Shanxi Liposome Research Center

Fengcheng, China

Shanxi Liposome Research Center

Fengcheng, China
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Zhao W.,Northwestern Polytechnical University | Zhang H.,Northwestern Polytechnical University | Lu T.-L.,Northwestern Polytechnical University | Chen T.,Northwestern Polytechnical University | Chen T.,Shanxi Liposome Research Center
Chinese Pharmaceutical Journal | Year: 2010

OBJECTIVE: To design and prepare new-structured magnetic liposome by self-assembly method. METHODS: Fe3O4 magnetic particles were prepared by co-precipitation. Doxorubicin liposomes were prepared by film dispersing method. The Zeta potential of the Fe3O4 magnetic particles and doxorubicin liposome was detected, and then appropriate polyelectrolyte interlayer was selected. Magnetic liposome was obtained by alternately assembling polyelectrolyte and Fe3O4 magnetic particles onto doxorubicin liposome. The morphology of the magnetic liposome was characterized by transmission electron microscopy (TEM). RESULTS: The Zeta potentials of the Fe3O4 magnetic particles and doxorubicin liposome were -22.0 and -22.6 mV, respectively, and the cation polyelectrolyte (PDAD-MAC) was selected as interlayer. TEM photograph of the magnetic liposome indicated that the liposome showed regular spherical profile and had rough surface for the uniform adsorption of Fe3O4 particles, which provided direct evidence for successful fabrication of the new-structured magnetic liposome. CONCLUSION: The new-structured magnetic liposome can be prepared by self-assembly method.

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