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Paterson, NJ, United States

Fireman S.,Ness Technologies | Toledano O.,Ness Technologies | Neimann K.,Ness Technologies | Loboda N.,Ness Technologies | Dayan N.,Lipo Chemicals Inc.
Dermatologic Therapy | Year: 2011

The introduction of new topical drugs based on new chemical entities has become a rare event. Instead, pharmaceutical companies have been focused on reformulating existing drugs resulting in an ever-growing number of topical drug products for every approved drug substance. In light of this trend, soon reformulations may not be as rewarding to their sponsors as they are today unless they offer a substantial improvement over other formulations of the same drug substance and the same indication, namely improved efficacy over existing drugs, reduced side effects, unique drug combinations, or applicability for new indications. This article reviews and compares topical drug delivery systems currently under active research that are designed to offer such advantages in the coming years. The reviewed delivery systems are: liposomes, niosomes, transferosomes, ethosomes, solid lipid nanoparticles, nanostructured lipid carriers, cyclodextrin, and sol-gel microcapsules. Among all the topical drug delivery systems currently undergoing active research, only the sol-gel microencapsulation is at clinical stages. © 2012 Wiley Periodicals, Inc.


Dayan N.,Lipo Chemicals Inc. | Shah V.,Rutgers University | Minko T.,Rutgers University
International Journal of Cosmetic Science | Year: 2011

Synopsis This study compared the genotoxic potential of a polymeric associative thickener used in topically applied emulsions preserved with three different preservative systems. The method used for the assessment of genotoxicity is the in vitro micronucleus test [Organization for Economic Cooperation and Development (OECD) guideline number 487]. When changing an additive such as a preservation system in a raw material, it is crucial to re-evaluate its toxicity potential because this change may significantly alter its properties. This study shows that at the levels tested neither of the systems evaluated demonstrated any cytotoxic or genotoxic effects. Skin exposure must take into consideration factors such as duration, skin condition and metabolism, but most importantly concentration. Although preservatives can be toxic at high concentrations, they are usually safe at the concentrations used in cosmetic raw materials and formulations. If used to preserve raw materials, they undergo further dilution when added to the formulation. © 2011 Society of Cosmetic Scientists and the Société Française de Cosmétologie.


Patent
Photoprotective Technologies Inc. and Lipo Chemicals Inc. | Date: 2011-03-03

A compound, composition, and method for the protection of skin from the harmful effects of radiation, and particularly the harmful effects of high energy visible (HEV) radiation, are disclosed. The compound is a melanin derivative that can be formulated into compositions containing the melanin derivative and a suitable carrier. The composition is topically applied to the skin to reduce the risk of photoaging and improve skin repair due to damage from radiation.


Trademark
Lipo Chemicals Inc. | Date: 2014-05-23

Microcapsules with core materials, namely, emollient oils, active ingredients, fragrances and flavors, and colorants sold to the trade for cosmetic, personal, household, and industrial uses.


Trademark
Lipo Chemicals Inc. | Date: 2014-05-23

Microcapsules with core materials, namely, emollient oils, active ingredients, fragrances and flavors, and colorants sold to the trade for cosmetic, personal, household, and industrial uses.

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