Lincoln Memorial University is a private four-year co-educational liberal arts college located in Harrogate, Tennessee, United States. LMU's 1,000-acre campus borders on Cumberland Gap National Historical Park. As a whole, LMU is accredited by the Southern Association of Colleges and Schools . In December 2014, the law school received provisional accreditation by the American Bar Association.LMU's Abraham Lincoln Library and Museum houses a large collection of memorabilia relating to the school's namesake, Abraham Lincoln, and the Civil War. The collection was initially formed from donations by the school's early benefactor, General Oliver O. Howard, and his friends. Wikipedia.
News Article | December 2, 2016
U.S. Surgeon General, Dr. Vivek Murthy, graces the cover of the print publication. Through an exclusive interview with Mediaplanet, Dr. Murthy explains how he was inspired to practice medicine at an early age by his father, who was also a doctor. “Early on I learned that medicine is about more than making diagnoses and prescribing medicine,” he states. “It is about building relationships with people; relationships that are based on trust and mutual understanding.” He touches on several important health care topics including the importance of prevention and emotional well-being. “We have spent relatively little attention on emotional well-being, which is vital when it comes to improving health”, says Dr. Murthy. As Surgeon General, Dr. Murthy also spends time promoting equity of access to health care for all, saying that “we are one of the richest countries in the world, but we have such a wide disparity in terms of access to care and health care outcomes. The print component of “Careers in Health Care” is distributed within the weekend edition of USA Today with a circulation of approximately 750,000 copies and an estimated readership of 1.3 million. The digital component is distributed nationally through a vast social media strategy and across a network of top news sites and partner outlets. To explore the digital version of the campaign, click here. This edition of “Careers in Health Care” was made possible with the support of The American Association of Colleges of Nursing, American Association of Physician Assistants, National Medical Association, Society for Simulation in Health Care, National League for Nursing, American Medical Student Association, American College of Nurse Midwives, U.S. Surgeon General, Dr. Vivek Murthy, Lincoln Memorial University, Purdue University, American University of Antigua College of Medicine, National Commission on Certification of PA’s, National Certification Corporation, and St. Vincent College. About Mediaplanet Mediaplanet is the leading independent publisher of content-marketing campaigns covering a variety of topics and industries. We turn consumer interest into action by providing readers with motivational editorial, pairing it with relevant advertisers, and distributing it within top newspapers and online platforms around the world.
News Article | November 10, 2016
The Best Veterinary Technician Schools in the nation are being featured by AccreditedSchoolsOnline.org, the Community for Accredited Online Schools 2016-2017 rankings. Comparing both online and on-campus programs at two- and four-year schools across the U.S., the online higher education resource provider ranked schools providing the best overall value for Veterinary Technician students. Colorado Mountain College, St. Petersburg College, Lincoln Memorial University, Becker College, Medaille College, San Juan College, Athens Technical College, Windward Community College, Chattanooga State Community College and Northshore Technical Community College were among the highest scorers. “Job outlook projections show veterinary technician positions growing much faster than the national average through 2024,” said Doug Jones, CEO and Founder of the Community for Accredited Online Schools. “Schools on these lists are not only providing quality veterinary technician programs, but are also making an extra effort to help students land a job after graduation.” Schools must meet specific baseline requirements to be considered for a spot on the Best Veterinary Technician Schools ranking. All institutions must hold regional accreditation and be registered as public or private not-for-profit entities. Schools are also required to provide career placement services to their students. Once a school’s eligibility is determined, the Community for Accredited Online Schools scores and ranks each based on more than a dozen data points, including graduation rates, student teacher ratios and financial aid availability, to determine the overall Best Schools in the U.S. An alphabetical listing of the Best Veterinary Technician Schools for 2016-2017 is included below. To learn where each specifically ranks and to find more details on the data and methodology used to determine scores visit: The 2016-2017 Best Veterinary Technician Programs at Two-Year Schools list: Alamance Community College Arkansas State University - Beebe Asheville-Buncombe Technical Community College Athens Technical College Bellingham Technical College Blue Ridge Community College Cedar Valley College Central Oregon Community College Chattanooga State Community College College of Southern Idaho Columbus State Community College Cosumnes River College Crowder College Delaware Technical Community College-Owens Delgado Community College Eastern Iowa Community College District Eastern Wyoming College Front Range Community College Gaston College Genesee Community College Gwinnett Technical College Harcum College Hillsborough Community College Hinds Community College Iowa Lakes Community College Jefferson College Jefferson State Community College Linn-Benton Community College Lone Star College Mesa Community College Middlesex Community College Murray State College Nebraska College of Technical Agriculture North Shore Community College Northeast Community College Northeast Iowa Community College-Calmar Northshore Technical Community College Northwest Mississippi Community College Norwalk Community College Ogeechee Technical College Owensboro Community and Technical College Pierpont Community and Technical College San Juan College Southern Regional Technical College Truckee Meadows Community College Tulsa Community College Volunteer State Community College Weatherford College Western Iowa Tech Community College Windward Community College The 2016-2017 Best Veterinary Technician Programs at Four-Year Schools list: Baker College of Clinton Township Baker College of Flint Baker College of Muskegon Baker College of Port Huron Becker College Brigham Young University-Idaho Colorado Mountain College Daytona State College Eastern Florida State College Fort Valley State University Kent State University at Tuscarawas Lincoln Memorial University Madison Area Technical College Medaille College Miami Dade College Michigan State University Mississippi State University Morehead State University Murray State University Navajo Technical University New England Institute of Technology North Dakota State University - Main Campus Northwestern State University of Louisiana Oklahoma State University - Oklahoma City Otterbein University Pensacola State College Purdue University - Main Campus Siena Heights University St. Petersburg College SUNY College of Technology at Alfred SUNY College of Technology at Canton SUNY College of Technology at Delhi Tuskegee University University of Alaska Anchorage University of Alaska Fairbanks University of Cincinnati - Blue Ash College University of Maine at Augusta University of Nebraska - Lincoln University of New Hampshire - Main Campus Vermont Technical College About Us: The Community for Accredited Online Schools (AccreditedSchoolsOnline.org) was founded in 2011 to provide students and parents with quality data and information about pursuing an affordable education that has been certified by an accrediting agency. Our community resource materials and tools span topics such as college accreditation, financial aid, opportunities available to veterans, people with disabilities, as well as online learning resources. We feature higher education institutions that have developed online learning programs that include highly trained faculty, new technology and resources, and online support services to help students achieve educational success. environments that include highly trained faculty, new technology and resources, and online support services to help students achieve educational and career success.
News Article | November 15, 2016
Florida Hospital and Lincoln Memorial University (LMU) are partnering to create an extended learning site for the LMU-Caylor School of Nursing in the West Florida Region. This partnership will establish synergy for continuous quality improvement in both education and the practice of nursing. The United States is projected to experience a shortage of registered nurses (RN) that is expected to intensify as “Baby Boomers” age and the need for health care grows. According to the American Association of Colleges of Nursing (AACN), nursing school enrollments are not growing fast enough to meet the projected demand for RN and Advanced Practice Registered Nurse (APRN) services. In addition, high nurse turnover and vacancy rates are affecting access to health care. “There is a significant nursing shortage problem nationally. In Florida, we’ve seen an increase of over 30% since 2013. In our hospital system, we have more than 300 vacancies at this time. We are excited to launch this partnership with LMU, a university with an excellent reputation and pass rates. They are also known for their distinguished faculty that are professional educators as well as practitioners in the field of nursing. By joining together, we strengthen nursing practices within our facilities and can help close the gap by filling positions. The clinical students will have the opportunity to learn and train with the best,” said Mike Schultz, Florida Hospital West Florida Region President and CEO. Founded in 1897, LMU is a values-based learning community dedicated to providing educational experiences in the liberal arts and professional studies. It’s located in Harrogate, Tennessee about 55 miles north of Knoxville and operates extended learning sites throughout Southern Appalachia. LMU is accredited by the Southern Association of Colleges and Schools Commission on Colleges (SACSCOC) and all programs in the Caylor School of Nursing are accredited by the Accreditation Commission for Education in Nursing (ACEN). “Nearly 120 years ago LMU was founded by visionary individuals who formed a partnership for the purpose of providing educational opportunities to underserved populations. In the years that have followed, the institution has evolved while continuing to serve its mission. Nearly every growth initiative the University has experienced started with a partnership,” said LMU President B. James Dawson. “That is why we are proud to have found a dynamic new partner in Florida Hospital to help us deliver educational opportunities to clinical students. The LMU-Caylor School of Nursing was built on excellence. We are proud that LMU nurses continue to be in-demand and enjoy excellent employment and pass rates, but the benchmark upon which our legacy has been established is the excellent patient care delivered through the hands of our alumni,” said Dawson. Together, Florida Hospital and the LMU-Caylor School of Nursing will start by offering an accelerated Bachelor of Science in Nursing (BSN) program designed to be completed in 16 months, after general education requirements have been met. Additional degree programs will be offered as well. Admissions to the various degree programs would be available at different times throughout the year, increasing the number of students per year. The class size for these programs would consist of 24 to 48 students per class. All clinical experiences are currently planned to be completed and contained within the Florida Hospital West Florida Region facilities. Clinical students would benefit from having direct access to learn and train at Florida Hospital facilities throughout the West Florida Region. Florida Hospital will continue to work with all area nursing schools to help provide clinical spots for student training. These degree offerings by the LMU-Caylor School of Nursing, Florida Hospital Tampa site will be located at 3102 East 138th Street Tampa, Florida 33613. The location will include administrative offices, classrooms, study rooms, a skills laboratory, and library. The plan is to host an official ground breaking ceremony which will be announced in the near future. To learn more about LMU Nursing and degree programs offered please visit: nursing.LMUnet.edu About Florida Hospital West Florida Region The Florida Hospital West Florida Region is a not- for- profit 1,295-bed hospital system composed of Florida Hospital Tampa/Pepin Heart Institute, Florida Hospital Carrollwood, Florida Hospital at Connerton Long Term Acute Care, Florida Hospital North Pinellas, Florida Hospital Wesley Chapel, Florida Hospital Zephyrhills, Florida Hospital Heartland Medical Center Sebring, Florida Hospital Heartland Medical Center Lake Placid and Florida Hospital Wauchula. Part of the Adventist Health System, Florida Hospital is a leading health network comprised of 26 hospitals throughout the state. For more information, visit FloridaHospital.com. About Lincoln Memorial University Lincoln Memorial University is a values-based learning community dedicated to providing educational experiences in the liberal arts and professional studies. The main campus is located in Harrogate, Tennessee. For more information about the undergraduate and graduate programs available at LMU, contact the Office of Admissions at 423.869.6280 or e-mail at admissions(at)LMUnet(dot)edu.
News Article | November 18, 2016
The Lincoln Memorial University (LMU) Board of Trustees has voted unanimously to appoint Provost and Vice President for Academic Affairs E. Clayton Hess as the University’s 21st president. Hess will succeed Dr. B. James Dawson on July 1, 2017, following a semester-long transition period. “LMU is very fortunate to call Dr. Hess as its next president,” Dawson said. “His distinguished service to this institution over three decades includes roles in virtually every division on campus and gives him tremendous institutional knowledge. He also brings a unique world view in higher education from his service on site visit committees for the Southern Association of Colleges and Schools Commission on Colleges (SACSCOC). He has been on the front line of LMU’s remarkable growth, chairing or serving on the planning committees for the DeBusk College of Osteopathic Medicine (LMU-DCOM), Duncan School of Law (LMU Law), Physician Assistant Program and the College of Veterinary Medicine (CVM).” Hess has served as the University’s provost since 2015 and the vice president for academic affairs since 2010. He has taught as an adjunct faculty member at LMU and was the founding chair of LMU’s Institutional Effectiveness Committee. Hess has served on the President’s Cabinet twice during his career; first from 1998-2001 and again from 2010 to the present. He chaired the University’s successful SACSCOC reaffirmation of accreditation from 2006-2009 and is poised to lead LMU through its next 10-year site visit. “When we started this search process we knew we would be looking for an innovative leader with a clear vision of how to navigate the changes that are coming in higher education,” said Dr. Brian DeBusk, LMU trustee and chair of the presidential search committee. “Once we identified Dr. Hess as a candidate, there was a groundswell of support both internally within the board and externally from higher education leaders across the country. It became clear that we didn’t have to look far for our next president.” Hess has guided LMU’s growth at all levels, chairing multiple committees responsible for substantive change proposals to initiate new extended learning sites offering associate, baccalaureate, post-baccalaureate, graduate and professional degree programs. He chaired the committee responsible for degree level accreditation change from Level IV to V to pave the way for LMU-DCOM and from Level V to VI for subsequent professional programs including LMU Law, the doctorate in education and CVM. He has assisted LMU faculty in preparing successful reports for initial and/or continuing accreditation by several professional accreditation associations/agencies. Hess coordinated LMU’s strategic planning and institutional effectiveness processes for more than 10 years and has chaired the University’s general education committee. Prior to becoming provost and VPAA, he was assistant vice president for academic affairs for planning and accreditation and was responsible for monitoring compliance with accreditation/approval requirements of several state and federal agencies/associations and conducting on-going efforts to assess the effectiveness of LMU’s academic and administrative operations. Hess began his career at LMU in 1981, shortly after his graduation, as the assistant director of admissions, director of testing and director of career planning and placement. He was named the director of institutional advancement in 1996, and the director of institutional research, effectiveness and accreditation in 1998. In 2008, he was promoted to the assistant vice president for academic affairs for planning and accreditation and was named vice president for academic affairs in 2010. Hess is a member of the SACSCOC Principles Review Committee, charged with reviewing and recommending changes to SACSCOC accreditation standards and processes. He has presented numerous sessions and talks at professional association meetings. Hess co-chaired the 2014 SACSCOC Annual Meeting Planning Committee. He has also served on American Bar Association (ABA) Sabbatical Site Teams. Hess earned a bachelor of arts in history and two masters degrees from LMU (one in counseling and the other in curriculum and instruction) and a Ph.D. in human services counseling from Walden University. Hess has four grown children and five grandchildren. He resides in LaFollette, Tennessee. Hess’s inauguration will take place during the University’s 2017 Homecoming festivities, which are set to take place October 12-14. Lincoln Memorial University is a values-based learning community dedicated to providing educational experiences in the liberal arts and professional studies. The main campus is located in Harrogate, Tennessee. For more information about the undergraduate and graduate programs available at LMU, contact the Office of Admissions at 423-869-6280 or e-mail at admissions(at)lmunet(dot)edu.
News Article | November 28, 2016
The Human Animal Bond Research Initiative (HABRI) announced today it has awarded a $27,000 grant to Lincoln Memorial University, for a study titled, Measuring the Impact of a Mutually Reinforcing Relationship Between Pet Owners and Their Pets. This research project will analyze data collected via a series of public health fairs and develop a general model of health and wellness behavior to examine the relationship between the health of humans and their pets and whether patterns of health and health-associated behaviors are similar. It is anticipated that the model will help determine that pets share the same health benefits and risks as their owners. “Healthy pets make healthy people,” said HABRI Executive Director Steve Feldman. “Lincoln Memorial University can help us establish this important connection so that the human-animal bond is universally accepted as an essential element of human wellness.” The one-year pilot study will aim to obtain data sufficient to describe the current state of health and health associated behaviors in pet owner-pet pairs in the Cumberland Gap Region (CGR) of Kentucky, Tennessee and Virginia. Health metric data including body weight, heart rate, blood pressure and height will be collected for 300 human subjects and their pet dogs or cats through conducting a series of public health fairs. The investigators seek to use the data to formulate a general model of health and health associated behavior. “Few studies have simultaneously investigated the health and health promoting behaviors of owners and pets,” said principal investigator Dr. Charles Faulkner, Associate Professor of Veterinary Medicine at Lincoln Memorial University. “We believe the model developed in this study will help provide evidence that the relationship between humans and companion animals mutually reinforces their health and quality of life. This is especially important in a geographic region where residents rank at the bottom in health outcomes for heart disease, hypertension, diabetes and lack of physical activity.” The HABRI Foundation maintains the world’s largest online library of human-animal bond research and information; to date has funded more than $750,000 dollars in innovative research projects to scientifically document the health benefits of companion animals; and informs the public about human-animal bond research and the beneficial role of companion animals in society. For more information about the HABRI Foundation, visit http://www.habri.org. Lincoln Memorial University (LMU) is a values-based learning community dedicated to providing educational experiences in the liberal arts and professional studies. The LMU-College of Veterinary Medicine is located on LMU’s main campus in Harrogate, Tennessee, with additional academic facilities in nearby Lee County, Virginia. LMU-CVM is an integral part of the University’s medical programs and provides real-world, community-based education in a collaborative learning environment. For more information about LMU-CVM, call 1-800-325-0900, ext. 7150 or visit us online at vetmed.LMUnet.edu. ###
News Article | April 19, 2016
ATLANTA — Homo naledi, a rock star among fossil species in the human genus, has made an encore. Its return highlighted debate over whether this hominid was a distinct Homo species that purposefully disposed of at least some of its dead. H. naledi made worldwide headlines last year when researchers announced the discovery of an unusually large collection of odd-looking Homo fossils in the bowels of a South African cave system. Presentations at the annual meeting of the American Association of Physical Anthropologists on April 16 underscored key uncertainties about the hominid. One of the biggest mysteries: H. naledi’s age. Efforts are under way to date the fossils and sediment from which they were excavated with a variety of techniques, said paleoanthropologist John Hawks of the University of Wisconsin–Madison. An initial age estimate may come later this year if different dating techniques converge on a consistent figure. A solid date for the fossils is essential for deciphering their place in Homo evolution and how the bones came to rest in a nearly inaccessible cave. Some presenters reasserted that H. naledi intentionally dropped dead comrades into an underground chamber, where their bones were later found by cave explorers and then scientists. But others raised questions. Even paleoanthropologist and team leader Lee Berger of the University of the Witwatersrand in Johannesburg hedged his bets. “It’s way too early to tell how H. naledi bodies got in the chamber,” Berger said. Berger’s group recovered 1,550 H. naledi fossils from a minimum of 15 individuals of all age groups (SN: 10/3/15, p. 6). Slender researchers wended through narrow passageways in South Africa’s Rising Star cave system and squeezed down a vertical chute to reach pitch-dark Dinaledi Chamber. There, they found hominid fossils scattered on the floor and in a shallow, 20-centimeter-deep excavation. Berger’s team assigned the bones to H. naledi based on an unexpected mix of humanlike features and traits typical of Australopithecus species from more than 3 million years ago. Fossil analyses presented at the meeting challenged a suggestion by some researchers, both before and during the meeting, that H. naledi actually represents a variant of Homo erectus, a species known to have existed by 1.8 million years ago (SN: 11/16/13, p. 6). H. naledi possessed a shoulder unlike those of other Homo species, said team member Elen Feuerriegel of the Australian National University in Canberra. The Rising Star hominid’s collarbone and upper arm bone resemble corresponding Australopithecus bones, she reported. H. naledi’s shoulder blades must have been positioned low and behind the chest, an arrangement more conducive to climbing trees than running long distances. H. naledi’s hand was built both for climbing and gripping stone implements, said Tracy Kivell of the University of Kent in England. Her analysis of 150 hand bones, including a nearly complete hand, showed a humanlike wrist and thumb combined with Australopithecus-like curved fingers. H. naledi’s curved toes and flaring pelvis also recall Australopithecus. Still, a preliminary lower-body reconstruction — incorporating fossil evidence of humanlike legs, knees and feet — suggests H. naledi walked almost as well as modern humans do, said Zach Throckmorton of Lincoln Memorial University in Harrogate, Tenn. West Asian H. erectus and H. naledi share several tooth features as well as relatively small braincases. In addition, adult H. naledi stood an estimated 147 centimeters tall (4 feet, 10 inches), within the height range for West Asian H. erectus. “That complicates matters,” said Christopher Walker of Duke University. Upper-body features that Berger’s team considers characteristic of H. naledi, such as the upper arm’s shape, possibly occurred in West Asian H. erectus as well, added Witwatersrand’s Tea Jashashvili, who has studied those finds. Explaining how H. naledi bones ended up in Dinaledi Chamber is also complicated. Ongoing studies of sediment and rock indicate that there was never a direct opening to the underground fossil site from above, said Witwatersrand’s Marina Elliott. Bones from some body parts, including five feet, three hands and part of a backbone, were found aligned as they would have been in living individuals, indicating at least some bodies reached the chamber intact, Hawks said. Curiously, some sets of aligned bones were found beneath scattered bones from diverse individuals. If the dead were dropped down a vertical chute into Dinaledi Chamber, bodies on top would have been least damaged and most likely to retain aligned bones. Along with that mystery, some sets of aligned bones somehow ended up far from the chute’s opening, Berger said. An alternative entrance to Dinaledi Chamber possibly existed in the past, Witwatersrand’s Aurore Val asserted online March 31 in the Journal of Human Evolution. Beetles or snails that damaged some H. naledi bones don’t inhabit dark, underground caves, Val argues. Such damage probably occurred on the surface or in a nearby, once-accessible part of the cave system, she proposes. The surfaces of many H. naledi fossils had been worn down enough to have possibly erased predators’ tooth marks and signs of animal trampling, which would be additional signs that another entrance to the chamber once existed, Val says. Given the large number of isolated and broken H. naledi fossils, bodies or body parts may have entered the chamber long after death, in Val’s view. Perhaps water from another part of the cave system carried bodies into Dinaledi Chamber, she speculates. Geologic studies show that water occasionally reached the chamber and mildly eroded sediment, Berger said. But he doubts water washed bones into Dinaledi Chamber. “Even if there was another entrance to the chamber, it still allowed access only to Homo naledi,” Berger argued. No remains of any other animals have been found in the cave. Like any rock star of lasting impact, the South African hominid plans to wow fans with new material. “Thousands of Homo naledi fossils are almost certainly left in the underground chamber,” Berger said. Editor’s note: This story was updated April 25, 2016, to correct the identification of organisms that have damaged some H. naledi bones.
Wood P.L.,Lincoln Memorial University
Alzheimer's Research and Therapy | Year: 2012
Alzheimer's disease (AD) is a cognitive disorder with a number of complex neuropathologies, including, but not limited to, neurofibrillary tangles, neuritic plaques, neuronal shrinkage, hypomyelination, neuroinflammation and cholinergic dysfunction. The role of underlying pathological processes in the evolution of the cholinergic deficit responsible for cognitive decline has not been elucidated. Furthermore, generation of testable hypotheses for defining points of pharmacological intervention in AD are complicated by the large scale occurrence of older individuals dying with no cognitive impairment despite having a high burden of AD pathology (plaques and tangles). To further complicate these research challenges, there is no animal model that reproduces the combined hallmark neuropathologies of AD. These research limitations have stimulated the application of 'omics' technologies in AD research with the goals of defining biologic markers of disease and disease progression and uncovering potential points of pharmacological intervention for the design of AD therapeutics. In the case of sporadic AD, the dominant form of dementia, genomics has revealed that the 4 allele of apolipoprotein E, a lipid transport/chaperone protein, is a susceptibility factor. This seminal observation points to the importance of lipid dynamics as an area of investigation in AD. In this regard, lipidomics studies have demonstrated that there are major deficits in brain structural glycerophospholipids and sphingolipids, as well as alterations in metabolites of these complex structural lipids, which act as signaling molecules. Peroxisomal dysfunction appears to be a key component of the changes in glycerophospholipid deficits. In this review, lipid alterations and their potential roles in the pathophysiology of AD are discussed. © 2012 BioMed Central Ltd.
Wood P.L.,Lincoln Memorial University
Neuropsychopharmacology | Year: 2014
Metabolomics research has the potential to provide biomarkers for the detection of disease, for subtyping complex disease populations, for monitoring disease progression and therapy, and for defining new molecular targets for therapeutic intervention. These potentials are far from being realized because of a number of technical, conceptual, financial, and bioinformatics issues. Mass spectrometry provides analytical platforms that address the technical barriers to success in metabolomics research; however, the limited commercial availability of analytical and stable isotope standards has created a bottleneck for the absolute quantitation of a number of metabolites. Conceptual and financial factors contribute to the generation of statistically under-powered clinical studies, whereas bioinformatics issues result in the publication of a large number of unidentified metabolites. The path forward in this field involves targeted metabolomics analyses of large control and patient populations to define both the normal range of a defined metabolite and the potential heterogeneity (eg, bimodal) in complex patient populations. This approach requires that metabolomics research groups, in addition to developing a number of analytical platforms, build sufficient chemistry resources to supply the analytical standards required for absolute metabolite quantitation. Examples of metabolomics evaluations of sulfur amino-acid metabolism in psychiatry, neurology, and neuro-oncology and of lipidomics in neurology will be reviewed. © 2014 American College of Neuropsychopharmacology.
Moncrieff J.,University College London |
Leo J.,Lincoln Memorial University
Psychological Medicine | Year: 2010
Background People with schizophrenia are often found to have smaller brains and larger brain ventricles than normal, but the role of antipsychotic medication remains unclear.Method We conducted a systematic review of magnetic resonance imaging (MRI) studies. We included longitudinal studies of brain changes in patients taking antipsychotic drugs and we examined studies of antipsychotic-naive patients for comparison purposes.Results Fourteen out of 26 longitudinal studies showed a decline in global brain or grey-matter volume or an increase in ventricular or cerebrospinal fluid (CSF) volume during the course of drug treatment, including the largest studies conducted. The frontal lobe was most consistently affected, but overall changes were diffuse. One large study found different degrees of volume loss with different antipsychotics, and another found that volume changes were associated with taking medication compared with taking none. Analyses of linear associations between drug exposure and brain volume changes produced mixed results. Five out of 21 studies of patients who were drug naive, or had only minimal prior treatment, showed some differences from controls in volumes of interest. No global differences were reported in three studies of drug-naive patients with long-term illness. Studies of high-risk groups have not demonstrated differences from controls in global or lobar brain volumes.Conclusions Some evidence points towards the possibility that antipsychotic drugs reduce the volume of brain matter and increase ventricular or fluid volume. Antipsychotics may contribute to the genesis of some of the abnormalities usually attributed to schizophrenia. Copyright © Cambridge University Press 2010.
Agency: NSF | Branch: Standard Grant | Program: | Phase: | Award Amount: 16.69K | Year: 2011
This award will support a planning visit for PI Adam Rollins (Lincoln Memorial University) and co-PI Steven Stephenson (University of Arkansas) to visit three locations in Kenya: the Center for Biodiversity housed at the National Museums of Kenya, the University of Nairobi, and the Maasai Mara National Reserve. The main objective of the proposed trip is for the PI (accompanied by a Lincoln Memorial University undergraduate student) and Co-PI to meet with Dr. George Ndiritu of the National Museums of Kenya and Dr. Francis Mwaura of the University of Nairobi. During the visit, the PIs and the foreign partners will (1) develop plans for future collaborative research centered around the eumycetozoans associated with grasslands and other ecosystems in eastern Africa, (2) begin the process of developing one or more international grant proposals to support the proposed collaborative efforts, (3) collect a preliminary set of samples to generate a set of baseline data, (4) present a workshop and one or more seminars on eumycetozoans to Kenyan university students and museum professionals at the National Museums of Kenya and the University of Nairobi.
Intellectual merit: Relatively little is known about the ecology of microbial communities associated with grassland ecosystems. This is especially true for the eumycetozoans (e.g., myxomycetes and dictyostelids). Only one comprehensive widespread study documenting dictyostelid cellular slime molds has been published relating specifically to this ecosystem (Rollins et al. 2010). Furthermore, there is not a single published paper specifically documenting the occurrence of myxomycetes associated with grassland ecosystems. The PI and Co-PI have a substantial data set documenting the occurrence of myxomycetes in the grasslands of the west-central United States (Rollins and Stephenson, manuscript in preparation), as well as smaller data sets from grassland sites in Belize, Costa Rica, and Australia (unpublished data). In general, very little is known with respect to the eumycetozoans associated with various ecosystems across the continent of Africa. This project would generate a set of preliminary data that would begin to address this void and could ultimately be used to address questions related to the ecological associations and biogeographical patterns associated with eumycetozoans across the continent of Africa and globally.
Broader impact: The planning visit seeks to establish a productive program of collaborative research between two US universities (Lincoln Memorial University in TN and the University of Arkansas in AR) and two Kenyan institutions (the National Museums of Kenya and the University of Nairobi). It is expected that this collaborative effort will produce an international research component that will ultimately benefit both undergraduate and graduate students within the United States and in Kenya. If funded, this planning visit would specifically benefit an undergraduate student from Lincoln Memorial University by providing the student with international experience in presenting information about their research experiences to Kenyan students and scientists as part of the training workshop component. Collectively, the experiences of the proposed trip would greatly benefit the student by exposing him/her to an international collaborative research effort, in turn strengthening the student?s concepts related to scientific methodologies, critical thinking skills, and cultural diversity.