Lipo Chemicals Inc.

Paterson, NJ, United States

Lipo Chemicals Inc.

Paterson, NJ, United States
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Fractionated melanin (Mel-HEV), a bleached version of natural melanin, offers protection against the high energy visible (HEV/UVA) and ultraviolet (specifically UVA) irradiation making it a potential compound to be added to skin care and sunscreen formulations and other cosmetic and personal care products. Chlorpromazine (CPZ) has been shown to exhibit photosensitivity and phototoxicity reaction in vitro and in vivo. Comparative evaluation of chemotoxicity and phototoxicity using Mel-HEV and CPZ (as positive control) was performed on mouse fibroblast cell line 'Balb/c 3T3'. This is the recommended method for evaluating the phototoxic potential of compounds under the European Center of Validation of Alternative Methods (ECVAM) guidelines (OECD, 2004). This study was expanded from a mouse cell line - Balb 3T3/c to two human cell lines - HDF and HEKn for two reasons: to compare the difference between the sensitivity and behavior of two fibroblast cell lines (Balb/c 3T3 vs. HDF) and to compare the differences between two fibroblast cell lines with the keratinocyte cell line (HDF & Balb/c 3T3 vs. HEKn). It was found that Balb/c 3T3 and HEKn were both sensitive to the phototoxic potential of CPZ. However, HDF showed insensitivity to phototoxic evaluation. The test compound, Mel-HEV, was found to be non-phototoxic. The mean toxic concentration (MTC) for CPZ during HEV and UVA exposure conditions was found to be similar using Balb/c 3T3 (36.25. μg/ml) and HEKn (39.99. μg/ml) showing that cells exhibit similar responses at HEV/UVA- conditions. However, Balb/c 3T3 showed more sensitivity to CPZ at HEV/UVA+ condition (MTC = 0.87. μg/ml; mean PIF = 55.33; MPE = 0.395) than HEKn (MTC = 5.35. μg/ml; PIF = 7.61; MPE = 0.276) making it the preferred cell line for phototoxicity evaluations. © 2010 Elsevier Ltd.


Fireman S.,Ness Technologies | Toledano O.,Ness Technologies | Neimann K.,Ness Technologies | Loboda N.,Ness Technologies | Dayan N.,Lipo Chemicals Inc.
Dermatologic Therapy | Year: 2011

The introduction of new topical drugs based on new chemical entities has become a rare event. Instead, pharmaceutical companies have been focused on reformulating existing drugs resulting in an ever-growing number of topical drug products for every approved drug substance. In light of this trend, soon reformulations may not be as rewarding to their sponsors as they are today unless they offer a substantial improvement over other formulations of the same drug substance and the same indication, namely improved efficacy over existing drugs, reduced side effects, unique drug combinations, or applicability for new indications. This article reviews and compares topical drug delivery systems currently under active research that are designed to offer such advantages in the coming years. The reviewed delivery systems are: liposomes, niosomes, transferosomes, ethosomes, solid lipid nanoparticles, nanostructured lipid carriers, cyclodextrin, and sol-gel microcapsules. Among all the topical drug delivery systems currently undergoing active research, only the sol-gel microencapsulation is at clinical stages. © 2012 Wiley Periodicals, Inc.


Dayan N.,Lipo Chemicals Inc. | Shah V.,Lipo Chemicals Inc. | Shah V.,Rutgers University | Minko T.,Lipo Chemicals Inc. | Minko T.,Rutgers University
Journal of Cosmetic Science | Year: 2011

An optical brightener (OB) powder (INCI: sodium silicoaluminate (and) glycidoxypropyl trimethyloxysilane/PEI-250 cross fluorescent brightener 230 salt (and) polyvinylalcohol crosspolymer) that is used in cosmetic facial products was tested for its genotoxic potential using the micronuclei test (MNT). It is a solid dry powder with an average size of 5 microns that is insoluble but dispersible in water. This study describes the exposure of cell culture to positive controls with and without enzymatic activation and to the test compound in different concentrations. We evaluated three end points: microscopic observation and quantification of micronuclei formation, and cell viability and proliferation. Both positive controls induced significant changes that were observed under the microscope and quantified. Based on its chemical nature, it was not anticipated that the test substance will degrade under the conditions of the experiments. However, the test is required to make sure that when solublized, impurities that may be present, even at trace levels, will not induce a genotoxic effect. The test compound did not promote micronuclei formation or change the viability or proliferation rate of cells. During this study we faced challenges such as solubilization and correlating viability data to genotoxicity data. These are described in the body of the paper. We believe that with the emergence of the 7th European amendment that bans animal testing, sharing these data and the study protocol serves as a key in building the understanding of the utilization of in vitro studies in the safety assessment of cosmetic ingredients.


Dayan N.,Lipo Chemicals Inc. | Shah V.,Rutgers University | Minko T.,Rutgers University
International Journal of Cosmetic Science | Year: 2011

Synopsis This study compared the genotoxic potential of a polymeric associative thickener used in topically applied emulsions preserved with three different preservative systems. The method used for the assessment of genotoxicity is the in vitro micronucleus test [Organization for Economic Cooperation and Development (OECD) guideline number 487]. When changing an additive such as a preservation system in a raw material, it is crucial to re-evaluate its toxicity potential because this change may significantly alter its properties. This study shows that at the levels tested neither of the systems evaluated demonstrated any cytotoxic or genotoxic effects. Skin exposure must take into consideration factors such as duration, skin condition and metabolism, but most importantly concentration. Although preservatives can be toxic at high concentrations, they are usually safe at the concentrations used in cosmetic raw materials and formulations. If used to preserve raw materials, they undergo further dilution when added to the formulation. © 2011 Society of Cosmetic Scientists and the Société Française de Cosmétologie.


Patent
Photoprotective Technologies Inc. and Lipo Chemicals Inc. | Date: 2011-03-03

A compound, composition, and method for the protection of skin from the harmful effects of radiation, and particularly the harmful effects of high energy visible (HEV) radiation, are disclosed. The compound is a melanin derivative that can be formulated into compositions containing the melanin derivative and a suitable carrier. The composition is topically applied to the skin to reduce the risk of photoaging and improve skin repair due to damage from radiation.


Trademark
Lipo Chemicals Inc. | Date: 2013-11-15

Chemicals used in the manufacture of cosmetics, body creams, hand creams, facial creams, and lotions for skin, hair, face and body.


Trademark
Lipo Chemicals Inc | Date: 2010-07-08

COMPOUNDS THAT SUPPORT HEALTHY SKIN FUNCTIONS, namely, compounds in the nature of peptides, anti-irritants, skin-tone actives, humectants, and anti-aging actives.


Trademark
Lipo Chemicals Inc. | Date: 2011-05-24

COMPOUNDS IN THE NATURE OF CHEMICAL ADDITIVES THAT PROTECT THE SKIN FROM ENVIRONMENTAL INSULTS OR DAMAGE FOR USE IN THE MANUFACTURE OF COSMETICS AND SUNSCREENS.


Trademark
Lipo Chemicals Inc. | Date: 2014-05-23

Microcapsules containing core materials consisting of emollient oils, active chemical ingredients and fragrances, and also featuring flavor and colorants, for use in the further manufacture of cosmetic, personal, household, and industrial products including food.


Trademark
Lipo Chemicals Inc. | Date: 2014-05-23

Microcapsules containing core materials consisting of emollient oils, active chemical ingredients and fragrances, and also featuring flavor and colorants, for use in the further manufacture of cosmetic, personal, household, and industrial products including food.

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