Little Flower Medical Research Center

Angamaly, India

Little Flower Medical Research Center

Angamaly, India
SEARCH FILTERS
Time filter
Source Type

Rajagopalan A.,Tamil University | Kumar S.,Little Flower Institute of Medical Science and Research | Mukkadan J.K.,Little Flower Medical Research Center
Journal of Advanced Pharmaceutical Technology and Research | Year: 2017

The present study was undertaken to provide scientific evidence and for beneficial effects of vestibular stimulation for the management of stress-induced changes in auditory and visual reaction time (RT). A total of 240 healthy college students of the age group of 18-24 of either gender were a part of this research after obtaining written consent from them. RT for right and left response was measured for two auditory stimuli (low and high pitch) and visual stimuli (red and green) were recorded. A significant decrease in the visual RT for green light and red light was observed and stress-induced changes was effectively prevented followed by vestibular stimulation. Auditory RT for high pitch right and left response was significantly decreased and stress-induced changes was effectively prevented followed by vestibular stimulation. Vestibular stimulation is effective in boosting auditory and visual RT and preventing stress-induced changes in RT in males and females. We recommend incorporation of vestibular stimulation by swinging in our lifestyle for improving cognitive functions. © 2017 Journal of Advanced Pharmaceutical Technology & Research | Published by Wolters Kluwer-Medknow.


Jinu K.V.,LIMSAR | Archana R.,Saveetha University | Sailesh K.S.,LIMSAR | Mukkadan J.K.,Little Flower Medical Research Center
International Journal of Research in Ayurveda and Pharmacy | Year: 2016

Pomegranate is one of the oldest, edible fruit with high nutritional values and has been a part of Mediterranean diet since ancient times. The fruit, bark, roots and leaves of pomegranate are reported to have medicinal benefits. Pomegranate is very rich in various poly-phenols, which are probably responsible for most of the beneficial properties of the fruit. The medicinal properties include, anti-ageing, anti-cancer, anti-diabetic, cardio protective, lipid-lowering, gastro protective, hepatoprotective, anti-trichomonial, anti-nociceptive, anti-diarrheal, anti-viral effects and beneficial effects against neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Neuroprotective effects of Pomegranate extract are reducing accumulation of amyloid plaques in hippocampus, preventing neuronal tissue loss, modulating GABA and glutamate levels, inhibiting acetylcholine esterase and inhibiting lipid peroxidation in brain. Here we review the possible mechanisms by which pomegranate may affect neuro-degeneration, and suggest necessary translational research in this area, for the benefit of neurodegenerative patients and the society in general.


Joy A.,Little Flower Institute of Medical science and Research | Sailesh K.S.,Little Flower Institute of Medical science and Research | Mukkadan J.K.,Little Flower Medical Research Center
International Journal of Research in Ayurveda and Pharmacy | Year: 2016

Nose is one among panchaganendriya, which is essential for olfaction and respiration but also provides a route for drug administration. Although extensive literature is existing on research and sensory system, but research and olfactory system is very minimum. Hence the present study was undertaken to compare olfactory sensitivity for black pepper (Piper nigrum), lemon (Citrus limon), camphor (Cinnamomum camphora) and jasmine (Jasminum) in healthy females of Kerala. A total of 170 apparently healthy, willing females (18-24 years) were included in the study. Blast injection method as used to measure olfactory sensitivity. We have observed that significant difference in the olfactory sensitivity to pepper, lemon, camphor and jasmine odors. Data was presented as mean ± SD. *P < 0.05 is significant, **P < 0.01 is significant, ***P < 0.001 was significant. Participants have more olfactory sensitivity to jasmine and least olfactory sensitivity to lemon.


Sailesh K.S.,Little Flower Medical Research Center | Archana R.,Saveetha Medical College | John J.,Little Flower Hospital and Research Center | Mukkadan J.K.,Little Flower Medical Research Center
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

In this case report we have applied vestibular stimulation for the first time as a supplementary treatment for hypothyroidism. The present case shows that controlled vestibular stimulation along with medication has altered the symptoms Miss A suffered from in a beneficial manner and can be of use in similar cases. Hence we recommend further detailed study in this area.


Sailesh K.S.,Little Flower Medical Research Center | Mukkadan J.K.,Little Flower Medical Research Center
Indian Journal of Physiology and Pharmacology | Year: 2015

The present study was designed to standardize optimal vestibular stimulation and to investigate its impact on anxiety levels in college students. Vestibular stimulation was achieved by swinging on a swing (Back to front direction) and the participants were advised to adjust frequency, duration and intensity, according to comfort. Frequency, intensity and duration were recorded manually. The anxiety status was assessed by using Spielberger state-trait anxiety inventory (STAI) before and after vestibular stimulation. It has been observed that the anxiety status was significantly decreased after vestibular stimulation. There is a need for future study with larger sample size to substantiate the therapeutic validity of vestibular stimulation as a physiological treatment for stress relief and stress related disorders among college students. © 2015, Association of Physiologists and Pharmacologists of India. All right reserved.


Sai Sailesh K.,Little Flower Institute of Medical science and Research Center | Archana R.,Saveetha Medical College | Mukkadan J.K.,Little Flower Medical Research Center
Asian Journal of Pharmaceutical and Clinical Research | Year: 2015

Objective: The present study was aimed to assess the role of vestibular stimulation in the management of diabetes care. Methods: We carried out the present study in 83-year-old man with 20 years history of Type 2 diabetes. Controlled vestibular stimulation was achieved by swinging on a swing (back to front direction). Blood Pressure and Blood glucose levels were measured by standard methods. Results: Fasting blood glucose and blood pressure levels came down significantly after controlled vestibular stimulation. Conclusion: The present study confirmed the useful role of vestibular stimulation in the control of diabetes mellitus. We recommend a further detailed study to elucidate the therapeutic value of controlled vestibular stimulation in diabetes care. © 2015, Asian Journal of Pharmaceutical and Clinical Research. All rights reserved.


Veetil P.K.,Little Flower Medical Research Center | Mukkadan J.K.,Little Flower Medical Research Center
Indian Journal of Physiology and Pharmacology | Year: 2011

The novel alternated dual task (ADT) arranged rats to learn Tmaze spontaneous alternation task and radial arm maze (RAM) task alternatively, and by doing ADT, rats could acquire the tasks more easily than non alternated dual task (NADT) group. Also retention capacity of ADT group was significantly more and ADT help to learn a complex task faster than learning it in isolation from other tasks. In the present study effect of methylphenidate (MPD), a mood elevator, known to enhance learning and memory, on ADT procedure is assessed. Also effect of ADT procedure and MPD on spatial learning and memory are compared. Different groups were assigned by administering MPD (intraperitoneal injection at a dose of 3 mg/kg body weight) during different phases of behavioural experiments, and control groups received saline injection. MPD administration increased both acquisition and retention capacities. The amelioration attained for retention of complex task by ADT procedure, could be achieved by NADT rats only by administration of MPD. The influence of ADT procedure on acquisition and retention of TM and RAM tasks were similar to the effects of MPD, especially for the RAM task. MPD at low dose is found to enhance the learning and memory capacity in rats, than deteriorating it, supporting the use of MPD as a drug to treat attention deficit hyperactive disorder. The recent reports suggesting the effect of MPD only on retention and not on acquisition could not be confirmed, as enhancement for both acquisition and retention was found in this study.


Sailesh K.S.,Little Flower Medical Research Center | Sailesh K.S.,Saveetha Medical college | Archana R.,Little Flower Medical Research Center | Archana R.,Saveetha Medical college | And 2 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

The Vestibular System: A Sixth Sense plays a vital role in everyday life, contributing to a surprising range of functions from reflexes to the highest levels of perception and consciousness. Vestibular stimulation modulates cognition through its connections with concerned brain structures. It is the need of time to identify the importance of vestibular stimulation and to start translational research for the wellbeing and peak performance of human being and also for patient care and treatment.


Devi N.P.,Little Flower Medical Research Center | Mukkadan J.K.,Little Flower Medical Research Center
Asian Journal of Pharmaceutical and Clinical Research | Year: 2016

Objective: This study was aimed at investigating the effect of rotatory vestibular stimulation and the capacity of the powerful antioxidant curry spice Curcuma longa (turmeric) on neuromorphological and brain cholinesterase activity in rats to analyze the behavioral changes and cognition in healthy Wistar albino rats. Methods: A total of 72 adult male Wistar albino rats were randomly assigned into four groups. For Group A (control group) neither vestibular stimulation nor the turmeric was administered, Group B (rotatory vestibular stimulated group), rotatory vestibular stimulation was given for 5 minutes in a rotatory vestibular apparatus at a rate of 50 revolutions per minute in clockwise direction for 30 days, Group C (turmeric alone) treated with 2 mg/kg of turmeric for 30 days, Group D (turmeric+vestibular), treated with 2 mg/kg of turmeric followed by 5 minutes of rotatory vestibular stimulation for 30 days. Results: Group B shows improvement in learning via a reduction in number of trails for acquisition and retention, and an increase in dendritic branching points and intersections and also a reduction in acetylcholinesterase level. Conclusion: Rotatory vestibular stimulation provides improvement in cognition via neuromorphological and biochemical changes than rotatory vestibular stimulation and turmeric in combination and turmeric alone, though there is no significant difference between the treated groups. Rotatory vestibular stimulation in combination with turmeric (Group D) shows a nonsignificant increase in dendritic arborization ensures a long lasting promising effect in cognition enhancement through a long period of treatment. Further detailed study on combination of rotatory vestibular stimulation and turmeric is required to explore the mechanism of therapeutic action of this intervention as a useful remedy for the management of cognitive disorders. © 2016, Asian Journal of Pharmaceutical and Clinical Research. All rights reserved.


Sailesh K.S.,Little Flower Medical Research Center
International Journal of Pharma and Bio Sciences | Year: 2014

The intake of the nutrients is under complex control involving signals from both the periphery and central nervous system The purpose of this article is to review research reports related to vestibular stimulation and its role in regulation of food intake and to suggest translational research in this area. Vestibular system is having extensive interactions with hypothalamus, dorsal raphe nucleus, nucleus tractus solitarius, locus coeruleus, hippocampal formation and regulates food intake. The present review provides evidence for the relationship between vestibular stimulation and food intake. Understanding these associations will be important in developing effective treatments for obesity and related metabolic diseases.

Loading Little Flower Medical Research Center collaborators
Loading Little Flower Medical Research Center collaborators