Limestone College is a private four-year, coeducational liberal arts college located in Gaffney, South Carolina. Limestone College is a Christian non-denominational college with programs leading to the Bachelor of Arts, Bachelor of Science, Bachelor of Social Work, Associate of Arts, Associate of Science, and Masters in Business Administration degrees.Limestone was established in 1845 by Dr. Thomas Curtis and his son, Dr. William Curtis, distinguished scholars born and educated in England. Limestone was the first women's college in South Carolina, and one of the first in the nation. Ten buildings on the campus, as well as the Limestone Springs and limestone quarry itself, are on the National Register of Historic Places. In the 1960s, Limestone became fully coeducational, and today student enrollment is about 55:45 male:female. It is the third-oldest college in South Carolina.The college has expanded with branch campuses in Yemassee, Greer, Charleston, Kingstree, Graniteville, Florence, and Columbia that offer evening classes. Wikipedia.
News Article | February 15, 2017
The Intercollegiate Men’s Lacrosse Coaches Association (IMLCA), the National Governing Body of Men’s Lacrosse, has formed a strategic alliance with Lacrosse Masters, a consulting and marketing firm. The alliance will afford the coaches association with business management and operational improvements, as well as expand awareness of the association and IMLCA brand. “We are excited about this new relationship with Lacrosse Masters. We expect this alliance will enhance our growing membership base, as we are able to provide more meaningful benefits to all of our constituents," said Coach J.B. Clarke, President of the IMLCA and Head Lacrosse Coach at Limestone College. “The college game drives the sport of Lacrosse, and representing the strongest and leading professional coaches in the sport is both an honor and a privilege. We have aligned with the IMLCA’s new strategic plan in order to help support its world class coaches and develop the IMLCA into the premier organization in the sport,” said Graham Leveston, Co-founder of Lacrosse Masters. Lacrosse Masters will lead the integration and implementation of the IMLCA’s strategic plan, secure partnerships that align with the IMLCA’s values and vision, coordinate and organize the IMLCA annual convention and support the IMLCA’s efforts to become the premier organization in the sport. “Lacrosse Masters provides us the operational excellence needed to execute at all levels of our new strategic plan. They have an in-depth understanding of how we operate as coaches. They understand how important a brand is and will be an integral part of growing the IMLCA brand in the men’s game,” said Coach Mike Murphy, First Vice President of the IMLCA and Head Coach at the University of Pennsylvania. The IMCLA: The IMLCA was created to help build the game of lacrosse, become the premier organization providing coaches development and monitor the integrity of the game. Its membership is comprised of individual collegiate coaches. To further expose its value, the IMLCA has created relationships with the high school boy’s lacrosse coaches and the collegiate club lacrosse coaches so that they too can benefit from the initiatives of the Association, http://www.LacrosseCoaches.org Lacrosse Masters Lacrosse Masters is a full service sports marketing and representation firm. Areas of focus include brand development and awareness, endorsements, sponsorship sales and the management of several of the nation’s top instructional Lacrosse prospect camps,http://www.LacrosseMasters.com
Liu S.,Limestone College |
Monks N.R.,Limestone College |
Hanes J.W.,Cornell University |
Begley T.P.,Cornell University |
And 2 more authors.
Cancer Chemotherapy and Pharmacology | Year: 2010
Purpose: We have previously shown that the expression of the thiamine transporter THTR2 is decreased sevenfold in breast cancer, which may leave breast cancer cells vulnerable to acute thiamine starvation. This concept was supported by the observation that MDA231 breast cancer xenografts demonstrated growth inhibition in mice fed a thiamine-free diet. Methods: We purified recombinant Bacillus thiaminolyticus thiaminase I enzyme, which digests thiamine, to study acute thiamine starvation in breast cancer. Results: Thiaminase I enzyme was cytotoxic in six breast cancer cell lines with IC 50s ranging from 0.012 to 0.022 U/ml. The growth inhibitory effects of the combination of thiaminase I with either doxorubicin or paclitaxel were also examined. Over a wide range of drug concentrations, thiaminase 1 was consistently synergistic or additive with doxorubicin and paclitaxel in MCF-7, ZR75, HS578T and T47D cell lines, with most combinations having a calculated combination index (CI) of less than 0.8, indicating synergy. Although thiaminase I exposure did not stimulate the energy-sensing signaling kinases AKT, AMPK and GSK-3β in MCF-7, ZR75, HS578T and T47D cell lines, thiaminase I exposure did stimulate expression of the ER stress response protein GRP78. In summary, thiaminase I is cytotoxic in breast cancer cell lines and triggers the unfolded protein response. Conclusion: These findings suggest that THTR2 downregulation in breast tumors may present a nutritional vulnerability that could be exploited by thiaminase I enzyme therapy. © Springer-Verlag 2009.
Fillmore P.T.,University of South Carolina |
Phillips-Meek M.C.,University of South Carolina |
Phillips-Meek M.C.,Limestone College |
Richards J.E.,University of South Carolina
Frontiers in Aging Neuroscience | Year: 2015
This study created and tested a database of adult, age-specific MRI brain and head templates. The participants included healthy adults from 20 through 89 years of age. The templates were done in 5-year, 10-year, and multi-year intervals from 20 through 89 years, and consist of average T1W for the head and brain, and segmenting priors for GM, WM, and CSF. It was found that age-appropriate templates provided less biased tissue classification estimates than ageinappropriate reference data and reference data based on young adult templates. This database is available for use by other investigators and clinicians for their MRI studies, as well as other types of neuroimaging and electrophysiological research. © 2015 Fillmore, Phillips-meek and Richards.
PubMed | Limestone College, Duke University and University of South Carolina
Type: Journal Article | Journal: NeuroImage | Year: 2015
This article summarizes a life-span neurodevelopmental MRI database. The study of neurostructural development or neurofunctional development has been hampered by the lack of age-appropriate MRI reference volumes. This causes misspecification of segmented data, irregular registrations, and the absence of appropriate stereotaxic volumes. We have created the Neurodevelopmental MRI Database that provides age-specific reference data from 2 weeks through 89 years of age. The data are presented in fine-grained ages (e.g., 3 months intervals through 1 year; 6 months intervals through 19.5 years; 5 year intervals from 20 through 89 years). The base component of the database at each age is an age-specific average MRI template. The average MRI templates are accompanied by segmented partial volume estimates for segmenting priors, and a common stereotaxic atlas for infant, pediatric, and adult participants. The database is available online (http://jerlab.psych.sc.edu/NeurodevelopmentalMRIDatabase/).
News Article | March 1, 2017
(PRLEAP.COM) March 1, 2017 Fort Worth TX FDS, Inc. recently announced that Michael Ziegler has been named Vice President, Product and Client Services. In this role, Mr. Ziegler will be responsible for FDS' reconciliation and claims management solutions as well as the EZ-DME Durable Medical Equipment Billing Solution.Mr. Ziegler has spent over 18 years in the pharmacy technology arena in roles responsible for customer service, operations, product development, business relations, and market analysis. Ziegler earned an MBA with a concentration in International Business from the University of South Carolina Moore School of Business at Columbia, SC and a B.S. in Management Information Technology from Limestone College in Gaffney SC."I am excited to join the team at FDS to continue to provide outstanding customer service and product excellence to community pharmacies," stated Mr. Ziegler. "Managing financial activities including the status of third party claims and payments is critical with today's narrowing margins," said Mr. Ziegler. "As we see the pharmacists' role in the healthcare arena move towards provider status, I am committed to drive our investments in expanding our products including the EZ-DME medical claims billing solution"."Michael has a strong background and understanding in a variety of pharmacy market segments including Retail Pharmacy, Home Medical Equipment, and Long-Term Care," said Peter Fianu, President of FDS. "We feel confident that his experience working with community pharmacies will help FDS to continue expanding our business and maintain service level excellence."About FDS, Inc.:FDS, Inc. offers professional, comprehensive and affordable business solutions that immediately impact your profitability by providing tools to manage your patients, third party receivables, Star Ratings, medication adherence, DIR fees and much, much more. FDS' leading edge business analytics tools are simple to use but provide a robust array of dashboards and graphical reports to make your data meaningful and useful. FDS products and services help you connect to your patients 24 hours a day, analyze and better understand your business and manage your patients. For additional information or to request a demonstration, please visit our website at: www.fdsrx.com or call us at 877.602.4179.
Fry C.S.,Limestone College |
Lee J.D.,Limestone College |
Jackson J.R.,Limestone College |
Kirby T.J.,University of Kentucky |
And 6 more authors.
FASEB Journal | Year: 2014
Our aim in the current study was to determine the necessity of satellite cells for long-term muscle growth and maintenance. We utilized a transgenic Pax7-DTA mouse model, allowing for the conditional depletion of > 90% of satellite cells with tamoxifen treatment. Synergist ablation surgery, where removal of synergist muscles places functional overload on the plantaris, was used to stimulate robust hypertrophy. Following 8 wk of overload, satellite celldepleted muscle demonstrated an accumulation of extracellular matrix (ECM) and fibroblast expansion that resulted in reduced specific force of the plantaris. Although the early growth response was normal, an attenuation of hypertrophy measured by both muscle wet weight and fiber cross-sectional area occurred in satellite cell-depleted muscle. Isolated primary myogenic progenitor cells (MPCs) negatively regulated fibroblast ECM mRNA expression in vitro, suggesting a novel role for activated satellite cells/MPCs in muscle adaptation. These results provide evidence that satellite cells regulate the muscle environment during growth. © FASEB.
McGovern T.M.,Clemson University |
McGovern T.M.,Limestone College |
Keever C.C.,Simon Fraser University |
Saski C.A.,Clemson University |
And 2 more authors.
Molecular Ecology | Year: 2010
Coalescent samplers are computational time machines for inferring the historical demographic genetic processes that have given rise to observable patterns of spatial genetic variation among contemporary populations. We have used traditional characterizations of population structure and coalescent-based inferences about demographic processes to reconstruct the population histories of two co-distributed marine species, the frilled dog whelk, Nucella lamellosa, and the bat star, Patiria miniata. Analyses of population structure were consistent with previous work in both species except that additional samples of N.lamellosa showed a larger regional genetic break on Vancouver Island (VI) rather than between the southern Alexander Archipelago as in P.miniata. Our understanding of the causes, rather than just the patterns, of spatial genetic variation was dramatically improved by coalescent analyses that emphasized variation in population divergence times. Overall, gene flow was greater in bat stars (planktonic development) than snails (benthic development) but spatially homogeneous within species. In both species, these large phylogeographic breaks corresponded to relatively ancient divergence times between populations rather than regionally restricted gene flow. Although only N.lamellosa shows a large break on VI, population separation times on VI are congruent between species, suggesting a similar response to late Pleistocene ice sheet expansion. The absence of a phylogeographic break in P.miniata on VI can be attributed to greater gene flow and larger effective population size in this species. Such insights put the relative significance of gene flow into a more comprehensive historical biogeographic context and have important implications for conservation and landscape genetic studies that emphasize the role of contemporary gene flow and connectivity in shaping patterns of population differentiation. © 2010 Blackwell Publishing Ltd.
Ismail L.,Limestone College
Reference and User Services Quarterly | Year: 2013
This study surveyed adult learners in a graduate social work program to determine their library help-seeking preferences and reasons behind their reluctance to seek help from a librarian. It also investigates the preferred method of seeking library help (online, face-to-face, etc) and whether age and location (students enrolled in the off campus/distance programs) had an impact on these preferences. Findings indicate that librarians are approached last for research help (the first being either their friends/classmates or instructors), that age does have some impact on library helpseeking, and that distance adult learners still preferred to seek librarian help face-to face if this option was available. © 2013 American Library Association. All rights reserved.
PubMed | Limestone College
Type: Journal Article | Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society | Year: 2016
The adenomatous polyposis coli (APC) gene is a known tumor suppressor gene, and mice with mutations in Apc (Apc