LIMSAR

Angamaly, India
Angamaly, India
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Jinu K.V.,LIMSAR | Archana R.,Saveetha University | Sailesh K.S.,LIMSAR | Mukkadan J.K.,Little Flower Medical Research Center
International Journal of Research in Ayurveda and Pharmacy | Year: 2016

Pomegranate is one of the oldest, edible fruit with high nutritional values and has been a part of Mediterranean diet since ancient times. The fruit, bark, roots and leaves of pomegranate are reported to have medicinal benefits. Pomegranate is very rich in various poly-phenols, which are probably responsible for most of the beneficial properties of the fruit. The medicinal properties include, anti-ageing, anti-cancer, anti-diabetic, cardio protective, lipid-lowering, gastro protective, hepatoprotective, anti-trichomonial, anti-nociceptive, anti-diarrheal, anti-viral effects and beneficial effects against neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Neuroprotective effects of Pomegranate extract are reducing accumulation of amyloid plaques in hippocampus, preventing neuronal tissue loss, modulating GABA and glutamate levels, inhibiting acetylcholine esterase and inhibiting lipid peroxidation in brain. Here we review the possible mechanisms by which pomegranate may affect neuro-degeneration, and suggest necessary translational research in this area, for the benefit of neurodegenerative patients and the society in general.


Jacob N.J.,LIMSAR | Pullockara J.K.,Little Flower Hospital And Research Center | Sailesh K.S.,LFMRC | Mukkadan J.K.,LFMRC
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

The incidence of Acute renal failure complicates 30%of the ICU admissions and 5 -10 % requires dialysis .Various traditional dialysis modalities like Continuous Renal Replacement Therapy , Intermittent Hemodialysis are often accompanied by many complications like hypotension. Slow Extended Daily Dialysis is a hybrid dialysis therapy introduced recently for renal failure patients. The present study is a prospective interventional study conducted in Medical ICU of Little Flower Hospital And Research Center ,Kerala in the period of 2013 -2014.74 Acute Renal Failure patients undergoing Slow Extended Daily Dialysis were included in the study .Serum electrolytes ,Arterial Blood Gas values ,Blood Urea Nitrogen ,use of anticoagulants and blood pressure changes were monitored before Slow Extended Daily Dialysis, after Slow Extended Daily Dialysis and at the time of discharge .The results indicated that blood pressure was maintained and there was significant change in the blood urea and serum creatinine levels. The performed study recommends Slow Extended Daily Dialysis as an effective dialysis modality.


Ambili G.,Gandhaki Medical College | Mathew E.,LIMSAR | Kumar S.S.,Travancore Medical College | Soumya M.,JIPMER | And 2 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Vascular disorders accounts for the major cause of mortality in the world. Stroke is the second most frequent cause of death worldwide, accounting for 6.2 million deaths of total. It is ranked after heart disease and before cancer. The present study was undertaken to assess the in-hospital outcome of ischemic stroke, to compare the initial stroke severity with outcome, to assess the mortality in patients with ischemic stroke. We conclude that there is significant association between therapeutic compliance and outcome of ischemic stroke, early identification and management should be considered for patients with ischemic stroke. The study is limited to patients admitted in stroke ICU of Little Flower Hospital, Angamaly so generalization is limited. Hence we recommend further study with longer follow up with higher sample size to get better perceptive on functioning and disability after ischemic stroke.


Padmanabha B.V.,Jazan University | Taj S.,LIMSAR | Kumar S.S.,Travancore Medical College | Soumya M.,JIPMER | Antony N.J.,LIMSAR
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

The present study was undertaken to compare the clinical features and severity of ischemic stroke affecting various areas of brain using neuro-imaging techniques. Based on our results, we conclude that there is no association between aphasia and area of brain affected and no significant association between brain area and facial palsy however the association between type of hemiplegia and brain area involved and association between severities of stroke with hemisphere affected is significant. However small sample size constrains the significance of the results. Hence we recommend further study with higher sample size and long term follow up.


Karthika C.S.,Gandhaki Medical College | Shabna P.M.,LIMSAR | Padmanabha,Jazan University | Kumar S.S.,Travancore Medical College | And 2 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

The present study was undertaken to assess the prevalence of diastolic dysfunction in hypertensive patients and to determine the association of diastolic dysfunction and hypertension with selected clinical variables. We conclude that the prevalence of diastolic dysfunction among hypertensive patients was alarmingly high and there is no correlation between gender, occupation with diastolic dysfunction and prevalence rate of diastolic dysfunction was significantly higher among the 30% of hypertensive patients.ie; those within 30 to 50 years of age range. The study group consisted of small homogeneous group of hypertensives. Hence, the prevalence of diastolic dysfunction obtained in the current study may not be identical when applied to a larger or different population of hypertensives. Hence we recommend further study with larger population to confirm the results.


Ambili G.,Gandhaki Medical College | Mathew E.,LIMSAR | Kumar S.S.,Travancore Medical College | Soumya M.,JIPMER | And 2 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Myocardial infarction commonly known as heart attack occurs when the blood supply to the heart is interrupted. This is most commonly due to occlusion of a coronary artery following the rupture of a atherosclerotic plaque, which is an unstable collection of lipids and white blood cells in the wall of an artery. The resulting ischemia, if left untreated can cause damage or death of heart muscle tissue or myocardium. The present study was undertaken to evaluate the hemodynamic responses in myocardial infarction and to compare the pulse & blood pressure changes in anterior wall MI & inferior wall MI. From the above study, I concluded that base line BP, pulse rate, mean BP, pulse pressure of patients with anterior wall myocardial infarction are higher when compared with patients having inferior wall myocardial infarction. A small groups of patients were included in the present study. Hence we recommend future study with larger population to confirm the results.


Aswathy G.,LIMSAR | Archana R.,Saveetha Medical College | Sailesh K.S.,Little Flower Institute of Medical science and Research | Mukkadan J.K.,LFMRC
International Journal of Pharma and Bio Sciences | Year: 2015

This study was undertaken to provide an authoritative database for beneficial effects of vestibular stimulation and to suggest vestibular stimulation as a therapy for enhancement of cognition. Vestibular stimulation is performed by caloric vestibular stimulation. Scopolamine is used to induce partial amnesia. T-maze task is used to record acquisition and retention of the memory score before and after vestibular stimulation. Memory scores were significantly different between scopolamine induced amnesia control and hot water vestibular stimulation groups (p <0.05). Memory scores between scopolamine induced amnesia cold and hot vestibular stimulation groups were highly significant. (p value <0.05). This study categorically confirms that caloric vestibular stimulation with hot water enhances cognition. Hence this study certainly merits further studies with higher sample size to confirm whether caloric vestibular stimulation can be recommended for enhancement of cognition.


Karthika C.S.,Gandhaki Medical College | Varghese S.,LIMSAR | Padmanabha,Jazan University | Kumar S.S.,Travancore Medical College | And 2 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

The present study was undertaken to assess the complications after ischemic stroke, to find the most common types, severity and frequency of complications associated with ischemic stroke, to compare the incidence of direct and indirect complications of stroke and to find the association of complications of stroke with demographic and clinical variables. We conclude that there is significant association between complications and socio-demographic and clinical variables.


Priya Roy P.,Korea Institute of Materials Science | Jadhav S.D.,VKPMC | Sailesh K.S.,LIMSAR | Doshi M.A.,Korea Institute of Materials Science | Ambali M.P.,Korea Institute of Materials Science
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

We have undertaken the present study to conduct morphometric analysis of supraorbital and infraorbital foramen and highlight its clinical implications. 120 dry skulls of both sexes without mandible of unknown age were studied. Distance of both foramen relative to different surgical landmarks were studied. Variations were evaluated according to gender and side. The location, shape, size, direction and number of accessory foramina were observed. All measurements were taken bilaterally. Supraorbital notch was present bilaterally in 35% of skulls. Majority of skull have foramen or absent foramen on one side and notch on the other side. In 5% of the skulls foramen was present bilaterally. We conclude that knowledge of supraorbital foramen and infraorbital foramen is important in different maxillofacial surgeries and regional anaesthesia of that part.

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