LifeScan, Inc. is a Johnson & Johnson company headquartered in Milpitas, California.LifeScan manufactures and markets Blood Glucose Monitoring Systems like the OneTouch Ultra family for home and hospital use. The company philosophy is to "create a world without limits for people with diabetes."LifeScan also has facilities in Inverness, Scotland; Burnaby, British Columbia, Canada; and Cabo Rojo, Puerto Rico. Animas Corporation of West Chester, Pennsylvania, acquired by Johnson & Johnson in 2006, reports to LifeScan. Animas produces and develops insulin pumps for people with diabetes. It is also developing a facility in Aguadilla in Puerto Rico for the production of test strips. Wikipedia.

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A method of determining glucose concentration in blood using a test strip biosensor in which a specified sampling time is extracted from a measured hematocrit.


Patent
LifeScan | Date: 2017-07-19

The present invention relates to the field of pluripotent stem cell culture and methods facilitate pluripotent stem cell culture at industrial levels.


Patent
LifeScan | Date: 2017-07-05

A method of determining a corrected glucose concentration in view of a hematocrit level is provided herein. The method comprises:introducing a sample to an electrochemical cell that includes a first electrode and a second electrode;applying a first test voltage Vi for a first time interval Ti between the first electrode and the second electrode, sufficient to measure a relatively small amount of current;applying a second test voltage V_(2) for a second time interval T_(2) between the first electrode and the second electrode sufficient to at least partially oxidize a reduced mediator at the second electrode, wherein the second test voltage V_(2) is applied after the first test voltage Vi;applying a third test voltage V_(3) for a third time interval T_(3) between the first electrode and the second electrode sufficient to at least partially oxidize the reduced mediator at the first electrode;calculating an initial analyte concentration of the sample based on test current values determined during the second time interval T_(2) and the third time interval T_(3) ;calculating an error source of the sample; andcalculating a corrected analyte concentration based on the initial analyte concentration and the error source,wherein the analyte is glucose and the error source is a hematocrit level H of the sample, such that the corrected glucose concentration G_(2) is based on the initial glucose concentration G_(i) and the hematocrit level H.


A hand-held test meter for use with an analytical test strip in the determination of an analyte in a bodily fluid sample includes a housing, a clock module disposed in the housing, a micro-controller disposed in the housing, a low-distortion signal generation circuit block (LDSGCB) disposed in the housing, and a strip port connector configured to operationally receive the analytical test strip. The LDSGCB includes a signal summation circuit (SSC) sub-block, a resistance-capacitance (RC) filter, and a single operational amplifier. The clock module and micro-controller are configured to generate phase-shifted square wave signals and output the phase-shifted square wave signals to the SSC. The SSC is configured to sum the phase-shifted square wave signals to generate a resultant summed-wave signal and output the resultant summed-wave signal to the RC filter. The RC filter is configured to filter harmonics from the resultant summed-wave signal thereby creating a reduced harmonic distortion signal.


Patent
LifeScan | Date: 2017-03-08

Methods and apparatus for electrochemically determining an analyte concentration value in a physiological sample are disclosed. The methods include using a test strip in which two time-current transients are measured by a meter electrically connected to an electrochemical test strip. Integrative current values are derived from the time-current transients and used in the calculation of analyte concentration.


An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample includes an electrically insulating base layer, an electrically conductive layer disposed on the electrically insulating base layer and including at least one electrode, an enzymatic reagent layer disposed on the at least one electrode, a patterned spacer layer, and a top layer. Moreover, the enzymatic reagent layer includes at least one naphthoquinone-based mediator and FAD-GDH enzyme. The naphthoquinone-based mediator can, for example, be at least one of, 2-naphthalenedione-4-(3-mercapto-1-propane sulfonic acid) and, 2-naphthalenedione-4-(3-mercaptopropionic acid).


A hand-held test meter (100) for use with an analytical test strip (TS, for example, an electrochemical-based analytical test strip) in the determination of an analyte (such as glucose) in a bodily fluid sample (e.g., a whole blood sample) includes a housing (110), a micro-controller (112) disposed in the housing (110), a body portion proximity sensor module (107) disposed at least partially in the housing (110), and a strip port connector (106) configured to operationally receive an analytical test strip (TS). The body portion proximity sensor module (107) of the analytical test strip is configured to sense presence of a users body portion (e.g., a users finger, forearm or palm) within a predetermined distance of the strip port connector (106) and, upon sensing the presence of such a body portion, transmit a signal to the micro-controller (110) indicating the presence of such a body portion. Such signal is used to switch the test meter (100) from a low-power standby mode to a high-power active mode.


Methods for determining a concentration of an analyte in a sample, and the devices and systems used in conjunction with the same, are provided herein. In one exemplary embodiment of a method for determining a concentration of an analyte in a sample, the method includes detecting a presence of a sample in an electrochemical sensor including two electrodes. A fill time of the sample is determined with the two electrodes and a correction factor is calculated in view of at least the fill time. The method also includes reacting an analyte that causes a physical transformation of the analyte between the two electrodes. A concentration of the analyte can then be determined in view of the correction factor with the same two electrodes. Systems and devices that take advantage of the fill time to make analyte concentration determinations are also provided.


An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) and/or a characteristic of the bodily fluid sample (e.g., hematocrit) includes a sample-entry chamber with a sample-application opening disposed on an end edge of the electrochemical-based analytical test strip, and first and second sample-determination chambers, each in direct fluidic communication with the sample-entry chamber. The electrochemical-based analytical test strip also includes first and second electrodes (such as first and second hematocrit electrodes) disposed in the first sample-determination chamber, and a third and fourth electrodes (for example working and reference electrodes) disposed in the second sample-determination chamber. Moreover, the first and second sample-determination chambers intersect the sample-entry chamber perpendicular (or nearly perpendicular) to one another and the first sample-determination chamber also intersects the sample-entry chamber in an aligned manner. The test strip can also include a shield electrode disposed in the sample-entry chamber, wherein the shield electrode is in electrical communication with one of the at least third electrode and fourth electrode.


A method that allow for an accurate glucose concentration with a biosensor by determining the hematocrit of the blood sample and deriving a calibration parameter relating to the biosensor to attain accurate glucose concentration.

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