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Liu Z.,Fudan University | Wu D.,Fudan University | Wu D.,Shanghai JiaoTong University | Huang J.,Fudan University | And 6 more authors.
Archives of Gerontology and Geriatrics | Year: 2016

Background: Sensory impairment affects an increasing number of elderly adults, with a negative psychological impact. Our objective was to examine the associations of visual and hearing impairment with subjective well-being (SWB), an important psychological concept defined by life satisfaction [LS], positive affect [PA], negative affect [NA], and affect balance [AB] among long-lived individuals (LLIs) over 95 years of age. Methods: Data on 442 LLIs from the Rugao longevity cohort, a population-based study in Rugao, China, were analyzed. Graded classifications of visual and hearing impairment (none, mild, moderate, and severe) were constructed from self-reported items. Bivariate correlation and multiple regression analysis were performed to test the associations. Results: Approximately 66.1% and 87.3% of the subjects reported varying degrees of visual and hearing impairment. Following the degree of vision impairment, LS, PA, and AB decreased linearly, whereas NA increased linearly (all p for trend<0.05). Vision was significantly related to LS (. r=. 0.238, p<. 0.001), PA (. r=. 0.142, p<. 0.01), NA (. r=. -0.157, p<. 0.001), and AB (. r=. 0.206, p<. 0.001). After adjustment for multiple variables including functional ability, an important factor of SWB, the associations of vision impairment with LS, NA, and AB, while diminished, still existed. Conclusions: Visual impairment, but not hearing impairment, was independently associated with low SWB among LLIs, and functional ability may play a mediating role in the observed relationship. The findings indicate that rehabilitation targeted for those with reduced vision and functioning in long-lived populations may be important for promoting well-being and quality of life. © 2015 Elsevier Ireland Ltd.


PubMed | Fudan University, Shanghai JiaoTong University and Longevity Research Institute of Rugao
Type: | Journal: Archives of gerontology and geriatrics | Year: 2015

Sensory impairment affects an increasing number of elderly adults, with a negative psychological impact. Our objective was to examine the associations of visual and hearing impairment with subjective well-being (SWB), an important psychological concept defined by life satisfaction [LS], positive affect [PA], negative affect [NA], and affect balance [AB] among long-lived individuals (LLIs) over 95 years of age.Data on 442 LLIs from the Rugao longevity cohort, a population-based study in Rugao, China, were analyzed. Graded classifications of visual and hearing impairment (none, mild, moderate, and severe) were constructed from self-reported items. Bivariate correlation and multiple regression analysis were performed to test the associations.Approximately 66.1% and 87.3% of the subjects reported varying degrees of visual and hearing impairment. Following the degree of vision impairment, LS, PA, and AB decreased linearly, whereas NA increased linearly (all p for trend<0.05). Vision was significantly related to LS (r=0.238, p<0.001), PA (r=0.142, p<0.01), NA (r=-0.157, p<0.001), and AB (r=0.206, p<0.001). After adjustment for multiple variables including functional ability, an important factor of SWB, the associations of vision impairment with LS, NA, and AB, while diminished, still existed.Visual impairment, but not hearing impairment, was independently associated with low SWB among LLIs, and functional ability may play a mediating role in the observed relationship. The findings indicate that rehabilitation targeted for those with reduced vision and functioning in long-lived populations may be important for promoting well-being and quality of life.


Liu Z.,Fudan University | Zhong G.,Capital Medical University | Li S.,Capital Medical University | Deng W.,Fudan University | And 4 more authors.
Age | Year: 2015

Both activities of daily living (ADL) and some blood biomarkers (such as albumin) have been associated with mortality in very elderly people, but scarce data is available on the predictive performance of them in isolation or in combination, which is important for clinicians in decision making. Here, based on prospective mortality data over a 6-year follow-up period from 433 long-lived individuals (LLIs) aged 95+ years in the Rugao longevity cohort, we aimed to evaluate Cox proportional hazard ratios (HRs) and discriminative power (ROC curve) of 14 biomarkers and ADL for all-cause mortality. We found that six biomarkers (total triglyceride, albumin, low-density lipoprotein cholesterol, platelet count, lymphocyte count, and neutrophil count) were associated with mortality with a p < .10 in the univariate model. Significant associations of albumin and neutrophil count with mortality were observed when they were simultaneously included in a multivariate model, with HRs of 0.97 (95 % CI 0.94, 0.99; p = .005) and 1.09 (95 % CI 1.00, 1.18; p = .043). With respect to ADL, the corresponding HR was 1.10 (95 % CI 1.07, 1.14; p < .001). Low albumin (<40 g/L) combined with ADL dependent had a significantly increased mortality risk (HR = 2.19; 95 % CI 1.63, 2.95). Albumin and ADL separately showed good discriminative accuracies (area under the curve [AUC] = 0.68 and 0.66, respectively), and their combination had an increased predictive utility (AUC = 0.73). In conclusion, both albumin and ADL are efficient predictors of all-cause mortality in long-lived populations and their combination further increases discriminative power. The preliminary findings, if validated and translated, would help clinicians to identify the elderly people at varying mortality risk. © 2015, American Aging Association.


Liu Z.,Fudan University | Huang J.,Fudan University | Qian D.,Longevity Research Institute of Rugao | Chen F.,Longevity Research Institute of Rugao | And 6 more authors.
Archives of Gerontology and Geriatrics | Year: 2015

Background: CKD, a functional decline or break down of kidney, has been increasingly recognized as a public health problem and a predictor of poor outcomes (i.e., cardiovascular disease, dementia) and mortality among general populations. However, little is known regarding the prevalence and related factors of CKD among Chinese LLI over 95 years of age. Methods: We used data of LLI from the Rugao longevity cohort, a population-based association study conducted in Rugao, a longevity town of China. CKD was defined as an estimated glomerular filtration rate (eGFR) of <60mL/min/1.73m2. Demographic exposures and biochemical markers were correlated with CKD. Results: The prevalence of CKD among LLI in Rugao is 23.8%. Traditional risk factors for CKD among general population, such as hypertension, diabetes, and dyslipidemia, did not have associations with CKD. However, overweight, central adiposity, and hyperuricemia were associated with increased risk of CKD, with crude odds ratios of 2.41 (95% CI. =. 1.23-4.69), 2.61 (95% CI. =. 1.42-4.77), and 5.69 (95% CI. =. 2.75-11.76), respectively. In addition, higher magnesium and filtration marker β2 microglobulin (β2M) were associated with CKD, with crude odds ratios of 2.47 (95% CI. =. 1.38-4.43) and 16.38 (95% CI. =. 6.76-39.64), respectively. Conclusions: We observe a high prevalence and unique related factors of CKD among the LLI in Rugao, which suggest that early screening and risk intervention of CKD are imperative to maintain a high quality of life and postpone the occurrence of poor outcomes. © 2015 Elsevier Ireland Ltd.


Liu Z.,Fudan University | Wang Y.,Rugao Peoples Hospital | Huang J.,Fudan University | Chu X.,Rugao Peoples Hospital | And 8 more authors.
Journals of Gerontology - Series A Biological Sciences and Medical Sciences | Year: 2015

Background. Several blood biomarkers have been linked to functional disability, a health problem in general populations. However, there are limited data for evaluating the potential association of biomarkers with functional disability in an extremely longevous (95+) population. Methods. We used data from 420 extremely longevous individuals from the Rugao longevity cohort, a population-based association study conducted in Rugao, a longevity town in China. Functional disability was assessed by the Katz Index of Independence in activities of daily living. Blood biomarkers, including serum lipid, lipoprotein cholesterol, serum albumin, and lymphocyte count, were correlated with activities of daily living. Results. Among extremely longevous women, following the degree of functional disability, serum albumin and lymphocyte count decreased significantly (all p for trend <. 001). In a univariate model, serum albumin (β = -0.279, p <. 001), lymphocyte count (β = -0.187, p <. 001), and neutrophil count (β = 0.140, p =. 012) were found to be significantly associated with activities of daily living in women. After adjustment for other covariates, the significance remained. Notably, multivariate regression analysis revealed independent effects of all the three biomarkers on activities of daily living (β = -0.242, -0.185, and 0.143, all p <. 05). We did not observe any association in men. Conclusions. We found significant associations between serum albumin, lymphocyte count, and neutrophil count and physical disability even after adjustment for potential confounders in extremely longevous women, which call for further study. The findings provide preliminary but crucial clues for future studies specifically aimed at exploring the longitudinal relationships of interest before proceeding with interventions. © 2014 © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.


Liu Z.,Fudan University | Li L.,Fudan University | Huang J.,Fudan University | Qian D.,Longevity Research Institute of Rugao | And 5 more authors.
Age | Year: 2014

To examine the associations of cognitive and emotional facets (measured by life satisfaction [LS], positive affect [PA], negative affect [NA], and affect balance [AB]) of subjective well-being (SWB) with exceptional longevity (EL), we conducted a population-based study with 463 EL individuals (95+, EL group) recruited from a longevity town of Rugao, China (N = 755, with a response rate of 71.6 %), and 926 elderly individuals (60-69, elderly/control group). The population-based controls were sampled from the resident registry according to the gender ratio of the EL group. We found that the EL group had significantly higher levels of LS (30.74 vs. 28.93), PA (3.91 vs. 3.67), and AB (7.89 vs. 7.40) and a lower level of NA (1.02 vs. 1.27) than the elderly group. Multivariate logistic regression analysis revealed that higher levels of LS, PA, AB, and NA were significantly associated with EL, with odds ratios (ORs) of 1.98 (95 % CI, 1.36-2.89), 2.35 (95 % CI, 1.59-3.48), 2.56 (95 % CI, 1.75-3.75), and 0.50 (95 % CI, 0.33-0.74), respectively. Stratification analysis showed that the associations were significant in the healthy subsample, with the following ORs: LS = 2.31, PA = 2.53, AB = 3.05, and NA = 0.39. In conclusion, SWB, with high cognitive and emotional facets, was associated with EL in the healthy Rugao population. The findings imply that interventions that aim to improve elderly individuals' SWB may promote their quality of life and, ultimately, EL. © 2014 American Aging Association.


Liu Z.,Fudan University | Huang J.,Fudan University | Qian D.,Longevity Research Institute of Rugao | Chen F.,Longevity Research Institute of Rugao | And 4 more authors.
Journal of Nutrition, Health and Aging | Year: 2016

Objectives: To examine the relationship between body mass index (BMI) and subjective well-being (SWB) among long-lived women over 95 years of age and evaluate whether this relationship is mediated by functional ability. Design: Retrospective cohort study. Setting: Data from the Rugao longevity cohort, a population-based study in Rugao, China. Participants: A sample of 342 long-lived women (mean age 97.4 ± 2.1, range 95–107) whose SWB and other covariates were available were included in this study. Measurements: BMI was calculated as weight in kilograms divided by height in meters-squared (kg/m2). SWB was measured by life satisfaction (LS), positive affect (PA), negative affect (NA) and affect balance (AB). Functional ability was assessed by the Katz Index of Activities of Daily Living (ADL). Results: According to BMI classification standards for China, the underweight group had lower levels of LS than the normal and overweight groups (28.62 vs. 30.51 and 31.57, respectively; p<.05). Correlation analysis showed that BMI was significantly related to LS (r = 0.166, p<.01). The strength of the BMI and LS association was diminished when ADL was included in the general linear regression models. Mediation analysis revealed that ADL mediated this relationship (effect size = 22.6%). We did not observe significant associations of BMI with other SWB components (PA, NA, and AB). Conclusion: For long-lived women, low BMI, rather than elevated BMI, is an indicator of poor psychological well-being. The findings call for public health awareness about low body weight in long-lived women, especially in those with physical disabilities when focusing on quality of life. © 2016, Serdi and Springer-Verlag France.


PubMed | Fudan University, Rugao Peoples Hospital and Longevity Research Institute of Rugao
Type: Journal Article | Journal: The journals of gerontology. Series A, Biological sciences and medical sciences | Year: 2015

Several blood biomarkers have been linked to functional disability, a health problem in general populations. However, there are limited data for evaluating the potential association of biomarkers with functional disability in an extremely longevous (95+) population.We used data from 420 extremely longevous individuals from the Rugao longevity cohort, a population-based association study conducted in Rugao, a longevity town in China. Functional disability was assessed by the Katz Index of Independence in activities of daily living. Blood biomarkers, including serum lipid, lipoprotein cholesterol, serum albumin, and lymphocyte count, were correlated with activities of daily living.Among extremely longevous women, following the degree of functional disability, serum albumin and lymphocyte count decreased significantly (all p for trend < .001). In a univariate model, serum albumin ( = -0.279, p < .001), lymphocyte count ( = -0.187, p < .001), and neutrophil count ( = 0.140, p = .012) were found to be significantly associated with activities of daily living in women. After adjustment for other covariates, the significance remained. Notably, multivariate regression analysis revealed independent effects of all the three biomarkers on activities of daily living ( = -0.242, -0.185, and 0.143, all p < .05). We did not observe any association in men.We found significant associations between serum albumin, lymphocyte count, and neutrophil count and physical disability even after adjustment for potential confounders in extremely longevous women, which call for further study. The findings provide preliminary but crucial clues for future studies specifically aimed at exploring the longitudinal relationships of interest before proceeding with interventions.

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