Harrogate, TN, United States

Lincoln Memorial University

www.lmunet.edu
Harrogate, TN, United States

Lincoln Memorial University is a private four-year co-educational liberal arts college located in Harrogate, Tennessee, United States. LMU's 1,000-acre campus borders on Cumberland Gap National Historical Park. As a whole, LMU is accredited by the Southern Association of Colleges and Schools . In December 2014, the law school received provisional accreditation by the American Bar Association.LMU's Abraham Lincoln Library and Museum houses a large collection of memorabilia relating to the school's namesake, Abraham Lincoln, and the Civil War. The collection was initially formed from donations by the school's early benefactor, General Oliver O. Howard, and his friends. Wikipedia.

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News Article | April 17, 2017
Site: www.prweb.com

LearnHowToBecome.org, a leading resource provider for higher education and career information, has selected the best universities and colleges in Tennessee for 2017. Based on an analysis of government-backed data, 37 four-year schools made the list, with Vanderbilt University, Lipscomb University, Christian Brothers University, Aquinas College and Union University earning highest overall scores. 15 two-year schools also made the list, with Chattanooga State Community College, Nashville State Community College, Dyersburg State Community College, Roane State Community College and Volunteer State Community College ranked as the best five. A full list of winning schools is included below. “Projections show Tennessee’s job market will continue to grow for the foreseeable future, which is great news for people interested in earning a degree,” said Wes Ricketts, senior vice president of LearnHowToBecome.Org. “The schools on our list have demonstrated their value to students who want to enter the workforce well-prepared by providing the high-level education, career and employment resources that lead to post-college success.” To be included on Tennessee’s “Best Colleges” list, schools must be regionally accredited, not-for-profit institutions. Each college is also appraised on additional data that includes annual alumni earnings 10 years after entering college, employment and academic services offered, student/teacher ratio, graduation rate and the availability of financial aid. Complete details on each college, their individual scores and the data and methodology used to determine the LearnHowToBecome.org “Best Colleges in Tennessee” list, visit: Tennessee’s Best Four-Year Colleges for 2017 include: Aquinas College Austin Peay State University Belmont University Bethel University Bryan College-Dayton Carson-Newman University Christian Brothers University Cumberland University East Tennessee State University Fisk University Freed-Hardeman University Johnson University King University Lane College Le Moyne-Owen College Lee University Lincoln Memorial University Lipscomb University Martin Methodist College Maryville College Middle Tennessee State University Milligan College Rhodes College Sewanee-The University of the South Southern Adventist University Tennessee State University Tennessee Technological University Tennessee Wesleyan College The University of Tennessee-Chattanooga The University of Tennessee-Knoxville The University of Tennessee-Martin Trevecca Nazarene University Tusculum College Union University University of Memphis Vanderbilt University Welch College Tennessee’s Best Two-Year Colleges for 2017 include: Chattanooga State Community College Cleveland State Community College Columbia State Community College Dyersburg State Community College Jackson State Community College Motlow State Community College Nashville State Community College Northeast State Community College Pellissippi State Community College Remington College-Nashville Campus Roane State Community College Southwest Tennessee Community College Volunteer State Community College Walters State Community College William Moore College of Technology ### About Us: LearnHowtoBecome.org was founded in 2013 to provide data and expert driven information about employment opportunities and the education needed to land the perfect career. Our materials cover a wide range of professions, industries and degree programs, and are designed for people who want to choose, change or advance their careers. We also provide helpful resources and guides that address social issues, financial aid and other special interest in higher education. Information from LearnHowtoBecome.org has proudly been featured by more than 700 educational institutions.


News Article | April 17, 2017
Site: www.prweb.com

The Lincoln Memorial University Duncan School of Law (LMU Law) and the East Tennessee Historical Society (ETHS) have joined forces to bring world renowned presidential historian, public speaker and Pulitzer Prize-winning author Doris Kearns Goodwin to Knoxville on Tuesday, April 25, 2017. Goodwin will present a community lecture at 7:30 p.m. at the historic Bijou Theatre. The author’s presentation will be on her award-winning book, "Team of Rivals: The Political Genius of Abraham Lincoln," an epic tome that illuminates Lincoln’s skills as political operative during the most trying time in our nation’s history. Goodwin’s Team of Rivals was also the basis of director Steven Spielberg’s film Lincoln, which earned 12 Academy Award nominations. Goodwin is the author of six critically acclaimed and The New York Times bestselling books, including her most recent, The Bully Pulpit: Theodore Roosevelt, William Howard Taft, and the Golden Age of Journalism. Spielberg’s DreamWorks Studios has also acquired the film and television rights to the book. She was awarded the Pulitzer Prize in history for No Ordinary Time: Franklin and Eleanor Roosevelt: The Home Front in World War II. Goodwin’s "The Fitzgeralds and the Kennedys" was adapted into an award-winning television miniseries that aired on ABC. In 2015, to celebrate the 50th anniversaries of many of President Lyndon Johnson’s domestic accomplishments, "Lyndon Johnson and the American Dream" was released in e-book format for the first time. Goodwin has made many appearances on television, where she is frequently on NBC, MSNBC, CBS, ABC, FOX, CNN, The Charlie Rose Show and Meet the Press. She has also made appearances on The Late Show with Stephen Colbert, The Daily Show with Jon Stewart, The Colbert Report, The Late Late Show with Craig Ferguson, The Oprah Winfrey Show, The Tonight Show with Jay Leno and has even been animated for an appearance on The Simpsons. Tickets for the community lecture will go on sale on March 10, 2017, at the Bijou box office or online. General admission tickets are $40, East Tennessee Historical Society members and Friends of the Knox County Library will receive a code for discounted tickets; student tickets will be available for $25 with a student id presented at the Bijou box office. ABOUT LINCOLN MEMORAL UNIVERSITY Lincoln Memorial University is a values-based learning community dedicated to providing educational experiences in the liberal arts and professional studies. The main campus is located in Harrogate, Tennessee. For more information about the undergraduate and graduate programs available at LMU, contact the Office of Admissions at 423-869-6280 or e-mail at admissions(at)lmunet.edu. ABOUT EAST TENNESSEE HISTORICAL SOCIETY Established in 1834, the East Tennessee Historical Society is widely acknowledged as one of the most active history organizations in the state and enjoys a national reputation for excellence in programming and education. For 182 years the East Tennessee Historical Society has been helping East Tennesseans hold on to our unique heritage—recording the events, collecting the artifacts, and saving the stories that comprise the history we all share.


News Article | June 16, 2017
Site: www.prweb.com

Florida Hospital and Lincoln Memorial University (LMU) have partnered to establish an accelerated BSN nursing program in the Tampa Bay area. Both local and national healthcare organizations are experiencing a shortage of nurses. With the deficiency of qualified nurses and the expanding need for them to help with the aging of the “Baby Boomer” generation, there has never been a better time to seek a professional career in the nursing field. Two informational sessions and open houses for interested applicants will be held on June 22nd and June 29th from 2:00 P.M. – 7:00 P.M. at Hunter’s Green Country Club located on 18101 Longwater Run Drive in Tampa, Florida. This fast track program can be completed in as little as 17 months, after general education requirements have been met. LMU is now accepting applications for their first class in Fall 2017 and classes will be held at the new extended learning site located at 3102 East 138th Street in Tampa. The site will offer administrative offices, classrooms, study rooms, a skills laboratory and a library to be utilized for training purposes. The class size for the program will range from 24 to 48 students. LMU prides themselves on being an elite nursing program that produces market ready nurses with unparalleled training that starts graduates off on the right foot in their new profession. LMU’s program prepares nurses for the national board exams and recently had an impressive pass rate of 98% for its December 2016 Bachelor of Science in Nursing (BSN) graduates. Nurses are the foundation of a hospital and at the heart of healthcare. Passionate about helping others, nurses have a rewarding career that creates an opportunity to be an advocate for people in need and make a last impression on their recovery and life. As healthcare becomes more readily available to the public with an aging population and an increase in nurses who are reaching retirement age, the shortage of nurses across the U.S. is a major dilemma in hospitals. “Florida Hospital values this partnership with LMU as they are a leading university in educating future nurses who are ready to be highly successful is this ever-growing field. With over 200 current nursing vacancies across our hospital network, we are in search of individuals who have the desire to provide compassionate care and join the Florida Hospital team. This program enables students to train with our expert clinical teams while learning within our hospitals in a real-world environment. We are glad to assist with their professional development,” said Dr. Robin McGuinness, Senior Executive Officer of Patient Outcomes, Florida Hospital, West Florida Division of the Adventist Health System. Founded in 1897, LMU is a values-based learning community dedicated to providing educational experiences in the liberal arts and professional studies. It’s located in Harrogate, Tennessee about 55 miles north of Knoxville and operates extended learning sites throughout Southern Appalachia. LMU is accredited by the Southern Association of Colleges and Schools Commission on Colleges (SACSCOC) and all programs in the Caylor School of Nursing are accredited by the Accreditation Commission for Education in Nursing (ACEN). In addition to the BSN program, LMU will offer its Associate of Science in Nursing (ASN) and Master of Science in Nursing (MSN) at the Tampa site beginning January 2018. To learn more about LMU nursing degrees, please visit nursing.LMUnet.edu. For more information, call (800) 325-0900 ext. 6324 or stop by the LMU Nursing Information Session on June 22nd and 29th from 2:00 – 7:00 PM at Hunter’s Green Country Club. About Florida Hospital, Adventist Health System, West Florida Division Florida Hospital, the West Florida Division of Adventist Health System, is a not-for-profit 1,295-bed hospital system composed of 9 hospitals including Florida Hospital Tampa/Florida Hospital Pepin Heart Institute, Florida Hospital Carrollwood, Florida Hospital at Connerton Long Term Acute Care, Florida Hospital North Pinellas, Florida Hospital Wesley Chapel, Florida Hospital Zephyrhills, Florida Hospital Heartland Medical Center Sebring, Florida Hospital Heartland Medical Center Lake Placid and Florida Hospital Wauchula. It also includes a free-standing ER in Palm Harbor. Part of the Adventist Health System, Florida Hospital is a leading health network comprised of 26 hospitals throughout the state. For more information, visit FloridaHospital.com. About Lincoln Memorial University Lincoln Memorial University is a values-based learning community dedicated to providing educational experiences in the liberal arts and professional studies. The main campus is located in Harrogate, Tennessee. For more information about the undergraduate and graduate programs available at LMU, contact the Office of Admissions at 423.869.6280 or e-mail at admissions(at)LMUnet(dot)edu.


News Article | November 15, 2016
Site: www.prweb.com

Florida Hospital and Lincoln Memorial University (LMU) are partnering to create an extended learning site for the LMU-Caylor School of Nursing in the West Florida Region. This partnership will establish synergy for continuous quality improvement in both education and the practice of nursing. The United States is projected to experience a shortage of registered nurses (RN) that is expected to intensify as “Baby Boomers” age and the need for health care grows. According to the American Association of Colleges of Nursing (AACN), nursing school enrollments are not growing fast enough to meet the projected demand for RN and Advanced Practice Registered Nurse (APRN) services. In addition, high nurse turnover and vacancy rates are affecting access to health care. “There is a significant nursing shortage problem nationally. In Florida, we’ve seen an increase of over 30% since 2013. In our hospital system, we have more than 300 vacancies at this time. We are excited to launch this partnership with LMU, a university with an excellent reputation and pass rates. They are also known for their distinguished faculty that are professional educators as well as practitioners in the field of nursing. By joining together, we strengthen nursing practices within our facilities and can help close the gap by filling positions. The clinical students will have the opportunity to learn and train with the best,” said Mike Schultz, Florida Hospital West Florida Region President and CEO. Founded in 1897, LMU is a values-based learning community dedicated to providing educational experiences in the liberal arts and professional studies. It’s located in Harrogate, Tennessee about 55 miles north of Knoxville and operates extended learning sites throughout Southern Appalachia. LMU is accredited by the Southern Association of Colleges and Schools Commission on Colleges (SACSCOC) and all programs in the Caylor School of Nursing are accredited by the Accreditation Commission for Education in Nursing (ACEN). “Nearly 120 years ago LMU was founded by visionary individuals who formed a partnership for the purpose of providing educational opportunities to underserved populations. In the years that have followed, the institution has evolved while continuing to serve its mission. Nearly every growth initiative the University has experienced started with a partnership,” said LMU President B. James Dawson. “That is why we are proud to have found a dynamic new partner in Florida Hospital to help us deliver educational opportunities to clinical students. The LMU-Caylor School of Nursing was built on excellence. We are proud that LMU nurses continue to be in-demand and enjoy excellent employment and pass rates, but the benchmark upon which our legacy has been established is the excellent patient care delivered through the hands of our alumni,” said Dawson. Together, Florida Hospital and the LMU-Caylor School of Nursing will start by offering an accelerated Bachelor of Science in Nursing (BSN) program designed to be completed in 16 months, after general education requirements have been met. Additional degree programs will be offered as well. Admissions to the various degree programs would be available at different times throughout the year, increasing the number of students per year. The class size for these programs would consist of 24 to 48 students per class. All clinical experiences are currently planned to be completed and contained within the Florida Hospital West Florida Region facilities. Clinical students would benefit from having direct access to learn and train at Florida Hospital facilities throughout the West Florida Region. Florida Hospital will continue to work with all area nursing schools to help provide clinical spots for student training. These degree offerings by the LMU-Caylor School of Nursing, Florida Hospital Tampa site will be located at 3102 East 138th Street Tampa, Florida 33613. The location will include administrative offices, classrooms, study rooms, a skills laboratory, and library. The plan is to host an official ground breaking ceremony which will be announced in the near future. To learn more about LMU Nursing and degree programs offered please visit: nursing.LMUnet.edu About Florida Hospital West Florida Region The Florida Hospital West Florida Region is a not- for- profit 1,295-bed hospital system composed of Florida Hospital Tampa/Pepin Heart Institute, Florida Hospital Carrollwood, Florida Hospital at Connerton Long Term Acute Care, Florida Hospital North Pinellas, Florida Hospital Wesley Chapel, Florida Hospital Zephyrhills, Florida Hospital Heartland Medical Center Sebring, Florida Hospital Heartland Medical Center Lake Placid and Florida Hospital Wauchula. Part of the Adventist Health System, Florida Hospital is a leading health network comprised of 26 hospitals throughout the state. For more information, visit FloridaHospital.com. About Lincoln Memorial University Lincoln Memorial University is a values-based learning community dedicated to providing educational experiences in the liberal arts and professional studies. The main campus is located in Harrogate, Tennessee. For more information about the undergraduate and graduate programs available at LMU, contact the Office of Admissions at 423.869.6280 or e-mail at admissions(at)LMUnet(dot)edu.


News Article | November 28, 2016
Site: www.prweb.com

The Human Animal Bond Research Initiative (HABRI) announced today it has awarded a $27,000 grant to Lincoln Memorial University, for a study titled, Measuring the Impact of a Mutually Reinforcing Relationship Between Pet Owners and Their Pets. This research project will analyze data collected via a series of public health fairs and develop a general model of health and wellness behavior to examine the relationship between the health of humans and their pets and whether patterns of health and health-associated behaviors are similar. It is anticipated that the model will help determine that pets share the same health benefits and risks as their owners. “Healthy pets make healthy people,” said HABRI Executive Director Steve Feldman. “Lincoln Memorial University can help us establish this important connection so that the human-animal bond is universally accepted as an essential element of human wellness.” The one-year pilot study will aim to obtain data sufficient to describe the current state of health and health associated behaviors in pet owner-pet pairs in the Cumberland Gap Region (CGR) of Kentucky, Tennessee and Virginia. Health metric data including body weight, heart rate, blood pressure and height will be collected for 300 human subjects and their pet dogs or cats through conducting a series of public health fairs. The investigators seek to use the data to formulate a general model of health and health associated behavior. “Few studies have simultaneously investigated the health and health promoting behaviors of owners and pets,” said principal investigator Dr. Charles Faulkner, Associate Professor of Veterinary Medicine at Lincoln Memorial University. “We believe the model developed in this study will help provide evidence that the relationship between humans and companion animals mutually reinforces their health and quality of life. This is especially important in a geographic region where residents rank at the bottom in health outcomes for heart disease, hypertension, diabetes and lack of physical activity.” The HABRI Foundation maintains the world’s largest online library of human-animal bond research and information; to date has funded more than $750,000 dollars in innovative research projects to scientifically document the health benefits of companion animals; and informs the public about human-animal bond research and the beneficial role of companion animals in society. For more information about the HABRI Foundation, visit http://www.habri.org. Lincoln Memorial University (LMU) is a values-based learning community dedicated to providing educational experiences in the liberal arts and professional studies. The LMU-College of Veterinary Medicine is located on LMU’s main campus in Harrogate, Tennessee, with additional academic facilities in nearby Lee County, Virginia. LMU-CVM is an integral part of the University’s medical programs and provides real-world, community-based education in a collaborative learning environment. For more information about LMU-CVM, call 1-800-325-0900, ext. 7150 or visit us online at vetmed.LMUnet.edu. ###


News Article | April 19, 2016
Site: www.sciencenews.org

ATLANTA — Homo naledi, a rock star among fossil species in the human genus, has made an encore. Its return highlighted debate over whether this hominid was a distinct Homo species that purposefully disposed of at least some of its dead. H. naledi made worldwide headlines last year when researchers announced the discovery of an unusually large collection of odd-looking Homo fossils in the bowels of a South African cave system. Presentations at the annual meeting of the American Association of Physical Anthropologists on April 16 underscored key uncertainties about the hominid. One of the biggest mysteries: H. naledi’s age. Efforts are under way to date the fossils and sediment from which they were excavated with a variety of techniques, said paleoanthropologist John Hawks of the University of Wisconsin–Madison. An initial age estimate may come later this year if different dating techniques converge on a consistent figure. A solid date for the fossils is essential for deciphering their place in Homo evolution and how the bones came to rest in a nearly inaccessible cave. Some presenters reasserted that H. naledi intentionally dropped dead comrades into an underground chamber, where their bones were later found by cave explorers and then scientists. But others raised questions. Even paleoanthropologist and team leader Lee Berger of the University of the Witwatersrand in Johannesburg hedged his bets. “It’s way too early to tell how H. naledi bodies got in the chamber,” Berger said. Berger’s group recovered 1,550 H. naledi fossils from a minimum of 15 individuals of all age groups (SN: 10/3/15, p. 6). Slender researchers wended through narrow passageways in South Africa’s Rising Star cave system and squeezed down a vertical chute to reach pitch-dark Dinaledi Chamber. There, they found hominid fossils scattered on the floor and in a shallow, 20-centimeter-deep excavation. Berger’s team assigned the bones to H. naledi based on an unexpected mix of humanlike features and traits typical of Australopithecus species from more than 3 million years ago. Fossil analyses presented at the meeting challenged a suggestion by some researchers, both before and during the meeting, that H. naledi actually represents a variant of Homo erectus, a species known to have existed by 1.8 million years ago (SN: 11/16/13, p. 6). H. naledi possessed a shoulder unlike those of other Homo species, said team member Elen Feuerriegel of the Australian National University in Canberra. The Rising Star hominid’s collarbone and upper arm bone resemble corresponding Australopithecus bones, she reported. H. naledi’s shoulder blades must have been positioned low and behind the chest, an arrangement more conducive to climbing trees than running long distances. H. naledi’s hand was built both for climbing and gripping stone implements, said Tracy Kivell of the University of Kent in England. Her analysis of 150 hand bones, including a nearly complete hand, showed a humanlike wrist and thumb combined with Australopithecus-like curved fingers. H. naledi’s curved toes and flaring pelvis also recall Australopithecus. Still, a preliminary lower-body reconstruction — incorporating fossil evidence of humanlike legs, knees and feet — suggests H. naledi walked almost as well as modern humans do, said Zach Throckmorton of Lincoln Memorial University in Harrogate, Tenn. West Asian H. erectus and H. naledi share several tooth features as well as relatively small braincases. In addition, adult H. naledi stood an estimated 147 centimeters tall (4 feet, 10 inches), within the height range for West Asian H. erectus. “That complicates matters,” said Christopher Walker of Duke University. Upper-body features that Berger’s team considers characteristic of H. naledi, such as the upper arm’s shape, possibly occurred in West Asian H. erectus as well, added Witwatersrand’s Tea Jashashvili, who has studied those finds. Explaining how H. naledi bones ended up in Dinaledi Chamber is also complicated. Ongoing studies of sediment and rock indicate that there was never a direct opening to the underground fossil site from above, said Witwatersrand’s Marina Elliott. Bones from some body parts, including five feet, three hands and part of a backbone, were found aligned as they would have been in living individuals, indicating at least some bodies reached the chamber intact, Hawks said. Curiously, some sets of aligned bones were found beneath scattered bones from diverse individuals. If the dead were dropped down a vertical chute into Dinaledi Chamber, bodies on top would have been least damaged and most likely to retain aligned bones. Along with that mystery, some sets of aligned bones somehow ended up far from the chute’s opening, Berger said. An alternative entrance to Dinaledi Chamber possibly existed in the past, Witwatersrand’s Aurore Val  asserted online March 31 in the Journal of Human Evolution. Beetles or snails that damaged some H. naledi bones don’t inhabit dark, underground caves, Val argues. Such damage probably occurred on the surface or in a nearby, once-accessible part of the cave system, she proposes. The surfaces of many H. naledi fossils had been worn down enough to have possibly erased predators’ tooth marks and signs of animal trampling, which would be additional signs that another entrance to the chamber once existed, Val says. Given the large number of isolated and broken H. naledi fossils, bodies or body parts may have entered the chamber long after death, in Val’s view. Perhaps water from another part of the cave system carried bodies into Dinaledi Chamber, she speculates. Geologic studies show that water occasionally reached the chamber and mildly eroded sediment, Berger said. But he doubts water washed bones into Dinaledi Chamber. “Even if there was another entrance to the chamber, it still allowed access only to Homo naledi,” Berger argued. No remains of any other animals have been found in the cave. Like any rock star of lasting impact, the South African hominid plans to wow fans with new material. “Thousands of Homo naledi fossils are almost certainly left in the underground chamber,” Berger said. Editor’s note: This story was updated April 25, 2016, to correct the identification of organisms that have damaged some H. naledi bones.


Wood P.L.,Lincoln Memorial University
Alzheimer's Research and Therapy | Year: 2012

Alzheimer's disease (AD) is a cognitive disorder with a number of complex neuropathologies, including, but not limited to, neurofibrillary tangles, neuritic plaques, neuronal shrinkage, hypomyelination, neuroinflammation and cholinergic dysfunction. The role of underlying pathological processes in the evolution of the cholinergic deficit responsible for cognitive decline has not been elucidated. Furthermore, generation of testable hypotheses for defining points of pharmacological intervention in AD are complicated by the large scale occurrence of older individuals dying with no cognitive impairment despite having a high burden of AD pathology (plaques and tangles). To further complicate these research challenges, there is no animal model that reproduces the combined hallmark neuropathologies of AD. These research limitations have stimulated the application of 'omics' technologies in AD research with the goals of defining biologic markers of disease and disease progression and uncovering potential points of pharmacological intervention for the design of AD therapeutics. In the case of sporadic AD, the dominant form of dementia, genomics has revealed that the 4 allele of apolipoprotein E, a lipid transport/chaperone protein, is a susceptibility factor. This seminal observation points to the importance of lipid dynamics as an area of investigation in AD. In this regard, lipidomics studies have demonstrated that there are major deficits in brain structural glycerophospholipids and sphingolipids, as well as alterations in metabolites of these complex structural lipids, which act as signaling molecules. Peroxisomal dysfunction appears to be a key component of the changes in glycerophospholipid deficits. In this review, lipid alterations and their potential roles in the pathophysiology of AD are discussed. © 2012 BioMed Central Ltd.


Wood P.L.,Lincoln Memorial University
Neuropsychopharmacology | Year: 2014

Metabolomics research has the potential to provide biomarkers for the detection of disease, for subtyping complex disease populations, for monitoring disease progression and therapy, and for defining new molecular targets for therapeutic intervention. These potentials are far from being realized because of a number of technical, conceptual, financial, and bioinformatics issues. Mass spectrometry provides analytical platforms that address the technical barriers to success in metabolomics research; however, the limited commercial availability of analytical and stable isotope standards has created a bottleneck for the absolute quantitation of a number of metabolites. Conceptual and financial factors contribute to the generation of statistically under-powered clinical studies, whereas bioinformatics issues result in the publication of a large number of unidentified metabolites. The path forward in this field involves targeted metabolomics analyses of large control and patient populations to define both the normal range of a defined metabolite and the potential heterogeneity (eg, bimodal) in complex patient populations. This approach requires that metabolomics research groups, in addition to developing a number of analytical platforms, build sufficient chemistry resources to supply the analytical standards required for absolute metabolite quantitation. Examples of metabolomics evaluations of sulfur amino-acid metabolism in psychiatry, neurology, and neuro-oncology and of lipidomics in neurology will be reviewed. © 2014 American College of Neuropsychopharmacology.


Moncrieff J.,University College London | Leo J.,Lincoln Memorial University
Psychological Medicine | Year: 2010

Background People with schizophrenia are often found to have smaller brains and larger brain ventricles than normal, but the role of antipsychotic medication remains unclear.Method We conducted a systematic review of magnetic resonance imaging (MRI) studies. We included longitudinal studies of brain changes in patients taking antipsychotic drugs and we examined studies of antipsychotic-naive patients for comparison purposes.Results Fourteen out of 26 longitudinal studies showed a decline in global brain or grey-matter volume or an increase in ventricular or cerebrospinal fluid (CSF) volume during the course of drug treatment, including the largest studies conducted. The frontal lobe was most consistently affected, but overall changes were diffuse. One large study found different degrees of volume loss with different antipsychotics, and another found that volume changes were associated with taking medication compared with taking none. Analyses of linear associations between drug exposure and brain volume changes produced mixed results. Five out of 21 studies of patients who were drug naive, or had only minimal prior treatment, showed some differences from controls in volumes of interest. No global differences were reported in three studies of drug-naive patients with long-term illness. Studies of high-risk groups have not demonstrated differences from controls in global or lobar brain volumes.Conclusions Some evidence points towards the possibility that antipsychotic drugs reduce the volume of brain matter and increase ventricular or fluid volume. Antipsychotics may contribute to the genesis of some of the abnormalities usually attributed to schizophrenia. Copyright © Cambridge University Press 2010.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: | Award Amount: 16.69K | Year: 2011

This award will support a planning visit for PI Adam Rollins (Lincoln Memorial University) and co-PI Steven Stephenson (University of Arkansas) to visit three locations in Kenya: the Center for Biodiversity housed at the National Museums of Kenya, the University of Nairobi, and the Maasai Mara National Reserve. The main objective of the proposed trip is for the PI (accompanied by a Lincoln Memorial University undergraduate student) and Co-PI to meet with Dr. George Ndiritu of the National Museums of Kenya and Dr. Francis Mwaura of the University of Nairobi. During the visit, the PIs and the foreign partners will (1) develop plans for future collaborative research centered around the eumycetozoans associated with grasslands and other ecosystems in eastern Africa, (2) begin the process of developing one or more international grant proposals to support the proposed collaborative efforts, (3) collect a preliminary set of samples to generate a set of baseline data, (4) present a workshop and one or more seminars on eumycetozoans to Kenyan university students and museum professionals at the National Museums of Kenya and the University of Nairobi.

Intellectual merit: Relatively little is known about the ecology of microbial communities associated with grassland ecosystems. This is especially true for the eumycetozoans (e.g., myxomycetes and dictyostelids). Only one comprehensive widespread study documenting dictyostelid cellular slime molds has been published relating specifically to this ecosystem (Rollins et al. 2010). Furthermore, there is not a single published paper specifically documenting the occurrence of myxomycetes associated with grassland ecosystems. The PI and Co-PI have a substantial data set documenting the occurrence of myxomycetes in the grasslands of the west-central United States (Rollins and Stephenson, manuscript in preparation), as well as smaller data sets from grassland sites in Belize, Costa Rica, and Australia (unpublished data). In general, very little is known with respect to the eumycetozoans associated with various ecosystems across the continent of Africa. This project would generate a set of preliminary data that would begin to address this void and could ultimately be used to address questions related to the ecological associations and biogeographical patterns associated with eumycetozoans across the continent of Africa and globally.

Broader impact: The planning visit seeks to establish a productive program of collaborative research between two US universities (Lincoln Memorial University in TN and the University of Arkansas in AR) and two Kenyan institutions (the National Museums of Kenya and the University of Nairobi). It is expected that this collaborative effort will produce an international research component that will ultimately benefit both undergraduate and graduate students within the United States and in Kenya. If funded, this planning visit would specifically benefit an undergraduate student from Lincoln Memorial University by providing the student with international experience in presenting information about their research experiences to Kenyan students and scientists as part of the training workshop component. Collectively, the experiences of the proposed trip would greatly benefit the student by exposing him/her to an international collaborative research effort, in turn strengthening the student?s concepts related to scientific methodologies, critical thinking skills, and cultural diversity.

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