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Nord-Pas-de-Calais, France

The Université Lille II is a French university for health, sports, management and law. It is located in Lille, Campus Lille II Droit Santé University of Lille II inherits from the Faculty of Law established as the Université de Douai in 1562. Today, science and technologies are taught in an independent campus of Université de Lille I - USTL, while literature and social science are taught as part of the independent campus of Université de Lille III - Charles de Gaulle. Altogether, the universities of Lille include more than 90,000 students and are the core parts of the European Doctoral College Lille-Nord-Pas de Calais that includes 3,000 PhD Doctorate students supported by university research laboratories.Since 1970, the main campus of University de Lille II in situated in Ronchin, in the southern part of Lille.It includes 24 000 students 1050 faculty members and 830 staff 50 research labs, associated to the European Doctoral College Lille Nord-Pas de Calais 250 courses towards nationally-accredited degrees and 170 courses towards university diploma. Wikipedia.

Bonnet C.T.,Lille 2 University of Health and Law
Journal of Motor Behavior | Year: 2012

Intuitively, a broad stance (i.e., standing with the feet farther apart than usual) should significantly improve postural stability. However, this intuition was not confirmed in quiet stance. Hence, a motion analysis system (markers attached to the trunk and head) and a force platform were used to investigate 13 healthy, young adults who performed 8 trials in standard and broad stances. In broad stance, the medialateral center of pressure (COP) sway mean power frequency was expected to be greater, whereas the variability (standard deviation) of COP, head, and trunk sway and the mean velocity of head and trunk sway was expected to be significantly lower. Accordingly, adoption of a broad stance significantly increased the medialateral mean power frequency of COP sway; decreased the standard deviation of medialateral COP, trunk, and head sway; and decreased the medialateral mean velocity of head sway. A broad stance was also associated with lower variability for head and COP sways in the anteroposterior axis. Unexpectedly, an effect of trial repetition was found for the variability of medialateral trunk sway. This was probably due to the break halfway through the study. In practical terms, broad stance conditions can improve postural control in the medialateral and anteroposterior axes. © 2012 Copyright Taylor and Francis Group, LLC.

Mathurin P.,Lille 2 University of Health and Law | Bataller R.,University of North Carolina at Chapel Hill
Journal of Hepatology | Year: 2015

Alcoholic liver disease (ALD) is the most prevalent cause of advanced liver disease in Europe and is the leading cause of death among adults with excessive alcohol consumption. There is a dose-response relationship between the amount of alcohol consumed and the risk of ALD. The relative risk of cirrhosis increases in subjects who consume more than 25 g/day. The burden of alcohol-attributable liver cirrhosis and liver cancer is high and is entirely preventable. Health agencies should develop population-based policies to reduce the prevalence of harmful and/or hazardous alcohol consumption and foster research in this field to provide new diagnostic and therapeutic tools. Disease progression of patients with ALD is heavily influenced by both genetic and environmental factors. Non-invasive methods for the diagnosis of fibrosis have opened new perspectives in the early detection of advanced ALD in asymptomatic patients. Alcoholic hepatitis, the most severe form of ALD, carries a high short-term mortality (around 30-50% at 3 months). Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis but duration of therapy should be adapted to early response. Liver transplantation is the best option for patients with severe liver dysfunction. However, alcohol relapse after transplantation remains a critical issue and drinking habits of transplanted patients need to be routinely screened. © 2015 Published by Elsevier B.V. on behalf of the European Association for the Study of the Liver.

Capron M.,Lille 2 University of Health and Law
Allergy: European Journal of Allergy and Clinical Immunology | Year: 2011

Vertebrates and helminths have co-evolved for 500 million years, developing mutual adaptation mechanisms between parasites and hosts. Today, however, helminth diseases are among the most neglected communicable diseases. Epidemiological evidence shows that exposure to helminth parasites is inversely correlated with allergy incidence, and helminths induce immune hyporeactivity in both the innate and adaptive systems. The mechanisms include parasite-derived regulatory molecules, the study of which opens new avenues for the control of allergic and autoimmune diseases. © 2011 John Wiley & Sons A/S.

Jardin F.,French Institute of Health and Medical Research | Figeac M.,Lille 2 University of Health and Law
Current Opinion in Oncology | Year: 2013

PURPOSE OF REVIEW: The crucial role of microRNAs (miRNAs) in major biological processes and cancer development has been extensively described. Some stage-specific miRNAs are involved in B-cell differentiation, from the naïve B-cell stage through germinal center maturation. Assuming that lymphoma cells are derived from B cells at different stages of maturation, miRNAs can be considered as both specific markers and putative target genes. Here, we review the most salient recent publications in this field, highlighting the clinical and therapeutic value of miRNAs in lymphomas. RECENT FINDINGS: miRNA array-based experiments have indicated that almost all mature lymphoid malignancies can be characterized by a distinct miRNA profile. Recent works have highlighted the crucial roles of miR-155 and miR-17-92 in the pathogeneses of diffuse large B-cell lymphoma and mantle cell lymphoma, respectively, indicating that they represent promising target genes. Novel mechanisms of miRNA deregulation have also been reported, including recurrent somatic mutations, MYC-driven miRNA repression, and cross-talk with other cells in the microenvironment. SUMMARY: In experimental models, some lymphomas are considered to be addicted to the sustained expression of targetable oncomiRs, such as miR-155 and miR-21. However, despite these results, which provide considerable information regarding lymphoma pathogenesis, the integration of miRNA analysis for lymphoma diagnosis or treatment in daily practice remains challenging. © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Williams J.,French Institute of Health and Medical Research | Amouyel P.,French Institute of Health and Medical Research | Amouyel P.,Lille 2 University of Health and Law | Amouyel P.,Institute Pasteur Of Lille
Nature Genetics | Year: 2013

Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer's disease cases and 37,154 controls. In stage 2, 11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer's disease cases and 11,312 controls. In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10-8) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.

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