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Lahore, Pakistan

Tufail S.,S Z Medical College | Fatima A.,LMDC | Niaz K.,IM and DC | Qusoos A.,FM and DC | Murad S.,IMDC
Pakistan Journal of Medical and Health Sciences | Year: 2015

Back ground: Hyperlipidemia is one of the important risk factor to develop coronary artery disease (CAD) leading to main cause of morbidity and mortality due to heart attack and cardiac arrhythmias. Decreased level of plasma HDL-cholesterol independently can cause CAD. Recent studies have proved that walnuts can increase plasma HDL-cholesterol if taken in specific amount per day regularly Place and duration of study: Lahore General Hospital, Lahore from January 2014 to April 2014. Methodology: The baseline values of HDL-cholesterol were measured at day-0 and day-60 by separating other lipoprotein fractions using chemical precipitation with Mg2+, then coupling the products of a cholesterol oxidase reaction. Forty hyperlipidemic patients were selected from Lahore General Hospital for the study. Age of patients ranged from 20 to 65 years. Both gender male and female patients were enrolled. They were advised to discontinue any hypolipidemic medications and foods. Patients suffering from any metabolic disease, renal impairment, liver disease, and already having any cardiac problems were excluded from the research study. Forty patients were divided in two groups, twenty individuals in each group. Group-1 was advised to take 30 grams of walnuts (without shell) per day for the period of eight weeks. Group-II was considered as control group and was advised not to take any dry fruit including walnuts. Results: In twenty hyperlipidemic patients, two months therapy with 30 grams of walnuts per day increase in HDL-cholesterol was 6.3 mg/dl which was significant change when analyzed biostatistically, showing p-value <0.01. Statistical analysis: Mean values with SD and SEM were analysed statistically by using SPSS version 16.1. P-value of <0.001 was considered as significant and p-value of >0.05 was considered as non-significant change. Conclusion: It was concluded that regular intake of specific amount of walnuts without shell can increase good cholesterol (HDL-cholesterol) in male and female patients of age range from 18-65 yrs. Source


Mansur G.,Sharif Medical and Dental College | Tariq N.,Sharif Medical and Dental College | Arooj M.,LMDC | Malik A.,The University of Lahore | And 2 more authors.
Medical Forum Monthly | Year: 2014

Objective: All over the world Hepatitis C virus (HCV) remains to be a main etiological mediator of liver disease. Approximately, 10 million people in Pakistan are diseased with HCV. Pegylated interferon plus ribavirin signifies the gold standard therapy but various side effects may occur. Study Design: Comparative study. Place and Duration of Study: This study was conducted at Jinnah Hospital Lahore from August 2013 to March, 2014. Materials and Methods: Thirty five patients of hepatitis C virus and Twenty three age and sex-matched clinically apparently healthy individuals were eligible for inclusion in the study at Jinnah Hospital Lahore during the year 2013-2014.1.0 ml blood sample were taken and subjected to centrifuge at 3000-4000 rpm for 10-15 minutes for the separation of serum. All the analytical work was performed at the Institute of molecular biology and biotechnology (IMBB), and Centre for research in molecular medicine (CRiMM), The University of Lahore-Pakistan. Results: The estimation of AST, ALT, ALP, TP and T.Bilirubin were estimated. The AST level in HCV patients was increases (47.88±40.49) as compared to the control persons (31.43±7.31) and statistically significant (0.02<0.05). Total Protein level in HCV patients was (4.20±0.61) and in healthy individuals (6.23±0.51) and statistically significant (0.000O.05). MDA level in HCV patients was increases remarkably (8.58±1.19) and in control persons (1.47±0.54) and it was statistically significant (0.000<0.05). Conclusion: There is a relationship between oxidative stress and ALP, ALT, AST and Albumin. The results of the present study confirmed a perfect sketch regarding the circulating biochemical markers and lipid peroxidation (MDA) profile between the studied groups i.e., control and HCV patients with interferon induced Hepatitis C virus infection. Source


Jamil W.,AIMC | Saleem S.,Physiology | Malik A.,LMDC | Shuja N.,The University of Lahore | And 3 more authors.
Medical Forum Monthly | Year: 2014

Objective: Current study was conducted to determine the fluctuations of various circulating biomarkers including thyroid hormones, hepatic enzymes, oxidative stress markers as well as electrolytes in schizophrenics. Study Design. Cross Sectional Study. Place and Duration of Study: This study was conducted at Psychiatric Clinic of Jinnah Hospital, Mental Hospital from Jan. 2013 to Oct. 2013. Materials and Methods: Seventy five acute schizophrenics and twenty five healthy individuals were selected for this study. Patients with chronic infections, diabetic history, liver disease or any other history of drugs including smoking and/or drinking alcohol were excluded from the study. Results: Elevated levels of oxidative stress in the form of malondialdehyde (MDA) (7.8±2.71∗) were observed in schizophrenics. Similarly raised levels of T3 (6.9±1.31∗) and T4 (61.2±15.44∗) were found in patients as compared to control. Electrolytes like Na, K, Ca and Mg showed alterations in the serum of both patients and control. Conclusion: All the circulating biochemical markers were statistically significant (P<0.05). It is concluded that lipid peroxidation may has association with thyroid hormones and electrolytes. Moreover, alleviated concentration of anti-oxidant biomarkers like SOD, catalase and GSH may play a central role in schizophrenics and anti-oxidant therapy may be useful for the management of this psychiatric disorder. Source


Fatima A.,Lahore Medical and Dental College | Shad M.N.,Islam Medical and Dental College | Asrar A.,LMDC | Murad S.,IMandDC
Pakistan Journal of Medical and Health Sciences | Year: 2014

Hyperlipidemia with increased body weight are main cause of consideration on CAD. These pathological states eventually leading to development of metabolic syndrome are leading cause of morbidity and mortality throughout the world. Various drug groups and regimen are being used to handle these problems but none is absolute satisfactory due to their widespread side effects and low compliance. Conventional use of nigella sativa for many diseases are now emerging in allopathic discipline of healthcare to cure various diseases with good compliance with least side effects. This study was conducted in Lipid Research Centre, Pakistan Institute of Cardiology, Lahore, Pakistan, from October to December 2013. Study period was one month. Sixty male and female hyperlipidemic patients age range from 20 to 70 years were included in the research with written explained and approved consent. All patients were divided in two equal groups. In Group-A, 30 patients were advised to take two spoons of kalonji after breakfast for the period of four weeks. In group-II, 30 hyperlipidemic patients were advised to take placebo capsules after breakfast everyday for the period of four weeks. At the end of research work, mean values of all parameters with ±SD were analyzed statistically using paired 't' test. These results were compared with placebo therapy and observed that both parameters showed highly significant change, with p-value <0.001. We concluded from these results that kalonji is very effective herbal drug to increase HDL-c and decrease body weight. Source


Shahbaz T.,Lahore Medical and Dental College | Raza S.M.,LMDC | Manzoor Z.,LMDC | Jamshid A.,LMDC
Pakistan Journal of Medical and Health Sciences | Year: 2014

Results: Total 280 medical students were interviewed. Among them 25.7% (60) were from first year, 21.4 %(60) from second year, 24.3% (68) from third year and 28.6%(80) were fourth year medical students. The age ranged from 18-25 years with 41.4% (116) of male students and 58.6%(164) were females. About 80-90% (224-250) showed a good knowledge about transmission and prevention of these infections. 63.6% (178) believe that hepatitis B and C can be transmitted as nosocomial infections and 72.5(203) know that these infections are widely transmitted like HIV/AIDS. 85% (238) were of the opinion that they are at greater risk of having them due to their profession. Among 270 students, 200(71.4%) were fully vaccinated against hepatitis B and 32(11.9%) were partially vaccinated.48 (17.1%) were the students who were not vaccinated at all.Background and Aims: Medical students like other health workers are being part of the health care delivery system are exposed to the same size of risk as other health care workers when they come in contact with patients and contaminated instruments. They are the first level of contact between patients and medical care. They are expected to undertake activities related to patient care with the beginning of their clinical years. They are involved in blood transfusion, injections and surgical operations in their practices. They should have awareness about the risk factors and appropriate precautionary measures to avoid these infections in handling these patients.Study Settings: Descriptive cross sectional study.Methods: A closed ended questionnaire consisting of questions to evaluate the knowledge regarding hepatitis B and C infection, attitude and perception of the medical students was duly filled by 280 students including First, Second, third and Fourth year. The data were entered and analyzed using Statistical Package for Social Sciences (SPSS) software version 20.Conclusion: Level of knowledge was associated with academic grade of the students. Overall knowledge was found to be high but vaccination status was low for this particular group. © 2014 Pakistan Journal of Medical and Health Sciences. All Rights Reserved. Source

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