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Moscow, Russia

Polyakov V.Yu.,Moscow State University | Golyshev S.A.,Moscow State University | Kir'aynov G.I.,Moscow State University | Arifulin E.A.,Moscow State University | And 4 more authors.
Biologicheskie Membrany | Year: 2011

Non-alcoholic steatohepatitis in rats induced by high-fat diet was used as an experimental model for testing hepatoprotective properties of a drug based on water-ethanol extract from oyster-mushroom mycelium. Progression of pathology development was monitored histologically and by biochemical assay of blood samples. Subcellular response was analyzed using electron microscopy. It was shown that administration of high-fat diet for 14 days leads to a development of adipose degeneration of liver (steatosis). Histological evidences were confirmed biochemically. Alkaline phosphatase, bilirubin, free cholesterol and low-density lipoprotein cholesterol levels were increased in blood of experimental animals in comparison to control. Administration of drug was performed in parallel with high-fat food. It was shown that pathological alterations of liver in this case were reduced at both organ and cellular levels. Cholesterol and triglyceride levels were close to those in control animals. The data obtained confirm that the drug assayed can be used in clinical practice for prevention and treatment of non-alcoholic steatohepatitis. Source


Polyakov V.Yu.,Moscow State University | Golyshev S.A.,Moscow State University | Kir'yanov G.I.,Moscow State University | Arifulin E.A.,Moscow State University | And 4 more authors.
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology | Year: 2011

Nonalcoholic steatohepatitis in rats induced by the high-fat diet was used as an experimental model for testing hepatoprotective properties of drug based on water-ethanol extract from oyster mushroom mycelium. Progression of pathology development was monitored histologically and by biochemical assay of blood samples. Subcellular response was analyzed using electron microscopy. It was shown that administration of the high-fat diet for 14 days leads to a development of adipose degeneration of liver (steatosis). Histological evidences were confirmed biochemically. Alkaline phosphatase, bilirubin, free cholesterol and lowdensity lipoprotein cholesterol levels were increased in blood of experimental animals in comparison to control. Administration of the drug was performed in parallel with high-fat food. It was shown that pathological alterations of liver in this case were reduced at both organ and cellular levels. Cholesterol and triglyceride levels were close to those in control animals. The data obtained confirm that the drug assayed can be used in clinical practice for prevention and treatment of nonalcoholic steatohepatitis. © Pleiades Publishing, Ltd., 2011. Source

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