Little Flower Medical Research Center

Angamaly, India

Little Flower Medical Research Center

Angamaly, India

Time filter

Source Type

Sailesh K.S.,Little Flower Medical Research Center | Archana R.,Saveetha Medical College | John J.,Little Flower Hospital and Research Center | Mukkadan J.K.,Little Flower Medical Research Center
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

In this case report we have applied vestibular stimulation for the first time as a supplementary treatment for hypothyroidism. The present case shows that controlled vestibular stimulation along with medication has altered the symptoms Miss A suffered from in a beneficial manner and can be of use in similar cases. Hence we recommend further detailed study in this area.


Sailesh K.S.,Little Flower Medical Research Center | Mukkadan J.K.,Little Flower Medical Research Center
Indian Journal of Physiology and Pharmacology | Year: 2015

The present study was designed to standardize optimal vestibular stimulation and to investigate its impact on anxiety levels in college students. Vestibular stimulation was achieved by swinging on a swing (Back to front direction) and the participants were advised to adjust frequency, duration and intensity, according to comfort. Frequency, intensity and duration were recorded manually. The anxiety status was assessed by using Spielberger state-trait anxiety inventory (STAI) before and after vestibular stimulation. It has been observed that the anxiety status was significantly decreased after vestibular stimulation. There is a need for future study with larger sample size to substantiate the therapeutic validity of vestibular stimulation as a physiological treatment for stress relief and stress related disorders among college students. © 2015, Association of Physiologists and Pharmacologists of India. All right reserved.


Sai Sailesh K.,Little Flower Institute of Medical science and Research Center | Archana R.,Saveetha Medical College | Mukkadan J.K.,Little Flower Medical Research Center
Asian Journal of Pharmaceutical and Clinical Research | Year: 2015

Objective: The present study was aimed to assess the role of vestibular stimulation in the management of diabetes care. Methods: We carried out the present study in 83-year-old man with 20 years history of Type 2 diabetes. Controlled vestibular stimulation was achieved by swinging on a swing (back to front direction). Blood Pressure and Blood glucose levels were measured by standard methods. Results: Fasting blood glucose and blood pressure levels came down significantly after controlled vestibular stimulation. Conclusion: The present study confirmed the useful role of vestibular stimulation in the control of diabetes mellitus. We recommend a further detailed study to elucidate the therapeutic value of controlled vestibular stimulation in diabetes care. © 2015, Asian Journal of Pharmaceutical and Clinical Research. All rights reserved.


Veetil P.K.,Little Flower Medical Research Center | Mukkadan J.K.,Little Flower Medical Research Center
Indian Journal of Physiology and Pharmacology | Year: 2011

The novel alternated dual task (ADT) arranged rats to learn Tmaze spontaneous alternation task and radial arm maze (RAM) task alternatively, and by doing ADT, rats could acquire the tasks more easily than non alternated dual task (NADT) group. Also retention capacity of ADT group was significantly more and ADT help to learn a complex task faster than learning it in isolation from other tasks. In the present study effect of methylphenidate (MPD), a mood elevator, known to enhance learning and memory, on ADT procedure is assessed. Also effect of ADT procedure and MPD on spatial learning and memory are compared. Different groups were assigned by administering MPD (intraperitoneal injection at a dose of 3 mg/kg body weight) during different phases of behavioural experiments, and control groups received saline injection. MPD administration increased both acquisition and retention capacities. The amelioration attained for retention of complex task by ADT procedure, could be achieved by NADT rats only by administration of MPD. The influence of ADT procedure on acquisition and retention of TM and RAM tasks were similar to the effects of MPD, especially for the RAM task. MPD at low dose is found to enhance the learning and memory capacity in rats, than deteriorating it, supporting the use of MPD as a drug to treat attention deficit hyperactive disorder. The recent reports suggesting the effect of MPD only on retention and not on acquisition could not be confirmed, as enhancement for both acquisition and retention was found in this study.


Sailesh K.S.,Little Flower Medical Research Center | Sailesh K.S.,Saveetha Medical College | Archana R.,Little Flower Medical Research Center | Archana R.,Saveetha Medical College | And 4 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

Unknowingly swing was incorporated in our tradition. However, in present day high-tech life style, people do not believe the importance of simple things. Hence the present article was undertaken with the intent of clarifying the present knowledge about swing and physiology of body. Swinging will stimulate vestibular apparatus, which is present in the inner ear and provides information essential for sense of equilibrium and for coordinating head movements with eye and postural movements. Gravity is the essential fact of life on earth; therefore it is not strange that the vestibular system, which relates us to gravity, is very closely connected with the entire physiology of the body. Swing can be incorporated in our routine day life style. Hence we conclude that swinging promotes health and recommend using the swing by all the age groups.


Sailesh K.S.,Little Flower Medical Research Center | Sailesh K.S.,Saveetha Medical college | Archana R.,Little Flower Medical Research Center | Archana R.,Saveetha Medical college | And 2 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

The Vestibular System: A Sixth Sense plays a vital role in everyday life, contributing to a surprising range of functions from reflexes to the highest levels of perception and consciousness. Vestibular stimulation modulates cognition through its connections with concerned brain structures. It is the need of time to identify the importance of vestibular stimulation and to start translational research for the wellbeing and peak performance of human being and also for patient care and treatment.


Krishnan J.,Little Flower Institute of Medical science and Research | Sailesh K.S.,Little Flower Institute of Medical science and Research | Archana R.,Saveetha Medical College | Mukkadan J.K.,Little Flower Medical Research Center
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

The objective of the present study was to observe the effect of cold water and fresh water swimming stress on physiological and biochemical parameters. 42 adult male 'albino rats of wistar strain with body weight ranging between (50-125g) were subjected to fresh water and cold water swimming stress. The body weight was measured before and after the stress period in all the rats. The animals were sacrificed by decapitation and blood samples were collected. The wet weight of the organs (heart, right and left kidneys, liver, spleen) was expressed per 100g of body weight. Total leucocyte count, red blood cell count, Platelet count, and Hemoglobin were estimated by standard physiological methods. Blood sugar level and serum total cholesterol level were measured by colorimetric method. We conclude that body weight, liver weight, spleen weight increased significantly followed by cold water swimming stress. Significant hypoglycemia was observed followed by both Fresh water and cold water swimming stress. Platelet count decreased significantly followed by both Fresh water and cold water swimming stress. Total leucocyte count increased significantly followed by Fresh water swimming stress.


Devi N.P.,Little Flower Medical Research Center | Mukkadan J.K.,Little Flower Medical Research Center
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

There are several methods to enhance cognition via altering brain plasticity and the present study was undertaken to observe the effect of Rotatory vestibular stimulation and Centella asiatica on cognition in healthy Wistar albino rats. A total of 72 adult male Wistar albino rats were randomly assigned into four groups. For Group A (Control Group) neither Vestibular Stimulation, nor the Centella asiatica was administered, Group B (Vestibular stimulated group), Rotatory Vestibular Stimulation was given for 5 minutes in a Rotatory vestibular apparatus at a rate of 50 revolutions per minute for 30 days, Group C (CeA alone) treated with 2mg/kg of Centella asiatica for 30days, Group D (CeA+Vestibular), treated with 2mg/kg of Centella asiatica followed by 5 minute of Rotatory Vestibular Stimulation for 30days. It has been concluded that Centella asiatica in combination of rotatory vestibular stimulation provides significant improvement in cognition than vestibular stimulation and Centella asiatica alone. However no reports are available on the combined action of both Rotatory vestibular stimulation and herbal extracts on brain plasticity, the present investigation was undertaken to evaluate the Cognition enhancement activity of combined Rotatory vestibular stimulation and CeA extract in rats and recommend further detailed study on combination of Rotatory vestibular stimulation and Centella asiatica to explore the mechanism of action of the interventions and therapeutic validity to recommend this intervention for treatment of cognitive disorders.


Devi N.P.,Little Flower Medical Research Center | Mukkadan J.K.,Little Flower Medical Research Center
Asian Journal of Pharmaceutical and Clinical Research | Year: 2016

Objective: This study was aimed at investigating the effect of rotatory vestibular stimulation and the capacity of the powerful antioxidant curry spice Curcuma longa (turmeric) on neuromorphological and brain cholinesterase activity in rats to analyze the behavioral changes and cognition in healthy Wistar albino rats. Methods: A total of 72 adult male Wistar albino rats were randomly assigned into four groups. For Group A (control group) neither vestibular stimulation nor the turmeric was administered, Group B (rotatory vestibular stimulated group), rotatory vestibular stimulation was given for 5 minutes in a rotatory vestibular apparatus at a rate of 50 revolutions per minute in clockwise direction for 30 days, Group C (turmeric alone) treated with 2 mg/kg of turmeric for 30 days, Group D (turmeric+vestibular), treated with 2 mg/kg of turmeric followed by 5 minutes of rotatory vestibular stimulation for 30 days. Results: Group B shows improvement in learning via a reduction in number of trails for acquisition and retention, and an increase in dendritic branching points and intersections and also a reduction in acetylcholinesterase level. Conclusion: Rotatory vestibular stimulation provides improvement in cognition via neuromorphological and biochemical changes than rotatory vestibular stimulation and turmeric in combination and turmeric alone, though there is no significant difference between the treated groups. Rotatory vestibular stimulation in combination with turmeric (Group D) shows a nonsignificant increase in dendritic arborization ensures a long lasting promising effect in cognition enhancement through a long period of treatment. Further detailed study on combination of rotatory vestibular stimulation and turmeric is required to explore the mechanism of therapeutic action of this intervention as a useful remedy for the management of cognitive disorders. © 2016, Asian Journal of Pharmaceutical and Clinical Research. All rights reserved.


Sailesh K.S.,Little Flower Medical Research Center
International Journal of Pharma and Bio Sciences | Year: 2014

The intake of the nutrients is under complex control involving signals from both the periphery and central nervous system The purpose of this article is to review research reports related to vestibular stimulation and its role in regulation of food intake and to suggest translational research in this area. Vestibular system is having extensive interactions with hypothalamus, dorsal raphe nucleus, nucleus tractus solitarius, locus coeruleus, hippocampal formation and regulates food intake. The present review provides evidence for the relationship between vestibular stimulation and food intake. Understanding these associations will be important in developing effective treatments for obesity and related metabolic diseases.

Loading Little Flower Medical Research Center collaborators
Loading Little Flower Medical Research Center collaborators