Lonza Biologics Inc.

Hopkinton, MA, United States

Lonza Biologics Inc.

Hopkinton, MA, United States

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News Article | May 12, 2017
Site: marketersmedia.com

— Global Laboratory Chemicals Market by products (Molecular biology, Cytokine and chemokine testing, Carbohydrate analysis, Immunochemistry, Cell/tissue culture, Environment testing, and Biochemistry), by end-user applications (Biotechnology, Academic segments, Nonacademic segment, corporate segment): Forecast to 2027 Basically, laboratory chemicals are the compounds or substances that are used in chemical reaction to measure produce and detect other chemical substance. These are being used in the large scale for commercial applications and research purpose. The laboratory chemicals market will rise mainly due to significant increase in use of laboratory chemical in basic research combined with commercial applications. Moreover, growing interest of world scientific community in laboratory chemical is anticipated to escalate the growth in the market. Study Objectives of Laboratory Chemicals Market: • To provide detailed analysis of the market structure along with forecast for the next 10 years of segments and sub • segments of the global laboratory chemicals Market. • To provide insights about factors affecting the market growth. • To analyze the global laboratory chemicals Market based on various factors- price analysis, supply chain analysis, Porter’s five force analysis etc. • To provide historical and forecast revenues of the market segments and sub-segments with respect to four main geographies and their countries- North America, Europe, Asia, and Rest of the World (ROW). • To provide country level analysis of the market with respect to the current market size and future prospects • To provide country level analysis of the market for segment by product types, and end-users. • To provide strategic profiling of key players in the market, comprehensively analyzing their core competencies, and drawing a competitive landscape for the market. • To track and analyze competitive developments such as joint ventures, strategic alliances, mergers and acquisitions, new product developments, and research and developments in the global laboratory chemicals market. The global laboratory chemicals market is segmented into product types, and end-user applications. On the basis of product types the market is segmented into Molecular biology, Cytokine and chemokine testing, Carbohydrate analysis, Immunochemistry, Cell/tissue culture, Environment testing, and Biochemistry. On the basis of end-user applications it is segmented as Biotechnology, Academic segments, Nonacademic segment, corporate segment. The key players present in the global laboratory chemical market mainly includes • Lonza Biologics ltd. • PerkinElmer Inc. • BD Biosciences • bioMerieux • Beckman Coulter Inc. • CALTAG Laboratories • GE healthcare • EMD Chemicals Inc. • Life technologies Corporation • Meridian Life science Inc. • Shimadzu Biotech • Takara Bio Inc. The report covers Geographies such as: Request for Table of Content at https://www.marketresearchfuture.com/request-toc/923 The market research report for Laboratory Chemicals of Market Research Future comprises of extensive primary research along with the detailed analysis of qualitative as well as quantitative aspects by various industry experts, key opinion leaders to gain the deeper insight of the market and industry performance. The report provides deep insights into current market scenario, historical and projected market size in terms of value and volume, technological advancement, macro economical and governing factors in the market. The report provides details information and strategies of the top key players in the industry. For more information, please visit https://www.marketresearchfuture.com/reports/laboratory-chemicals-market

Kim S.-H.,Bristol Myers Squibb | De Mas N.,Process Research and Development | De Mas N.,Lonza Biologics Inc. | Parlanti L.,Process Research and Development | And 20 more authors.
Organic Process Research and Development | Year: 2011

We describe the synthesis, chromatographic purification, and isolation of the epothilone-folic acid conjugate BMS-753493, an investigational new drug candidate for the treatment of cancer. The main challenges for process development were the instability of BMS-753493 in aqueous solution, the design and optimization of the preparative chromatography, and the removal of phosphate salts and water from the purified material. The operating conditions of the batch chromatographic purification were optimized using a column adsorption model. The free-salt active pharmaceutical ingredient was isolated via the precipitation of its zwitterion following a careful determination of the isolation parameters that controlled thermal and pH-related decomposition. This process enabled the manufacturing of several batches (10-30 g) of cGMP quality BMS-753493. © 2011 American Chemical Society.

Zang R.,Ohio State University | Zang R.,Genzyme | Zhang X.,Ohio State University | Zhang X.,Lonza Biologics Inc. | And 2 more authors.
Process Biochemistry | Year: 2013

Cell-based high throughput proliferation and cytotoxicity assays are increasingly used in drug screening and bioprocess development. However, online monitoring of cell proliferation, pH, and dissolved oxygen (DO) has been a challenge in 3D cell-based assays. In this work, a 40-microwell bioreactor (40-MBR) system was developed from a 384-well plate for real-time, noninvasive monitoring of pH, DO, and cell proliferation in 3D microenvironments. Chinese hamster ovary (CHO) and MCF-07 breast cancer cells cultured in 40-MBR confirmed that the 40-MBR was capable of simultaneously monitoring DO and cell proliferation based on culture fluorescence and pH by measuring the absorbance of phenol red. Cytotoxicity studies of sodium butyrate on CHO cells demonstrated that 40-MBR with dynamic background fluorescence correction gave more reliable and highly reproducible growth kinetic data compared to conventional multiwells with static background correction. Furthermore, the dosage effects of two new anticancer drug candidates, 5,7-dihydroxy-2-(4-hydroxyphenyl)-8-[(E)-2- phenylethenyl]-3,4-dihydro-2H-1-benzopyran-4-one (DH-8P-DB) and 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-[(E)-2-phenylethenyl]-3,4-dihydro-2H-1- benzopyran-4-one (DH-6P-DB), on HT-29 colon cancer cells were assessed using the 40-MBR, and the results indicated that DH-6P-DB would be a more potent drug in treating colon cancer than DH-8P-DB. These studies demonstrated that 40-MBR could serve as a high throughput platform for screening potential cancer drugs in early-stage drug discovery. © 2012 Elsevier Ltd. All rights reserved.

Tripathi S.A.,Mascoma Corporation | Tripathi S.A.,Oak Ridge National Laboratory | Olson D.G.,Mascoma Corporation | Olson D.G.,Dartmouth College | And 20 more authors.
Applied and Environmental Microbiology | Year: 2010

We report development of a genetic system for making targeted gene knockouts in Clostridium thermocellum, a thermophilic anaerobic bacterium that rapidly solubilizes cellulose. A toxic uracil analog, 5-fluoroorotic acid (5-FOA), was used to select for deletion of the pyrF gene. The ΔpyrF strain is a uracil auxotroph that could be restored to a prototroph via ectopic expression of pyrF from a plasmid, providing a positive genetic selection. Furthermore, 5-FOA was used to select against plasmid-expressed pyrF, creating a negative selection for plasmid loss. This technology was used to delete a gene involved in organic acid production, namely pta, which encodes the enzyme phosphotransacetylase. The C. thermocellum Δpta strain did not produce acetate. These results are the first examples of targeted homologous recombination and metabolic engineering in C. thermocellum, a microbe that holds an exciting and promising future in the biofuel industry and development of sustainable energy resources. © 2010, American Society for Microbiology.

Erler A.,Lonza AG | de Mas N.,Lonza Biologics Inc. | de Mas N.,Bristol Myers Squibb | Ramsey P.,University of New Hampshire | Henderson G.,Lonza Biologics Inc.
Biotechnology Letters | Year: 2013

As part of the process-characterization campaign of a candidate vaccine product, a recently developed class of three-level designs-definitive-screening designs-was employed to select a quadratic model that describes the effect of six input process parameters, including protein concentration, formaldehyde-to-protein ratio, lysine concentration, reaction duration, pH, and reaction temperature, on a formylation protein-crosslinking reaction. This design requires only 17 experimental runs. The resulting model was then used to simulate 10,000 runs that account for the variability in the inputs expected on manufacturing scale. The extent of protein polymerization was predicted to be within specifications for all simulated runs, demonstrating the robustness of the unit operation for subsequent process validation and future commercial manufacturing. © 2012 Springer Science+Business Media Dordrecht.

Zhang X.,Ohio State University | Zhang X.,Lonza Biologics Inc. | Yang S.-T.,Ohio State University
Process Biochemistry | Year: 2011

An online, analytical technology was developed that utilized fluorescence to detect cells during an immobilized cell culture process. Chinese hamster ovary (CHO) cells that produced monoclonal antibodies (mAb) were transfected to express green fluorescent protein (GFP), and stable, fluorescence-positive cells were obtained by fluorescence-activated cell sorting (FACS). The immobilized cell culture process was then used to test the effects of sodium butyrate on cells. In this study, cells were cultured in porous, fibrous matrices that were placed in spinner flasks. A lab-scale, perfusion bioreactor with computer-controlled, online fluorescence sensors that continuously detected GFP fluorescence and quantified cell growth was utilized. In addition, the level of GFP fluorescence was used to predict mAb production in the culture without sampling for cell counting and protein analysis. Thus, non-invasive, fluorescence detection of cells provided a rapid, reliable and robust approach for developing an immobilized cell culture process. © 2011 Elsevier Ltd. All rights reserved.

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