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Guangzhou, China

Fu R.,Guangdong Cardiovascular Institute | Wu S.,Guangdong Cardiovascular Institute | Wu P.,Nangfang Hospital | Qiu J.,Liuhuaqiao Hospital
Europace | Year: 2011

AimsA prothrombotic state with elevated levels of soluble P-selectin (sP-sel), fibrinogen, von Willebrand factor (vWf), and other haemostatic indices has been reported in some patients with atrial fibrillation (AF). Whether these changes are due to AF itself or coexistent cardiovascular diseases remains a matter of debate. Therefore, in the present study, the differences in plasma levels of sP-sel, fibrinogen, and vWf between patients with idiopathic/lone AF and sex-, age-, and risk factor-matched controls were investigated to determine whether AF itself might be associated with a hypercoagulable state.Methods and resultsNinety consecutive patients (63 males, 54.1 ± 10.1 years) with idiopathic AF were studied, 60 (43 males, 48.8 ± 7.5 years) of whom were diagnosed as lone AF. Plasma sP-sel and vWf were measured by enzyme-linked immunosorbent assay. Plasma fibrinogen was measured by chromometry. These indices in AF patients were compared with those in sex-, age- and risk factor-matched controls.Compared with the controls, patients with idiopathic AF had higher levels of sP-sel (AF vs. control: 33.4 ± 7.4 vs. 29.2 ± 6.5 ng/mL, P < 0.001) and fibrinogen (AF vs. control: 3.3 ± 0.9 vs. 3.0 ± 0.6 g/L, P 0.02), but not vWf, whether with the adjustment of covariates or not. As for those <60 years, between lone AF and age-matched controls, significant difference existed in the levels of sP-sel (AF vs. control: 34.5 ± 7.3 vs. 30.2 ± 7.3 ng/mL, P 0.002), but not in those of fibrinogen and vWf, whether with the adjustment of covariates or not.ConclusionsBoth platelet activation and abnormal changes in coagulation were suggested in idiopathic AF and a platelet activation state in lone AF. This supports the notion that AF per se contributes to a state of hypercoagulation. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2010. Source

Yu H.,Liuhuaqiao Hospital | Yu H.,Schepens Eye Research Institute | Vu T.H.K.,Schepens Eye Research Institute | Vu T.H.K.,Leiden University | And 3 more authors.
Translational Research | Year: 2014

Irreversible vision loss is most often caused by the loss of function and subsequent death of retinal neurons, such as photoreceptor cells - the cells that initiate vision by capturing and transducing signals of light. One reason why retinal degenerative diseases are devastating is that, once retinal neurons are lost, they don't grow back. Stem cell-based cell replacement strategy for retinal degenerative diseases are leading the way in clinical trials of transplantation therapy, and the exciting findings in both human and animal models point to the possibility of restoring vision through a cell replacement regenerative approach. A less invasive method of retinal regeneration by mobilizing endogenous stem cells is, thus, highly desirable and promising for restoring vision. Although many obstacles remain to be overcome, the field of endogenous retinal repair is progressing at a rapid pace, with encouraging results in recent years. © 2014 Mosby, Inc. All rights reserved. Source

Yao W.,Southern Medical University | Luo C.,Southern Medical University | Ai F.,Liuhuaqiao Hospital | Chen Q.,Southern Medical University
Pain Medicine (United States) | Year: 2012

Objectives. The objective of this study was to gain a basic understanding of the influential factors for nonspecific low-back pain (LBP) among adolescents of southern China. Design. The study was designed as a school-based case control study. Setting. Nonspecific LBP is a common health problem in adolescence. Although some behaviors and socio-demographic factors are believed to contribute to the disorder, influential factors of LBP remain undefined. Moreover, until now there is no available information of influential factors for LBP in Chinese adolescents. Subjects. A total of 1,214 adolescents were involved in the study, including 607 cases with nonspecific LBP and 607 controls without history of nonspecific LBP. Outcome Measures. A self-administered questionnaire was designed for epidemiological survey to investigate the risk factors for nonspecific LBP. All cases and controls were investigated for their family histories of nonspecific LBP, physical activities, sedentary activities, schoolbag weights, school performances, living conditions, and etc. Method. A 1:1 matched case-control study was conducted on 1,214 adolescents from an elementary school and a secondary school in Guangzhou City, southern China. Results. Family history (odds ratio [OR] 2.57, 95% confidence interval [CI] 1.85-3.58), long duration of carrying schoolbag (OR 1.38, 95% CI 1.11-1.72) and rest position between classes (OR 1.18, 95% CI 1.01-1.39) were positively correlated with self-reported nonspecific LBP. Students regularly playing basketball (OR 1.58, 95% CI 1.09-2.30) was found to be significantly more likely to have LBP. Also, students who feel schoolbag uncomfortable (OR 1.38, 95% CI 1.11-1.72) was found to experience more LBP. Conclusions. Family history, feeling schoolbag uncomfortable, duration of schoolbag carrying, basketball playing and rest position between classes are the major risk factors for nonspecific LBP in adolescents. Wiley Periodicals, Inc. Source

Mai X.,Southern Medical University | Luo C.,Southern Medical University | Ai F.,Liuhuaqiao Hospital | Chen Q.,Southern Medical University
Spine | Year: 2011

Study Design. A cross-sectional survey of 2083 schoolchildren. Objective. To investigate the prevalence of nonspecific low back pain (LBP) among schoolchildren aged between 10 and 18 years in China. Summary of Background Data. LBP have been a serious health problem in schoolchildren. On the basis of literature, the lifetime occurrence of nonspecific LBP in children and adolescents varies between 7% and 72%, but little is known about LBP among this demographic group in China. Methods. Schoolchildren aged 10 to 18 years were sampled from two grades in an elementary school and four grades in a secondary school. Participants were asked to fill in a questionnaire on LBP. The questionnaire addressed demographic items, anthropometric factors and characteristics of nonspecific LBP, such as frequency, duration, nature, pain scale. Nonspecific LBP is defined as the pain in the back from the 12th ribs to the buttock area without organic factors. A total of 2235 questionnaires were distributed, of which 2100 were answered, a response rate of 93.7%. Among those answers, 2083 (977 from male students and 1106 from female students) provided measurable data. Results. The occurrence of nonspecific LBP was high, with 29.1% students suffering from this condition in the past 3 months (24.7% in boys, 33.1% in girls). In addition, an increased occurrence was observed with age. The occurrences of LBP in 10 to 14 years and 15 to 18 years were 21.5% and 38.2%, respectively. In several aspects of LBP, statistically significant differences were observed between boys and girls, including the frequency of the pain (P = 0.003), the nature of the pain (P = 0.000), the likelihood of seeking for medical assistance (P = 0.007), the impact on normal daily life (P = 0.016), and the occurrence of LBP after bending over the desk for a period of time (P = 0.024). Female students had more frequent LBP and were less willing to see a physician. In addition, more female students (45/366) had LBP accompanied with radiating pain than male students (20/241). Conclusion. There is a high prevalence of LBP in Chinese schoolchildren. The occurrence of LBP increases with age in both sexes. LBP is significantly more prevalent in girls. © 2011, Lippincott Williams & Wilkins. Source

Pan L.,Peoples Hospital of Sanshui District | Zhang P.,First Peoples Hospital of Foshan | Yin Q.,Liuhuaqiao Hospital
International Journal of Surgery | Year: 2014

Objectives: This study aimed to compare the clinical efficacies of percutaneous endoscopic lumbar discectomy (PELD) and traditional open lumbar discectomy (OD). Methods: The pre-operative and post-operative blood loss, hospital stays and wound sizes of the patients in the two groups were recorded. Enzyme-Linked immunosorbent assay was used to measure the changes of interleukin-6 (IL-6), C-reactive protein (CRP) and creatine phosphokinase (CPK) pre-operation and 1h, 6h, 12h, 24h and 48h after corresponding surgery. Visual Analog Scale and Modified MacNab Criteria were used to assess post-operative results. Results: Patients in the PELD group had less blood loss (p<0.01), shorter hospitalization hours (p<0.01) and smaller surgical wounds (p<0.01) than the patients underwent traditional OD surgery. MacNab evaluated that the levels of satisfaction were above 90% in both groups post-operative six months. There was no significant difference in pain index between the two groups (p>0.05). Furthermore, the levels of CRP, CPK and IL-6 in the PELD group were all lower than those in the OD group with a significant difference (p<0.01). Conclusion: The PELD had less damage to human tissues than the traditional OD. PELD has a clear promotional value in clinical. © 2014 Surgical Associates Ltd. Source

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