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Tavafi M.,Lorestan University of Medical Sciences
Journal of Nephropathology | Year: 2013

Context: Oxidative stress has crucial role in pathogenesis of diabetic nephropathy (DN). Despite satisfactory results from antioxidant therapy in rodent, antioxidant therapy showed conflicting results in combat with DN in diabetic patients. Evidence Acquisitions: Directory of Open Access Journals (DOAJ), Google Scholar,Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched. Results: Treatment of DN in human are insufficient with rennin angiotensin system (RAS) blockers, so additional agent ought to combine with this management. Meanwhile based on DN pathogenesis and evidences in experimental and human researches, the antioxidants are the best candidate. New multi-property antioxidants may be improved human DN that show high power antioxidant capacity, long half-life time, high permeability to mitochondrion, improve body antioxidants enzymes activity and anti-inflammatory effects. Conclusions: Based on this review and our studies on diabetic rats, rosmarinic acid a multi-property antioxidant may be useful in DN patients, but of course, needs to be proven in clinical trials studies. © 2013, Society of Diabetic Nephropathy Prevention. All rights reserved.


Khalatbary A.R.,Mazandaran University of Medical Sciences | Zarrinjoei G.R.,Lorestan University of Medical Sciences
Iranian Red Crescent Medical Journal | Year: 2012

Background: Spinal cord injury stimulates an inflammatory reaction that causes substantial secondary damage inside the injured spinal tissue. The purpose of this study was to determine the anti-inflammatory effect of oleuropein on traumatized spinal cord. Methods: Rats were randomly divided into four groups of 7 rats each as follows: Sham-operated group, trauma group, and oleuropein treatment groups (20 mg/kg, ip, immediately and 1 hour after spinal cord injury). Spinal cord samples were taken 24 hours after injury and studied for immunohistochemistry of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), nitrotyrosine, inducible nitric-oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and poly(ADP-ribose) polymerase (PARP). Results: Attenuated TNF-α, IL-1β, nitrotyrosine, iNOS, COX-2, and PARP expression could be detected in the oleuropein-treated rats. Conclusion: Oleuropein modulates inflammatory reactions following spinal cord injury. © Iranian Red Crescent Medical Journal.


Asadi-Samani M.,Shahrekord University of Medical Sciences | Bahmani M.,Lorestan University of Medical Sciences | Rafieian-Kopaei M.,Shahrekord University of Medical Sciences
Asian Pacific Journal of Tropical Medicine | Year: 2014

Borage (Borago officinalis) is an annual herb which is cultivated for medicinal and culinary uses, although it is commercially cultivated for borage seed oil. Borage seed oil is the plant rich in the gamma-linolenic acid (26%-38%) which is used as dietary or food supplement. Other than seed oil it contains a lot of fatty acids such as linoleic acid (35%-38%), oleic acid (16%-20%), palmitic acid (10%-11%), stearic acid (3.5%-4.5%), eicosenoic acid (3.5%-5.5%) and erucic acid (1.5%-3.5%). It is used for the treatment of various diseases such as multiple sclerosis, diabetes, heart diseases, arthritis and eczema. In this study different aspects of borage such as plant characteristics, production, applications in traditional medicine, clinical considerations, its effects on patients' blood and urine biochemistry, and also the effect of the its products on liver and kidney performance tests are presented using published articles in scientific sites. © 2014 Hainan Medical College.


Saki K.,Shahid Beheshti University of Medical Sciences | Bahmani M.,Lorestan University of Medical Sciences | Rafieian-Kopaei M.,Shahrekord University of Medical Sciences
Asian Pacific Journal of Tropical Medicine | Year: 2014

Anxiety and depression are highly comorbid psychiatric conditions that the prevalence will be increased to the second greatest risk of morbidity, causing a significant socioeconomic burden. Due to side effects and destructive effects of some chemical drugs, many patients prefer herbal medicines to treat diseases. Although there are key review papers in the area of medicinal plants and psychiatry disorders, they have either covered the area in a relatively cursory manner or focused on a specific plant medicine. In the present study, we tried to present the effect of most important medicinal plants on two important highly comorbid psychiatric conditions-anxiety and depression. © 2014 Hainan Medical College.


Zibaei M.,Lorestan University of Medical Sciences
Nepal Medical College journal : NMCJ | Year: 2010

Toxocariasis is a parasitic zoonose caused by the infection of larval nematode Toxocara species. A total of 285 soil samples from January to March 2009 in 18 public parks were collected to test for soil contamination with Toxocara eggs. Soil samples were investigated for the present of Toxocara eggs using sucrose flotation method. Distribution of Toxocara spp. eggs in samples collected from public parks was 63.3%. The highest number of eggs recovered from 200 g of soil was 128. A total 304 eggs were recovered and 42.1% fully developed to embryonated egg stages. The contamination rate in second region in the studied areas was higher than the other regions. A similar tendency was observed in parks size, so that parks higher than 10,000 m2 were more highly contaminated. The present investigation clearly shows that public parks have been contaminated with Toxocara eggs in Khorram Abad, suggesting that care should be taken when using public parks.

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