Linjiang College

Hangzhou, China

Linjiang College

Hangzhou, China
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Yu W.,Zhejiang University of Technology | Yu W.,Linjiang College | Jiang L.,Hangzhou Normal University | Shen C.,Hangzhou Normal University | Zhang P.,Hangzhou Normal University
Drug Development Research | Year: 2016

(Table presented.). A series of novel carbohydrate-derived Erlotinib derivatives were prepared by the copper-catalyzed cycloaddition reaction of erlotinib with various azido-sugars. The structures of the newly synthesized compounds were characterized and their cytostatic effects evaluated in vitro on human cancer cell lines MDA-MB-231, HEPG-2, A549, and MCF-7 using an MTS assay. The novel erlotinib derivatives had the expected inhibitory effects on MDA-MB-231 and HEPG-2 cell llines. Among the compounds evaluated the carbohydrate-derived compounds 5b, 5d, 6a, and 6c had more potent activities against MDA-MB-231 or HEPG-2 than Erlotinib. Drug Dev Res, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.


Ding X.,Linjiang College | Zhai Z.,Zhejiang University of Technology | Lv L.,Linjiang College | Sun Z.,Zhejiang University of Technology | Liu X.,Zhejiang University of Technology
Frontiers of Chemical Science and Engineering | Year: 2017

A variety of pyrazole derivatives containing 1,3,4-thiadiazole moiety were synthesized under microwave irradiation, and their structures were confirmed by 1H NMR and HRMS. They were evaluated for herbicidal and antifungal activities, and the results indicated that two compounds with a phenyl group (6a) and 4-tert-butylphenyl group (6n) possess good herbicidal activity for dicotyledon Brassica campestris and Raphanus sativus with the inhibition of 90% for root and 80%–90% for stalk at 100 ppm respectively. The structure-activity relationship of compounds 6a and 6n was also studied by density function theory method.[Figure not available: see fulltext.] © 2017 Higher Education Press and Springer-Verlag Berlin Heidelberg


Lv L.-P.,Linjiang College | Lv W.-D.,Linjiang College | Rao J.-F.,Linjiang College | Chen J.-Y.,Linjiang College
Zeitschrift fur Kristallographie - New Crystal Structures | Year: 2017

C13H19N3O3, monoclinic, P21/c (no. 14), a = 11.594(5) Å, b = 11.311(5) Å, c = 11.688(5) Å, β = 117.347(19)°, V = 1361.4(10) Å3, Z = 4, Rgt(F) = 0.0479, wRref(F2) = 0.1630, T = 296 K. © 2017 Lu-Ping Lv et al., published by De Gruyter.


Lv L.-P.,Linjiang College | Lv L.-P.,Zhejiang University of Technology | Tong G.-T.,Linjiang College | Xia C.-C.,Taishan Medical University | Liu Y.-L.,Hangzhou Technology Chemicals CO.
Zeitschrift fur Kristallographie - New Crystal Structures | Year: 2014

C11H14N2O4, triclinic, P1¯ (no. 2), a = 11.174(4) Å, b = 11.260(4) Å, c = 19.769(7) Å, α = 93.66(2)°, β = 101.25(1)°, γ = 93.08(2)°, V = 2429.9 Å3, Z = 8, Rgt(F) = 0.0504, wRref(F2) = 0.1537, T = 223 K. © 2014 by Walter de Gruyter Berlin/Boston.


Lv L.-P.,Zhejiang University of Technology | Lv L.-P.,Linjiang College | Tong G.-T.,Linjiang College | Feng T.,Linjiang College | And 2 more authors.
Zeitschrift fur Kristallographie - New Crystal Structures | Year: 2014

C11H14N2O5, trigonal, R3c (no. 161), a = 25.868(8) Å, c = 10.074(4) Å, V = 5838.0 Å3, Z = 18, Rgt(F) = 0.0397, wRref(F 2) = 0.1013, T = 223 K. © 2014 by Walter de Gruyter Berlin/Boston.


Lv L.-P.,Linjiang College | Liu S.,Linjiang College
Acta Crystallographica Section E: Structure Reports Online | Year: 2010

The title compound, C9H8Br2N2O 3, crystallizes with two very similar independent molecules in the asymmetric unit, each of which adopts a trans configuration with respect to the C=N bond. Intramolecular O-H⋯N hydrogen bonds are observed in each independent molecule. In the crystal structure, molecules are linked into chains propagating along [010] by N-H⋯O and C-H⋯O hydrogen bonds. In addition, C-H⋯π interactions stabilize the structure.


Yu T.-M.,Linjiang College | Lv L.-P.,Linjiang College
Acta Crystallographica Section E: Structure Reports Online | Year: 2010

In the title molecule, C10H12N2O 2, the acetohydrazide group is almost planar [within 0.0306 (12) Å] and forms a dihedral angle of 12.15 (14)° with the benzene ring. The meth-oxy group deviates from the attached benzene ring with a C - O - C - C torsion angle of 4.2 (4)°·The molecule adopts a trans configuration with respect to the C=N bond. In the crystal, molecules are linked into centrosymmetric dimers by pairs of N - H⋯O hydrogen bonds and intermolecular C - H⋯O interactions further stabilize the structure.


Yu W.-B.,Zhejiang University of Technology | Yu W.-B.,Linjiang College | Xu J.,Hangzhou Normal University | Zhang P.-F.,Hangzhou Normal University
Zeitschrift fur Kristallographie - New Crystal Structures | Year: 2016

C21H17N3O4S, triclinic, P1 (no. 2), a = 10.0424(5) Å, b = 10.4142(4) Å, c = 18.7420(10) Å, α = 91.746(4)°, β = 90.169(4)°, γ = 100.878(4), V = 1923.92(16) Å3, Z = 4, Rgt(F) = 0.0487, wRref(F2) = 0.1036, T = 293(2) K. © 2016 Wen-Bo Yu et al., published by De Gruyter.


Li W.-W.,Linjiang College | Yu T.-M.,Linjiang College | Lv L.-P.,Linjiang College | Hu X.-C.,Zhejiang University of Technology
Acta Crystallographica Section E: Structure Reports Online | Year: 2011

The title compound, C 9H 10N 2O 3·2H2O, crystallizes with two organic molecules and four water molecules in the asymmetric unit. Both organic molecules adopt a trans conformation with respect to the C=N bond and are close to planar [dihedral angles between the side chain and the aromatic ring = 9.34 (8) and 4.96 (8)°]. In the crystal, the components are linked into three-dimensional network by N- H⋯O and O- H⋯O hydrogen bonds.


Lv L.-P.,Linjiang College | Yu T.-M.,Linjiang College | Yu W.-B.,Linjiang College | Hu X.-C.,Zhejiang University of Technology
Acta Crystallographica Section E: Structure Reports Online | Year: 2011

The asymmetric unit of the title compound, C 11H 11N 3O 2·0.25H 2O, contains two independent organic molecules and a water molecule, which lies on a twofold rotation axis. The side chains of the two molecules have slightly different orientations, the C=N - N - C torsion angle being -163.03 (15)° in one and -177.52 (14)° in the other, with each adopting a trans configuration with respect to the C=N bond. In the crystal, molecules are linked into chains extending along b by N - H⋯O, O - H⋯N and O - H⋯O hydrogen bonds and in addition, four inter-molecular C - H⋯π interactions are present.

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