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Saint-André-lez-Lille, France

Dubois-Chevalier J.,LInserm UMRU1011 | Dubois-Chevalier J.,Lille University of Science and Technology | Dubois-Chevalier J.,Institute Pasteur Of Lille | Dubois-Chevalier J.,European Genomic Institute for Diabetes EGID | And 12 more authors.
Nucleus | Year: 2015

ell diíferentiation relies on tissue-specific transcription factors (TFs) that cooperate to establish unique tran-scriptomes and phenotypes. However, the role of ubiquitous TFs in these pro-cesses remains poorly deined. Recently, we have shown that the CCCTC-binding factor (CTCF) is required for adipocyte differentiation through epigenomic remodelling of adipose tissue-speciic enhancers and transcriptional activation of Peroxisome proliferator-activated receptor gamma (PPARG), the main driver of the adipogenic program (PPARG), and its target genes. Here, we discuss how these indings, together with the recent literature, illuminate a func-tional role for ubiquitous TFs in lineage-determining transcriptional networks. © 2015 Taylor & Francis Group, LLC.

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