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University of Technology of Compiègne, France

Andrejak C.,University of Picardie Jules Verne | Delhaes L.,University of Lille Nord de France | Delhaes L.,University Lille2 | Delhaes L.,Bordeaux University Hospital Center

Recent development of high-throughput sequencing methods has shown that the human respiratory tract (including lower airways) is not sterile as formerly thought, but composed of a previously unappreciated complex microbial community referred as the lung microbiome and composed of bacteria, viruses and fungi. However, many questions remain unresolved, especially in terms of lung microbiome role, its interactions with host but also with environmental pathogens. Although data are still limited, links have already been demonstrated between lung microbiome and chronic respiratory diseases (such as asthma, chronic obstructive pulmonary disease or cystic fibrosis). This lung microbiome appears to play an important role both in disease genesis and evolution, and consequently offers an emerging research field. © 2015 médecine/sciences - Inserm. Source

Hatron P.Y.,University Lille2
Presse médicale (Paris, France : 1983)

Sjögren's syndrome is a chronic inflammatory disorder characterized by lymphocytic infiltration of exocrine glands, mainly the lacrimal and salivary glands. However, extraglandular organ systems may frequently be involved, including the lungs. Although subclinical pulmonary inflammation exists in more than 50% of patients, clinically significant pulmonary involvement affects approximately 10% of patients and may be the first manifestation of the disease. The entire respiratory tract may be involved, with a wide spectrum of manifestations including xerotrachea and bronchial sicca, obstructive small airway disease, various patterns of interstitial lung disease, lymphoinfiltrative or lymphoproliferative lung disease, such as lymphoma (usually of MALT type), pulmonary hypertension, pleural involvement, lung cysts, and pulmonary amyloidosis. Copyright © 2010 Elsevier Masson SAS. All rights reserved. Source

Rodriguez G.,University of Zaragoza | Rodriguez G.,Hospital Clinico Universitario | Rodriguez G.,Instituto Aragones Of Ciencias Of La Salud | Gallego S.,Servicio de Pediatria Hospital Ernest Lluch de Calatayud | And 4 more authors.
Nutricion Hospitalaria

Pediatric obesity has increased dramatically all over the world and nonalcoholic fatty liver disease (NAFLD) is one of the most frequent complications associated with excess adiposity. NAFLD causes serum transaminase elevation and liver disease, which could end up in fibrosis, cirrhosis and eventually hepatocellular carcinoma. NAFLD seems to be associated with the metabolic complications of obesity, mainly insulin resistance. The aim of the present article is to review the role of serum liver enzyme assessment as asuitable non invasive predictor of NAFLD in children. Although serum liver enzyme elevation does not accurately measure liver damage, it may be a valuable and non invasive test to screen NAFLD in children and adolescents and a marker to control NAFLD evolution. To detect NAFLD in obese children and adolescents, transaminases serum concentrations should be routinely determined in these patients. In this sense, it seems necessary to obtain transaminase reference standards for children and adolescents. Source

Mainguet B.,Lille 2 University of Health and Law | Hamon A.,University Lille2 | Descatoire A.,Center Hospitalier Of Roubaix

Introduction: Physical and psychological complications in obese individuals are important and lead to health spending (about 7% in 2011). Two thirds of adult population in Europe have not sufficient physical activity to maintain a satisfactory health state. To induce behavioral change, play on the adapted physical activity program would strengthen feeling of competence, considered as a powerful vector to change these behaviors. Objectives: The main objective is to enhance the sense of competence in the field of adapted physical activity, and long-term goal is to generate commitment in regular practice. Methods: The management is done in Roubaix Hospital (10 weeks, with two sessions per week, one supervised in STEP 1h30 and the other independently walking). Five patients have participated in this study where we measured psychological variables with SEPOB (the emotional, cognitive and behavioural questionnaire of self-efficacy in weight management) and physical variables using a stress test. © 2015, Springer-Verlag France. Source

Madre C.,University Paris Diderot | Serhal L.,University Lille2 | Michaud L.,University Lille2 | Bonnevalle M.,University Lille2 | And 3 more authors.
Journal of Pediatric Gastroenterology and Nutrition

Background: Total esophagogastric dissociation (TED) was first described in 1997 by Bianchi as a new surgical procedure to treat severe gastroesophageal reflux disease (GERD) in children with neurological impairment. Recently, TED has been proposed in other conditions, such as esophageal atresia, esotracheal cleft, or caustic esophageal lesions. Although the long-term results in terms of GERD control have been previously reported, those regarding the nutritional and metabolic status have never been documented. Patients and Methods: All patients without neurological impairment with TED between 1999 and 2004 at Robert Debre Hospital and Jeanne de Flandre Hospital, France, were prospectively investigated, paying particular attention to their metabolic and nutritional status (blood concentration of iron and vitamins A, D, E, and B12; lipid malabsorption; and hyperglycemia test) and growth. Results: Seventeen children underwent TED. Six received primary procedures, whereas 11 were operated on because of severe respiratory diseases or failure to thrive. The mean follow-up was 6 years (range 3-8 years). Two children died (12%). Seven children were weaned from enteral nutrition support, but 5 of them had failure to thrive, steatorrhea, and/or malabsorption of vitamin B12 and/or fat-soluble vitamins. Eight patients had dumping syndrome, which was symptomatic in 6 cases. Conclusions: TED is an effective procedure for treatment of GERD. However, nutritional and metabolic complications including dumping syndrome and chronic digestive malabsorption are frequent after TED, especially after enteral nutrition weaning. A long-term follow-up of these patients is thus necessary and prolonged enteral nutrition support is recommended. Copyright © 2010 by Lippincott Williams & Wilkins. Source

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