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Krishnan J.,Little Flower Institute of Medical science and Research | Sailesh K.S.,Little Flower Institute of Medical science and Research | Archana R.,Saveetha Medical college | Mukkadan J.K.,Little Flower Medical Research Center
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

The objective of the present study was to observe the effect of cold water and fresh water swimming stress on physiological and biochemical parameters. 42 adult male 'albino rats of wistar strain with body weight ranging between (50-125g) were subjected to fresh water and cold water swimming stress. The body weight was measured before and after the stress period in all the rats. The animals were sacrificed by decapitation and blood samples were collected. The wet weight of the organs (heart, right and left kidneys, liver, spleen) was expressed per 100g of body weight. Total leucocyte count, red blood cell count, Platelet count, and Hemoglobin were estimated by standard physiological methods. Blood sugar level and serum total cholesterol level were measured by colorimetric method. We conclude that body weight, liver weight, spleen weight increased significantly followed by cold water swimming stress. Significant hypoglycemia was observed followed by both Fresh water and cold water swimming stress. Platelet count decreased significantly followed by both Fresh water and cold water swimming stress. Total leucocyte count increased significantly followed by Fresh water swimming stress. Source


Sailesh K.S.,Little Flower Medical Research Center
International Journal of Pharma and Bio Sciences | Year: 2014

The intake of the nutrients is under complex control involving signals from both the periphery and central nervous system The purpose of this article is to review research reports related to vestibular stimulation and its role in regulation of food intake and to suggest translational research in this area. Vestibular system is having extensive interactions with hypothalamus, dorsal raphe nucleus, nucleus tractus solitarius, locus coeruleus, hippocampal formation and regulates food intake. The present review provides evidence for the relationship between vestibular stimulation and food intake. Understanding these associations will be important in developing effective treatments for obesity and related metabolic diseases. Source


Sai Sailesh K.,Little Flower Institute of Medical science and Research Center | Archana R.,Saveetha Medical college | Mukkadan J.K.,Little Flower Medical Research Center
Asian Journal of Pharmaceutical and Clinical Research | Year: 2015

Objective: The present study was aimed to assess the role of vestibular stimulation in the management of diabetes care. Methods: We carried out the present study in 83-year-old man with 20 years history of Type 2 diabetes. Controlled vestibular stimulation was achieved by swinging on a swing (back to front direction). Blood Pressure and Blood glucose levels were measured by standard methods. Results: Fasting blood glucose and blood pressure levels came down significantly after controlled vestibular stimulation. Conclusion: The present study confirmed the useful role of vestibular stimulation in the control of diabetes mellitus. We recommend a further detailed study to elucidate the therapeutic value of controlled vestibular stimulation in diabetes care. © 2015, Asian Journal of Pharmaceutical and Clinical Research. All rights reserved. Source


Sailesh K.S.,Little Flower Medical Research Center | Archana R.,Saveetha Medical college | John J.,Little Flower Hospital and Research Center | Mukkadan J.K.,Little Flower Medical Research Center
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

In this case report we have applied vestibular stimulation for the first time as a supplementary treatment for hypothyroidism. The present case shows that controlled vestibular stimulation along with medication has altered the symptoms Miss A suffered from in a beneficial manner and can be of use in similar cases. Hence we recommend further detailed study in this area. Source


Sailesh K.S.,Little Flower Medical Research Center | Mukkadan J.K.,Little Flower Medical Research Center
Indian Journal of Physiology and Pharmacology | Year: 2015

The present study was designed to standardize optimal vestibular stimulation and to investigate its impact on anxiety levels in college students. Vestibular stimulation was achieved by swinging on a swing (Back to front direction) and the participants were advised to adjust frequency, duration and intensity, according to comfort. Frequency, intensity and duration were recorded manually. The anxiety status was assessed by using Spielberger state-trait anxiety inventory (STAI) before and after vestibular stimulation. It has been observed that the anxiety status was significantly decreased after vestibular stimulation. There is a need for future study with larger sample size to substantiate the therapeutic validity of vestibular stimulation as a physiological treatment for stress relief and stress related disorders among college students. © 2015, Association of Physiologists and Pharmacologists of India. All right reserved. Source

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