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Bhopal, India

Jain R.,Lnmedical College | Ratre B.K.,Lnmedical College | Patel N.,Lnmedical College | Singh D.P.,Lnmedical College | Raghuvanshi P.,Lnmedical College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

To evaluate the association of dyslipidemia as a risk factor of retinopathy in a population based study on a specific age group of patients with DM-2 with retinal hard exudates formation, the occurrence clinically significant macular edema (CSME), occurrence and severity of diabetic retinopathy (DR) and loss of vision in type 2 diabetics. Type 2 diabetic patients seeking ocular evaluation for diabetic retinopathy were included in this cross-sectional study. They were assessed for presence and severity of diabetic retinopathy (DR), presence of hard exudates, clinically significant macular oedema (CSME) and best corrected visual acuity (BCVA). Retinal findings were correlated to serum lipids levels using univariate and multivariate analysis. Totally 100 patients were included, of which 42/100 had diabetic retinopathy of any grade. Retinal hard exudate formation, was found to have statistically significant correlation with the presence of hyperlipidemia (p=0.02), increased total cholesterol (p=0.002) and LDL levels (p=0.001). On multivariate analysis, after correcting for duration, glycemic control and albuminuria, increased cholesterol remained significantly associated with increased hard exudate formation (p=0.02). Elevated cholesterol also showed independent association with visual loss (p=0.04). The occurrence CSME showed a statistically significant correlation with hyperlipidemia (p=0.04) and increased LDL levels (0.04), which did not persist on multivariate analysis. However the there was no correlation with the occurrence and severity of diabetic retinopathy. Dyslipidemia showed a significant association in diabetic retinopathy with retinal hard exudate formation, CSME and loss of vision in type 2 diabetics. Lipid lowering agents may help in reducing the occurrence of these retinal findings and loss of vision in diabetic patients.

Patel N.P.,Lnmedical College | Ratre B.,Lnmedical College | Jain R.,Lnmedical College | Raghuvanshi P.,Lnmedical College | Singh D.P.,Lnmedical College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

A rare case of tubercular brain abscess is reported. Our patient is a immunocompetent adult who was diagnosed to be tubercular brain following the histopathological demonstration of acid fast bacilli in the pus. Our patient improved following treatment with neurosurgical drainage and antitubercular therapy and was discharged successfully without any neurological deficit.

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