Sokolova E.,RAS Shemyakin Ovchinnikov Institute of Bioorganic Chemistry |
Guryev E.,Lobachevsky University |
Yudintsev A.,Lobachevsky University |
Vodeneev V.,Lobachevsky University |
And 2 more authors.
Oncotarget | Year: 2017
Immunotoxin 4D5scFv-PE40 is a recombinant protein that comprises 4D5scFv antibody as a targeting module and fragment of Pseudomonas exotoxin A as an effector (toxic) one. The immunotoxin has shown pronounced antitumor effect on cancer cells overexpressing HER2 receptor in vitro and on HER2-positive experimental tumors in vivo. We clarified the mechanism of 4D5scFv-PE40 activity that is of particular importance in the case of targeted therapeutic agent aimed at personalizing treatment of disease in relation to molecular genetic characteristics of each patient. After specific binding to HER2 on the cell surface and clathrin-mediated endocytosis the immunotoxin passes through retrograde trafficking route. During this route the immunotoxin molecule is supposed to undergo enzymatic processing that ends in separation of C-terminal and N-terminal fragments of the immunotoxin. Finally, C-terminal functionally active fragment of 4D5scFv-PE40 arrests protein synthesis in cytoplasm followed by cell death via apoptosis.
Es'kin V.A.,Lobachevsky University |
Ivoninsky A.V.,Lobachevsky University |
Kudrin A.V.,Lobachevsky University |
Popova L.L.,Lobachevsky University
Journal of Experimental and Theoretical Physics | Year: 2017
Electromagnetic radiation from filamentary electric-dipole and magnetic-current sources of infinite length in the presence of gyrotropic cylindrical scatterers in the surrounding free space is studied. The scatterers are assumed to be infinitely long, axially magnetized circular plasma columns parallel to the axis of the filamentary source. The field and the radiation pattern of each source are calculated in the case where the source frequency is equal to one of the surface plasmon resonance frequencies of the cylindrical scatterers. It is shown that the presence of even a single resonant magnetized plasma scatterer of small electrical radius or a few such scatterers significantly affects the total fields of the filamentary sources, so that their radiation patterns become essentially different from those in the absence of scatterers or the presence of isotropic scatterers of the same shape and size. It is concluded that the radiation characteristics of the considered sources can efficiently be controlled using their resonance interaction with the neighboring gyrotropic scatterers. © 2017, Pleiades Publishing, Inc.
Yusipov I.,Lobachevsky University |
Laptyeva T.,Lobachevsky University |
Denisov S.,University of Augsburg |
Denisov S.,Novgorod State University |
Ivanchenko M.,Novgorod State University
Physical Review Letters | Year: 2017
In an isolated single-particle quantum system, a spatial disorder can induce Anderson localization. Being a result of interference, this phenomenon is expected to be fragile in the face of dissipation. Here we show that a proper dissipation can drive a disordered system into a steady state with tunable localization properties. This can be achieved with a set of identical dissipative operators, each one acting nontrivially on a pair of sites. Operators are parametrized by a uniform phase, which controls the selection of Anderson modes contributing to the state. On the microscopic level, quantum trajectories of a system in the asymptotic regime exhibit intermittent dynamics consisting of long-time sticking events near selected modes interrupted by intermode jumps. © 2017 American Physical Society.
Grachev D.A.,Lobachevsky University |
Legkov A.M.,Lobachevsky University |
Chunin I.I.,Lobachevsky University |
Ershov A.V.,Lobachevsky University
Journal of Physics: Conference Series | Year: 2017
We have studied the composite nanoperiodic (3-8 nm) SiO x /Al2O3 structures fabricated by physical deposition from separate sources. The structures annealed in nitrogen atmosphere at 900-1100 °C included Si-NCs that showed intense room-temperature photoluminescence at 1.6 eV. The quantum-confinement peak shift was observed under varying the SiO x layer thickness. Up to fourfold intensity enhancement was observed after hydrogenation of the structures in the range of 400-450 °C for 2 hours. © Published under licence by IOP Publishing Ltd.
Knyazev A.V.,Lobachevsky University |
Komshina M.E.,Lobachevsky University |
Savushkin I.A.,Lobachevsky University
Radiochemistry | Year: 2017
The α-ThSiO4 phase, a synthetic analog of thorite mineral, was prepared by hydrothermal synthesis and converted to β-ThSiO4, a synthetic analog of huttonite mineral. The temperature dependences of the unit cell parameters were studied by high-temperature X-ray diffraction, and the thermal expansion coefficients of the compounds were determined. © 2017, Pleiades Publishing, Inc.
Knyazev A.V.,Lobachevsky University |
Krasheninnikov O.V.,Lobachevsky University |
Syrov E.V.,Lobachevsky University
Russian Journal of General Chemistry | Year: 2017
The Aurivillius phases Bi7Ti4NbO21, CaBi8Ti7O27, and SrBi8Ti7O27 were synthesized by solid-phase reactions. The results of high-temperature X-ray diffraction and thermal analyses of certain Aurivillius phases are presented. Principal regularities of thermal expansion of the synthesized compounds are established. A correlation between the Curie temperature and the structure of the compounds was found. © 2017, Pleiades Publishing, Ltd.
Perova T.V.,Lobachevsky University |
Kustov T.V.,Saint Petersburg Electrotechnical University l
2015 4th Forum Strategic Partnership of Universities and Enterprises of Hi-Tech Branches (Science. Education. Innovation) | Year: 2015
The article deals with the most current students' career development and employment promotion technologies. The paper describes the experience of the career center Lobachevsky university. The structure and main activities of the student council's Potential activity of the Career Centre. © 2015 IEEE.
PubMed | Lobachevsky University and RAS Institute of Macromolecular Compounds
Type: | Journal: Journal of biophotonics | Year: 2016
Efficient drug delivery can be assigned to tasks that attract the most acute attention of researchers in the field of anticancer drug design. We have reported the first case of using amphiphilic polymer brushes as nanocontainers for photosensitizer delivery to cancer cells. Regular graft-copolymers of hydrophobic polyimides with hydrophilic polymethacrylic acid side chains were loaded with photosensitive dye tetra(4-fluorophenyl)tetracyanoporphyrazine (Pz) providing a sufficiently stable homogeneous fraction of fluorescent Pz-loaded nanoparticles with a size of 100-150 nm. Pz-loaded polymer brushes were substantially more efficient for Pz delivery into cells compared with other types of particles examined, Pz-polyethyleneglycol and Pz-methylcellulose. In vivo, an efficient Pz delivery to tumor can also be expected since the Pz-PB particle size is in the optimal range for passive targeting. Pz-PB showed pronounced photodynamic activity, while, that is important, in the absence of irradiation the PB carrier itself was significantly less toxic than the dye itself. Summing up, water-soluble polymer brushes with polyimide backbones and polymethacrylic acid side chains can be regarded as a novel type of nanocontainers providing efficient intracellular drug delivery for photodynamic therapy of cancers.
Agrba P.D.,Lobachevsky University |
Kirillin M.Y.,RAS Institute of Applied Physics
Photonics and Lasers in Medicine | Year: 2016
Optical coherence tomography (OCT) is a modern technique for imaging of internal structures of biotissue of up to several millimeters in depth with a resolution of several micrometers. However, various external conditions can distort the diagnostic capabilities of an OCT image. Mechanical compression and temperature regime are the two conditions which mostly affect the diagnostic OCT images obtained with a contact probe. It is shown here that the application of compression to human skin induces a decrease in contrast of the stratum corneum-epidermis junction and an increase in contrast of the epidermis-dermis junction. With regard to these junctions, a preliminary change of biotissue temperature induces additional changes in the contrast, with opposing effects in case of heating and cooling. © 2016 by De Gruyter 2016.
Kudrin A.V.,Lobachevsky University |
Kudrina O.A.,Lobachevsky University |
Petrov E.Y.,Lobachevsky University
Journal of Experimental and Theoretical Physics | Year: 2016
We consider electromagnetic nonlinear normal modes in cylindrical cavity resonators filled with a nonlinear nondispersive medium. The key feature of the analysis is that exact analytic solutions of the nonlinear field equations are employed to study the mode properties in detail. Based on such a nonperturbative approach, we rigorously prove that the total energy of free nonlinear oscillations in a distributed conservative system, such as that considered in our work, can exactly coincide with the sum of energies of the normal modes of the system. This fact implies that the energy orthogonality property, which has so far been known to hold only for linear oscillations and fields, can also be observed in a nonlinear oscillatory system. © 2016, Pleiades Publishing, Inc.