Yi H.-S.,Laboratory of Liver Research |
Jeong W.-I.,Laboratory of Liver Research |
Journal of Gastroenterology and Hepatology (Australia) | Year: 2013
Activated hepatic stellate cells (HSCs) have been considered as a major type of cells in liver fibrosis by producing a huge amount of extracellular matrix, especially collagen fibers, and profibrotic mediators such as transforming growth factor-beta, interleukin-6 and monocyte chemoattractant protein-1. Recently, accumulated evidence suggests that the liver is an immunologic organ because of enrichment of diverse types of immune cells and that their interactions with HSCs are closely related with the progression of liver fibrosis. However, the underlying mechanisms of interaction between HSCs and immune cells remain largely unknown. Recently, several studies have demonstrated that natural killer cells, M2 macrophages, regulatory T cells, and bone marrow derived CD11b+Gr1+ immature cells ameliorate liver fibrosis, whereas neutrophils, M1 macrophages, CD8 T cells, natural killer T cells and interleukin-17-producing cells accelerate liver fibrosis. However, there are still controversial issues about their functions during liver fibrogenesis. In this review, we summarize the diversity roles of immune cells (e.g. profibrotic/antifibrotic or both) in regulating the activation of HSCs during hepatic fibrogenesis, in which several producible mediators by HSCs play important roles in the interaction with them. Moreover, the current cell-based therapies using immune cells against liver fibrosis are discussed. © 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.
Song S.H.,Korea Advanced Institute of Science and Technology |
Jang M.-H.,Korea Advanced Institute of Science and Technology |
Jeong J.-M.,Laboratory of Liver Research |
Yoon H.,Korea Advanced Institute of Science and Technology |
And 4 more authors.
Chemical Communications | Year: 2015
Water soluble GQDs were systematically characterized as a multiphoton fluorophore and a cell imaging probe. When mouse primary hepatocytes were incubated with GQDs, no significant cytotoxicity was observed up to the treatment concentration of 100 μg ml-1. Using these GQDs, mouse primary hepatocytes were successfully imaged by multiphoton fluorescence. This journal is © The Royal Society of Chemistry.