Ln Medical College And Research Center

Bhopal, India

Ln Medical College And Research Center

Bhopal, India

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Hulke S.M.,Ln Medical College And Research Center | Patil P.M.,Ln Medical College And Research Center | Thakare A.E.,Ln Medical College And Research Center | Vaidya Y.P.,Mahatma Gandhi Institute
National Journal of Physiology, Pharmacy and Pharmacology | Year: 2012

Background: Occupational exposure of petroleum product and its exhaust are causing significant health problem in petrol pump workers. The present study was planned to assess the lung function according to the duration of occupational exposure in petrol pump workers. Aims: To assess the lung function according to the duration of occupational exposure in petrol pump workers. Materials and methods: This was a cross sectional study done on the 119 petrol pump workers, who were involved in filling the petrol or diesel. Hundred and nineteen petrol pump workers were divided into four groups depending on the duration of exposure; their pulmonary function test was done and was compared with 33 healthy nonsmokers. Results: Significant reduction was seen in the FEV1 (Forced expiratory volume in 1 sec), FVC (forced vital capacity) in petrol pump workers who were exposed to more than 5 years. Flow rates i.e. FEF 25-75%, PEFR and PIFR also decreased significantly in the workers exposed more than 10 years. Conclusion: Petrol pump workers are vulnerable to develop restrictive lung disease especially those who are involved in the occupation for long duration (more than 5 years).


Hulke S.M.,Ln Medical College And Research Center | Vaidya Y.P.,Mahatma Gandhi Institute | Ratta A.R.,Indira Gandhi Medical College
National Journal of Physiology, Pharmacy and Pharmacology | Year: 2012

Background: Exercise training-induced hemodynamic and electrophysiological changes in the myocardium lead to physiological left ventricular (LV) hypertrophy with preserved cardiac contractility and function, how much exact duration and intensity is enough for that?, is still not known. This must be known to clinician as the increasing involvement of young athletes in intensive training regimens. Aims & Objective: To evaluate morphological changes in heart by echocardiography with sixteen weeks of exercise. Materials and methods: Study comprises of sixteen weeks duration and was done on the students of physical education. This was a longitudinal study in which eighty-five subjects (43 male, 20.11 yrs ±1.137, 42 female, 19.81 yrs ± 1.89) were assessed using echocardiography and Medical Graphics CPX-D (for aerobic power) before the start of exercise program and at the end of exercise program. Statistical analysis was done using paired t test using Graph pad prism 5 software. Results: No significant change was found in left ventricular morphology and ejection fraction after exercise program. Conclusion: The results of this study suggest that the exercise training over a period of sixteen weeks doesn't influence cardiovascular morphology, but causes improvement in aerobic power.


Anand M.,Ln Medical College And Research Center | Karoo C.,Ln Medical College And Research Center
Biomedicine | Year: 2011

Background & Objectives: Epilepsy is one of the world's oldest recognized conditions. Fear, misunderstanding, discrimination and social stigma have surrounded epilepsy for centuries. Treatments are available but with therapeutic dose limitations & unavoidable cumbersome side effects. Taking into account the vital role of calcium in the epileptogenesis, Calcium channel blockers could offer a new hope by potentiating the effects of classical antiepileptic drugs. Methods: The study was conducted in Sprague-Dawley albino rats of either sex weighing between 100-150 gms. The doses used were: Nifedipine 2 and 5, Diltiazem 1.5 and 3 and Verapamil 5 and 10mg/kg. Reduction in the duration of tonic hind limb extensor phase (THLEP) was taken as positive criterion in MES model. In PTZ model, increased latency in onset of seizure was marker of anticonvulsant activity. Data was statistically analyzed using the student t-test. Results: Nifedipine decreased the duration of THLEP in MES model. In PTZ model also, it delayed the onset of seizure. When compared with control groups, Nifedipine showed statistically significant difference with 2mg/kg (p<0.05) and 5mg/kg (p<0.01) in MES model. In PTZ model, statistically significant difference (p<0.01) was observed with Nifedipine 2mg/ kg and 5mg/kg doses. Diltiazem and Verapamil were not able to decrease the duration of THLEP in MES model and also no delay in onset of seizure was noted in PTZ model. Both drugs show no statistically significant difference in both MES and PTZ models. Interpretation & Conclusion: Nifedipine possesses some anticonvulsant property and is more effective in PTZ seizure model in comparison to MES model. Diltiazem and Verapamil offer no protection in both MES and PTZ seizure models.


Raghuwanshi B.,Ln Medical College And Research Center | Jain N.,Ln Medical College And Research Center | Jain M.,Ln Medical College And Research Center
Journal of Clinical and Diagnostic Research | Year: 2013

Aim: The aim of this study was to reliably measure and define the normal wave velocity values in a healthy liver by Acoustic radiation force impulse imaging (ARFI) technology in central India. Subjects and Methods: Fifty two healthy volunteers underwent acoustic radiation force impulse imaging tissue quantification and were enrolled in this prospective study. All patients were examined clinically by a clinician and blood samples were drawn and tested for liver function test and viral markers for hepatitis B virus, hepatitis C virus. The healthy volunteers were then examined by a certified sonologist and twenty-four measurements per subject were obtained and evaluations were performed. Statistical comparison of all mean data was performed with Student's t-test was done. A valueof p < 0.05 was considered significant. A comparative analysis was performed, and interclasscorrelation coefficients were calculated. Results: The sonologist obtained 416 measurements. A statistically significant difference was found between the mean shear wave velocity values in deep of the right lobe of the liver and the values obtained on the surface of the right lobe (1.2vs1.05 m/s) and between the mean values obtained deep in the right lobe and those obtained deep in the left lobe (1.2vs 1.0 m/s). In almost all cases, the shear wave speeds were between 1 and 2 m/s. Conclusion: Acoustic radiation force impulse imaging quantification of hepatic tissue is more reproducible when applied to the deeper portion of the right lobe of the liver.

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