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Brescia, Italy

Panizza C.,Local Health Unit ASL | Bai E.,Environmental Epidemiology and Cancer Registry Unit | Oddone E.,University of Pavia | Scaburri A.,Environmental Epidemiology and Cancer Registry Unit | And 5 more authors.
American Journal of Industrial Medicine | Year: 2012

Background: Occupational Cancer Monitoring (OCCAM) is an Italian organization that monitors occupational cancers, by area and industrial sector, by retrieving cases and employment history from official databases. OCCAM previously estimated a relative risk (RR) of lung cancer of about 1.32 among "metal treatment" workers in Lombardy, northern Italy, potentially exposed to chrome and nickel. In the present study, lung cancer risk was estimated among electroplating workers only. Methods: Lombardy electroplating companies were identified from descriptions in Social Security files. Lung cancer risk was evaluated from 2001 to 2008 incident cases identified from hospital discharge records. Results: The RR for lung cancer among electroplating workers was 2.03 (90% CI 1.33-3.10, 18 cases) for men; 3.00 (90% CI 1.38-9.03, 4 cases) for women. Conclusions: Electroplaters had higher risks than "metal treatment" workers. Although the risks were due to past exposure, case histories and recent acute effects indicate a present carcinogenic hazard in some Lombardy electroplating factories. © 2011 Wiley Periodicals, Inc. Source


Karligkiotis A.,University of Sassari | Machouchas N.,University of Sassari | Bozzo C.,University of Sassari | Melis A.,University of Sassari | And 6 more authors.
Acta Medica Mediterranea | Year: 2014

The aim of this study was to analyze and describe the epidemiological characteristics and trends of head and neck cancer in North Sardinia, Italy, in the period 1992-2010. Data were obtained from the tumor registry of the province of Sassari which is part of a wider registry web, coordinated, today, by the Italian Association for Tumor Registries. The overall number of head and neck cancer cases registered was 1650. The male-to-female ratio was 5.1:1 and the mean age 62.1 years for males and 63.1 years for females. The standardized incidence rates were 30.2/100,000 and 5.1/100,000 and the standardized mortality rates 11.6/100,000 and 1.6/100,000 for males and females respectively. An increasing trend in incidence of head and neck cancer in women was evidenced. Conversely, incidence was found to slightly decrease in males. Relative survival at 5 years from diagnosis was 50% for males and 55.5% for females. Furthermore, an increase in mortality rates was observed in both sexes in the period under investigation. Our data showed an increasing trend in the incidence of head and neck cancer in women in North Sardinia in recent decades. Conversely, a slight reduction of incidence rates was observed in males. Furthermore, an increasing trend in mortality rates was observed in both sexes, suggesting the need to enhance surveillance policies and to improve diagnosis and treatment methods. Source


Saracino M.A.,University of Bologna | Mercolini L.,University of Bologna | Carbini G.,University of Bologna | Volterra V.,University of Bologna | And 3 more authors.
Journal of Pharmaceutical and Biomedical Analysis | Year: 2014

A rapid and reliable analytical method has been developed to quantify the melatonergic antidepressant agomelatine in three matrices, and namely saliva, plasma and dried blood spots. The method is based on the use of liquid chromatography with fluorimetric detection exploiting the native fluorescence of agomelatine. For saliva and plasma samples an original microextraction by packed sorbent procedure was implemented obtaining satisfactory extraction yield of the analyte (always higher than 89%) and a good clean-up of the matrices. On the contrary, agomelatine was extracted from dried blood spots by suitable solvent microwave-assisted extraction and injected into chromatographic system. Satisfactory results in terms of sensitivity, linearity, precision, selectivity and accuracy were obtained. Thus, the developed method seems to be suitable for therapeutic drug monitoring of depressed patients under agomelatine therapy. © 2014 Elsevier B.V. Source


Roberti M.L.,Private Practice | Ricottini L.,Sinergheia Medical Center | Capponi A.,Private Practice | Sclauzero E.,OSTEMDA | And 10 more authors.
Journal of biological regulators and homeostatic agents | Year: 2014

Psoriasis is a chronic inflammatory skin disease affecting approximately 2-3 percent of the world population; it is characterised by hyperproliferation and hyperplasia of the superficial layers of the epidermis. Inappropriate signals released by the immune system determine an altered keratinocyte differentiation, resulting in the formation of desquamating, thickened, inflamed and erythematous plaques. The aim of this investigation was to study the pharmacological activity and safety of three low dose cytokines, Guna-Interleukin 4, Guna-Interleukin 10 and Guna-Interleukin 11 at the concentration of 10 fg/ml in patients affected by moderate to slight psoriasis vulgaris. The multicenter, double-blind, randomized, placebo-controlled clinical trial involved 48 patients who were enrolled and followed up according to a 8-month experimental project. All patients received, according to a cross-over model, either the experimental treatment or placebo, alternatively. Globally, in the 41 evaluated patients it was observed a PASI significant reduction (Friedman test: p=0.00960). The DLQI too decreased significantly in all subjects compared to baseline (Friedman test: p=0.00007). The safety of the treatment with three low dose cytokines administered simultaneously was proved; no adverse event was reported during the whole trial. Source


Panatto D.,University of Genoa | Amicizia D.,University of Genoa | Bragazzi N.L.,University of Genoa | Rizzitelli E.,University of Genoa | And 3 more authors.
Advances in Protein Chemistry and Structural Biology | Year: 2015

Human Papillomavirus (HPV) is a widely distributed and common virus, that causes benign lesions (such as warts and papillomas) but, if not cleared, can lead to malignant lesions as well, such as intraepithelial lesions and neoplasia. An extensive body of researches has demonstrated that E1 and E2 are involved in viral transcription and replication, E5, E6, and E7 act as oncoproteins, whilst L1 and L2 contribute to the formation of the capsid. However, this view has been recently challenged, since also E2 could play a role in HPV-induced carcinogenesis. Therefore, a complex picture is emerging, opening new ways and perspectives.The present article provides an overview of the biology of HPV, paying particular attention to its structural details and molecular mechanisms. The article also shows how this knowledge has been exploited for developing effective vaccines, both prophilactic/preventive and therapeutic ones. L1-based prophylactic vaccines, like Gardasil®, Cervarix®, and Gardasil 9®, have been already licensed, whilst L2-based second generation preventive vaccines are still under clinical trials. New, highly immunogenic and effective vaccines can be further developed thanks to computer-aided design and bioinformatics/computational biology. The optimization of combinational therapies is another promising opportunity. © 2015 Elsevier Inc. Source

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