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Jugdaohsingh R.,MRC Human Nutrition Research | Jugdaohsingh R.,King's College London | Sripanyakorn S.,King's College London | Sripanyakorn S.,Loei Rajabhat University | Powell J.J.,MRC Human Nutrition Research
British Journal of Nutrition | Year: 2013

Host factors influencing the absorption and excretion of Si are poorly understood, although previous murine and human studies have suggested that age, sex and oestrogen status may affect Si metabolism and thus function. Here, serum and urine samples were collected from twenty-six healthy adults at baseline and over a 6Â h period following ingestion of 17·4Â mg Si (orthosilicic acid) and analysed by inductively coupled plasma optical emission spectrometry. Fasting baseline serum and urinary Si concentrations were marginally higher in older adults (51-66 years old) compared with young adults (20-47 years old); however, there was no difference in the absorption of Si into serum (overall profile, rate of Si appearance, peak concentration and time to peak) between the different adult groups. The rate of elimination of Si from serum did not significantly differ with age or sex, although serum concentration at 6Â h was higher in older adults and significantly correlated with age (r 0·5; P=Â 0·01). There were, however, no significant differences in the excretion of Si into urine (a proxy for overall uptake) between the groups, averaging approximately 45Â %. Oestradiol levels did not correlate with any of the above measures of Si. Thus, overall, host age and sex did not appear to markedly influence Si absorption or excretion in human adults and no correlations were found with serum oestradiol status. The marginally higher baseline and 6Â h post-dose Si levels in older adults may reflect modestly impaired renal function and/or the loss of Si from connective tissues with ageing. Copyright © The Authors 2013.

Chockchaisawasdee S.,Loei Rajabhat University | Poosaran N.,Chiang Mai University
Journal of the Science of Food and Agriculture | Year: 2013

Background: Banana is one of the important crops native to tropical Southeast Asia. Since overproduction frequently leads to excessive waste of produce, alternative uses are continuously sought in order to utilise fruits at all stages of maturity. The aim of this study was to investigate the production of isomaltooligosaccharides (IMOs) from banana flour. Results: Banana slurries liquefied by Termamyl SC and saccharified by either Fungamyl 800 L or barley β-amylase were used for IMO synthesis by Transglucosidase L. After 12 h of transglucosylation, maximum IMO yields of 76.67 ± 2.71 and 70.74 ± 4.09 g L-1 respectively were achieved.Although the yieldswere comparable, the IMOprofiles obtained through the use of the two saccharification enzymes were different. Glucose andmaltose were removed by 10 g L-1 bakers' yeast fermentation for 12 h. Regarding total sugars, the final IMO mixture was composed of 53% isomaltotriose, 21% isomaltotetraose and 26% maltooligoheptaose and larger oligomers. Conclusion: Banana flour could be used as a potential rawmaterial for IMO synthesis. © 2012 Society of Chemical Industry.

Suphim B.,Khon Kaen University | Suphim B.,Loei Rajabhat University | Prawan A.,Khon Kaen University | Kukongviriyapan U.,Khon Kaen University | And 4 more authors.
Food and Chemical Toxicology | Year: 2010

Curcumin, a major component from tumeric and well-known dietary spice, possesses various pharmacological effects. The cancer chemoprevention effect is suggested to act through its pro-oxidant property. The study was to clarify effects of curcumin on cholangiocarcinoma cells, a cancer of the bile duct that refractory to chemotherapeutic drugs. We examined time-course of oxidant formation in relation to antitumor and the adaptive antioxidant response of the cells. Curcumin induced antiproliferation and apoptosis in KKU-M214 CCA cells with concentration- and time- dependent manners. The antiproliferative effect of curcumin was observed at concentrations as low as 3 μM and was not necessarily associated with oxidative stress, while induction of apoptosis required significant production of superoxide anion, suppression of cellular redox and collapse of mitochondrial transmembrane potential. Western blot analysis showed a temporal relationship between the suppression of nuclear NF-κB with Bcl-XL protein levels. Up-regulation of p53 and Bax was associated with marked oxidative stress and apoptosis. Curcumin also induced Nrf2 protein expression with up-regulation of γ-glutamylcysteine ligase mRNA and increased cellular antioxidant, glutathione. The study suggests that curcumin could be developed into an effective chemoprevention against CCA. © 2010 Elsevier Ltd.

Kakchapati S.,Prince of Songkla University | Ardkaew J.,Loei Rajabhat University
Journal of Research in Health Sciences | Year: 2011

Background: Malaria is a major cause of morbidity and mortality in Nepal. The magnitude of malaria across the country is alarming and varies with location. Therefore, the present study aimed to model malaria incidence rates during 1998 to 2009 in Nepal. Methods: Data for the study were obtained from Health Management Information System (HMIS), Ministry of Public Health. A negative binomial model was used to fit malaria incidence rates as a function of year and location and provided a good fit, as indicated by residual plots. Results: In total, 83,345 cases of malaria were reported from 1998 to 2009. The mean incidence rate was 0.30 per 1000 population. The models show trends and spatial variations in disease incidence. There was decreasing trend in the incidence rates of malaria (1998-2004), followed by a more moderate upward trend until 2008, when the rate decreases again. Zero malaria incidences occurred in six districts including Humla, Jajarkot, Manang, Kathmandu, Bhakthapur and Solukhumbu districts for over twelve years. Higher incidence occurred in Kanchanpur, Kailali, Bardiya, Kavre, and Jhapa districts for the study period. Conclusion: Malaria is still a public health problem in Nepal. This study showed a steady decreasing trend in malaria incidence but the numbers of cases are still very high. Higher rates were observed in Terai Region and border areas. These findings highlight the need for more systematic and effective malaria control measures on malaria burden areas of Nepal.

Pimpabute N.,Khon Kaen University | Burinprakhon T.,Khon Kaen University | Somkhunthot W.,Loei Rajabhat University
Optica Applicata | Year: 2011

Gallium phosphide (GaP) thin film was prepared by an asymmetric bipolar pulsed-dc magnetron sputtering technique onto glass substrate at room temperature in an Ar atmosphere. A compacted GaP powder was used as a target. The X-ray diffraction patterns show that the film is amorphous. The transmittance of the film was measured in the incident photon wavelength range of 300-2000 nm. The film's refractive index, thickness and absorption coefficient as a function of wavelength were determined by using Swanepoel's method. The deduced absorption data indicate that the optical transition in the film is dominated by the indirect type. The corresponding energy of 1.51 eV was obtained for the 563±16 nm thin film.

Sukprasert S.,Loei Rajabhat University
International Journal of Interdisciplinary Environmental Studies | Year: 2015

Community capital plays a large role in herb conservation. Our objectives were to study the conditions of herbal plant diversity in the Na-o municipality of Loei, Thailand, to investigate community capital characteristics and herbal utilization, to explore directions for conserving herbal plant diversity by applying community capitals, and to evaluate directions for conservation. A participatory action research method was applied with qualitative multitechniques of observation, focus group discussions, interviews, and workshops. The target group was seventy-two key informants. Data were analyzed by content analysis. The results found that community contexts were suitable for natural herbs and plants. Herbs were categorized as perennial, annual, water, climbing plants, and kitchen vegetables in home gardens. Community capital included: a natural resource capital of soils, mountains, forests, and reservoirs; a social capital of unity and mutual help; a cultural capital of local religious traditions; an intellectual and local wisdom capital of resource management and ancestral indigenous knowledge. The community exemplified herbal values and various utilizations. Directions for conservation included the determination of utilization, rehabilitation, and development. They were: increased planting, more learning resources, and knowledge dissemination. Evaluation of the directions indicated that the community was satisfied with the herb values leaflet and exchange of vegetation. All aspects of herbal use were worth conserving. © 2015 Common Ground, Saowapa Sukprasert, All Rights Reserved.

Pruksa S.,Loei Rajabhat University | Siripinyanond A.,Mahidol University | Powell J.J.,MRC Human Nutrition Research | Jugdaohsingh R.,MRC Human Nutrition Research
Nutrition and Metabolism | Year: 2014

Background: Accumulating evidence suggests a role for silicon in optimal connective tissue health. Further proof of its importance/essentiality may be provided by studies involving imposed depletion followed by 29Si challenge to estimate metabolic balance. Prior to conducting these expensive studies, we first established the variance of estimating normal Si excretion versus intake using a single oral dose of typical dietary Si, orthosilicic acid. Methods. Healthy volunteers were recruited from Loei Rajabhat University, separated into two matched groups (three males and three females/group) and maintained on a standardized diet for the three study days. One group ingested 500 ml water containing orthosilicic acid (28.9 mg Si) and the other group received 500 ml water alone, all on a fasted stomach. Blood samples and total urine and faeces were collected over the 48 h post-dose period and 24 h before-hand (baseline) and analysed for silicon by inductively coupled plasma optical emission spectrometry. Results: Serum Si analysis confirmed the ready absorption of silicon from the orthosilicic acid solution. Mean total urinary and faecal Si excretions over the 24 h post-dose period accounted for 57 ± 9.5% and 39 ± 9.4% of the ingested dose, respectively. Thus in total 96.3 ± 5.8% of the ingested dose was recovered in faecal plus urinary excretions over the 24 h post-dose period. Conclusions: We report that in healthy subjects (presumably in Si balance), the ingestion of a soluble dose of dietary Si results in the same quantity (within analytical error) being excreted within 24 h. It is currently not known if this all originated from the dose solution or if there was some exchange with the body Si pool but, given the low variance in these silicon balance data, isotopic studies are now merited. © 2014 Pruksa et al.; licensee BioMed Central Ltd.

Ardkaew J.,Loei Rajabhat University | Tongkumchum P.,Prince of Songkla University
Asia-Pacific Journal of Public Health | Year: 2011

This study aims to identify the incidence patterns of the most common infectious diseases, including acute diarrhea, pyrexia of unknown origin, hemorrhagic conjunctivitis, and pneumonia, in the 7 provinces of northeastern Thailand, based on individual hospital case records of infectious disease routinely reported from 1999 to 2004. Log-linear regression analysis with age-group, season, and district as factors was used, with data from all 4 diseases as outcomes combined into 1 model. Results confirmed that the highest incidence of each infectious disease occurred in children aged less than 5 years of age, with particularly high rates for diarrhea. In addition, the burden of pyrexia of unknown origin was found to be lower in districts bordering Laos, and the incidence rates were higher from April to June in 1999-2001 and 2004 and from July to September in 2002-2003. Higher incidence rates also occurred in most rural districts of Loei and Udon Thani provinces. © 2011 Asia-Pacific Academic Consortium for Public Health.

Pothi N.,Loei Rajabhat University
Advanced Materials Research | Year: 2014

This paper presents a design of a one-degree-of-freedom haptic interface system with an aim to investigate control of the system. The system comprised master devices, a system interacting with a user, and slave devices, a system interacting with environments. Both sets of devices were coupled with a gripper, which was designed in a shape of a cantilever beam, to measure force, and a DC motor was employed to drive precision ball screws, which were attached to the gripper, so as to create linear motion. In addition, an encoder was installed so as to investigate motion of the gripper, and the analysis results were employed for a design of a controller, based on the P, PI, PD, and PID type. The aim of this is to provide an operator with tactile sensing through control of the master devices while the slave devices were in contact with an object. The simulation results showed that the stiffness of an object affects stability of the system with a designed controller, causing, limitation of operation, that is, the system was stable when stiffness of the object was less than 43.3 kN/m, and the operator obtained a good response of positions and resistance while contacting with an object as though the operator has direct interaction with such an object. © (2014) Trans Tech Publications, Switzerland.

PubMed | Khon Kaen University, Loei Rajabhat University and Silpakorn University
Type: | Journal: Domestic animal endocrinology | Year: 2016

The experiment was conducted to evaluate corpus luteum (CL) growth, progesterone (P4) concentration, and endothelial nitric oxide synthase (eNOS) expression in nutrient stair-step fed goats. Female goats (n = 32) that exhibited at least 2, normal, consecutive estrous cycles were randomly assigned to either the control or stair-step fed group. In the control group, goats were fed ad libitum (100% of nutrient requirement for goats). The goats in the stair-step group were fed 70% of the control consumption for the first 42d and 130% for the later 42d during 4 consecutive estrous cycles (84d). Blood and luteal samples were collected on days 3, 8, 13, and 18 of the estrous cycle to determine concentration of glucose, insulin, P4, luteal growth, and eNOS expression. Luteal growth was determined using fresh CL weight, DNA content, DNA and protein concentrations, and cell proliferation (labeling index of Ki-67). During realimentation phase at 4h, glucose and insulin concentrations were greater (P < 0.05) in stair-step fed goat than those in control goats. Fresh CL weight, DNA content, protein concentrations, and labeling index of Ki67 on day 8 of the estrous cycle in the stair-step group were greater (P < 0.05) than that in the control group. Protein for eNOS was located in the capillaries of CL throughout of the estrous cycle in both groups. Greater serum P4 concentrations and eNOS protein (P < 0.05) were observed in the stair-step fed goats on day 3 (1.83ng/mL and 6.79%) compared with the control goats (0.98ng/mL and 6.02%) and on day 8 (5.15ng/mL and 7.88%) compared with the control goats (4.54ng/mL and 7.07%). These data demonstrate that luteal growth, progesterone concentration, and eNOS protein were partially affected by nutrient compensatory gain in goats.

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