Lithuanian University of Health science ) is a medical school in Kaunas, Lithuania. The present-day Lithuanian University of Health science is a consolidation of two institutions of higher education, Kaunas University of Medicine and the Lithuanian Veterinary Academy. It uses the Hospital of Lithuanian University of Health science Kaunas Clinics and the Kaunas Red Cross Hospital as a teaching hospitals. Wikipedia.
News Article | February 15, 2017
Kaunas University of Technology (KTU) and Lithuanian University of Health Sciences (LSMU) are developing the monitoring system for seniors: Upon registering a fall of a person, the system sends a notification to the carers "When faced with problems of the elderly in our closest family, it is us who experience major stress, not them", says Egidijus Kazanavicius, Professor at Kaunas University of Technology (KTU), Director at the Centre of Real Time Computer Systems. Kazanavicius is heading the team of researchers from KTU and Lithuanian University of Health Sciences (LSMU), who are developing the monitoring system for seniors: upon registering a fall of a person, the system sends a notification to the carers. "Falls are the leading cause of death in the elderly population and are very common problem in geriatrics, symptomatic to a wide variety of health conditions. Besides causing physical injuries, falls lower person's self-confidence to move independently, and are often a reason of various psychological problems", says Dr Vita Lesauskaite, researcher at LSMU. Collaborating, KTU and LSMU researchers created a prototype of a monitoring system for seniors GRIUTIS, consisting of a set of fixed sensors placed in premises, and of the software. When sensors register a change in a person's behaviour or in his or her position, the alert is being sent to their family and / or carers. The next step for the researchers is patenting of technologies and product commercialisation. It is planned that the senior monitoring system GRIUTIS will be used in geriatrics clinics as soon as the next year. Lithuanian Research Council has allocated funds for the realisation of the project. "I tested the prototype at home, myself. It works perfectly, and I feel more relaxed knowing how my elderly mother is doing, when I am not nearby. It is a great advantage to be able to work with a team of researchers with different competencies -- together we can create truly innovative products", says Kazanavičius. The project GRIUTIS is one of almost 10 joint projects of KTU and LSMU, which were funded by the institutional R&D funds of both Kaunas universities.
Efficacy and safety of erlotinib versus chemotherapy in second-line treatment of patients with advanced, non-small-cell lung cancer with poor prognosis (TITAN): A randomised multicentre, open-label, phase 3 study
Ciuleanu T.,Institute of Oncology Ion Chiricuta |
Stelmakh L.,St. Petersburg State Medical University |
Cicenas S.,Vilnius University |
Miliauskas S.,Lithuanian University of Health Sciences |
And 5 more authors.
The Lancet Oncology | Year: 2012
Background: Erlotinib, docetaxel, and pemetrexed are approved for the second-line treatment of non-small-cell lung cancer (NSCLC), but no head-to-head data from large clinical trials are available. We undertook the Tarceva In Treatment of Advanced NSCLC (TITAN) study to assess the efficacy and tolerability of second-line erlotinib versus chemotherapy in patients with refractory NSCLC. Methods: TITAN was an international, randomised multicentre, open-label, phase 3 study that was done at 77 sites in 24 countries. Chemotherapy-naive patients with locally advanced, recurrent, or metastatic NSCLC received up to four cycles of first-line platinum doublet chemotherapy, after which patients with disease progression during or immediately after chemotherapy were offered enrolment into TITAN. Enrolled patients were randomly assigned (1:1) by a minimisation method to ensure balanced stratification, to receive erlotinib 150 mg/day or chemotherapy (standard docetaxel or pemetrexed regimens, at the treating investigators' discretion), until unacceptable toxicity, disease progression, or death. Patients were stratified by disease stage, Eastern Cooperative Oncology Group performance status, smoking history, and region of residence. The primary endpoint was overall survival in the intention-to-treat population. TITAN was halted prematurely because of slow recruitment. This study is registered with ClinicalTrials.gov, number NCT00556322. Findings: Between April 10, 2006, and Feb 24, 2010, 2590 chemotherapy-naive patients were treated with first-line platinum doublet chemotherapy, of whom 424 had disease progression and were enrolled into TITAN. 203 patients were randomly assigned to receive erlotinib and 221 were assigned to receive chemotherapy. Median follow-up was 27·9 months (IQR 11·0-36·0) in the erlotinib group and 24·8 months (12·1-41·6) in the chemotherapy group. Median overall survival was 5·3 months (95% CI 4·0-6·0) with erlotinib and 5·5 months (4·4-7·1) with chemotherapy (hazard ratio [HR] 0·96, 95% CI 0·78-1·19; log-rank p=0·73). The adverse-event profile of each group was in line with previous studies. Rash (98/196 [50%] in the erlotinib group vs 10/213 [5%] in the chemotherapy group for all grades; nine [5%] vs none for grade 3 or 4) and diarrhoea (36 [18%] vs four [2%] for all grades; five [3%] vs none for grade 3 or 4) were the most common treatment-related adverse events with erlotinib, whereas alopecia (none vs 23 [11%] for all grades; none vs one [<1%] for grade 3/4) was the most common treatment-related adverse event with chemotherapy. Interpretation: No significant differences in efficacy were noted between patients treated with erlotinib and those treated with docetaxel or pemetrexed. Since the toxicity profiles of erlotinib and chemotherapy differ, second-line treatment decisions should take into account patient preference and specific toxicity risk profiles. Funding: F Hoffmann-La Roche. © 2012 Elsevier Ltd.
News Article | October 27, 2016
The International Association of HealthCare Professionals is pleased to welcome Henrietta Fridman, MD, Internist, to their prestigious organization with her upcoming publication in The Leading Physicians of the World. She is a highly trained and qualified internist with a vast expertise in all facets of her work, especially general internal medicine and geriatrics. Dr. Fridman has been in practice for more than 26 years and is currently serving patients at Doylestown Health in Doylestown, Pennsylvania. Furthermore, she is affiliated with Doylestown Hospital. Dr. Henrietta Fridman received her Medical Degree in 1990 from the Kaunas Medical Institute of the Lithuanian University of Health Sciences in Kaunas, Lithuania. An internship then followed at Allegheny University of the Health Sciences in Philadelphia, prior to completing residencies at Drexel University College of Medicine and Hahnemann University Hospital. Dr. Fridman is certified by the American Board of Internal Medicine, and maintains a professional memberships with the American Medical Association. She attributes her success to her love of medicine, as it has always been her dream to work in medicine. When she is not assisting patients, Dr. Fridman enjoys listening to music, playing the piano, and singing. Learn more about Dr. Fridman by reading her upcoming publication in The Leading Physicians of the World. FindaTopDoc.com is a hub for all things medicine, featuring detailed descriptions of medical professionals across all areas of expertise, and information on thousands of healthcare topics. Each month, millions of patients use FindaTopDoc to find a doctor nearby and instantly book an appointment online or create a review. FindaTopDoc.com features each doctor’s full professional biography highlighting their achievements, experience, patient reviews and areas of expertise. A leading provider of valuable health information that helps empower patient and doctor alike, FindaTopDoc enables readers to live a happier and healthier life. For more information about FindaTopDoc, visit http://www.findatopdoc.com
Borutaite V.,Lithuanian University of Health Sciences |
Toleikis A.,Lithuanian University of Health Sciences |
Brown G.C.,University of Cambridge
FEBS Journal | Year: 2013
We review research investigating mitochondrial damage during heart and brain ischaemia, focusing on the mechanisms and consequences of ischaemia-induced and/or reperfusion-induced: (a) inhibition of mitochondrial respiratory complex I; (b) release of cytochrome c from mitochondria; (c) changes to mitochondrial phospholipids; and (d) nitric oxide inhibition of mitochondria. Heart ischaemia causes inhibition of cytochrome oxidase and complex I, release of cytochrome c, and induction of permeability transition and hydrolysis and oxidation of mitochondrial phospholipids, but some of the mechanisms are unclear. Brain ischaemia causes inhibition of complexes I and IV, but other effects are less clear. © 2013 FEBS.
Brown G.C.,University of Cambridge |
Borutaite V.,Lithuanian University of Health Sciences
Mitochondrion | Year: 2012
It is often assumed that mitochondria are the main source of reactive oxygen species (ROS) in mammalian cells, but there is no convincing experimental evidence for this in the literature. What evidence there is suggests mitochondria are a significant source for ROS, which may have physiological and pathological effects. But quantitatively, endoplasmic reticulum and peroxisomes have a greater capacity to produce ROS than mitochondria, at least in liver. In most cells and physiological or pathological conditions there is a lack of evidence for or against mitochondria being the main source of cellular ROS. Mitochondria can rapidly degrade ROS and thus are potential sinks for ROS, but whether mitochondria act as net sources or sinks within cells in particular conditions is unknown. © 2011 Elsevier B.V. and Mitochondria Research Society.
Kybartaite A.,Lithuanian University of Health Sciences
International Journal for Numerical Methods in Biomedical Engineering | Year: 2012
Computational head and brain volume conductor modeling is a practical and non-invasive method to investigate neuroelectrical activity in the brain. Anatomical structures included in a model affect the flow of volume currents and the resulting scalp surface potentials. The influence of different tissues within the head on scalp surface potentials was investigated by constructing five highly detailed, realistic head models from segmented and processed Visible Human Man digital images. The models were: (1) model with 20 different tissues, that is, skin, dense connective tissue (fat), aponeurosis (muscle), outer, middle and inner tables of the scalp, dura matter, arachnoid layer (including cerebrospinal fluid), pia matter, six cortical layers, eye tissue, muscle around the eye, optic nerve, temporal muscle, white matter and internal air, (2) model with three main inhomogeneities, that is, scalp, skull, brain, (3) model with homogeneous scalp and remaining inhomogeneities, (4) model with homogeneous skull and remaining inhomogeneities, and (5) model with homogeneous brain matter and remaining inhomogeneities. Scalp potentials because of three different dipolar sources in the parietal-occipital lobe were computed for all five models. Results of a forward solution revealed that tissues included in the model and the dipole source location directly affect the simulated scalp surface potentials. The major finding indicates that significant change in the scalp surface potentials is observed when the brain's distinctions are removed. The other modifications, for example, layers of the scalp and skull are important too, but they have less effect on the overall results. © 2012 John Wiley & Sons, Ltd.
Radzeviciene L.,Lithuanian University of Health Sciences |
Ostrauskas R.,Lithuanian University of Health Sciences
Public Health Nutrition | Year: 2012
Objective: Type 2 diabetes mellitus appears to involve an interaction between susceptible genetic backgrounds and environmental factors including highly calorific diets. As it is important to identify modifiable risk factors that may help reduce the risk of type 2 diabetes mellitus, the aim of the present study was to determine the association between egg consumption and the risk of type 2 diabetes mellitus. Design: A specifically designed questionnaire was used to collect information on possible risk factors of type 2 diabetes mellitus. The odds ratios and 95% confidence intervals for type 2 diabetes mellitus were calculated by conditional logistic regression. Setting: A case-control study in a Lithuanian out-patient clinic was performed in 2001. Subjects: A total of 234 cases with a newly confirmed diagnosis of type 2 diabetes mellitus and 468 controls free of the disease. Results: Variables such as BMI, family history of diabetes, cigarette smoking, education, morning exercise and plasma TAG level were retained in multivariate logistic regression models as confounders because their inclusion changed the value of the odds ratio by more than 10% in any exposure category. After adjustment for possible confounders more than twofold increased risk of type 2 diabetes mellitus was determined for individuals consuming 3-4.9 eggs/week (OR2.60; 95% CI 1.34, 5.08) and threefold increased risk of the disease was determined for individuals consuming ≥5 eggs/week (OR3.02; 95% CI 1.14, 7.98) compared with those eating ,< egg/week. Conclusions: Our data support a possible relationship of egg consumption and increased risk of type 2 diabetes mellitus. © 2012 The Authors.
Svagzdys S.,Lithuanian University of Health Sciences
The Tohoku journal of experimental medicine | Year: 2011
Common prognostic factors do not fully predict clinical outcomes in colorectal cancer, one of the most common malignancies in developed countries. Therefore, biological prognostic markers are under investigation. We investigated the prognostic value of expression of matrix metalloproteinases (MMP-2 and MMP-9) and their inhibitors (TIMP-2 and TIMP-3) in rectal carcinoma to predict survival of the patients. Retrospective analysis of clinicopathological findings of 64 patients who underwent rectal resection due to carcinoma and were followed-up from 2 to 96 months (median 48) was performed. Semi-quantitative scoring was used to assess the expression levels of MMP-2, MMP-9, TIMP-2 and TIMP-3 in rectal carcinoma. During the follow-up, 28 patients died. The deceased patients demonstrated significantly higher expression of MMP-9 and lower expression of TIMP-3 in parenchyma of carcinoma and lower expression of TIMP-2 in stroma of carcinoma, compared to survivors. Moreover, the deceased patients were associated with advanced tumor, metastases in lymph nodes and distant metastases. According to univariate analysis longer survival was predicted by lower expression of MMP-9 in parenchymal cells (p = 0.03), tumor size (early tumor) (p = 0.026), absence of metastases in lymph nodes (p = 0.02) or distant metastases (p = 0.04). Multivariate analysis revealed that metastases in lymph nodes, higher expression of MMP-9 in parenchyma, and lower expression of MMP-9 in stromal cells significantly increased mortality. Expression of MMP-9 in rectal carcinoma is a prognostic marker for overall survival. It is important to identify the origin of MMP-9 to predict better overall survival of the patients.
Macijauskiene J.,Lithuanian University of Health Sciences
Medicina (Kaunas, Lithuania) | Year: 2012
Dementia with Lewy bodies was first recognized as a separate entity about 30 years ago. The prevalence varies from 0% to 5% in the general population, and this disease accounts for 0% to 30.5% of all dementia cases. Dementia with Lewy bodies is considered the second most common cause of degenerative dementia after Alzheimer's disease. The disease is characterized by alpha-synuclein immunoreactive protein deposits in both neurons and glial cells. The protein deposits are especially prominent in dopaminergic neurons, where they can be detected using conventional histological stains, such as hematoxylin and eosin, and are commonly referred to as Lewy bodies. The diagnosis of dementia with Lewy bodies is based on the presence of dementia as well as 2 of the following 3 core diagnostic features: 1) fluctuating cognition, 2) visual hallucinations, and 3) movement disorder. Diagnostic tests include laboratory data, structural and functional imaging, and electroencephalography. Differential diagnosis of dementia with Lewy bodies focuses on other later life dementia syndromes, other parkinsonian diseases (Parkinson's disease, progressive supranuclear palsy, corticobasal degeneration), and primary psychiatric illnesses. There is type 1b evidence to support treatment with cholinesterase inhibitors. Glutamatergic and dopaminergic therapies are used as well. Standard neuroleptics are contraindicated, and atypical agents should be used cautiously. Nonpharmacologic measures - therapeutic environment, psychological and social support, physical activity, behavioral management strategies, caregivers' education and support, and different services - could be suggested.
Kuciene R.,Lithuanian University of Health Sciences |
Dulskiene V.,Lithuanian University of Health Sciences
BMC Public Health | Year: 2014
Background: Recent epidemiological studies have found that the prevalence of high blood pressure (BP) has significantly increased among children and adolescents. The aim of this study was to examine the associations between short sleep duration and prehypertension and hypertension in Lithuanian children and adolescents aged 12 to 15 years. Methods. A cross-sectional study was conducted from November 2010 to April 2012. The participants with high BP (≥90th percentile) were screened on two separate occasions. Self-reported sleep duration was evaluated using questionnaires. Data on 6,940 subjects aged 12-15 years were analyzed. Adjusted odds ratios (aORs) with 95% confidence intervals for the associations were estimated using multivariate logistic regression models. Short sleep duration was defined as <8 hours per day (h/day). Results: The prevalence of prehypertension and hypertension in the current sample was 12.6% and 22.5%, respectively. The percentages of the subjects with sleep durations of <7 (h/day), 7- < 8 h/day, and ≥8 h/day were 8.7%, 21.0%, and 70.3%, respectively. After adjusting for age, sex, body mass index, physical activity, and smoking, significant associations were found between short sleep duration and high BP, including prehypertension (7- < 8 h/day: aOR = 1.77; 95% CI, 1.48-2.12; <7 h/day: aOR = 2.18; 95% CI, 1.70-2.79) and hypertension (7- < 8 h/day: aOR = 1.99; 95% CI, 1.72-2.31; <7 h/day: aOR = 2.28; 95% CI, 1.85-2.80) (all P values <0.001), compared to participants who were sleeping longer (≥8 h/day). Conclusions: Prehypertension and hypertension were associated with short sleep duration among Lithuanian children and adolescents aged 12 to 15 years. © 2014 Kuciene and Dulskiene; licensee BioMed Central Ltd.