Lithuanian University of Health Sciences

www.lsmuni.lt
Kaunas, Lithuania

Lithuanian University of Health science ) is a medical school in Kaunas, Lithuania. The present-day Lithuanian University of Health science is a consolidation of two institutions of higher education, Kaunas University of Medicine and the Lithuanian Veterinary Academy. It uses the Hospital of Lithuanian University of Health science Kaunas Clinics and the Kaunas Red Cross Hospital as a teaching hospitals. Wikipedia.

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Bunevicius A.,Lithuanian University of Health Sciences
Health and Quality of Life Outcomes | Year: 2017

Background: Deterioration of health related quality of life (HRQoL) is common in brain tumor patients. This study evaluated validity and reliability of the Medical Outcomes Study 36-Item Short Form (SF-36) in patients with brain tumors. Methods: Two hundred and seventy-seven patients admitted for brain tumor surgery were evaluated for HRQoL (SF-36 questionnaire); depressive symptoms (Beck Depression Inventory-II or BDI-II); and functional status (Barthel index or BI). Final histological diagnosis was obtained from pathology reports. Results: Two-hundred and twenty-seven (completion rate of 82%) patients (69% women; mean age 55.8±14.4years) completed the SF-36 questionnaire. The most common brain tumor diagnosis was meningioma (40%), followed high-grade glioma (19%). Missing data rates were ≤4%. Internal consistency was adequate for all (Cronbach α≥.728) but Social Functioning (Cronbach α=.527) and General Health (Cronbach α=.693) subscales. Ceiling (≥36%) and floor (≥22%) effect rates were the greatest for the Role Limitations subscales. The SF-36 subscales pertaining physical health correlated the strongest with the BI score, while the SF-36 subscales pertaining emotional health correlated the strongest with the BDI-II score. Patients with mild-moderate depressive symptoms (BDI-II score ≥20) scored lower across all SF-36 subscales, and handicap patients (BI score <90) scored the lower across all, but Mental Health, subscales. Conclusions: The SF-36 is a valid and reliable instrument in brain tumor patients and therefore can be reliably applied for evaluation of HRQoL in neuro-oncology setting. Further studies exploring other psychometric properties of the SF-36 in brain tumor patients across disease progression stages are warranted. © 2017 The Author(s).


Baranauskas G.,Lithuanian University of Health Sciences
Frontiers in Systems Neuroscience | Year: 2015

There is no doubt that optogenetic tools caused a paradigm shift in many fields of neuroscience. These tools enable rapid and reversible intervention with a specific neuronal circuit and then the impact on the remaining circuit and/or behavior can be studied. However, so far the ability of these optogenetic tools to interfere with neuronal signal transmission in the time scale of milliseconds has been used much less frequently although they may help to answer a fundamental question of neuroscience: how important temporal codes are to information processing in the brain. This perspective paper examines why optogenetic tools were used so little to perturb or imitate temporal codes. Although some technical limitations do exist, there is a clear need for a systems approach. More research about action potential pattern formation by interactions between several brain areas is necessary in order to exploit the full potential of optogenetic methods in probing temporal codes. © 2015 Baranauskas.


Garre J.M.,New York University | Garre J.M.,Yeshiva University | Yang G.,New York University | Bukauskas F.F.,Yeshiva University | And 2 more authors.
Journal of Neuroscience | Year: 2016

We show here that the growth factor FGF-1 is proinflammatory in the spinal cord and explore the inflammatory mechanisms. FGF-1 applied to rat spinal astrocytes in culture initiates calcium signaling and induces secretion of ATP that within minutes increases membrane permeability to ethidium (Etd+) and Ca2+by activatingP2X7 receptors (P2X7Rs) that open pannexin hemichannels (Px1 HCs) that release further ATP; by 7 h treatment, connexin 43 hemichannels (Cx43 HCs) are also opened. In acute mouse spinal cord slices ex vivo, we found that FGF-1 treatment for 1 h increases the percentage of GFAP-positive astrocytes that show enhanced Px1 HC-mediated Etd+ uptake. This response to FGF-1 was not observed in astrocytes in slices of cerebral cortex. FGF-1-induced dye uptake by astrocytes is prevented byBAPTA-AMor a phospholipaseC(PLC) inhibitor. Furthermore, in spinal cord slices,P2X7Rantagonists (BBG and A740003) and Px1HCblockers (10Panx1 and carbenoxolone) prevent the increase in Etd+uptake by astrocytes, whereas Gap19, a selective Cx43HC blocker, has no effect on dye uptake at this time. Microglia are not required for the increase in Etd+ uptake by astrocytes induced by FGF-1, although they are activated by FGF-1 treatment. The morphological signs of microglia activation are inhibited by P2X7R antagonists and 10Panx1 and are associated with elevated levels of proinflammatory cytokines in cord slices treated with FGF-1. The FGF-1 initiated cascade may play an important role in spinal cord inflammation in vivo. © 2016 the authors.


Baranauskas G.,Lithuanian University of Health Sciences
Frontiers in Systems Neuroscience | Year: 2014

The concept of a brain-machine interface (BMI) or a computer-brain interface is simple: BMI creates a communication pathway for a direct control by brain of an external device. In reality BMIs are very complex devices and only recently the increase in computing power of microprocessors enabled a boom in BMI research that continues almost unabated to this date, the high point being the insertion of electrode arrays into the brains of 5 human patients in a clinical trial run by Cyberkinetics with few other clinical tests still in progress. Meanwhile several EEG-based BMI devices (non-invasive BMIs) were launched commercially. Modern electronics and dry electrode technology made possible to drive the cost of some of these devices below few hundred dollars. However, the initial excitement of the direct control by brain waves of a computer or other equipment is dampened by large efforts required for learning, high error rates and slow response speed. All these problems are directly related to low information transfer rates typical for such EEG-based BMIs. In invasive BMIs employing multiple electrodes inserted into the brain one may expect much higher information transfer rates than in EEG-based BMIs because, in theory, each electrode provides an independent information channel. However, although invasive BMIs require more expensive equipment and have ethical problems related to the need to insert electrodes in the live brain, such financial and ethical costs are often not offset by a dramatic improvement in the information transfer rate. Thus the main topic of this review is why in invasive BMIs an apparently much larger information content obtained with multiple extracellular electrodes does not translate into much higher rates of information transfer? This paper explores possible answers to this question by concluding that more research on what movement parameters are encoded by neurons in motor cortex is needed before we can enjoy the next generation BMIs. © 2014 Baranauskas.


News Article | February 15, 2017
Site: www.eurekalert.org

Kaunas University of Technology (KTU) and Lithuanian University of Health Sciences (LSMU) are developing the monitoring system for seniors: Upon registering a fall of a person, the system sends a notification to the carers "When faced with problems of the elderly in our closest family, it is us who experience major stress, not them", says Egidijus Kazanavicius, Professor at Kaunas University of Technology (KTU), Director at the Centre of Real Time Computer Systems. Kazanavicius is heading the team of researchers from KTU and Lithuanian University of Health Sciences (LSMU), who are developing the monitoring system for seniors: upon registering a fall of a person, the system sends a notification to the carers. "Falls are the leading cause of death in the elderly population and are very common problem in geriatrics, symptomatic to a wide variety of health conditions. Besides causing physical injuries, falls lower person's self-confidence to move independently, and are often a reason of various psychological problems", says Dr Vita Lesauskaite, researcher at LSMU. Collaborating, KTU and LSMU researchers created a prototype of a monitoring system for seniors GRIUTIS, consisting of a set of fixed sensors placed in premises, and of the software. When sensors register a change in a person's behaviour or in his or her position, the alert is being sent to their family and / or carers. The next step for the researchers is patenting of technologies and product commercialisation. It is planned that the senior monitoring system GRIUTIS will be used in geriatrics clinics as soon as the next year. Lithuanian Research Council has allocated funds for the realisation of the project. "I tested the prototype at home, myself. It works perfectly, and I feel more relaxed knowing how my elderly mother is doing, when I am not nearby. It is a great advantage to be able to work with a team of researchers with different competencies -- together we can create truly innovative products", says Kazanavičius. The project GRIUTIS is one of almost 10 joint projects of KTU and LSMU, which were funded by the institutional R&D funds of both Kaunas universities.


The International Association of HealthCare Professionals is pleased to welcome Henrietta Fridman, MD, Internist, to their prestigious organization with her upcoming publication in The Leading Physicians of the World. She is a highly trained and qualified internist with a vast expertise in all facets of her work, especially general internal medicine and geriatrics. Dr. Fridman has been in practice for more than 26 years and is currently serving patients at Doylestown Health in Doylestown, Pennsylvania. Furthermore, she is affiliated with Doylestown Hospital. Dr. Henrietta Fridman received her Medical Degree in 1990 from the Kaunas Medical Institute of the Lithuanian University of Health Sciences in Kaunas, Lithuania. An internship then followed at Allegheny University of the Health Sciences in Philadelphia, prior to completing residencies at Drexel University College of Medicine and Hahnemann University Hospital. Dr. Fridman is certified by the American Board of Internal Medicine, and maintains a professional memberships with the American Medical Association. She attributes her success to her love of medicine, as it has always been her dream to work in medicine. When she is not assisting patients, Dr. Fridman enjoys listening to music, playing the piano, and singing. Learn more about Dr. Fridman by reading her upcoming publication in The Leading Physicians of the World. FindaTopDoc.com is a hub for all things medicine, featuring detailed descriptions of medical professionals across all areas of expertise, and information on thousands of healthcare topics.  Each month, millions of patients use FindaTopDoc to find a doctor nearby and instantly book an appointment online or create a review.  FindaTopDoc.com features each doctor’s full professional biography highlighting their achievements, experience, patient reviews and areas of expertise.  A leading provider of valuable health information that helps empower patient and doctor alike, FindaTopDoc enables readers to live a happier and healthier life.  For more information about FindaTopDoc, visit http://www.findatopdoc.com


Borutaite V.,Lithuanian University of Health Sciences | Toleikis A.,Lithuanian University of Health Sciences | Brown G.C.,University of Cambridge
FEBS Journal | Year: 2013

We review research investigating mitochondrial damage during heart and brain ischaemia, focusing on the mechanisms and consequences of ischaemia-induced and/or reperfusion-induced: (a) inhibition of mitochondrial respiratory complex I; (b) release of cytochrome c from mitochondria; (c) changes to mitochondrial phospholipids; and (d) nitric oxide inhibition of mitochondria. Heart ischaemia causes inhibition of cytochrome oxidase and complex I, release of cytochrome c, and induction of permeability transition and hydrolysis and oxidation of mitochondrial phospholipids, but some of the mechanisms are unclear. Brain ischaemia causes inhibition of complexes I and IV, but other effects are less clear. © 2013 FEBS.


Brown G.C.,University of Cambridge | Borutaite V.,Lithuanian University of Health Sciences
Mitochondrion | Year: 2012

It is often assumed that mitochondria are the main source of reactive oxygen species (ROS) in mammalian cells, but there is no convincing experimental evidence for this in the literature. What evidence there is suggests mitochondria are a significant source for ROS, which may have physiological and pathological effects. But quantitatively, endoplasmic reticulum and peroxisomes have a greater capacity to produce ROS than mitochondria, at least in liver. In most cells and physiological or pathological conditions there is a lack of evidence for or against mitochondria being the main source of cellular ROS. Mitochondria can rapidly degrade ROS and thus are potential sinks for ROS, but whether mitochondria act as net sources or sinks within cells in particular conditions is unknown. © 2011 Elsevier B.V. and Mitochondria Research Society.


Svagzdys S.,Lithuanian University of Health Sciences
The Tohoku journal of experimental medicine | Year: 2011

Common prognostic factors do not fully predict clinical outcomes in colorectal cancer, one of the most common malignancies in developed countries. Therefore, biological prognostic markers are under investigation. We investigated the prognostic value of expression of matrix metalloproteinases (MMP-2 and MMP-9) and their inhibitors (TIMP-2 and TIMP-3) in rectal carcinoma to predict survival of the patients. Retrospective analysis of clinicopathological findings of 64 patients who underwent rectal resection due to carcinoma and were followed-up from 2 to 96 months (median 48) was performed. Semi-quantitative scoring was used to assess the expression levels of MMP-2, MMP-9, TIMP-2 and TIMP-3 in rectal carcinoma. During the follow-up, 28 patients died. The deceased patients demonstrated significantly higher expression of MMP-9 and lower expression of TIMP-3 in parenchyma of carcinoma and lower expression of TIMP-2 in stroma of carcinoma, compared to survivors. Moreover, the deceased patients were associated with advanced tumor, metastases in lymph nodes and distant metastases. According to univariate analysis longer survival was predicted by lower expression of MMP-9 in parenchymal cells (p = 0.03), tumor size (early tumor) (p = 0.026), absence of metastases in lymph nodes (p = 0.02) or distant metastases (p = 0.04). Multivariate analysis revealed that metastases in lymph nodes, higher expression of MMP-9 in parenchyma, and lower expression of MMP-9 in stromal cells significantly increased mortality. Expression of MMP-9 in rectal carcinoma is a prognostic marker for overall survival. It is important to identify the origin of MMP-9 to predict better overall survival of the patients.


Kuciene R.,Lithuanian University of Health Sciences | Dulskiene V.,Lithuanian University of Health Sciences
BMC Public Health | Year: 2014

Background: Recent epidemiological studies have found that the prevalence of high blood pressure (BP) has significantly increased among children and adolescents. The aim of this study was to examine the associations between short sleep duration and prehypertension and hypertension in Lithuanian children and adolescents aged 12 to 15 years. Methods. A cross-sectional study was conducted from November 2010 to April 2012. The participants with high BP (≥90th percentile) were screened on two separate occasions. Self-reported sleep duration was evaluated using questionnaires. Data on 6,940 subjects aged 12-15 years were analyzed. Adjusted odds ratios (aORs) with 95% confidence intervals for the associations were estimated using multivariate logistic regression models. Short sleep duration was defined as <8 hours per day (h/day). Results: The prevalence of prehypertension and hypertension in the current sample was 12.6% and 22.5%, respectively. The percentages of the subjects with sleep durations of <7 (h/day), 7- < 8 h/day, and ≥8 h/day were 8.7%, 21.0%, and 70.3%, respectively. After adjusting for age, sex, body mass index, physical activity, and smoking, significant associations were found between short sleep duration and high BP, including prehypertension (7- < 8 h/day: aOR = 1.77; 95% CI, 1.48-2.12; <7 h/day: aOR = 2.18; 95% CI, 1.70-2.79) and hypertension (7- < 8 h/day: aOR = 1.99; 95% CI, 1.72-2.31; <7 h/day: aOR = 2.28; 95% CI, 1.85-2.80) (all P values <0.001), compared to participants who were sleeping longer (≥8 h/day). Conclusions: Prehypertension and hypertension were associated with short sleep duration among Lithuanian children and adolescents aged 12 to 15 years. © 2014 Kuciene and Dulskiene; licensee BioMed Central Ltd.

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