings showed that SKE exerts beneficial effects on the antioxidant enzymes activity in alloxan-induced Type 1 diabetic rats. © 2014 China Pharmaceutical University.


Saki K.,Shahid Beheshti University of Medical Sciences | Bahmani M.,Lorestan University of Medical Sciences | Rafieian-Kopaei M.,Shahrekord University of Medical Sciences
Asian Pacific Journal of Tropical Medicine | Year: 2014

Anxiety and depression are highly comorbid psychiatric conditions that the prevalence will be increased to the second greatest risk of morbidity, causing a significant socioeconomic burden. Due to side effects and destructive effects of some chemical drugs, many patients prefer herbal medicines to treat diseases. Although there are key review papers in the area of medicinal plants and psychiatry disorders, they have either covered the area in a relatively cursory manner or focused on a specific plant medicine. In the present study, we tried to present the effect of most important medicinal plants on two important highly comorbid psychiatric conditions-anxiety and depression. © 2014 Hainan Medical College.


Tavafi M.,Lorestan University of Medical Sciences
Journal of Nephropathology | Year: 2013

Context: Oxidative stress has crucial role in pathogenesis of diabetic nephropathy (DN). Despite satisfactory results from antioxidant therapy in rodent, antioxidant therapy showed conflicting results in combat with DN in diabetic patients. Evidence Acquisitions: Directory of Open Access Journals (DOAJ), Google Scholar,Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched. Results: Treatment of DN in human are insufficient with rennin angiotensin system (RAS) blockers, so additional agent ought to combine with this management. Meanwhile based on DN pathogenesis and evidences in experimental and human researches, the antioxidants are the best candidate. New multi-property antioxidants may be improved human DN that show high power antioxidant capacity, long half-life time, high permeability to mitochondrion, improve body antioxidants enzymes activity and anti-inflammatory effects. Conclusions: Based on this review and our studies on diabetic rats, rosmarinic acid a multi-property antioxidant may be useful in DN patients, but of course, needs to be proven in clinical trials studies. © 2013, Society of Diabetic Nephropathy Prevention. All rights reserved.


Zibaei M.,Lorestan University of Medical Sciences
Nepal Medical College journal : NMCJ | Year: 2010

Toxocariasis is a parasitic zoonose caused by the infection of larval nematode Toxocara species. A total of 285 soil samples from January to March 2009 in 18 public parks were collected to test for soil contamination with Toxocara eggs. Soil samples were investigated for the present of Toxocara eggs using sucrose flotation method. Distribution of Toxocara spp. eggs in samples collected from public parks was 63.3%. The highest number of eggs recovered from 200 g of soil was 128. A total 304 eggs were recovered and 42.1% fully developed to embryonated egg stages. The contamination rate in second region in the studied areas was higher than the other regions. A similar tendency was observed in parks size, so that parks higher than 10,000 m2 were more highly contaminated. The present investigation clearly shows that public parks have been contaminated with Toxocara eggs in Khorram Abad, suggesting that care should be taken when using public parks.

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