Cuxhaven, Germany
Cuxhaven, Germany

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Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-07b-2015 | Award Amount: 9.01M | Year: 2016

This aim of IMAGE is to enhance the use of genetic collections and to upgrade animal gene bank management. IMAGE will better exploit DNA information and develop methodologies, biotechnologies, and bioinformatics for rationalising animal genetic resources. It will demonstrate the benefits brought by gene banks to the development of sustainable livestock systems by: enhancing the usefulness of genetic collections to allow the livestock sector to respond to environment and market changes; using latest DNA technology and reproductive physiology for collecting, storing and distributing biological resources; Minimising genetic accidents such as abnormalities or genetic variability tipping points; Developing synergies between ex-situ and in-situ conservation to maximise resources for the future. To this end, the project will involve stakeholders, SME, and academic partners to achieve the following objectives. At the scientific level, the project will: Assess the diversity available in genetic collections; Search for adaptive traits through landscape genetics in local populations; Contribute to elucidate local populations and major genes history; Identify detrimental variants that can contribute to inbreeding depression; Predict cryobank samples reproductive performance; Facilitate the use of collections for genome-assisted breeding. At the technological level, it will develop: Procedures for harmonising gene bank operations and rationalising collections; Conservation and reproductive biotechnologies; A central information system to connect available data on germplasm and genomic collections. At the applied level, it will develop methods and tools for stakeholders to: Restore genetic diversity in livestock populations; Create or reconstruct breeds fitting new environmental constraints and consumer demands; Facilitate cryobanking for local breeds; Define and track breed-based product brands; Implement access and benefit sharing regulations.


Philipp H.-C.,Lohmann Tierzucht GmbH | Kolla I.,Lohmann Animal Health
Biologicals | Year: 2010

The regulation for batch testing of avian live viral vaccines for extraneous agents was modified recently in order to reduce animal use, and routine batch testing had to be adapted to this new regulation. As a result, however, some tests have become more complicated and time-consuming. Due to systematic technical problems, the new methods required could only be applied to a small proportion of the batches produced. As a consequence, the majority of batches are still tested in animals. © 2010 The International Association for Biologicals.


Sitzenstock F.,University of Gottingen | Ytournel F.,University of Gottingen | Sharifi A.R.,University of Gottingen | Cavero D.,Lohmann Tierzucht GmbH | And 3 more authors.
Genetics Selection Evolution | Year: 2013

Background: In breeding programs for layers, selection of hens and cocks is based on recording phenotypic data from hens in different housing systems. Genomic information can provide additional information for selection and/or allow for a strong reduction in the generation interval. In this study, a typical conventional layer breeding program using a four-line cross was modeled and the expected genetic progress was derived deterministically with the software ZPLAN+. This non-genomic reference scenario was compared to two genomic breeding programs to determine the best strategy for implementing genomic information in layer breeding programs. Results: In scenario I, genomic information was used in addition to all other information available in the conventional breeding program, so the generation interval was the same as in the reference scenario, i.e. 14.5 months. Here, we assumed that either only young cocks or young cocks and hens were genotyped as selection candidates. In scenario II, we assumed that breeders of both sexes were used at the biologically earliest possible age, so that at the time of selection only performance data of the parent generation and genomic information of the selection candidates were available. In this case, the generation interval was reduced to eight months. In both scenarios, the number of genotyped male selection candidates was varied between 800 and 4800 males and two sizes of the calibration set (500 or 2000 animals) were considered. All genomic scenarios increased the expected genetic gain and the economic profit of the breeding program. In scenario II, the increase was much more pronounced and even in the most conservative implementation led to a 60% improvement in genetic gain and economic profit. This increase was in all cases associated with higher breeding costs. Conclusions: While genomic selection is shown to have the potential to improve genetic gain in layer breeding programs, its implementation remains a business decision of the breeding company; the possible extra profit for the breeding company depends on whether the customers of breeding stock are willing to pay more for improved genetic quality. © 2013 Sitzenstock et al.; licensee BioMed Central Ltd.


Qanbari S.,University of Gottingen | Hansen M.,University of Gottingen | Weigend S.,Institute of Farm Animal Genetics | Preisinger R.,Lohmann Tierzucht GmbH | Simianer H.,University of Gottingen
BMC Genetics | Year: 2010

Background: The availability of larger-scale SNP data sets in the chicken genome allows to achieve a higher resolution of the pattern of linkage disequilibrium (LD). In this study, 36 k and 57 k genotypes from two independent genotyping chips were used to systematically characterize genome-wide extent and structure of LD in the genome of four chicken populations. In total, we analyzed genotypes of 454 animals from two commercial and two experimental populations of white and brown layers which allows to some extent a generalization of the results.Results: The number of usable SNPs in this study was 19 k to 37 k in brown layers and 8 k to 19 k in white layers. Our analyzes showed a large difference of LD between the lines of white and brown layers. A mean value of r2= 0.73 ± 0.36 was observed in pair-wise distances of < 25 Kb for commercial white layers, and it dropped to 0.60 ± 0.38 with distances of 75 to 120 Kb, the interval which includes the average inter-marker space in this line. In contrast, an overall mean value of r2= 0.32 ± 0.33 was observed for SNPs less than 25 Kb apart from each other and dropped to 0.21 ± 0.26 at a distance of 100 kb in commercial brown layers. There was a remarkable similarity of the LD patterns among the two populations of white layers. The same was true for the two populations of brown layers, while the LD pattern between white and brown layers was clearly different. Inferring the population demographic history from LD data resulted in a larger effective population size in brown than white populations, reflecting less inbreeding among brown compared to white egg layers.Conclusions: We report comprehensive LD map statistics for the genome of egg laying chickens with an up to 3 times higher resolution compared to the maps available so far. The results were found to be consistent between analyzes based on the parallel SNP chips and across different populations (commercial vs. experimental) within the brown and the white layers. It is concluded that the current density of usable markers in this study is sufficient for association mapping and the implementation of genomic selection in these populations to achieve a similar accuracy as in implementations of association mapping and genomic selection in mammalian farm animals. © 2010 Qanbari et al; licensee BioMed Central Ltd.


The layer breeding business can supply an effective and sustaining contribution in feeding the increasing world population. Improved breeding strategies, for example genomic selection, provide a good foundation for it. So far, however, it hasn't been possible to verify the practical benefits of these strategies in commercial poultry breeding programs. It is already obvious that savings in performance testing cannot be opposed to increasing costs. Company-owned SNP-chips are being utilised in both the layer and broiler breeding business. The first practical results are expected to be available in 2010. The aims are to shorten the generation intervals as well as to obtain a possibility to select within groups of full male siblings based on sex-limited performance tests. Based on case-control studies, animals with extreme phenotypic variations are used as a basis to establish SNP-markers for selection on improved vitality. © Verlag Eugen Ulmer, Stuttgart.


Jeroch H.,University of Warmia and Mazury | Tiller H.,Lohmann Tierzucht GmbH
European Poultry Science | Year: 2014

In the present contribution the research of poultry nutrition of about the last 100 years is mainly presented at the example of vitamins in a straight form. After an overview of relevant German contributions concerning scientific poultry nutrition the further expressions are concentrating on following main topics: expression on vitamins, definition and active forms, vitamin detections, research topics and research installations, disease syndromes with associations to vitamins, additional requirements of vitamins, supply recommendations and ways of supply (earlier, today). Finally a few future research topics are mentioned. © Verlag Eugen Ulmer, Stuttgart.


In poultry breeding programmes owned by private companies, selection is done within closed populations based on comprehensive phenotypic data recording in both pure and cross line birds under standardised housing conditions. Due to sex limited data recording, male selection for egg quality and production traits is based mainly on female sibling tests. Early selection of the most promising male within full sib families will improve the rate of genetic progress and can substantially reduce generation interval. Several studies based mainly on microsatellites have identified QTLs for production and quality traits. The identification of a single nucleotide mutation in brown layers has been used to eradicate mutant variants with the consequence of a non-restricted use of canola in layer diets. Genome wide selection is still in the initial stages in which 10 to 40 K SNP chips have been used so far. Due to sequencing of all major pure lines from DNA pools, a customised 600K chip has been developed for comprehensive genotyping of all commercial lines. Small scale line-specific SNP chips will be developed afterwards in order to reduce costs for genotyping of male progeny during rearing periods. Only most promising young males will be transferred to the breeding farm for performance testing and pedigree reproduction. Parental generation will still be genotyped with the comprehensive SNP chip and used for retraining and for input. The first results using 30K chips were obtained from a commercial line used for training, validation and selection, which have shown improved accuracy of prediction at a young age and so resulted in increased genetic gain. Genome wide marker-assisted selection must prove its advantages over traditional methods including cost benefits. © Verlag Eugen Ulmer, Stuttgart.


Preisinger R.,Lohmann Tierzucht GmbH
Animal Production Science | Year: 2012

In poultry breeding programs owned by private companies, selection is done within closed populations based on comprehensive phenotypic data recording in both pure and cross line birds under standardised housing conditions. Due to sex-limited data recording, male selection for egg quality and production traits is based mainly on female sibling tests. Early selection of the most promising male within full sib families will improve the rate of genetic progress and can substantially reduce the generation interval. Several past studies, based mainly on microsatellites, have identified quantitative trait loci (QTL) for production and quality traits with only limited use in commercial programs. Genome-wide selection is still in its initial stages in which 1040-K single nucleotide polymorphism (SNP) chips have been used so far. Due to sequencing of all major pure lines from DNA pools, a customised 600-K SNP chip has been developed for comprehensive genotyping of all commercial lines. Small-scale line-specific SNP chips will be developed afterwards in order to reduce costs for genotyping of male progeny during rearing periods. Only the most promising young males will be transferred to the breeding farm for performance testing and pedigree reproduction. Parental generation will still be genotyped with the comprehensive SNP chip and used for retraining and for imputing. The first results using 30-K SNP chips were obtained from a commercial line used for training, validation and selection, which have shown improved accuracy of prediction at a young age and so resulted in increased genetic gain. Genome-wide marker-assisted selection must prove its advantages over traditional methods including cost benefits. © 2012 CSIRO.


This invention is directed to an isolated nucleic acid or an isolated polypeptide encoded by said nucleic acid for use in treatment or diagnosis of infectious diseases, wherein the nucleic acid comprises or consists of: - the nucleic acid sequence of the yqi gene with SEQ ID NO. 1 or the reverse complement thereof; - a nucleic acid sequence with at least 95% sequence identity to SEQ ID NO. 1 or a reverse complement thereof; - a nucleic acid sequence hybridizing under stringent conditions to the nucleic acid sequence with SEQ ID NO. 1 or to its reverse complement.


Patent
Lohmann Tierzucht GmbH | Date: 2010-02-10

The present invention relates to a nucleic acid molecule contributing to or indicative of low feather pecking. The present invention also relates to a nucleic acid molecule deviating by at least one mutation from the nucleic acid molecule of the invention, wherein said mutation is contributing to or indicative of high feather pecking and is a substitution, an insertion or a deletion. The present invention further relates to methods of testing an avian for its predisposition for low or high feather pecking comprising analysing in a sample the nucleic acid molecules of the invention for nucleotide polymorphisms which are linked to said predisposition. The present invention also relates to a method for selecting an avian or part of an avian for low or high feather pecking and to a kit for the detection of avians having a predisposition for low or high feather pecking comprising a nucleic acid molecule of the invention or a fragment thereof, in one or more container.

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