Chen L.,Lishui City Central Hospital |
Wang J.,Guangfu Hospital of Jinhua |
Fu L.,Lishui City Central Hospital |
Zhang H.,Shanxi Medical University |
Ye B.,Lishui City Central Hospital
Journal of Cancer Research and Therapeutics | Year: 2014
Background: The clinical significance of metastasis associated in colon cancer 1 (MACC1), in human gallbladder cancer, is not yet established. This study was performed to assess the expression of MACC1 in benign and malignant gallbladder lesions, and to assess its clinicopathological significance. Materials and Methods: Tissue samples from resected gallbladder cancer (n = 70) and cholelithiasis (n = 70) were evaluated for MACC1 expression by immunohistochemical staining. Their expression was correlated with different clinicopathological parameters. Results: Cytoplasmic MACC1 expression was significantly higher (58.6%) in gallbladder cancer than in chronic cholecystitis (27.1%, P < 0.001). High MACC1 levels were associated with lymph node metastasis (P < 0.05), tumor node metastasis (TNM) stage (P < 0.01), and perineural invasion (P < 0.01), but not with sex, age, history of gallstones or histological grade (P > 0.05). The univariate Kaplan-Meier analysis showed that a positive MACC1 expression was associated with decreased overall survival (P < 0.001). The multivariate Cox regression analysis showed that MACC1 expression and the histopathological subtypes were independent risk factors for disease-free survival. Conclusion: The expression of MACC1 might be closely related to carcinogenesis, clinical biological behaviors, and prognosis of gallbladder adenocarcinoma.
Tian X.,Lishui City Central Hospital |
Fang W.,Lishui City Central Hospital |
Wu J.,Lishui City Central Hospital
Chinese Critical Care Medicine | Year: 2014
Objective To observe the method of mechanical ventilation in the chest compressions during cardiopulmonary resuscitation (CPR), and to explore the influence of the flow pattern selection of square-wave and decelerating-wave on airway pressure of patients.Methods A prospective self-pairing study was conducted. Forty patients undergoing CPR admitted to Department of Emergency of Lishui City Central Hospital from January 2011 to February 2013 were enrolled. Using Respironics Eisprit ventilator, the working mode and parameters of ventilator were set reasonably according to previous research while the chest compressions was performed in a stable state by the same doctor . Each patient received different flow waves including square-wave and decelerating-wave and the highest peak airway pressure was recorded as a pair of data when the time-pressure and time-flow waveform were frozen. Two pairs of data by different doctors were collected in each patient. Eighty pairs of data from 40 patients were collected for statistical analysis by paired t test.Results The highest peak airway pressure of decelerating-wave was (38.15 ± 5.99)cmH2O (1 cmH2O = 0.098 kPa), which was (5.71 ±1.98) cmH2O lower than that of square wave [ (43.86 ± 6.68) cmH2O] with significantly statistical difference (t=22.010, P=0.000). 73.75% patients undergoing square wave with peak airway pressure over 40 cmH2O were found, but only 45.00% patients were found in decelerating-wave.Conclusion Because decelerating-wave used in mechanical ventilation during CPR can obviously reduce the peak airway pressure the occurrence of barotrauma and the probability of triggering high pressure ventilator alarm and improve the compliance of ventilator so decelerating-wave is more reasonable than square-wave.