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Loei, Thailand

Chockchaisawasdee S.,Loei Rajabhat University | Poosaran N.,Chiang Mai University
Journal of the Science of Food and Agriculture | Year: 2013

Background: Banana is one of the important crops native to tropical Southeast Asia. Since overproduction frequently leads to excessive waste of produce, alternative uses are continuously sought in order to utilise fruits at all stages of maturity. The aim of this study was to investigate the production of isomaltooligosaccharides (IMOs) from banana flour. Results: Banana slurries liquefied by Termamyl SC and saccharified by either Fungamyl 800 L or barley β-amylase were used for IMO synthesis by Transglucosidase L. After 12 h of transglucosylation, maximum IMO yields of 76.67 ± 2.71 and 70.74 ± 4.09 g L-1 respectively were achieved.Although the yieldswere comparable, the IMOprofiles obtained through the use of the two saccharification enzymes were different. Glucose andmaltose were removed by 10 g L-1 bakers' yeast fermentation for 12 h. Regarding total sugars, the final IMO mixture was composed of 53% isomaltotriose, 21% isomaltotetraose and 26% maltooligoheptaose and larger oligomers. Conclusion: Banana flour could be used as a potential rawmaterial for IMO synthesis. © 2012 Society of Chemical Industry. Source


Suphim B.,Khon Kaen University | Suphim B.,Loei Rajabhat University | Prawan A.,Khon Kaen University | Kukongviriyapan U.,Khon Kaen University | And 4 more authors.
Food and Chemical Toxicology | Year: 2010

Curcumin, a major component from tumeric and well-known dietary spice, possesses various pharmacological effects. The cancer chemoprevention effect is suggested to act through its pro-oxidant property. The study was to clarify effects of curcumin on cholangiocarcinoma cells, a cancer of the bile duct that refractory to chemotherapeutic drugs. We examined time-course of oxidant formation in relation to antitumor and the adaptive antioxidant response of the cells. Curcumin induced antiproliferation and apoptosis in KKU-M214 CCA cells with concentration- and time- dependent manners. The antiproliferative effect of curcumin was observed at concentrations as low as 3 μM and was not necessarily associated with oxidative stress, while induction of apoptosis required significant production of superoxide anion, suppression of cellular redox and collapse of mitochondrial transmembrane potential. Western blot analysis showed a temporal relationship between the suppression of nuclear NF-κB with Bcl-XL protein levels. Up-regulation of p53 and Bax was associated with marked oxidative stress and apoptosis. Curcumin also induced Nrf2 protein expression with up-regulation of γ-glutamylcysteine ligase mRNA and increased cellular antioxidant, glutathione. The study suggests that curcumin could be developed into an effective chemoprevention against CCA. © 2010 Elsevier Ltd. Source


Jugdaohsingh R.,MRC Human Nutrition Research | Anderson S.H.C.,St. Thomas Hospital | Lakasing L.,Kings College | Sripanyakorn S.,Loei Rajabhat University | And 2 more authors.
British Journal of Nutrition | Year: 2013

Earlier studies in animals have suggested an essential role for Si in connective tissues, but such works have not been replicated per se. Nonetheless, a study conducted in 2000 has reported that Si may be essential during pregnancy for the growing fetus, since serum Si concentrations in infants were approximately 300 % higher than those in older children and adults and serum Si concentrations in pregnant women were approximately 300 % lower than those in age-matched non-pregnant controls. To reproduce these potentially important findings, in the present study, serum Si concentrations were measured in fourteen pregnant women (15-24 weeks of gestation) and compared with those of seventeen non-pregnant, non-lactating female controls. Serum Si concentrations were also measured in fourteen full-term mothers at the time of delivery and in the umbilical cord (UC) vein and artery where possible. Fasting serum Si concentrations in pregnant women were not significantly different from those of the female controls and showed little change with advancing gestation (r 0·2). Mean serum Si concentrations in the UC vein samples were 52 % higher, while those in the UC artery samples were 235 % higher than those in the maternal forearm vein samples, although data were widely spread and differences were not significant. Mean maternal forearm vein Si concentrations at delivery were 50 % lower than those of pregnant women and female controls, but, again, these were not significant. Overall, we note that there are significant analytical challenges in comparing baseline Si levels between different groups; notwithstanding, our findings cannot confirm a reduction in fasting serum Si levels during pregnancy, but, equally, we cannot rule out higher serum Si levels in newborns than in their mothers, and further work is required. © The Authors 2013. Source


Kakchapati S.,Prince of Songkla University | Ardkaew J.,Loei Rajabhat University
Journal of Research in Health Sciences | Year: 2011

Background: Malaria is a major cause of morbidity and mortality in Nepal. The magnitude of malaria across the country is alarming and varies with location. Therefore, the present study aimed to model malaria incidence rates during 1998 to 2009 in Nepal. Methods: Data for the study were obtained from Health Management Information System (HMIS), Ministry of Public Health. A negative binomial model was used to fit malaria incidence rates as a function of year and location and provided a good fit, as indicated by residual plots. Results: In total, 83,345 cases of malaria were reported from 1998 to 2009. The mean incidence rate was 0.30 per 1000 population. The models show trends and spatial variations in disease incidence. There was decreasing trend in the incidence rates of malaria (1998-2004), followed by a more moderate upward trend until 2008, when the rate decreases again. Zero malaria incidences occurred in six districts including Humla, Jajarkot, Manang, Kathmandu, Bhakthapur and Solukhumbu districts for over twelve years. Higher incidence occurred in Kanchanpur, Kailali, Bardiya, Kavre, and Jhapa districts for the study period. Conclusion: Malaria is still a public health problem in Nepal. This study showed a steady decreasing trend in malaria incidence but the numbers of cases are still very high. Higher rates were observed in Terai Region and border areas. These findings highlight the need for more systematic and effective malaria control measures on malaria burden areas of Nepal. Source


Pimpabute N.,Khon Kaen University | Burinprakhon T.,Khon Kaen University | Somkhunthot W.,Loei Rajabhat University
Optica Applicata | Year: 2011

Gallium phosphide (GaP) thin film was prepared by an asymmetric bipolar pulsed-dc magnetron sputtering technique onto glass substrate at room temperature in an Ar atmosphere. A compacted GaP powder was used as a target. The X-ray diffraction patterns show that the film is amorphous. The transmittance of the film was measured in the incident photon wavelength range of 300-2000 nm. The film's refractive index, thickness and absorption coefficient as a function of wavelength were determined by using Swanepoel's method. The deduced absorption data indicate that the optical transition in the film is dominated by the indirect type. The corresponding energy of 1.51 eV was obtained for the 563±16 nm thin film. Source

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