Time filter

Source Type

Zhang Q.,Anhui University | Zhang Q.,Linkoing University | Tian X.,University College London | Hu Z.,Linkoing University | And 9 more authors.
Journal of Materials Chemistry B | Year: 2015

It is still a challenge to obtain two-photon excited fluorescent bioimaging probes with intense emission, high photo-stability and low cytotoxicity. In the present work, four Zn(ii)-coordinated complexes (1-4) constructed from two novel D-A and D-π-A ligands (L1 and L2) are investigated both experimentally and theoretically, aiming to explore efficient two-photon probes for bioimaging. Molecular geometry optimization used for theoretical calculations is achieved using the crystallographic data. Notably, the results indicate that complexes 1 and 2 display enhanced two-photon absorption (2PA) cross sections compared to their corresponding D-A ligand (L1). Furthermore, it was found that complex 1 has the advantages of moderate 2PA cross section in the near-infrared region, longer fluorescence lifetime, higher quantum yield, good biocompatibility and enhanced two-photon excited fluorescence. Therefore, complex 1 is evaluated as a bioimaging probe for in vitro imaging of HepG2 cells, in which it is observed under a two-photon scanning microscope that complex 1 exhibits effective co-staining with endoplasmic reticulum (ER) and nuclear membrane; as well as for in vivo imaging of zebrafish larva, in which it is observed that complex 1 exhibits specificity in the intestinal system. © The Royal Society of Chemistry 2015.

Ljung L.,Linkoing University
Proceedings of the 29th Chinese Control Conference, CCC'10 | Year: 2010

System Identification for linear systems and models is a well established and mature topic. Identifying nonlinear models is a much more rich and demanding problem area. In this presentation some major approaches and concepts for that are outlined.

Loading Linkoing University collaborators
Loading Linkoing University collaborators